Annotations: 2BA0

Domain Annotation: SCOP/SCOPe Classification SCOP-e Database Homepage

Chains	Domain Info	Class	Fold	Superfamily	Family	Domain	Species	Provenance Source (Version)
G [auth I]	d2ba0i1	Alpha and beta proteins (a+b)	Ribosomal protein S5 domain 2-like	Ribosomal protein S5 domain 2-like	Ribonuclease PH domain 1-like	Exosome complex exonuclease 2,ECX2	(Archaeoglobus fulgidus ) [TaxId: 2234 ],	SCOPe (2.08)
G [auth I]	d2ba0i2	Alpha and beta proteins (a+b)	Ribonuclease PH domain 2-like	Ribonuclease PH domain 2-like	Ribonuclease PH domain 2-like	Exosome complex exonuclease 2, ECX2	(Archaeoglobus fulgidus ) [TaxId: 2234 ],	SCOPe (2.08)
H	d2ba0h1	Alpha and beta proteins (a+b)	Ribosomal protein S5 domain 2-like	Ribosomal protein S5 domain 2-like	Ribonuclease PH domain 1-like	Exosome complex exonuclease 2,ECX2	(Archaeoglobus fulgidus ) [TaxId: 2234 ],	SCOPe (2.08)
H	d2ba0h2	Alpha and beta proteins (a+b)	Ribonuclease PH domain 2-like	Ribonuclease PH domain 2-like	Ribonuclease PH domain 2-like	Exosome complex exonuclease 2, ECX2	(Archaeoglobus fulgidus ) [TaxId: 2234 ],	SCOPe (2.08)
I [auth G]	d2ba0g1	Alpha and beta proteins (a+b)	Ribosomal protein S5 domain 2-like	Ribosomal protein S5 domain 2-like	Ribonuclease PH domain 1-like	Exosome complex exonuclease 2,ECX2	(Archaeoglobus fulgidus ) [TaxId: 2234 ],	SCOPe (2.08)
I [auth G]	d2ba0g2	Alpha and beta proteins (a+b)	Ribonuclease PH domain 2-like	Ribonuclease PH domain 2-like	Ribonuclease PH domain 2-like	Exosome complex exonuclease 2, ECX2	(Archaeoglobus fulgidus ) [TaxId: 2234 ],	SCOPe (2.08)
A	d2ba0a1	All beta proteins	OB-fold	Nucleic acid-binding proteins	Cold shock DNA-binding domain-like	S1-domain of exosome complex RNA-binding protein 1, ECR1	(Archaeoglobus fulgidus ) [TaxId: 2234 ],	SCOPe (2.08)
A	d2ba0a2	All beta proteins	Barrel-sandwich hybrid	Ribosomal L27 protein-like	ECR1 N-terminal domain-like	Exosome complex RNA-binding protein 1, ECR1	(Archaeoglobus fulgidus ) [TaxId: 2234 ],	SCOPe (2.08)
A	d2ba0a3	Alpha and beta proteins (a+b)	Eukaryotic type KH-domain (KH-domain type I)	Eukaryotic type KH-domain (KH-domain type I)	Eukaryotic type KH-domain (KH-domain type I)	Exosome complex RNA-binding protein 1, ECR1	(Archaeoglobus fulgidus ) [TaxId: 2234 ],	SCOPe (2.08)
B	d2ba0b1	All beta proteins	OB-fold	Nucleic acid-binding proteins	Cold shock DNA-binding domain-like	S1-domain of exosome complex RNA-binding protein 1, ECR1	(Archaeoglobus fulgidus ) [TaxId: 2234 ],	SCOPe (2.08)
B	d2ba0b2	All beta proteins	Barrel-sandwich hybrid	Ribosomal L27 protein-like	ECR1 N-terminal domain-like	Exosome complex RNA-binding protein 1, ECR1	(Archaeoglobus fulgidus ) [TaxId: 2234 ],	SCOPe (2.08)
B	d2ba0b3	Alpha and beta proteins (a+b)	Eukaryotic type KH-domain (KH-domain type I)	Eukaryotic type KH-domain (KH-domain type I)	Eukaryotic type KH-domain (KH-domain type I)	Exosome complex RNA-binding protein 1, ECR1	(Archaeoglobus fulgidus ) [TaxId: 2234 ],	SCOPe (2.08)
C	d2ba0c1	All beta proteins	OB-fold	Nucleic acid-binding proteins	Cold shock DNA-binding domain-like	S1-domain of exosome complex RNA-binding protein 1, ECR1	(Archaeoglobus fulgidus ) [TaxId: 2234 ],	SCOPe (2.08)
C	d2ba0c2	All beta proteins	Barrel-sandwich hybrid	Ribosomal L27 protein-like	ECR1 N-terminal domain-like	Exosome complex RNA-binding protein 1, ECR1	(Archaeoglobus fulgidus ) [TaxId: 2234 ],	SCOPe (2.08)
C	d2ba0c3	Alpha and beta proteins (a+b)	Eukaryotic type KH-domain (KH-domain type I)	Eukaryotic type KH-domain (KH-domain type I)	Eukaryotic type KH-domain (KH-domain type I)	Exosome complex RNA-binding protein 1, ECR1	(Archaeoglobus fulgidus ) [TaxId: 2234 ],	SCOPe (2.08)
D [auth F]	d2ba0f1	Alpha and beta proteins (a+b)	Ribosomal protein S5 domain 2-like	Ribosomal protein S5 domain 2-like	Ribonuclease PH domain 1-like	Exosome complex exonuclease 1, ECX1	(Archaeoglobus fulgidus ) [TaxId: 2234 ],	SCOPe (2.08)
D [auth F]	d2ba0f2	Alpha and beta proteins (a+b)	Ribonuclease PH domain 2-like	Ribonuclease PH domain 2-like	Ribonuclease PH domain 2-like	Exosome complex exonuclease 1, ECX1	(Archaeoglobus fulgidus ) [TaxId: 2234 ],	SCOPe (2.08)
E	d2ba0e1	Alpha and beta proteins (a+b)	Ribosomal protein S5 domain 2-like	Ribosomal protein S5 domain 2-like	Ribonuclease PH domain 1-like	Exosome complex exonuclease 1, ECX1	(Archaeoglobus fulgidus ) [TaxId: 2234 ],	SCOPe (2.08)
E	d2ba0e2	Alpha and beta proteins (a+b)	Ribonuclease PH domain 2-like	Ribonuclease PH domain 2-like	Ribonuclease PH domain 2-like	Exosome complex exonuclease 1, ECX1	(Archaeoglobus fulgidus ) [TaxId: 2234 ],	SCOPe (2.08)
F [auth D]	d2ba0d1	Alpha and beta proteins (a+b)	Ribosomal protein S5 domain 2-like	Ribosomal protein S5 domain 2-like	Ribonuclease PH domain 1-like	Exosome complex exonuclease 1, ECX1	(Archaeoglobus fulgidus ) [TaxId: 2234 ],	SCOPe (2.08)
F [auth D]	d2ba0d2	Alpha and beta proteins (a+b)	Ribonuclease PH domain 2-like	Ribonuclease PH domain 2-like	Ribonuclease PH domain 2-like	Exosome complex exonuclease 1, ECX1	(Archaeoglobus fulgidus ) [TaxId: 2234 ],	SCOPe (2.08)

Domain Annotation: SCOP2 Classification SCOP2 Database Homepage

Chains	Type	Family Name	Domain Identifier	Family Identifier	Provenance Source (Version)
G [auth I]	SCOP2B Superfamily	Ribosomal protein S5 domain 2-like	8033526	3000100	SCOP2B (2022-06-29)
G [auth I]	SCOP2B Superfamily	Ribonuclease PH domain 2-like	8033527	3000346	SCOP2B (2022-06-29)
H	SCOP2B Superfamily	Ribonuclease PH domain 2-like	8033527	3000346	SCOP2B (2022-06-29)
H	SCOP2B Superfamily	Ribosomal protein S5 domain 2-like	8033526	3000100	SCOP2B (2022-06-29)
I [auth G]	SCOP2 Family	Ribonuclease PH domain 1-like	8021146	4000958	SCOP2 (2022-06-29)
I [auth G]	SCOP2 Family	Ribonuclease PH domain 2-like	8021147	4001767	SCOP2 (2022-06-29)
I [auth G]	SCOP2 Superfamily	Ribosomal protein S5 domain 2-like	8033526	3000100	SCOP2 (2022-06-29)
I [auth G]	SCOP2 Superfamily	Ribonuclease PH domain 2-like	8033527	3000346	SCOP2 (2022-06-29)
A	SCOP2 Family	Cold shock DNA-binding domain-like	8021140	4001909	SCOP2 (2022-06-29)
A	SCOP2 Family	ECR1 N-terminal domain-like	8021142	4001938	SCOP2 (2022-06-29)
A	SCOP2 Family	Eukaryotic type KH-domain (KH-domain type I)	8021144	4001190	SCOP2 (2022-06-29)
A	SCOP2 Superfamily	Nucleic acid-binding proteins	8033520	3000135	SCOP2 (2022-06-29)
A	SCOP2 Superfamily	Ribosomal L27 protein-like	8033522	3000539	SCOP2 (2022-06-29)
A	SCOP2 Superfamily	Eukaryotic type KH-domain (KH-domain type I)	8033524	3001023	SCOP2 (2022-06-29)
B	SCOP2B Superfamily	Ribosomal L27 protein-like	8033522	3000539	SCOP2B (2022-06-29)
B	SCOP2B Superfamily	Eukaryotic type KH-domain (KH-domain type I)	8033524	3001023	SCOP2B (2022-06-29)
B	SCOP2B Superfamily	Nucleic acid-binding proteins	8033520	3000135	SCOP2B (2022-06-29)
C	SCOP2B Superfamily	Nucleic acid-binding proteins	8033520	3000135	SCOP2B (2022-06-29)
C	SCOP2B Superfamily	Ribosomal L27 protein-like	8033522	3000539	SCOP2B (2022-06-29)
C	SCOP2B Superfamily	Eukaryotic type KH-domain (KH-domain type I)	8033524	3001023	SCOP2B (2022-06-29)
D [auth F]	SCOP2B Superfamily	Ribonuclease PH domain 2-like	8033521	3000346	SCOP2B (2022-06-29)
D [auth F]	SCOP2B Superfamily	Ribosomal protein S5 domain 2-like	8033518	3000100	SCOP2B (2022-06-29)
E	SCOP2B Superfamily	Ribosomal protein S5 domain 2-like	8033518	3000100	SCOP2B (2022-06-29)
E	SCOP2B Superfamily	Ribonuclease PH domain 2-like	8033521	3000346	SCOP2B (2022-06-29)
F [auth D]	SCOP2 Family	Ribonuclease PH domain 1-like	8021138	4000958	SCOP2 (2022-06-29)
F [auth D]	SCOP2 Family	Ribonuclease PH domain 2-like	8021141	4001767	SCOP2 (2022-06-29)
F [auth D]	SCOP2 Superfamily	Ribosomal protein S5 domain 2-like	8033518	3000100	SCOP2 (2022-06-29)
F [auth D]	SCOP2 Superfamily	Ribonuclease PH domain 2-like	8033521	3000346	SCOP2 (2022-06-29)

Domain Annotation: ECOD Classification ECOD Database Homepage

Chains	Family Name	Domain Identifier	Architecture	Possible Homology	Homology	Topology	Family	Provenance Source (Version)
G [auth I]	RNase_PH_2	e2ba0I4	A: a+b two layers	X: Ribosomal protein S5 domain 2-like (From Topology)	H: Ribosomal protein S5 domain 2-like (From Topology)	T: Ribosomal protein S5 domain 2-like	F: RNase_PH_2	ECOD (1.6)
G [auth I]	RNase_PH_C_1	e2ba0I3	A: a+b two layers	X: Ribonuclease PH domain 2-like	H: Ribonuclease PH domain 2 (From Topology)	T: Ribonuclease PH domain 2	F: RNase_PH_C_1	ECOD (1.6)
H	RNase_PH_2	e2ba0H2	A: a+b two layers	X: Ribosomal protein S5 domain 2-like (From Topology)	H: Ribosomal protein S5 domain 2-like (From Topology)	T: Ribosomal protein S5 domain 2-like	F: RNase_PH_2	ECOD (1.6)
H	RNase_PH_C_1	e2ba0H1	A: a+b two layers	X: Ribonuclease PH domain 2-like	H: Ribonuclease PH domain 2 (From Topology)	T: Ribonuclease PH domain 2	F: RNase_PH_C_1	ECOD (1.6)
I [auth G]	RNase_PH_2	e2ba0G2	A: a+b two layers	X: Ribosomal protein S5 domain 2-like (From Topology)	H: Ribosomal protein S5 domain 2-like (From Topology)	T: Ribosomal protein S5 domain 2-like	F: RNase_PH_2	ECOD (1.6)
I [auth G]	RNase_PH_C_1	e2ba0G1	A: a+b two layers	X: Ribonuclease PH domain 2-like	H: Ribonuclease PH domain 2 (From Topology)	T: Ribonuclease PH domain 2	F: RNase_PH_C_1	ECOD (1.6)
A	S1_5	e2ba0A1	A: beta barrels	X: OB-fold	H: Nucleic acid-binding proteins (From Topology)	T: Nucleic acid-binding proteins	F: S1_5	ECOD (1.6)
A	KH_6_2	e2ba0A2	A: a+b two layers	X: Alpha-lytic protease prodomain-like	H: KH-domains	T: Eukaryotic type KH-domain (KH-domain type I)	F: KH_6_2	ECOD (1.6)
A	ECR1_N_2	e2ba0A3	A: a+b complex topology	X: alpha/beta-Hammerhead/Barrel-sandwich hybrid	H: alpha/beta-Hammerhead/Barrel-sandwich hybrid	T: Ribosomal L27 protein	F: ECR1_N_2	ECOD (1.6)
B	S1_5	e2ba0B1	A: beta barrels	X: OB-fold	H: Nucleic acid-binding proteins (From Topology)	T: Nucleic acid-binding proteins	F: S1_5	ECOD (1.6)
B	KH_6_2	e2ba0B2	A: a+b two layers	X: Alpha-lytic protease prodomain-like	H: KH-domains	T: Eukaryotic type KH-domain (KH-domain type I)	F: KH_6_2	ECOD (1.6)
B	ECR1_N_2	e2ba0B3	A: a+b complex topology	X: alpha/beta-Hammerhead/Barrel-sandwich hybrid	H: alpha/beta-Hammerhead/Barrel-sandwich hybrid	T: Ribosomal L27 protein	F: ECR1_N_2	ECOD (1.6)
C	S1_5	e2ba0C1	A: beta barrels	X: OB-fold	H: Nucleic acid-binding proteins (From Topology)	T: Nucleic acid-binding proteins	F: S1_5	ECOD (1.6)
C	KH_6_2	e2ba0C2	A: a+b two layers	X: Alpha-lytic protease prodomain-like	H: KH-domains	T: Eukaryotic type KH-domain (KH-domain type I)	F: KH_6_2	ECOD (1.6)
C	ECR1_N_2	e2ba0C3	A: a+b complex topology	X: alpha/beta-Hammerhead/Barrel-sandwich hybrid	H: alpha/beta-Hammerhead/Barrel-sandwich hybrid	T: Ribosomal L27 protein	F: ECR1_N_2	ECOD (1.6)
D [auth F]	RNase_PH	e2ba0F2	A: a+b two layers	X: Ribosomal protein S5 domain 2-like (From Topology)	H: Ribosomal protein S5 domain 2-like (From Topology)	T: Ribosomal protein S5 domain 2-like	F: RNase_PH	ECOD (1.6)
D [auth F]	RNase_PH_C_3	e2ba0F1	A: a+b two layers	X: Ribonuclease PH domain 2-like	H: Ribonuclease PH domain 2 (From Topology)	T: Ribonuclease PH domain 2	F: RNase_PH_C_3	ECOD (1.6)
E	RNase_PH	e2ba0E2	A: a+b two layers	X: Ribosomal protein S5 domain 2-like (From Topology)	H: Ribosomal protein S5 domain 2-like (From Topology)	T: Ribosomal protein S5 domain 2-like	F: RNase_PH	ECOD (1.6)
E	RNase_PH_C_3	e2ba0E1	A: a+b two layers	X: Ribonuclease PH domain 2-like	H: Ribonuclease PH domain 2 (From Topology)	T: Ribonuclease PH domain 2	F: RNase_PH_C_3	ECOD (1.6)
F [auth D]	RNase_PH	e2ba0D2	A: a+b two layers	X: Ribosomal protein S5 domain 2-like (From Topology)	H: Ribosomal protein S5 domain 2-like (From Topology)	T: Ribosomal protein S5 domain 2-like	F: RNase_PH	ECOD (1.6)
F [auth D]	RNase_PH_C_3	e2ba0D1	A: a+b two layers	X: Ribonuclease PH domain 2-like	H: Ribonuclease PH domain 2 (From Topology)	T: Ribonuclease PH domain 2	F: RNase_PH_C_3	ECOD (1.6)

Domain Annotation: CATH CATH Database Homepage

Chain	Domain	Class	Architecture	Topology	Homology	Provenance Source (Version)
G [auth I]	3.30.230.70	Alpha Beta	2-Layer Sandwich	Ribosomal Protein S5	domain 2	CATH (4.3.0)
H	3.30.230.70	Alpha Beta	2-Layer Sandwich	Ribosomal Protein S5	domain 2	CATH (4.3.0)
I [auth G]	3.30.230.70	Alpha Beta	2-Layer Sandwich	Ribosomal Protein S5	domain 2	CATH (4.3.0)
A	2.40.50.100	Mainly Beta	Beta Barrel	OB fold (Dihydrolipoamide Acetyltransferase, E2P)	RNA polymerase II/Efflux pump adaptor protein, barrel-sandwich hybrid domain	CATH (4.3.0)
A	2.40.50.140	Mainly Beta	Beta Barrel	OB fold (Dihydrolipoamide Acetyltransferase, E2P)	Nucleic acid-binding proteins	CATH (4.3.0)
A	3.30.1370.10	Alpha Beta	2-Layer Sandwich	Ribosomal Protein S8	Chain: A, domain 1	CATH (4.3.0)
B	2.40.50.100	Mainly Beta	Beta Barrel	OB fold (Dihydrolipoamide Acetyltransferase, E2P)	RNA polymerase II/Efflux pump adaptor protein, barrel-sandwich hybrid domain	CATH (4.3.0)
B	2.40.50.140	Mainly Beta	Beta Barrel	OB fold (Dihydrolipoamide Acetyltransferase, E2P)	Nucleic acid-binding proteins	CATH (4.3.0)
B	3.30.1370.10	Alpha Beta	2-Layer Sandwich	Ribosomal Protein S8	Chain: A, domain 1	CATH (4.3.0)
C	2.40.50.100	Mainly Beta	Beta Barrel	OB fold (Dihydrolipoamide Acetyltransferase, E2P)	RNA polymerase II/Efflux pump adaptor protein, barrel-sandwich hybrid domain	CATH (4.3.0)
C	2.40.50.140	Mainly Beta	Beta Barrel	OB fold (Dihydrolipoamide Acetyltransferase, E2P)	Nucleic acid-binding proteins	CATH (4.3.0)
C	3.30.1370.10	Alpha Beta	2-Layer Sandwich	Ribosomal Protein S8	Chain: A, domain 1	CATH (4.3.0)
D [auth F]	3.30.230.70	Alpha Beta	2-Layer Sandwich	Ribosomal Protein S5	domain 2	CATH (4.3.0)
E	3.30.230.70	Alpha Beta	2-Layer Sandwich	Ribosomal Protein S5	domain 2	CATH (4.3.0)
F [auth D]	3.30.230.70	Alpha Beta	2-Layer Sandwich	Ribosomal Protein S5	domain 2	CATH (4.3.0)

Protein Family Annotation Pfam Database Homepage

Chains	Accession	Name	Description	Comments	Source
G [auth I], H, I [auth G]	PF03725	3' exoribonuclease family, domain 2 (RNase_PH_C)	3' exoribonuclease family, domain 2	This family includes 3'-5' exoribonucleases. Ribonuclease PH contains a single copy of this domain, and removes nucleotide residues following the -CCA terminus of tRNA. Polyribonucleotide nucleotidyltransferase (PNPase) contains two tandem copies of ...	This family includes 3'-5' exoribonucleases. Ribonuclease PH contains a single copy of this domain, and removes nucleotide residues following the -CCA terminus of tRNA. Polyribonucleotide nucleotidyltransferase (PNPase) contains two tandem copies of the domain. PNPase is involved in mRNA degradation in a 3'-5' direction. The exosome is a 3'-5' exoribonuclease complex that is required for 3' processing of the 5.8S rRNA. Three of its five protein components, Swiss:P46948 Swiss:Q12277 and Swiss:P25359 contain a copy of this domain [1]. Swiss:Q10205, a hypothetical protein from S. pombe appears to belong to an uncharacterised subfamily. This subfamily is found in both eukaryotes and archaebacteria.	Domain
G [auth I], H, I [auth G]	PF01138	3' exoribonuclease family, domain 1 (RNase_PH)	3' exoribonuclease family, domain 1	This family includes 3'-5' exoribonucleases. Ribonuclease PH contains a single copy of this domain, and removes nucleotide residues following the -CCA terminus of tRNA. Polyribonucleotide nucleotidyltransferase (PNPase) contains two tandem copies of ...	This family includes 3'-5' exoribonucleases. Ribonuclease PH contains a single copy of this domain, and removes nucleotide residues following the -CCA terminus of tRNA. Polyribonucleotide nucleotidyltransferase (PNPase) contains two tandem copies of the domain. PNPase is involved in mRNA degradation in a 3'-5' direction. The exosome is a 3'-5' exoribonuclease complex that is required for 3' processing of the 5.8S rRNA. Three of its five protein components, Swiss:P46948 Swiss:Q12277 and Swiss:P25359 contain a copy of this domain [1]. Swiss:Q10205, a hypothetical protein from S. pombe appears to belong to an uncharacterised subfamily. This subfamily is found in both eukaryotes and archaebacteria.	Domain
A, B, C	PF21266	RRP4, S1 domain (RRP4_S1)	RRP4, S1 domain	Exosome complex component RRP4 is a non-catalytic component of the RNA exosome complex which has 3'->5' exoribonuclease activity and participates in a multitude of cellular RNA processing and degradation events. It consists of a N-terminal beta-sandw ...	Exosome complex component RRP4 is a non-catalytic component of the RNA exosome complex which has 3'->5' exoribonuclease activity and participates in a multitude of cellular RNA processing and degradation events. It consists of a N-terminal beta-sandwich hybrid domain (Pfam:PF14382), a central S1 domain and a C-terminal KH domain (Pfam:PF15985). This entry represents the S1 RNA binding domain, which has an OB fold [1,2].	Domain
A, B, C	PF00013	KH domain (KH_1)	KH domain	KH motifs bind RNA in vitro. Autoantibodies to Nova, a KH domain protein, cause paraneoplastic opsoclonus ataxia.	Domain
A, B, C	PF22625	Exosome RNA binding protein RRP4 N-terminal domain (ECR1_N_2)	Exosome RNA binding protein RRP4 N-terminal domain	This domain is found N-terminal in exosome RNA binding protein RRP4 and related proteins [1-5]. RRP4 is a part of the exosome regulatory substrate recognition platform. This domain is structurally similar to ribosomal L27 protein.	Domain
D [auth F], E, F [auth D]	PF03725	3' exoribonuclease family, domain 2 (RNase_PH_C)	3' exoribonuclease family, domain 2	This family includes 3'-5' exoribonucleases. Ribonuclease PH contains a single copy of this domain, and removes nucleotide residues following the -CCA terminus of tRNA. Polyribonucleotide nucleotidyltransferase (PNPase) contains two tandem copies of ...	This family includes 3'-5' exoribonucleases. Ribonuclease PH contains a single copy of this domain, and removes nucleotide residues following the -CCA terminus of tRNA. Polyribonucleotide nucleotidyltransferase (PNPase) contains two tandem copies of the domain. PNPase is involved in mRNA degradation in a 3'-5' direction. The exosome is a 3'-5' exoribonuclease complex that is required for 3' processing of the 5.8S rRNA. Three of its five protein components, Swiss:P46948 Swiss:Q12277 and Swiss:P25359 contain a copy of this domain [1]. Swiss:Q10205, a hypothetical protein from S. pombe appears to belong to an uncharacterised subfamily. This subfamily is found in both eukaryotes and archaebacteria.	Domain
D [auth F], E, F [auth D]	PF01138	3' exoribonuclease family, domain 1 (RNase_PH)	3' exoribonuclease family, domain 1	This family includes 3'-5' exoribonucleases. Ribonuclease PH contains a single copy of this domain, and removes nucleotide residues following the -CCA terminus of tRNA. Polyribonucleotide nucleotidyltransferase (PNPase) contains two tandem copies of ...	This family includes 3'-5' exoribonucleases. Ribonuclease PH contains a single copy of this domain, and removes nucleotide residues following the -CCA terminus of tRNA. Polyribonucleotide nucleotidyltransferase (PNPase) contains two tandem copies of the domain. PNPase is involved in mRNA degradation in a 3'-5' direction. The exosome is a 3'-5' exoribonuclease complex that is required for 3' processing of the 5.8S rRNA. Three of its five protein components, Swiss:P46948 Swiss:Q12277 and Swiss:P25359 contain a copy of this domain [1]. Swiss:Q10205, a hypothetical protein from S. pombe appears to belong to an uncharacterised subfamily. This subfamily is found in both eukaryotes and archaebacteria.	Domain

Gene Ontology: Gene Product Annotation Gene Ontology Database Homepage

Chains	Polymer	Molecular Function	Biological Process	Cellular Component
G [auth I], H, I [auth G]	Archaeal exosome RNA binding protein RRP42	-	catabolic process RNA metabolic process primary metabolic process rRNA catabolic process nucleic acid metabolic process macromolecule catabolic process nucleobase-containing compound catabolic process nucleobase-containing compound metabolic process nucleic acid catabolic process metabolic process cellular process macromolecule metabolic process rRNA metabolic process RNA catabolic process	exosome (RNase complex) protein-containing complex cellular anatomical structure intracellular anatomical structure catalytic complex cytoplasm cytoplasmic exosome (RNase complex) exoribonuclease complex
A, B, C	Archaeal exosome RNA binding protein RRP4	RNA binding binding organic cyclic compound binding poly(A) binding poly-purine tract binding nucleic acid binding single-stranded RNA binding	catabolic process RNA metabolic process primary metabolic process nucleic acid metabolic process macromolecule catabolic process nucleobase-containing compound catabolic process nucleobase-containing compound metabolic process nucleic acid catabolic process metabolic process cellular process macromolecule metabolic process RNA catabolic process CUT metabolic process CUT catabolic process catabolic process RNA metabolic process primary metabolic process nucleic acid metabolic process macromolecule catabolic process nucleobase-containing compound catabolic process nucleobase-containing compound metabolic process nucleic acid catabolic process metabolic process cellular process macromolecule metabolic process RNA catabolic process CUT metabolic process CUT catabolic process sno(s)RNA processing gene expression nucleobase-containing compound biosynthetic process macromolecule biosynthetic process RNA biosynthetic process nucleic acid biosynthetic process sno(s)RNA 3'-end processing biosynthetic process sno(s)RNA metabolic process RNA 3'-end processing RNA processing poly(A)-dependent snoRNA 3'-end processing ribonucleoprotein complex biogenesis exonucleolytic trimming to generate mature 3'-end of 5.8S rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA) rRNA processing cellular component biogenesis ribosome biogenesis cellular component organization or biogenesis rRNA metabolic process maturation of 5.8S rRNA maturation of 5.8S rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA) rRNA 3'-end processing U4 snRNA 3'-end processing snRNA 3'-end processing snRNA metabolic process snRNA processing	exosome (RNase complex) protein-containing complex intracellular anatomical structure cellular anatomical structure catalytic complex exoribonuclease complex cytoplasm
D [auth F], E, F [auth D]	Archaeal exosome RNA binding protein RRP41	3'-5'-RNA exonuclease activity catalytic activity, acting on RNA RNA exonuclease activity, producing 5'-phosphomonoesters catalytic activity, acting on a nucleic acid 3'-5' exonuclease activity RNA exonuclease activity RNA nuclease activity hydrolase activity exonuclease activity, active with either ribo- or deoxyribonucleic acids and producing 5'-phosphomonoesters nuclease activity hydrolase activity, acting on ester bonds exonuclease activity catalytic activity	catabolic process RNA metabolic process primary metabolic process rRNA catabolic process nucleic acid metabolic process macromolecule catabolic process nucleobase-containing compound catabolic process nucleobase-containing compound metabolic process nucleic acid catabolic process metabolic process cellular process macromolecule metabolic process rRNA metabolic process RNA catabolic process	exosome (RNase complex) protein-containing complex cellular anatomical structure intracellular anatomical structure catalytic complex cytoplasm cytoplasmic exosome (RNase complex) exoribonuclease complex

InterPro: Protein Family Classification InterPro Database Homepage

Chains	Accession	Name	Type
G [auth I], H, I [auth G]	IPR027408	PNPase/RNase PH domain superfamily	Homologous Superfamily
G [auth I], H, I [auth G]	IPR001247	Exoribonuclease, phosphorolytic domain 1	Domain
G [auth I], H, I [auth G]	IPR050590	Exosome complex component Rrp42 subfamily	Family
G [auth I], H, I [auth G]	IPR036345	Exoribonuclease, PH domain 2 superfamily	Homologous Superfamily
G [auth I], H, I [auth G]	IPR020568	Ribosomal protein uS5 domain 2-type superfamily	Homologous Superfamily
G [auth I], H, I [auth G]	IPR015847	Exoribonuclease, phosphorolytic domain 2	Domain
G [auth I], H, I [auth G]	IPR020869	Exosome complex component Rrp42, archaea	Family
A, B, C	IPR054371	Exosome RNA binding protein RRP4, N-terminal domain	Domain
A, B, C	IPR003029	S1 domain	Domain
A, B, C	IPR023474	Exosome complex component Rrp4	Family
A, B, C	IPR004087	K Homology domain	Domain
A, B, C	IPR048565	RRP4, S1 domain	Domain
A, B, C	IPR036612	K Homology domain, type 1 superfamily	Homologous Superfamily
A, B, C	IPR012340	Nucleic acid-binding, OB-fold	Homologous Superfamily
A, B, C	IPR026699	Exosome complex RNA-binding protein 1/RRP40/RRP4	Family
A, B, C	IPR004088	K Homology domain, type 1	Domain
D [auth F], E, F [auth D]	IPR011807	Exosome complex component Rrp41	Family
D [auth F], E, F [auth D]	IPR027408	PNPase/RNase PH domain superfamily	Homologous Superfamily
D [auth F], E, F [auth D]	IPR001247	Exoribonuclease, phosphorolytic domain 1	Domain
D [auth F], E, F [auth D]	IPR036345	Exoribonuclease, PH domain 2 superfamily	Homologous Superfamily
D [auth F], E, F [auth D]	IPR020568	Ribosomal protein uS5 domain 2-type superfamily	Homologous Superfamily
D [auth F], E, F [auth D]	IPR015847	Exoribonuclease, phosphorolytic domain 2	Domain
D [auth F], E, F [auth D]	IPR050080	Ribonuclease PH	Family