Domain Annotation: SCOP2 Classification SCOP2 Database Homepage

ChainsTypeFamily Name Domain Identifier Family IdentifierProvenance Source (Version)
BSCOP2B SuperfamilyNucleotide cyclase/DNA polymerase palm domain-like 8036908 3001272 SCOP2B (2022-06-29)
BSCOP2B SuperfamilyNucleotide cyclase/DNA polymerase palm domain-like 8036908 3001272 SCOP2B (2022-06-29)
ASCOP2B SuperfamilyRibonuclease H-like 8044518 3000143 SCOP2B (2022-06-29)
ASCOP2B SuperfamilyNucleotide cyclase/DNA polymerase palm domain-like 8036908 3001272 SCOP2B (2022-06-29)
ASCOP2B SuperfamilyNucleotide cyclase/DNA polymerase palm domain-like 8036908 3001272 SCOP2B (2022-06-29)

Domain Annotation: ECOD Classification ECOD Database Homepage

ChainsFamily NameDomain Identifier ArchitecturePossible HomologyHomologyTopologyFamilyProvenance Source (Version)
BRVT_thumbe3medB1 A: alpha bundlesX: helical bundle domain in reverse transcriptase-like polymerases (From Topology)H: helical bundle domain in reverse transcriptase-like polymerases (From Topology)T: helical bundle domain in reverse transcriptase-like polymerasesF: RVT_thumbECOD (1.6)
BRVT_1e3medB2 A: a+b two layersX: Alpha-beta plaitsH: Adenylyl and guanylyl cyclase catalytic domain-likeT: Adenylyl and guanylyl cyclase catalytic domain-likeF: RVT_1ECOD (1.6)
BRVT_connecte3medB3 A: mixed a+b and a/bX: Ribonuclease H-likeH: RNaseH-like domain in reverse transcriptase (From Topology)T: RNaseH-like domain in reverse transcriptaseF: RVT_connectECOD (1.6)
ARVT_thumbe3medA7 A: alpha bundlesX: helical bundle domain in reverse transcriptase-like polymerases (From Topology)H: helical bundle domain in reverse transcriptase-like polymerases (From Topology)T: helical bundle domain in reverse transcriptase-like polymerasesF: RVT_thumbECOD (1.6)
ARVT_1e3medA8 A: a+b two layersX: Alpha-beta plaitsH: Adenylyl and guanylyl cyclase catalytic domain-likeT: Adenylyl and guanylyl cyclase catalytic domain-likeF: RVT_1ECOD (1.6)
ARNase_He3medA6 A: mixed a+b and a/bX: Ribonuclease H-likeH: Ribonuclease H-like (From Topology)T: Ribonuclease H-likeF: RNase_HECOD (1.6)
ARVT_connecte3medA5 A: mixed a+b and a/bX: Ribonuclease H-likeH: RNaseH-like domain in reverse transcriptase (From Topology)T: RNaseH-like domain in reverse transcriptaseF: RVT_connectECOD (1.6)

Domain Annotation: CATH CATH Database Homepage

Protein Family Annotation Pfam Database Homepage

ChainsAccessionNameDescriptionCommentsSource
PF06817Reverse transcriptase thumb domain (RVT_thumb)Reverse transcriptase thumb domainThis domain is known as the thumb domain. It is composed of a four helix bundle [1].Domain
PF06815Reverse transcriptase connection domain (RVT_connect)Reverse transcriptase connection domainThis domain is known as the connection domain. This domain lies between the thumb and palm domains [1].Domain
PF00078Reverse transcriptase (RNA-dependent DNA polymerase) (RVT_1)Reverse transcriptase (RNA-dependent DNA polymerase)A reverse transcriptase gene is usually indicative of a mobile element such as a retrotransposon or retrovirus. Reverse transcriptases occur in a variety of mobile elements, including retrotransposons, retroviruses, group II introns, bacterial msDNAs ...A reverse transcriptase gene is usually indicative of a mobile element such as a retrotransposon or retrovirus. Reverse transcriptases occur in a variety of mobile elements, including retrotransposons, retroviruses, group II introns, bacterial msDNAs, hepadnaviruses, and caulimoviruses.
Domain
PF06817Reverse transcriptase thumb domain (RVT_thumb)Reverse transcriptase thumb domainThis domain is known as the thumb domain. It is composed of a four helix bundle [1].Domain
PF06815Reverse transcriptase connection domain (RVT_connect)Reverse transcriptase connection domainThis domain is known as the connection domain. This domain lies between the thumb and palm domains [1].Domain
PF00075RNase H (RNase_H)RNase HRNase H digests the RNA strand of an RNA/DNA hybrid. Important enzyme in retroviral replication cycle, and often found as a domain associated with reverse transcriptases. Structure is a mixed alpha+beta fold with three a/b/a layers.Domain
PF00078Reverse transcriptase (RNA-dependent DNA polymerase) (RVT_1)Reverse transcriptase (RNA-dependent DNA polymerase)A reverse transcriptase gene is usually indicative of a mobile element such as a retrotransposon or retrovirus. Reverse transcriptases occur in a variety of mobile elements, including retrotransposons, retroviruses, group II introns, bacterial msDNAs ...A reverse transcriptase gene is usually indicative of a mobile element such as a retrotransposon or retrovirus. Reverse transcriptases occur in a variety of mobile elements, including retrotransposons, retroviruses, group II introns, bacterial msDNAs, hepadnaviruses, and caulimoviruses.
Domain

Gene Ontology: Gene Product Annotation Gene Ontology Database Homepage

ChainsPolymerMolecular FunctionBiological ProcessCellular Component
p51 Reverse transcriptase
p66 Reverse transcriptase

InterPro: Protein Family Classification InterPro Database Homepage

ChainsAccessionNameType
IPR036397Ribonuclease H superfamilyHomologous Superfamily
IPR043128Reverse transcriptase/Diguanylate cyclase domainHomologous Superfamily
IPR001995Peptidase A2A, retrovirus, catalyticDomain
IPR001878Zinc finger, CCHC-typeDomain
IPR008919Retrovirus capsid, N-terminalHomologous Superfamily
IPR012344Matrix protein, lentiviral and alpha-retroviral, N-terminalHomologous Superfamily
IPR036862Integrase, C-terminal domain superfamily, retroviralHomologous Superfamily
IPR018061RetropepsinsDomain
IPR010661Reverse transcriptase thumbDomain
IPR002156Ribonuclease H domainDomain
IPR036875Zinc finger, CCHC-type superfamilyHomologous Superfamily
IPR003308Integrase, N-terminal zinc-binding domainDomain
IPR001584Integrase, catalytic coreDomain
IPR045345Retroviral nucleocapsid Gag protein p24, C-terminal domainDomain
IPR010999Retroviral matrix proteinHomologous Superfamily
IPR021109Aspartic peptidase domain superfamilyHomologous Superfamily
IPR001969Aspartic peptidase, active siteActive Site
IPR012337Ribonuclease H-like superfamilyHomologous Superfamily
IPR017856Integrase-like, N-terminalHomologous Superfamily
IPR000071Immunodeficiency lentiviral matrix, N-terminalDomain
IPR043502DNA/RNA polymerase superfamilyHomologous Superfamily
IPR001037Integrase, C-terminal, retroviralDomain
IPR034170Retropepsin-like catalytic domainDomain
IPR000477Reverse transcriptase domainDomain
IPR010659Reverse transcriptase connectionDomain
IPR008916Retrovirus capsid, C-terminalHomologous Superfamily
IPR036397Ribonuclease H superfamilyHomologous Superfamily
IPR043128Reverse transcriptase/Diguanylate cyclase domainHomologous Superfamily
IPR001995Peptidase A2A, retrovirus, catalyticDomain
IPR001878Zinc finger, CCHC-typeDomain
IPR008919Retrovirus capsid, N-terminalHomologous Superfamily
IPR012344Matrix protein, lentiviral and alpha-retroviral, N-terminalHomologous Superfamily
IPR036862Integrase, C-terminal domain superfamily, retroviralHomologous Superfamily
IPR018061RetropepsinsDomain
IPR010661Reverse transcriptase thumbDomain
IPR002156Ribonuclease H domainDomain
IPR036875Zinc finger, CCHC-type superfamilyHomologous Superfamily
IPR003308Integrase, N-terminal zinc-binding domainDomain
IPR001584Integrase, catalytic coreDomain
IPR045345Retroviral nucleocapsid Gag protein p24, C-terminal domainDomain
IPR010999Retroviral matrix proteinHomologous Superfamily
IPR021109Aspartic peptidase domain superfamilyHomologous Superfamily
IPR001969Aspartic peptidase, active siteActive Site
IPR012337Ribonuclease H-like superfamilyHomologous Superfamily
IPR017856Integrase-like, N-terminalHomologous Superfamily
IPR000071Immunodeficiency lentiviral matrix, N-terminalDomain
IPR043502DNA/RNA polymerase superfamilyHomologous Superfamily
IPR001037Integrase, C-terminal, retroviralDomain
IPR034170Retropepsin-like catalytic domainDomain
IPR000477Reverse transcriptase domainDomain
IPR010659Reverse transcriptase connectionDomain
IPR008916Retrovirus capsid, C-terminalHomologous Superfamily