Annotations: 3BO1

Domain Annotation: SCOP2 Classification SCOP2 Database Homepage

Chains	Type	Family Name	Domain Identifier	Family Identifier	Provenance Source (Version)
E [auth A]	SCOP2B Superfamily	SecY-like	8040629	3000333	SCOP2B (2022-06-29)
F [auth B]	SCOP2B Superfamily	Protein translocase subunit SecE-like	8040630	3002174	SCOP2B (2022-06-29)
G [auth C]	SCOP2B Superfamily	Sec-beta subunit	8040632	3000289	SCOP2B (2022-06-29)

Domain Annotation: ECOD Classification ECOD Database Homepage

Chains	Family Name	Domain Identifier	Architecture	Possible Homology	Homology	Topology	Family	Provenance Source (Version)
E [auth A]	SecY	e3bo1A1	A: alpha complex topology	X: Preprotein translocase SecY subunit (From Topology)	H: Preprotein translocase SecY subunit (From Topology)	T: Preprotein translocase SecY subunit	F: SecY	ECOD (1.6)
F [auth B]	SecE_1	e3bo1B1	A: extended segments	X: Preprotein translocase SecE subunit (From Topology)	H: Preprotein translocase SecE subunit (From Topology)	T: Preprotein translocase SecE subunit	F: SecE_1	ECOD (1.6)
G [auth C]	Sec61_beta	e3bo1C1	A: extended segments	X: Sec-beta subunit (From Topology)	H: Sec-beta subunit (From Topology)	T: Sec-beta subunit	F: Sec61_beta	ECOD (1.6)

Protein Family Annotation Pfam Database Homepage

Chains	Accession	Name	Description	Comments	Source
E [auth A]	PF10559	Plug domain of Sec61p (Plug_translocon)	Plug domain of Sec61p	The Sec61/SecY translocon mediates translocation of proteins across the membrane and integration of membrane proteins into the lipid bilayer. The structure of the translocon revealed a plug domain blocking the pore on the lumenal side.The plug is unl ...	The Sec61/SecY translocon mediates translocation of proteins across the membrane and integration of membrane proteins into the lipid bilayer. The structure of the translocon revealed a plug domain blocking the pore on the lumenal side.The plug is unlikely to be important for sealing the translocation pore in yeast but it plays a role in stabilising Sec61p during translocon formation. The domain runs from residues 52-74 [1].	Domain
E [auth A]	PF00344	SecY (SecY)	SecY	-	Family
F [auth B]	PF00584	SecE/Sec61-gamma subunits of protein translocation complex (SecE)	SecE/Sec61-gamma subunits of protein translocation complex	-	Family
G [auth C]	PF03911	Sec61beta family (Sec61_beta)	Sec61beta family	-	Family

Gene Ontology: Gene Product Annotation Gene Ontology Database Homepage

Chains	Polymer	Molecular Function	Biological Process	Cellular Component
A [auth D]	23S RIBOSOMAL RNA	-	-	-
B [auth E]	23S RIBOSOMAL RNA	-	-	-
C [auth F]	23S RIBOSOMAL RNA	-	-	-
D [auth G]	23S RIBOSOMAL RNA	-	-	-
E [auth A]	PREPROTEIN TRANSLOCASE SecY SUBUNIT	macromolecule transmembrane transporter activity protein transporter activity protein transmembrane transporter activity transporter activity transmembrane transporter activity signal sequence binding binding peptide binding	protein localization establishment of protein localization cellular localization nitrogen compound transport transport protein targeting localization SRP-dependent cotranslational protein targeting to membrane protein transmembrane transport cellular macromolecule localization establishment of localization in cell cotranslational protein targeting to membrane establishment of protein localization to endoplasmic reticulum protein localization to endoplasmic reticulum protein localization establishment of protein localization cellular localization nitrogen compound transport transport protein targeting localization SRP-dependent cotranslational protein targeting to membrane protein transmembrane transport cellular macromolecule localization establishment of localization in cell cotranslational protein targeting to membrane establishment of protein localization to endoplasmic reticulum protein localization to endoplasmic reticulum establishment of protein localization to membrane intracellular protein transmembrane transport intracellular transport localization within membrane protein localization to membrane establishment of localization protein targeting to membrane transmembrane transport establishment of protein localization to organelle protein transport macromolecule localization protein localization to organelle SRP-dependent cotranslational protein targeting to membrane, translocation cellular process intracellular protein transport protein targeting to ER	cell periphery cellular anatomical structure plasma membrane membrane
F [auth B]	PREPROTEIN TRANSLOCASE SecE SUBUNIT	macromolecule transmembrane transporter activity protein transporter activity protein transmembrane transporter activity transporter activity transmembrane transporter activity	protein localization localization establishment of protein localization cellular localization protein targeting cellular macromolecule localization macromolecule localization cellular process establishment of localization nitrogen compound transport transport secretion establishment of protein localization to extracellular region export from cell protein localization localization establishment of protein localization cellular localization protein targeting cellular macromolecule localization macromolecule localization cellular process establishment of localization nitrogen compound transport transport secretion establishment of protein localization to extracellular region export from cell protein secretion protein localization to extracellular region secretion by cell protein transport intracellular protein transmembrane transport intracellular transport transmembrane transport protein transmembrane transport establishment of localization in cell intracellular protein transport	cell periphery cellular anatomical structure plasma membrane membrane
G [auth C]	Preprotein translocase secG subunit	-	protein localization establishment of protein localization cellular localization nitrogen compound transport transport establishment of localization localization protein transport cellular macromolecule localization macromolecule localization cellular process	cell periphery cellular anatomical structure plasma membrane membrane

InterPro: Protein Family Classification InterPro Database Homepage

Chains	Accession	Name	Type
E [auth A]	IPR002208	SecY/SEC61-alpha family	Family
E [auth A]	IPR030659	SecY conserved site	Conserved Site
E [auth A]	IPR026593	Protein translocase subunit SecY	Family
E [auth A]	IPR019561	Translocon Sec61/SecY, plug domain	Domain
E [auth A]	IPR023201	SecY domain superfamily	Homologous Superfamily
F [auth B]	IPR008158	Protein translocase SEC61 complex, gamma subunit	Family
F [auth B]	IPR001901	Protein translocase complex, SecE/Sec61-gamma subunit	Family
F [auth B]	IPR023391	Protein translocase SecE domain superfamily	Homologous Superfamily
G [auth C]	IPR016482	Protein transport protein SecG/Sec61-beta/Sbh	Family
G [auth C]	IPR023531	Preprotein translocase subunit SecG	Family

Membrane Protein Annotation: PDBTM PDBTM Database Homepage

Chains	External Link	Comment
E [auth A], F [auth B], G [auth C]	PDBTM	Annotated as membrane protein by PDBTM

Membrane Protein Annotation: MemProtMD MemProtMD Database Homepage

Chains	External Link	Comment
E [auth A], F [auth B], G [auth C]	MemProtMD	Annotated as membrane protein by MemProtMD

RCSB PDB Core Operations are funded by the U.S. National Science Foundation (DBI-2321666), the US Department of Energy (DE-SC0019749), and the National Cancer Institute, National Institute of Allergy and Infectious Diseases, and National Institute of General Medical Sciences of the National Institutes of Health under grant R01GM157729.