3TDC | pdb_00003tdc

Crystal Structure of Human Acetyl-CoA carboxylase 2

External Resource: Annotation

Domain Annotation: SCOP/SCOPe Classification
Domain Annotation: ECOD Classification
Domain Annotation: CATH
Protein Family Annotation
Gene Ontology: Gene Product Annotation
InterPro: Protein Family Classification
Pharos: Disease Associations

Domain Annotation: SCOP/SCOPe Classification SCOP-e Database Homepage

Chains	Domain Info	Class	Fold	Superfamily	Family	Domain	Species	Provenance Source (Version)
A	d3tdca1	Alpha and beta proteins (a/b)	ClpP/crotonase	ClpP/crotonase	automated matches	automated matches	human (Homo sapiens ) [TaxId: 9606 ],	SCOPe (2.08)

Domain Annotation: ECOD Classification ECOD Database Homepage

Chains	Family Name	Domain Identifier	Architecture	Possible Homology	Homology	Topology	Family	Provenance Source (Version)
A	Carboxyl_trans_C	e3tdcA1	A: a/b three-layered sandwiches	X: ClpP/crotonase (From Topology)	H: ClpP/crotonase (From Topology)	T: ClpP/crotonase	F: Carboxyl_trans_C	ECOD (1.6)

Domain Annotation: CATH CATH Database Homepage

Chain	Domain	Class	Architecture	Topology	Homology	Provenance Source (Version)
A	3.90.226.10	Alpha Beta	Alpha-Beta Complex	2-enoyl-CoA Hydratase	Chain A, domain 1	CATH (4.3.0)
A	2.40.460.10	Mainly Beta	Beta Barrel	ClpP/crotonase fold	Biotin dependent carboxylase carboxyltransferase	CATH (4.3.0)

Protein Family Annotation Pfam Database Homepage

Chains	Accession	Name	Description	Comments	Source
A	PF01039	Carboxyl transferase domain (Carboxyl_trans)	Carboxyl transferase domain	-	Family

Gene Ontology: Gene Product Annotation Gene Ontology Database Homepage

Chains	Polymer	Molecular Function	Biological Process	Cellular Component
A	Acetyl-CoA carboxylase 2 variant	binding adenyl ribonucleotide binding nucleotide binding purine ribonucleotide binding purine ribonucleoside triphosphate binding nucleoside phosphate binding ion binding purine nucleotide binding anion binding adenyl nucleotide binding ATP binding heterocyclic compound binding carbohydrate derivative binding ribonucleotide binding binding adenyl ribonucleotide binding nucleotide binding purine ribonucleotide binding purine ribonucleoside triphosphate binding nucleoside phosphate binding ion binding purine nucleotide binding anion binding adenyl nucleotide binding ATP binding heterocyclic compound binding carbohydrate derivative binding ribonucleotide binding small molecule binding CoA carboxylase activity acetyl-CoA carboxylase activity ligase activity, forming carbon-carbon bonds catalytic activity ligase activity biotin binding amide binding organic acid binding vitamin binding carboxylic acid binding monocarboxylic acid binding sulfur compound binding cation binding metal ion binding identical protein binding protein binding	response to stimulus response to chemical response to xenobiotic stimulus tricarboxylic acid metabolic process oxoacid metabolic process carboxylic acid metabolic process small molecule metabolic process metabolic process cellular process organic acid metabolic process D-glucose import hexose transmembrane transport transport carbohydrate transport response to stimulus response to chemical response to xenobiotic stimulus tricarboxylic acid metabolic process oxoacid metabolic process carboxylic acid metabolic process small molecule metabolic process metabolic process cellular process organic acid metabolic process D-glucose import hexose transmembrane transport transport carbohydrate transport establishment of localization transmembrane transport localization D-glucose transmembrane transport monosaccharide transmembrane transport carbohydrate transmembrane transport intracellular amino acid homeostasis cellular homeostasis chemical homeostasis homeostatic process intracellular chemical homeostasis intracellular aspartate homeostasis organic acid transmembrane transport organic anion transport lactic acid secretion lactate transmembrane transport carboxylic acid transmembrane transport carboxylic acid transport secretion organic hydroxy compound transport acid secretion organic acid transport lactate transport monocarboxylic acid transport plasma membrane lactate transport malonyl-CoA metabolic process thioester biosynthetic process nucleobase-containing compound metabolic process acyl-CoA metabolic process nucleobase-containing small molecule metabolic process purine-containing compound biosynthetic process acyl-CoA biosynthetic process malonyl-CoA biosynthetic process phosphate-containing compound metabolic process sulfur compound metabolic process amide metabolic process thioester metabolic process phosphorus metabolic process nucleoside phosphate metabolic process primary metabolic process amide biosynthetic process nucleobase-containing compound biosynthetic process purine-containing compound metabolic process sulfur compound biosynthetic process biosynthetic process organophosphate metabolic process organophosphate biosynthetic process nucleoside phosphate biosynthetic process protein-containing complex organization protein homotetramerization cellular component organization cellular component biogenesis cellular component assembly protein complex oligomerization protein tetramerization protein-containing complex assembly protein homooligomerization cellular component organization or biogenesis regulation of localization regulation of biological process regulation of cellular process lipid storage biological regulation positive regulation of biological process lipid localization positive regulation of lipid localization regulation of lipid storage regulation of lipid localization macromolecule localization nutrient storage positive regulation of lipid storage positive regulation of cellular process multicellular organismal process multicellular organismal-level homeostasis energy homeostasis intracellular glutamate homeostasis system process striated muscle adaptation regulation of system process regulation of muscle hypertrophy regulation of cardiac muscle hypertrophy in response to stress muscle adaptation cardiac muscle adaptation regulation of response to stress response to stress cardiac muscle hypertrophy regulation of multicellular organismal process cardiac muscle hypertrophy in response to stress muscle hypertrophy regulation of muscle adaptation striated muscle hypertrophy regulation of muscle system process muscle system process regulation of cardiac muscle hypertrophy regulation of response to stimulus regulation of cardiac muscle adaptation muscle hypertrophy in response to stress fatty acid metabolic process monocarboxylic acid biosynthetic process small molecule biosynthetic process lipid biosynthetic process organic acid biosynthetic process fatty acid biosynthetic process carboxylic acid biosynthetic process monocarboxylic acid metabolic process lipid metabolic process nicotinamide nucleotide metabolic process carbohydrate derivative metabolic process generation of precursor metabolites and energy glucose 6-phosphate metabolic process nucleotide metabolic process NADP metabolic process NADPH regeneration purine nucleotide metabolic process pentose-phosphate shunt pyridine-containing compound metabolic process pyridine nucleotide metabolic process lipid modification fatty acid oxidation lipid oxidation regulation of growth regulation of developmental process developmental growth organ growth positive regulation of developmental process multicellular organism development regulation of organ growth regulation of heart growth anatomical structure development positive regulation of developmental growth positive regulation of heart growth system development developmental process heart development heart growth regulation of multicellular organismal development regulation of developmental growth positive regulation of organ growth growth animal organ development circulatory system development positive regulation of growth positive regulation of multicellular organismal process acetyl-CoA metabolic process response to nutrient levels response to nutrient monosaccharide metabolic process carbohydrate metabolic process hexose metabolic process regulation of primary metabolic process regulation of small molecule metabolic process regulation of carbohydrate metabolic process regulation of glucose metabolic process regulation of metabolic process glucose metabolic process catabolic process negative regulation of fatty acid oxidation negative regulation of small molecule metabolic process negative regulation of fatty acid beta-oxidation ketone metabolic process regulation of lipid metabolic process negative regulation of biological process organic acid catabolic process regulation of fatty acid oxidation monocarboxylic acid catabolic process carboxylic acid catabolic process fatty acid beta-oxidation negative regulation of cellular process negative regulation of lipid catabolic process negative regulation of catabolic process lipid catabolic process negative regulation of fatty acid metabolic process negative regulation of metabolic process regulation of fatty acid beta-oxidation regulation of catabolic process regulation of lipid catabolic process regulation of ketone metabolic process fatty acid catabolic process regulation of fatty acid metabolic process small molecule catabolic process negative regulation of lipid metabolic process	membrane-bounded organelle intracellular organelle cellular anatomical structure intracellular anatomical structure mitochondrion organelle cytoplasm intracellular membrane-bounded organelle cytosol mitochondrial protein-containing complex protein-containing complex catalytic complex membrane-enclosed lumen transferase complex membrane-bounded organelle intracellular organelle cellular anatomical structure intracellular anatomical structure mitochondrion organelle cytoplasm intracellular membrane-bounded organelle cytosol mitochondrial protein-containing complex protein-containing complex catalytic complex membrane-enclosed lumen transferase complex mitochondrial matrix intracellular organelle lumen fatty acid beta-oxidation multienzyme complex organelle lumen mitochondrial fatty acid beta-oxidation multienzyme complex oxidoreductase complex mitochondrial membrane membrane organelle outer membrane organelle envelope bounding membrane of organelle mitochondrial envelope mitochondrial outer membrane outer membrane organelle membrane nucleus

InterPro: Protein Family Classification InterPro Database Homepage

Chains	Accession	Name	Type
A	IPR011763	Acetyl-coenzyme A carboxyltransferase, C-terminal	Domain
A	IPR029045	ClpP/crotonase-like domain superfamily	Homologous Superfamily
A	IPR011762	Acetyl-coenzyme A carboxyltransferase, N-terminal	Domain
A	IPR049074	Acetyl-CoA carboxylase, BT domain	Domain
A	IPR011764	Biotin carboxylation domain	Domain
A	IPR034733	Acetyl-coenzyme A carboxylase carboxyl transferase subunit beta	Domain
A	IPR049076	Acetyl-CoA carboxylase	Family
A	IPR011054	Rudiment single hybrid motif	Homologous Superfamily
A	IPR013537	Acetyl-CoA carboxylase, central domain	Domain
A	IPR011053	Single hybrid motif	Homologous Superfamily
A	IPR000089	Biotin/lipoyl attachment	Domain
A	IPR005481	Biotin carboxylase-like, N-terminal domain	Domain
A	IPR011761	ATP-grasp fold	Domain
A	IPR013815	ATP-grasp fold, subdomain 1	Homologous Superfamily
A	IPR005482	Biotin carboxylase, C-terminal	Domain
A	IPR005479	Carbamoyl-phosphate synthetase large subunit-like, ATP-binding domain	Domain
A	IPR016185	Pre-ATP-grasp domain superfamily	Homologous Superfamily

Pharos: Disease Associations Pharos Homepage Annotation

Chains	Drug Target	Associated Disease
A	Pharos: O00763	pancreatic ductal adenocarcinoma Insulin Resistance obesity disorder Sjogren syndrome breast cancer dermatomyositis lung adenocarcinoma malignant glioma medulloblastoma osteosarcoma pilocytic astrocytoma breast carcinoma ductal breast carcinoma in situ invasive ductal breast carcinoma lung cancer pancreatic ductal adenocarcinoma Insulin Resistance obesity disorder Sjogren syndrome breast cancer dermatomyositis lung adenocarcinoma malignant glioma medulloblastoma osteosarcoma pilocytic astrocytoma breast carcinoma ductal breast carcinoma in situ invasive ductal breast carcinoma lung cancer malignant mesothelioma non-small cell lung carcinoma ovarian cancer psoriasis cervical cancer large cell medulloblastoma malignant colon neoplasm malignant pancreatic neoplasm

RCSB PDB Core Operations are funded by the U.S. National Science Foundation (DBI-2321666), the US Department of Energy (DE-SC0019749), and the National Cancer Institute, National Institute of Allergy and Infectious Diseases, and National Institute of General Medical Sciences of the National Institutes of Health under grant R01GM157729.