2AIN | pdb_00002ain

Solution structure of the AF-6 PDZ domain complexed with the C-terminal peptide from the Bcr protein

External Resource: Annotation

Domain Annotation: SCOP2 Classification
Domain Annotation: ECOD Classification
Domain Annotation: CATH
Protein Family Annotation
Gene Ontology: Gene Product Annotation
InterPro: Protein Family Classification
Pharos: Disease Associations

Domain Annotation: SCOP2 Classification SCOP2 Database Homepage

Chains	Type	Family Name	Domain Identifier	Family Identifier	Provenance Source (Version)
A	SCOP2B Superfamily	PDZ domain-like	8032442	3000388	SCOP2B (2022-06-29)

Domain Annotation: ECOD Classification ECOD Database Homepage

Chains	Family Name	Domain Identifier	Architecture	Possible Homology	Homology	Topology	Family	Provenance Source (Version)
A	PDZ	e2ainA1	A: beta barrels	X: PDZ domain (From Topology)	H: PDZ domain (From Topology)	T: PDZ domain	F: PDZ	ECOD (1.6)

Domain Annotation: CATH CATH Database Homepage

Chain	Domain	Class	Architecture	Topology	Homology	Provenance Source (Version)
A	2.30.42.10	Mainly Beta	Roll	Pdz3 Domain	PDZ domain	CATH (4.3.0)

Protein Family Annotation Pfam Database Homepage

Chains	Accession	Name	Description	Comments	Source
A	PF00595	PDZ domain (PDZ)	PDZ domain	PDZ domains are found in diverse signaling proteins.	Domain

Gene Ontology: Gene Product Annotation Gene Ontology Database Homepage

Chains	Polymer	Molecular Function	Biological Process	Cellular Component
A	Afadin	small GTPase binding protein binding binding enzyme binding GTPase binding cytoskeletal protein binding actin binding protein-containing complex binding actin filament binding cell adhesion molecule binding cadherin binding	regulation of biological process regulation of cellular process positive regulation of cell adhesion regulation of cell adhesion biological regulation positive regulation of biological process positive regulation of cell-cell adhesion cell adhesion cell-cell adhesion positive regulation of cell-cell adhesion mediated by cadherin cell-cell adhesion mediated by cadherin cellular process regulation of cell-cell adhesion positive regulation of cellular process regulation of biological process regulation of cellular process positive regulation of cell adhesion regulation of cell adhesion biological regulation positive regulation of biological process positive regulation of cell-cell adhesion cell adhesion cell-cell adhesion positive regulation of cell-cell adhesion mediated by cadherin cell-cell adhesion mediated by cadherin cellular process regulation of cell-cell adhesion positive regulation of cellular process regulation of cell-cell adhesion mediated by cadherin regulation of biosynthetic process regulation of macromolecule metabolic process gene expression macromolecule biosynthetic process positive regulation of macromolecule biosynthetic process regulation of gene expression positive regulation of metabolic process biosynthetic process positive regulation of gene expression positive regulation of biosynthetic process regulation of macromolecule biosynthetic process metabolic process positive regulation of macromolecule metabolic process macromolecule metabolic process regulation of metabolic process developmental process epithelium development endothelial cell differentiation cellular developmental process endothelium development cell development tissue development epithelial cell differentiation endothelial cell development establishment of endothelial intestinal barrier epithelial cell development cell differentiation establishment of endothelial barrier anatomical structure development signaling cell-cell signaling cell communication cellular component organization cellular component biogenesis cellular component assembly protein-containing complex organization protein-containing complex assembly cellular component organization or biogenesis pore complex assembly cellular response to stimulus response to stimulus signal transduction bicellular tight junction assembly tight junction organization apical junction assembly cell junction organization cell junction assembly tight junction assembly cell-cell junction assembly cell-cell junction organization negative regulation of locomotion regulation of cell motility negative regulation of biological process regulation of locomotion negative regulation of cellular process regulation of cell migration negative regulation of cell motility cell migration cell motility negative regulation of cell migration locomotion protein localization regulation of localization cellular localization regulation of protein localization localization regulation of cellular localization cellular macromolecule localization macromolecule localization establishment of protein localization protein localization to cell periphery establishment of protein localization to membrane protein localization to plasma membrane establishment of protein localization to plasma membrane localization within membrane protein localization to membrane establishment of localization	cellular anatomical structure cell junction cell-cell junction anchoring junction membrane-bounded organelle intracellular anatomical structure nucleus membrane-enclosed lumen intracellular membrane-bounded organelle intracellular organelle lumen nuclear speck nuclear body intracellular organelle nucleoplasm cellular anatomical structure cell junction cell-cell junction anchoring junction membrane-bounded organelle intracellular anatomical structure nucleus membrane-enclosed lumen intracellular membrane-bounded organelle intracellular organelle lumen nuclear speck nuclear body intracellular organelle nucleoplasm organelle lumen organelle nuclear lumen cytoplasm cytosol cell periphery plasma membrane membrane cell-cell contact zone adherens junction tight junction protein-containing complex pore complex membrane protein complex
B	6-mer peptide from Breakpoint cluster region protein	protein serine/threonine kinase activity catalytic activity, acting on a protein kinase activity protein kinase activity transferase activity phosphotransferase activity, alcohol group as acceptor transferase activity, transferring phosphorus-containing groups histone H2AS121 kinase activity histone modifying activity histone H2A kinase activity catalytic activity histone kinase activity AMP-activated protein kinase activity DNA-dependent protein kinase activity protein serine/threonine kinase activity catalytic activity, acting on a protein kinase activity protein kinase activity transferase activity phosphotransferase activity, alcohol group as acceptor transferase activity, transferring phosphorus-containing groups histone H2AS121 kinase activity histone modifying activity histone H2A kinase activity catalytic activity histone kinase activity AMP-activated protein kinase activity DNA-dependent protein kinase activity pyrophosphatase activity enzyme regulator activity GTPase activity molecular function activator activity nucleoside-triphosphatase regulator activity hydrolase activity GTPase regulator activity enzyme activator activity ribonucleoside triphosphate phosphatase activity GTPase activator activity hydrolase activity, acting on acid anhydrides, in phosphorus-containing anhydrides molecular function regulator activity hydrolase activity, acting on acid anhydrides histone H3T45 kinase activity histone H3 kinase activity eukaryotic translation initiation factor 2alpha kinase activity protein tyrosine kinase activity binding adenyl ribonucleotide binding nucleotide binding purine ribonucleotide binding purine ribonucleoside triphosphate binding nucleoside phosphate binding ion binding purine nucleotide binding anion binding adenyl nucleotide binding ATP binding heterocyclic compound binding carbohydrate derivative binding ribonucleotide binding small molecule binding histone H3T6 kinase activity histone H3T3 kinase activity histone H2BS14 kinase activity histone H2B kinase activity histone H3S57 kinase activity Rho-dependent protein serine/threonine kinase activity histone H2AT120 kinase activity histone H2AXS139 kinase activity histone H2AX kinase activity histone H4S1 kinase activity histone H4 kinase activity protein serine kinase activity guanyl nucleotide binding GTP binding guanyl ribonucleotide binding GDP binding guanyl-nucleotide exchange factor activity histone H3T11 kinase activity histone H3S28 kinase activity 3-phosphoinositide-dependent protein kinase activity histone H2BS36 kinase activity histone H2AS1 kinase activity ribosomal protein S6 kinase activity histone H3S10 kinase activity	developmental process multicellular organism development multicellular organismal process head development central nervous system development anatomical structure development animal organ development brain development nervous system development system development renal system process system process localization import into cell developmental process multicellular organism development multicellular organismal process head development central nervous system development anatomical structure development animal organ development brain development nervous system development system development renal system process system process localization import into cell transport phagocytosis cellular process endocytosis establishment of localization vesicle-mediated transport protein localization establishment of protein localization cellular localization nitrogen compound transport intracellular protein transmembrane transport intracellular transport transmembrane transport protein transmembrane transport protein transport cellular macromolecule localization macromolecule localization establishment of localization in cell intracellular protein transport regulation of vascular permeability circulatory system process biological regulation vascular process in circulatory system regulation of biological quality blood circulation negative regulation of tissue remodeling regulation of biological process regulation of developmental process negative regulation of developmental process negative regulation of biological process regulation of tissue remodeling regulation of blood vessel remodeling anatomical structure morphogenesis blood vessel remodeling negative regulation of blood vessel remodeling tissue remodeling regulation of multicellular organismal process negative regulation of multicellular organismal process regulation of anatomical structure morphogenesis regulation of localization positive regulation of cellular component organization regulation of cellular process regulation of cellular component organization positive regulation of biological process cellular component organization positive regulation of endocytosis cellular component organization or biogenesis positive regulation of cellular process regulation of endocytosis regulation of transport regulation of phagocytosis regulation of vesicle-mediated transport positive regulation of phagocytosis positive regulation of transport organelle organization actin cytoskeleton organization actin filament-based process cytoskeleton organization cellular response to stimulus regulation of signaling small GTPase-mediated signal transduction response to stimulus signaling regulation of small GTPase mediated signal transduction regulation of signal transduction regulation of Rho protein signal transduction intracellular signal transduction Rho protein signal transduction cell communication regulation of intracellular signal transduction regulation of response to stimulus intracellular signaling cassette regulation of cell communication signal transduction trans-synaptic signaling modulation of chemical synaptic transmission cell-cell signaling chemical synaptic transmission synaptic signaling regulation of trans-synaptic signaling anterograde trans-synaptic signaling negative regulation of metabolic process reactive oxygen species metabolic process negative regulation of reactive oxygen species metabolic process negative regulation of cellular process metabolic process regulation of metabolic process regulation of reactive oxygen species metabolic process protein phosphorylation phosphorylation primary metabolic process macromolecule modification phosphate-containing compound metabolic process protein metabolic process macromolecule metabolic process protein modification process phosphorus metabolic process focal adhesion assembly cell-substrate junction assembly cell-substrate adhesion cellular component biogenesis cell adhesion cell junction organization cellular component assembly cell-matrix adhesion cell junction assembly cell-substrate junction organization definitive hemopoiesis cellular developmental process hemopoiesis cell differentiation cell development regulation of immune effector process neutrophil activation regulation of myeloid leukocyte mediated immunity regulated exocytosis negative regulation of transport cell activation involved in immune response leukocyte degranulation myeloid leukocyte mediated immunity myeloid leukocyte activation negative regulation of secretion neutrophil activation involved in immune response leukocyte mediated immunity regulation of immune system process negative regulation of secretion by cell negative regulation of myeloid leukocyte mediated immunity immune response negative regulation of immune response negative regulation of immune effector process immune effector process regulation of secretion regulation of leukocyte mediated immunity exocytosis regulation of immune response negative regulation of neutrophil degranulation negative regulation of regulated secretory pathway negative regulation of leukocyte degranulation leukocyte activation regulation of regulated secretory pathway secretion by cell regulation of secretion by cell neutrophil mediated immunity negative regulation of exocytosis regulation of neutrophil degranulation leukocyte activation involved in immune response neutrophil degranulation regulation of leukocyte degranulation secretion negative regulation of response to stimulus cell activation export from cell myeloid cell activation involved in immune response negative regulation of immune system process immune system process regulation of exocytosis negative regulation of leukocyte mediated immunity granulocyte activation epithelium development epidermal cell differentiation epidermis development tissue development epithelial cell differentiation skin development keratinocyte differentiation multicellular organismal-level homeostasis homeostatic process homeostasis of number of cells ear morphogenesis embryonic organ morphogenesis ear development sensory organ development embryonic morphogenesis embryo development sensory organ morphogenesis inner ear development inner ear morphogenesis animal organ morphogenesis embryonic organ development regulation of defense response regulation of response to external stimulus negative regulation of inflammatory response defense response response to external stimulus regulation of inflammatory response response to stress negative regulation of response to external stimulus regulation of response to stress negative regulation of defense response inflammatory response biological process involved in interspecies interaction between organisms response to lipid response to other organism cellular response to lipopolysaccharide response to oxygen-containing compound cellular response to molecule of bacterial origin response to lipopolysaccharide cellular response to oxygen-containing compound response to biotic stimulus cellular response to biotic stimulus cellular response to chemical stimulus response to chemical response to bacterium cellular response to lipid response to external biotic stimulus response to molecule of bacterial origin nervous system process neuromuscular process neuromuscular process controlling balance negative regulation of respiratory burst respiratory burst regulation of respiratory burst negative regulation of locomotion regulation of cell motility negative regulation of cellular extravasation regulation of cell migration cellular extravasation cell migration cell motility negative regulation of cell migration locomotion regulation of leukocyte migration leukocyte migration negative regulation of leukocyte migration regulation of locomotion negative regulation of cell motility regulation of cellular extravasation mononuclear cell migration myeloid leukocyte migration macrophage migration activation of GTPase activity positive regulation of molecular function regulation of molecular function positive regulation of hydrolase activity regulation of catalytic activity regulation of hydrolase activity positive regulation of catalytic activity regulation of GTPase activity positive regulation of GTPase activity cell cycle regulation of cell cycle negative regulation of mononuclear cell migration regulation of macrophage migration regulation of mononuclear cell migration negative regulation of macrophage migration	cellular anatomical structure membrane extracellular exosome membrane-bounded organelle extracellular vesicle extracellular organelle extracellular region organelle extracellular space vesicle extracellular membrane-bounded organelle intracellular anatomical structure cytoplasm cytosol cellular anatomical structure membrane extracellular exosome membrane-bounded organelle extracellular vesicle extracellular organelle extracellular region organelle extracellular space vesicle extracellular membrane-bounded organelle intracellular anatomical structure cytoplasm cytosol synapse cell junction glutamatergic synapse neuron spine neuron projection dendritic spine plasma membrane bounded cell projection somatodendritic compartment cell projection postsynapse dendrite dendritic tree axon cell periphery plasma membrane protein-containing complex postsynaptic density neuron to neuron synapse postsynaptic specialization asymmetric synapse Schaffer collateral - CA1 synapse

InterPro: Protein Family Classification InterPro Database Homepage

Chains	Accession	Name	Type
A	IPR002710	Dilute domain	Domain
A	IPR028842	Afadin	Family
A	IPR000159	Ras-associating domain	Domain
A	IPR008984	SMAD/FHA domain superfamily	Homologous Superfamily
A	IPR000253	Forkhead-associated (FHA) domain	Domain
A	IPR036034	PDZ superfamily	Homologous Superfamily
A	IPR037977	Afadin, cargo binding domain	Domain
A	IPR001478	PDZ domain	Domain
A	IPR029071	Ubiquitin-like domain superfamily	Homologous Superfamily
B	IPR000219	Dbl homology domain	Domain
B	IPR008936	Rho GTPase activation protein	Homologous Superfamily
B	IPR037769	Abr/Bcr	Family
B	IPR035899	Dbl homology (DH) domain superfamily	Homologous Superfamily
B	IPR036481	Bcr-Abl oncoprotein oligomerisation domain superfamily	Homologous Superfamily
B	IPR001849	Pleckstrin homology domain	Domain
B	IPR000008	C2 domain	Domain
B	IPR011993	PH-like domain superfamily	Homologous Superfamily
B	IPR001331	Guanine-nucleotide dissociation stimulator, CDC24, conserved site	Conserved Site
B	IPR000198	Rho GTPase-activating protein domain	Domain
B	IPR015123	Bcr-Abl oncoprotein oligomerisation	Domain
B	IPR035892	C2 domain superfamily	Homologous Superfamily

Pharos: Disease Associations Pharos Homepage Annotation

Chains	Drug Target	Associated Disease
A	Pharos: P55196	astrocytic tumor glioblastoma malignant glioma medulloblastoma osteosarcoma pilocytic astrocytoma atypical teratoid rhabdoid tumor hereditary spastic paraplegia malignant mesothelioma mucocutaneous lymph node syndrome ovarian cancer pituitary cancer cancer malignant ependymoma malignant pancreatic neoplasm astrocytic tumor glioblastoma malignant glioma medulloblastoma osteosarcoma pilocytic astrocytoma atypical teratoid rhabdoid tumor hereditary spastic paraplegia malignant mesothelioma mucocutaneous lymph node syndrome ovarian cancer pituitary cancer cancer malignant ependymoma malignant pancreatic neoplasm oligodendroglioma pancreatic ductal adenocarcinoma spina bifida
B	Pharos: P11274	chronic myelogenous leukemia, BCR-ABL1 positive chromosome 22q11.2 deletion syndrome, distal blast phase chronic myelogenous leukemia, BCR-ABL1 positive Neoplasms, Experimental bone marrow neoplasm pancreatic intraductal papillary-mucinous neoplasm with low grade dysplasia psoriasis acute T cell leukemia bladder transitional cell carcinoma Burkitt lymphoma leukemia myeloproliferative neoplasm osteosarcoma subependymal giant cell astrocytoma atypical teratoid rhabdoid tumor chronic myelogenous leukemia, BCR-ABL1 positive chromosome 22q11.2 deletion syndrome, distal blast phase chronic myelogenous leukemia, BCR-ABL1 positive Neoplasms, Experimental bone marrow neoplasm pancreatic intraductal papillary-mucinous neoplasm with low grade dysplasia psoriasis acute T cell leukemia bladder transitional cell carcinoma Burkitt lymphoma leukemia myeloproliferative neoplasm osteosarcoma subependymal giant cell astrocytoma atypical teratoid rhabdoid tumor cancer leukemia, acute lymphocytic, susceptibility to, 1 major depressive disorder ovarian cancer bipolar disorder childhood acute lymphoblastic leukemia large cell medulloblastoma