Annotations: 3QWY

Domain Annotation: ECOD Classification ECOD Database Homepage

Chains	Family Name	Domain Identifier	Architecture	Possible Homology	Homology	Topology	Family	Provenance Source (Version)
A	SH3_1	e3qwyA1	A: beta barrels	X: SH3	H: SH3	T: SH3	F: SH3_1	ECOD (1.6)
A	SH2	e3qwyA2	A: a+b two layers	X: SH2 (From Topology)	H: SH2 (From Topology)	T: SH2	F: SH2	ECOD (1.6)
B	SH3_1	e3qwyB1	A: beta barrels	X: SH3	H: SH3	T: SH3	F: SH3_1	ECOD (1.6)
B	SH2	e3qwyB2	A: a+b two layers	X: SH2 (From Topology)	H: SH2 (From Topology)	T: SH2	F: SH2	ECOD (1.6)

Domain Annotation: CATH CATH Database Homepage

Chain	Domain	Class	Architecture	Topology	Homology	Provenance Source (Version)
A	3.30.505.10	Alpha Beta	2-Layer Sandwich	SHC Adaptor Protein	SH2 domain	CATH (4.3.0)
A	2.30.30.40	Mainly Beta	Roll	SH3 type barrels.	SH3 Domains	CATH (4.3.0)
B	3.30.505.10	Alpha Beta	2-Layer Sandwich	SHC Adaptor Protein	SH2 domain	CATH (4.3.0)
B	2.30.30.40	Mainly Beta	Roll	SH3 type barrels.	SH3 Domains	CATH (4.3.0)

Protein Family Annotation Pfam Database Homepage

Chains	Accession	Name	Description	Comments	Source
A, B	PF00017	SH2 domain (SH2)	SH2 domain		Domain
A, B	PF00018	SH3 domain (SH3_1)	SH3 domain	SH3 (Src homology 3) domains are often indicative of a protein involved in signal transduction related to cytoskeletal organisation. First described in the Src cytoplasmic tyrosine kinase Swiss:P12931. The structure is a partly opened beta barrel.	Domain

Gene Ontology: Gene Product Annotation Gene Ontology Database Homepage

Chains	Polymer	Molecular Function	Biological Process	Cellular Component
A, B	Cell death abnormality protein 2	protein-macromolecule adaptor activity molecular adaptor activity signaling adaptor activity protein-containing complex binding binding protein tyrosine kinase binding protein binding kinase binding signaling receptor binding receptor tyrosine kinase binding enzyme binding protein kinase binding	apoptotic process involved in development developmental process anatomical structure development cellular process apoptotic process cell death programmed cell death cellular response to stimulus regulation of biological process regulation of cellular process cell surface receptor signaling pathway response to stimulus signaling biological regulation apoptotic process involved in development developmental process anatomical structure development cellular process apoptotic process cell death programmed cell death cellular response to stimulus regulation of biological process regulation of cellular process cell surface receptor signaling pathway response to stimulus signaling biological regulation cell communication signal transduction enzyme-linked receptor protein signaling pathway positive regulation of locomotion regulation of cell motility positive regulation of biological process regulation of distal tip cell migration positive regulation of cell migration distal tip cell migration regulation of locomotion positive regulation of cell motility regulation of cell migration cell migration positive regulation of distal tip cell migration cell motility locomotion positive regulation of cellular process cellular component organization organelle organization actin cytoskeleton organization actin filament-based process cellular component organization or biogenesis cytoskeleton organization import into cell regulation of localization regulation of cellular component organization positive regulation of cellular component organization transport positive regulation of membrane invagination positive regulation of apoptotic cell clearance vesicle-mediated transport engulfment of apoptotic cell localization positive regulation of endocytosis positive regulation of engulfment of apoptotic cell regulation of phagocytosis, engulfment membrane invagination phagocytosis apoptotic cell clearance plasma membrane invagination regulation of endocytosis membrane organization regulation of engulfment of apoptotic cell regulation of transport regulation of phagocytosis regulation of vesicle-mediated transport establishment of localization phagocytosis, engulfment positive regulation of phagocytosis positive regulation of transport positive regulation of phagocytosis, engulfment regulation of membrane invagination endocytosis regulation of apoptotic cell clearance	cell periphery cellular anatomical structure plasma membrane membrane intracellular anatomical structure cytoplasm

InterPro: Protein Family Classification InterPro Database Homepage

Chains	Accession	Name	Type
A, B	IPR036860	SH2 domain superfamily	Homologous Superfamily
A, B	IPR000980	SH2 domain	Domain
A, B	IPR051184	Tyrosine-phosphorylated adapter molecule	Family
A, B	IPR001452	SH3 domain	Domain
A, B	IPR036028	SH3-like domain superfamily	Homologous Superfamily

RCSB PDB Core Operations are funded by the U.S. National Science Foundation (DBI-2321666), the US Department of Energy (DE-SC0019749), and the National Cancer Institute, National Institute of Allergy and Infectious Diseases, and National Institute of General Medical Sciences of the National Institutes of Health under grant R01GM157729.