2UYV

L-RHAMNULOSE-1-PHOSPHATE ALDOLASE FROM ESCHERICHIA COLI (MUTANT Q6Y- E192A)

External Resource: Annotation

Domain Annotation: SCOP/SCOPe Classification
Domain Annotation: SCOP2 Classification
Domain Annotation: ECOD Classification
Domain Annotation: CATH
Protein Family Annotation
Gene Ontology: Gene Product Annotation
InterPro: Protein Family Classification

Domain Annotation: SCOP/SCOPe Classification SCOP-e Database Homepage

Chains	Domain Info	Class	Fold	Superfamily	Family	Domain	Species	Provenance Source (Version)
A	d2uyva_	Alpha and beta proteins (a/b)	AraD/HMP-PK domain-like	AraD/HMP-PK domain-like	AraD-like aldolase/epimerase	L-rhamnulose-1-phosphate aldolase	(Escherichia coli ) [TaxId: 562 ],	SCOPe (2.08)
C	d2uyvc_	Alpha and beta proteins (a/b)	AraD/HMP-PK domain-like	AraD/HMP-PK domain-like	AraD-like aldolase/epimerase	L-rhamnulose-1-phosphate aldolase	(Escherichia coli ) [TaxId: 562 ],	SCOPe (2.08)
D	d2uyvd_	Alpha and beta proteins (a/b)	AraD/HMP-PK domain-like	AraD/HMP-PK domain-like	AraD-like aldolase/epimerase	L-rhamnulose-1-phosphate aldolase	(Escherichia coli ) [TaxId: 562 ],	SCOPe (2.08)
B	d2uyvb_	Alpha and beta proteins (a/b)	AraD/HMP-PK domain-like	AraD/HMP-PK domain-like	AraD-like aldolase/epimerase	L-rhamnulose-1-phosphate aldolase	(Escherichia coli ) [TaxId: 562 ],	SCOPe (2.08)

Domain Annotation: SCOP2 Classification SCOP2 Database Homepage

Chains	Type	Family Name	Domain Identifier	Family Identifier	Provenance Source (Version)
A	SCOP2B Superfamily	AraD/HMP-PK domain-like	8037530	3001331	SCOP2B (2022-06-29)
C	SCOP2B Superfamily	AraD/HMP-PK domain-like	8037530	3001331	SCOP2B (2022-06-29)
D	SCOP2B Superfamily	AraD/HMP-PK domain-like	8037530	3001331	SCOP2B (2022-06-29)
B	SCOP2B Superfamily	AraD/HMP-PK domain-like	8037530	3001331	SCOP2B (2022-06-29)

Domain Annotation: ECOD Classification ECOD Database Homepage

Chains	Family Name	Domain Identifier	Architecture	Possible Homology	Homology	Topology	Family	Provenance Source (Version)
A	Aldolase_II	e2uyvA1	A: a+b three layers	X: AraD-like aldolase/epimerase (From Topology)	H: AraD-like aldolase/epimerase (From Topology)	T: AraD-like aldolase/epimerase	F: Aldolase_II	ECOD (1.6)
C	Aldolase_II	e2uyvC1	A: a+b three layers	X: AraD-like aldolase/epimerase (From Topology)	H: AraD-like aldolase/epimerase (From Topology)	T: AraD-like aldolase/epimerase	F: Aldolase_II	ECOD (1.6)
D	Aldolase_II	e2uyvD1	A: a+b three layers	X: AraD-like aldolase/epimerase (From Topology)	H: AraD-like aldolase/epimerase (From Topology)	T: AraD-like aldolase/epimerase	F: Aldolase_II	ECOD (1.6)
B	Aldolase_II	e2uyvB1	A: a+b three layers	X: AraD-like aldolase/epimerase (From Topology)	H: AraD-like aldolase/epimerase (From Topology)	T: AraD-like aldolase/epimerase	F: Aldolase_II	ECOD (1.6)

Domain Annotation: CATH CATH Database Homepage

Chain	Domain	Class	Architecture	Topology	Homology	Provenance Source (Version)
A	3.40.225.10	Alpha Beta	3-Layer(aba) Sandwich	L-fuculose-1-phosphate Aldolase	Class II aldolase/adducin N-terminal domain	CATH (4.3.0)
C	3.40.225.10	Alpha Beta	3-Layer(aba) Sandwich	L-fuculose-1-phosphate Aldolase	Class II aldolase/adducin N-terminal domain	CATH (4.3.0)
D	3.40.225.10	Alpha Beta	3-Layer(aba) Sandwich	L-fuculose-1-phosphate Aldolase	Class II aldolase/adducin N-terminal domain	CATH (4.3.0)
B	3.40.225.10	Alpha Beta	3-Layer(aba) Sandwich	L-fuculose-1-phosphate Aldolase	Class II aldolase/adducin N-terminal domain	CATH (4.3.0)

Protein Family Annotation Pfam Database Homepage

Chains	Accession	Name	Description	Comments	Source
A, B, C, D	PF00596	Class II Aldolase and Adducin N-terminal domain (Aldolase_II)	Class II Aldolase and Adducin N-terminal domain	This family includes class II aldolases and adducins which have not been ascribed any enzymatic function.	Domain

Gene Ontology: Gene Product Annotation Gene Ontology Database Homepage

Chains	Polymer	Molecular Function	Biological Process	Cellular Component
A, B, C, D	RHAMNULOSE-1-PHOSPHATE ALDOLASE	lyase activity catalytic activity carbon-carbon lyase activity aldehyde-lyase activity rhamnulose-1-phosphate aldolase activity cation binding ion binding binding metal ion binding small molecule binding identical protein binding protein binding	monosaccharide metabolic process carbohydrate metabolic process catabolic process carbohydrate catabolic process primary metabolic process small molecule metabolic process metabolic process cellular process monosaccharide catabolic process small molecule catabolic process pentose metabolic process pentose catabolic process rhamnose catabolic process hexose catabolic process monosaccharide metabolic process carbohydrate metabolic process catabolic process carbohydrate catabolic process primary metabolic process small molecule metabolic process metabolic process cellular process monosaccharide catabolic process small molecule catabolic process pentose metabolic process pentose catabolic process rhamnose catabolic process hexose catabolic process hexose metabolic process rhamnose metabolic process	cellular anatomical structure intracellular anatomical structure cytoplasm cytosol

InterPro: Protein Family Classification InterPro Database Homepage

Chains	Accession	Name	Type
A, B, C, D	IPR013447	Rhamnulose-1-phosphate aldolase	Family
A, B, C, D	IPR036409	Class II aldolase/adducin N-terminal domain superfamily	Homologous Superfamily
A, B, C, D	IPR001303	Class II aldolase/adducin N-terminal	Domain
A, B, C, D	IPR050197	Aldolase class II family, sugar metabolism enzymes	Family

RCSB PDB Core Operations are funded by the U.S. National Science Foundation (DBI-2321666), the US Department of Energy (DE-SC0019749), and the National Cancer Institute, National Institute of Allergy and Infectious Diseases, and National Institute of General Medical Sciences of the National Institutes of Health under grant R01GM157729.