2B3U

Human Spermine spermidine acetyltransferase K26R mutant

External Resource: Annotation

Domain Annotation: SCOP/SCOPe Classification
Domain Annotation: SCOP2 Classification
Domain Annotation: ECOD Classification
Domain Annotation: CATH
Protein Family Annotation
Gene Ontology: Gene Product Annotation
InterPro: Protein Family Classification
Pharos: Disease Associations

Domain Annotation: SCOP/SCOPe Classification SCOP-e Database Homepage

Chains	Domain Info	Class	Fold	Superfamily	Family	Domain	Species	Provenance Source (Version)
A	d2b3ua1	Alpha and beta proteins (a+b)	Acyl-CoA N-acyltransferases (Nat)	Acyl-CoA N-acyltransferases (Nat)	N-acetyl transferase, NAT	Diamine acetyltransferase 1	human (Homo sapiens ) [TaxId: 9606 ],	SCOPe (2.08)
B	d2b3ub_	Alpha and beta proteins (a+b)	Acyl-CoA N-acyltransferases (Nat)	Acyl-CoA N-acyltransferases (Nat)	N-acetyl transferase, NAT	Diamine acetyltransferase 1	human (Homo sapiens ) [TaxId: 9606 ],	SCOPe (2.08)

Domain Annotation: SCOP2 Classification SCOP2 Database Homepage

Chains	Type	Family Name	Domain Identifier	Family Identifier	Provenance Source (Version)
A	SCOP2B Superfamily	Acyl-CoA N-acyltransferases (Nat)	8041645	3000403	SCOP2B (2022-06-29)
B	SCOP2B Superfamily	Acyl-CoA N-acyltransferases (Nat)	8041645	3000403	SCOP2B (2022-06-29)

Domain Annotation: ECOD Classification ECOD Database Homepage

Chains	Family Name	Domain Identifier	Architecture	Possible Homology	Homology	Topology	Family	Provenance Source (Version)
A	Acetyltransf_10_5	e2b3uA1	A: a+b three layers	X: Nat/Ivy	H: Acyl-CoA N-acyltransferases (Nat) (From Topology)	T: Acyl-CoA N-acyltransferases (Nat)	F: Acetyltransf_10_5	ECOD (1.6)
B	Acetyltransf_10_5	e2b3uB1	A: a+b three layers	X: Nat/Ivy	H: Acyl-CoA N-acyltransferases (Nat) (From Topology)	T: Acyl-CoA N-acyltransferases (Nat)	F: Acetyltransf_10_5	ECOD (1.6)

Domain Annotation: CATH CATH Database Homepage

Chain	Domain	Class	Architecture	Topology	Homology	Provenance Source (Version)
A	3.40.630.30	Alpha Beta	3-Layer(aba) Sandwich	Aminopeptidase	Gcn5-related N-acetyltransferase (GNAT)	CATH (4.3.0)
B	3.40.630.30	Alpha Beta	3-Layer(aba) Sandwich	Aminopeptidase	Gcn5-related N-acetyltransferase (GNAT)	CATH (4.3.0)

Protein Family Annotation Pfam Database Homepage

Chains	Accession	Name	Description	Comments	Source
A, B	PF00583	Acetyltransferase (GNAT) family (Acetyltransf_1)	Acetyltransferase (GNAT) family	-	Family

Gene Ontology: Gene Product Annotation Gene Ontology Database Homepage

Chains	Polymer	Molecular Function	Biological Process	Cellular Component
A, B	Diamine acetyltransferase 1	cation binding spermidine binding polyamine binding binding ion binding amine binding small molecule binding acetyltransferase activity N-acetyltransferase activity acyltransferase activity acyltransferase activity, transferring groups other than amino-acyl groups transferase activity catalytic activity N-acyltransferase activity cation binding spermidine binding polyamine binding binding ion binding amine binding small molecule binding acetyltransferase activity N-acetyltransferase activity acyltransferase activity acyltransferase activity, transferring groups other than amino-acyl groups transferase activity catalytic activity N-acyltransferase activity diamine N-acetyltransferase activity identical protein binding protein binding	amine metabolic process biogenic amine biosynthetic process biosynthetic process amine biosynthetic process polyamine biosynthetic process metabolic process cellular process polyamine metabolic process biogenic amine metabolic process spermidine metabolic process spermidine acetylation polyamine acetylation catabolic process biogenic amine catabolic process amine metabolic process biogenic amine biosynthetic process biosynthetic process amine biosynthetic process polyamine biosynthetic process metabolic process cellular process polyamine metabolic process biogenic amine metabolic process spermidine metabolic process spermidine acetylation polyamine acetylation catabolic process biogenic amine catabolic process putrescine catabolic process putrescine metabolic process polyamine catabolic process amine catabolic process developmental process multicellular organismal process blood vessel morphogenesis tube development angiogenesis vasculature development circulatory system development multicellular organism development anatomical structure morphogenesis tube morphogenesis anatomical structure development anatomical structure formation involved in morphogenesis blood vessel development system development	cellular anatomical structure intracellular anatomical structure cytoplasm cytosol

InterPro: Protein Family Classification InterPro Database Homepage

Chains	Accession	Name	Type
A, B	IPR016181	Acyl-CoA N-acyltransferase	Homologous Superfamily
A, B	IPR000182	GNAT domain	Domain
A, B	IPR051016	Diverse Substrate Acetyltransferase	Family

Pharos: Disease Associations Pharos Homepage Annotation

Chains	Drug Target	Associated Disease
A, B	Pharos: P21673	obesity disorder allergic contact dermatitis keratosis follicularis spinulosa decalvans, X-linked large cell medulloblastoma major depressive disorder MALT lymphoma multiple sclerosis acute myeloid leukemia pancreatic intraductal papillary-mucinous carcinoma pituitary cancer bipolar disorder schizoaffective disorder depressive disorder subependymal giant cell astrocytoma Emery-Dreifuss muscular dystrophy obesity disorder allergic contact dermatitis keratosis follicularis spinulosa decalvans, X-linked large cell medulloblastoma major depressive disorder MALT lymphoma multiple sclerosis acute myeloid leukemia pancreatic intraductal papillary-mucinous carcinoma pituitary cancer bipolar disorder schizoaffective disorder depressive disorder subependymal giant cell astrocytoma Emery-Dreifuss muscular dystrophy IgA glomerulonephritis limb-girdle muscular dystrophy malignant mesothelioma medulloblastoma myopathy Alcohol Use Disorder ovarian cancer pancreatic intraductal papillary-mucinous neoplasm astrocytic tumor psoriasis breast cancer schizophrenia dermatomyositis facioscapulohumeral muscular dystrophy interstitial cystitis lung carcinoma malignant pancreatic neoplasm pancreatic ductal adenocarcinoma pancreatic intraductal papillary-mucinous neoplasm with low grade dysplasia Becker muscular dystrophy cystic fibrosis spina bifida Duchenne muscular dystrophy glioblastoma juvenile dermatomyositis

RCSB PDB Core Operations are funded by the U.S. National Science Foundation (DBI-2321666), the US Department of Energy (DE-SC0019749), and the National Cancer Institute, National Institute of Allergy and Infectious Diseases, and National Institute of General Medical Sciences of the National Institutes of Health under grant R01GM157729.