2LS4 | pdb_00002ls4

1H Chemical Shift Assignments for the third transmembrane domain from the human copper transport 1

External Resource: Annotation

Gene Ontology: Gene Product Annotation
InterPro: Protein Family Classification
Pharos: Disease Associations
Membrane Protein Annotation: OPM
Membrane Protein Annotation: PDBTM

Gene Ontology: Gene Product Annotation Gene Ontology Database Homepage

Chains	Polymer	Molecular Function	Biological Process	Cellular Component
A	High affinity copper uptake protein 1	monoatomic cation transmembrane transporter activity inorganic molecular entity transmembrane transporter activity copper ion transmembrane transporter activity inorganic cation transmembrane transporter activity monoatomic ion transmembrane transporter activity transporter activity transition metal ion transmembrane transporter activity metal ion transmembrane transporter activity transmembrane transporter activity silver ion transmembrane transporter activity cation binding transition metal ion binding copper ion binding ion binding monoatomic cation transmembrane transporter activity inorganic molecular entity transmembrane transporter activity copper ion transmembrane transporter activity inorganic cation transmembrane transporter activity monoatomic ion transmembrane transporter activity transporter activity transition metal ion transmembrane transporter activity metal ion transmembrane transporter activity transmembrane transporter activity silver ion transmembrane transporter activity cation binding transition metal ion binding copper ion binding ion binding binding metal ion binding small molecule binding xenobiotic transmembrane transporter activity identical protein binding protein binding	cellular component organization cellular component biogenesis cellular component assembly protein-containing complex organization protein complex oligomerization protein-containing complex assembly cellular process cellular component organization or biogenesis localization transport copper ion import copper ion transport transition metal ion transport monoatomic ion transport cellular component organization cellular component biogenesis cellular component assembly protein-containing complex organization protein complex oligomerization protein-containing complex assembly cellular process cellular component organization or biogenesis localization transport copper ion import copper ion transport transition metal ion transport monoatomic ion transport monoatomic cation transport establishment of localization metal ion transport monoatomic ion transmembrane transport inorganic ion transmembrane transport silver ion transport inorganic cation transmembrane transport transmembrane transport monoatomic cation transmembrane transport silver ion transmembrane transport developmental process multicellular organismal process blood vessel morphogenesis tube development angiogenesis vasculature development circulatory system development anatomical structure morphogenesis multicellular organism development tube morphogenesis anatomical structure formation involved in morphogenesis anatomical structure development blood vessel development system development inorganic ion homeostasis homeostatic process intracellular copper ion homeostasis copper ion homeostasis cellular homeostasis chemical homeostasis intracellular monoatomic cation homeostasis monoatomic ion homeostasis intracellular chemical homeostasis monoatomic cation homeostasis intracellular monoatomic ion homeostasis cellular response to stimulus regulation of biological process regulation of cellular process cell surface receptor signaling pathway response to stimulus signaling biological regulation cell surface receptor protein tyrosine kinase signaling pathway cell communication vascular endothelial growth factor receptor signaling pathway vascular endothelial growth factor receptor-2 signaling pathway signal transduction enzyme-linked receptor protein signaling pathway xenobiotic transport copper ion transmembrane transport plasma membrane copper ion transport cellular localization establishment of localization in cell	endosome membrane membrane-bounded organelle intracellular anatomical structure membrane endosome intracellular vesicle intracellular membrane-bounded organelle recycling endosome endomembrane system intracellular organelle cytoplasmic vesicle membrane cellular anatomical structure bounding membrane of organelle recycling endosome membrane endosome membrane membrane-bounded organelle intracellular anatomical structure membrane endosome intracellular vesicle intracellular membrane-bounded organelle recycling endosome endomembrane system intracellular organelle cytoplasmic vesicle membrane cellular anatomical structure bounding membrane of organelle recycling endosome membrane vesicle membrane cytoplasmic vesicle organelle cytoplasm vesicle organelle membrane cell periphery apical part of cell plasma membrane plasma membrane region apical plasma membrane early endosome early endosome membrane basal part of cell basal plasma membrane basolateral plasma membrane cell-cell junction intercalated disc anchoring junction cell junction cell-cell contact zone late endosome membrane late endosome

InterPro: Protein Family Classification InterPro Database Homepage

Chains	Accession	Name	Type
A	IPR007274	Ctr copper transporter	Family

Pharos: Disease Associations Pharos Homepage Annotation

Chains	Drug Target	Associated Disease
A	Pharos: O15431	intellectual disability Embryo Loss manganese poisoning pulmonary hypertension congenital abnormality prostate cancer glioblastoma exocrine pancreatic carcinoma ovarian cancer subependymal giant cell astrocytoma malignant pancreatic neoplasm pancreatic ductal adenocarcinoma

Membrane Protein Annotation: OPM OPM Database Homepage

Chains	External Link	Type	Class	Superfamily	Family
A	OPM	Peptides	Alpha-helical peptides	Peptides of transmembrane proteins	Copper transporter 1 peptides

Membrane Protein Annotation: PDBTM PDBTM Database Homepage

Chains	External Link	Comment
A	PDBTM	Annotated as membrane protein by PDBTM

RCSB PDB Core Operations are funded by the U.S. National Science Foundation (DBI-2321666), the US Department of Energy (DE-SC0019749), and the National Cancer Institute, National Institute of Allergy and Infectious Diseases, and National Institute of General Medical Sciences of the National Institutes of Health under grant R01GM157729.