3RIE
The structure of Plasmodium falciparum spermidine synthase in complex with 5'-methylthioadenosine and N-(3-aminopropyl)-trans-cyclohexane-1,4-diamine
Domain Annotation: SCOP/SCOPe Classification SCOP-e Database Homepage
Chains | Domain Info | Class | Fold | Superfamily | Family | Domain | Species | Provenance Source (Version) |
---|---|---|---|---|---|---|---|---|
B | d3rieb_ | Alpha and beta proteins (a/b) | S-adenosyl-L-methionine-dependent methyltransferases | S-adenosyl-L-methionine-dependent methyltransferases | automated matches | automated matches | (Plasmodium falciparum 3D7 ) [TaxId: 36329 ], | SCOPe (2.08) |
C | d3riec_ | Alpha and beta proteins (a/b) | S-adenosyl-L-methionine-dependent methyltransferases | S-adenosyl-L-methionine-dependent methyltransferases | automated matches | automated matches | (Plasmodium falciparum 3D7 ) [TaxId: 36329 ], | SCOPe (2.08) |
A | d3riea_ | Alpha and beta proteins (a/b) | S-adenosyl-L-methionine-dependent methyltransferases | S-adenosyl-L-methionine-dependent methyltransferases | automated matches | automated matches | (Plasmodium falciparum 3D7 ) [TaxId: 36329 ], | SCOPe (2.08) |
Domain Annotation: SCOP2 Classification SCOP2 Database Homepage
Chains | Type | Family Name | Domain Identifier | Family Identifier | Provenance Source (Version) |
---|---|---|---|---|---|
B | SCOP2B Superfamily | S-adenosyl-L-methionine-dependent methyltransferases | 8061327 | 3000118 | SCOP2B (2022-06-29) |
C | SCOP2B Superfamily | S-adenosyl-L-methionine-dependent methyltransferases | 8061327 | 3000118 | SCOP2B (2022-06-29) |
A | SCOP2B Superfamily | S-adenosyl-L-methionine-dependent methyltransferases | 8061327 | 3000118 | SCOP2B (2022-06-29) |
Domain Annotation: ECOD Classification ECOD Database Homepage
Chains | Family Name | Domain Identifier | Architecture | Possible Homology | Homology | Topology | Family | Provenance Source (Version) |
---|---|---|---|---|---|---|---|---|
B | Spermine_synt_N | e3rieB3 | A: beta meanders | X: Spermidine synthase tetramerisation domain (From Topology) | H: Spermidine synthase tetramerisation domain (From Topology) | T: Spermidine synthase tetramerisation domain | F: Spermine_synt_N | ECOD (1.6) |
B | Spermine_synth | e3rieB2 | A: a/b three-layered sandwiches | X: Rossmann-like | H: Rossmann-related | T: S-adenosyl-L-methionine-dependent methyltransferases | F: Spermine_synth | ECOD (1.6) |
C | Spermine_synt_N | e3rieC3 | A: beta meanders | X: Spermidine synthase tetramerisation domain (From Topology) | H: Spermidine synthase tetramerisation domain (From Topology) | T: Spermidine synthase tetramerisation domain | F: Spermine_synt_N | ECOD (1.6) |
C | Spermine_synth | e3rieC2 | A: a/b three-layered sandwiches | X: Rossmann-like | H: Rossmann-related | T: S-adenosyl-L-methionine-dependent methyltransferases | F: Spermine_synth | ECOD (1.6) |
A | Spermine_synt_N | e3rieA3 | A: beta meanders | X: Spermidine synthase tetramerisation domain (From Topology) | H: Spermidine synthase tetramerisation domain (From Topology) | T: Spermidine synthase tetramerisation domain | F: Spermine_synt_N | ECOD (1.6) |
A | Spermine_synth | e3rieA2 | A: a/b three-layered sandwiches | X: Rossmann-like | H: Rossmann-related | T: S-adenosyl-L-methionine-dependent methyltransferases | F: Spermine_synth | ECOD (1.6) |
Domain Annotation: CATH CATH Database Homepage
Chain | Domain | Class | Architecture | Topology | Homology | Provenance Source (Version) |
---|---|---|---|---|---|---|
B | 2.30.140.10 | Mainly Beta | Roll | Spermidine Synthase | Chain: A, domain 2 | CATH (4.3.0) |
B | 3.40.50.150 | Alpha Beta | 3-Layer(aba) Sandwich | Rossmann fold | Vaccinia Virus protein VP39 | CATH (4.3.0) |
C | 2.30.140.10 | Mainly Beta | Roll | Spermidine Synthase | Chain: A, domain 2 | CATH (4.3.0) |
C | 3.40.50.150 | Alpha Beta | 3-Layer(aba) Sandwich | Rossmann fold | Vaccinia Virus protein VP39 | CATH (4.3.0) |
A | 2.30.140.10 | Mainly Beta | Roll | Spermidine Synthase | Chain: A, domain 2 | CATH (4.3.0) |
A | 3.40.50.150 | Alpha Beta | 3-Layer(aba) Sandwich | Rossmann fold | Vaccinia Virus protein VP39 | CATH (4.3.0) |
Protein Family Annotation Pfam Database Homepage
Chains | Accession | Name | Description | Comments | Source |
---|---|---|---|---|---|
PF17284 | Spermidine synthase tetramerisation domain (Spermine_synt_N) | Spermidine synthase tetramerisation domain | This domain represents the N-terminal tetramerization domain from spermidine synthase. | Domain | |
PF01564 | Spermine/spermidine synthase domain (Spermine_synth) | Spermine/spermidine synthase domain | Spermine and spermidine are polyamines. This family includes spermidine synthase that catalyses the fifth (last) step in the biosynthesis of spermidine from arginine, and spermine synthase. | Domain |
Gene Ontology: Gene Product Annotation Gene Ontology Database Homepage
Chains | Polymer | Molecular Function | Biological Process | Cellular Component |
---|---|---|---|---|
Spermidine synthase |
InterPro: Protein Family Classification InterPro Database Homepage
Chains | Accession | Name | Type |
---|---|---|---|
IPR001045 | Spermidine/spermine synthases | Family | |
IPR029063 | S-adenosyl-L-methionine-dependent methyltransferase superfamily | Homologous Superfamily | |
IPR030374 | Polyamine biosynthesis domain | Domain | |
IPR037163 | Spermidine synthase, tetramerisation domain superfamily | Homologous Superfamily | |
IPR030373 | Polyamine biosynthesis domain, conserved site | Conserved Site | |
IPR035246 | Spermidine synthase, tetramerisation domain | Domain |