2CM7
Structural Basis for Inhibition of Protein Tyrosine Phosphatase 1B by Isothiazolidinone Heterocyclic Phosphonate Mimetics
External Resource: Annotation
Domain Annotation: SCOP/SCOPe Classification SCOP-e Database Homepage
Chains | Domain Info | Class | Fold | Superfamily | Family | Domain | Species | Provenance Source (Version) |
---|---|---|---|---|---|---|---|---|
A | d2cm7a_ | Alpha and beta proteins (a/b) | (Phosphotyrosine protein) phosphatases II | (Phosphotyrosine protein) phosphatases II | Higher-molecular-weight phosphotyrosine protein phosphatases | Tyrosine phosphatase | HUMAN (Homo sapiens ) [TaxId: 9606 ], | SCOPe (2.08) |
Domain Annotation: SCOP2 Classification SCOP2 Database Homepage
Domain Annotation: ECOD Classification ECOD Database Homepage
Chains | Family Name | Domain Identifier | Architecture | Possible Homology | Homology | Topology | Family | Provenance Source (Version) |
---|---|---|---|---|---|---|---|---|
A | Y_phosphatase | e2cm7A1 | A: a/b three-layered sandwiches | X: Flavodoxin-like | H: Flavoproteins/Phosphotyrosine protein phosphatases-like | T: (Phosphotyrosine protein) phosphatases II | F: Y_phosphatase | ECOD (1.6) |
Domain Annotation: CATH CATH Database Homepage
Chain | Domain | Class | Architecture | Topology | Homology | Provenance Source (Version) |
---|---|---|---|---|---|---|
A | 3.90.190.10 | Alpha Beta | Alpha-Beta Complex | Protein-Tyrosine Phosphatase | Chain A | CATH (4.3.0) |
Protein Family Annotation Pfam Database Homepage
Chains | Accession | Name | Description | Comments | Source |
---|---|---|---|---|---|
PF00102 | Protein-tyrosine phosphatase (Y_phosphatase) | Protein-tyrosine phosphatase | - | Domain |
Gene Ontology: Gene Product Annotation Gene Ontology Database Homepage
InterPro: Protein Family Classification InterPro Database Homepage
Chains | Accession | Name | Type |
---|---|---|---|
IPR016130 | Protein-tyrosine phosphatase, active site | Active Site | |
IPR051985 | Non-receptor type tyrosine-specific phosphatase | Family | |
IPR012265 | Protein-tyrosine phosphatase, non-receptor type-1/2 | Family | |
IPR003595 | Protein-tyrosine phosphatase, catalytic | Domain | |
IPR029021 | Protein-tyrosine phosphatase-like | Homologous Superfamily | |
IPR000242 | Tyrosine-specific protein phosphatase, PTPase domain | Domain | |
IPR000387 | Tyrosine-specific protein phosphatases domain | Domain |
Pharos: Disease Associations Pharos Homepage Annotation
Chains | Drug Target | Associated Disease |
---|---|---|
P18031 | :