1UYG
Human Hsp90-alpha with 8-(2,5-dimethoxy-benzyl)-2-fluoro-9H-purin-6-ylamine
External Resource: Annotation
Domain Annotation: SCOP/SCOPe Classification SCOP-e Database Homepage
Chains | Domain Info | Class | Fold | Superfamily | Family | Domain | Species | Provenance Source (Version) |
---|---|---|---|---|---|---|---|---|
A | d1uyga_ | Alpha and beta proteins (a+b) | ATPase domain of HSP90 chaperone/DNA topoisomerase II/histidine kinase | ATPase domain of HSP90 chaperone/DNA topoisomerase II/histidine kinase | Heat shock protein 90, HSP90, N-terminal domain | HSP90 | HUMAN (Homo sapiens ) [TaxId: 9606 ], | SCOPe (2.08) |
Domain Annotation: SCOP2 Classification SCOP2 Database Homepage
Domain Annotation: ECOD Classification ECOD Database Homepage
Chains | Family Name | Domain Identifier | Architecture | Possible Homology | Homology | Topology | Family | Provenance Source (Version) |
---|---|---|---|---|---|---|---|---|
A | HATPase_c | e1uygA1 | A: a+b two layers | X: ATPase domain of HSP90 chaperone/DNA topoisomerase II/histidine kinase-like | H: ATPase domain of HSP90 chaperone/DNA topoisomerase II/histidine kinase (From Topology) | T: ATPase domain of HSP90 chaperone/DNA topoisomerase II/histidine kinase | F: HATPase_c | ECOD (1.6) |
Domain Annotation: CATH CATH Database Homepage
Chain | Domain | Class | Architecture | Topology | Homology | Provenance Source (Version) |
---|---|---|---|---|---|---|
A | 3.30.565.10 | Alpha Beta | 2-Layer Sandwich | Heat Shock Protein 90 | Histidine kinase-like ATPase, C-terminal domain | CATH (4.3.0) |
Protein Family Annotation Pfam Database Homepage
Chains | Accession | Name | Description | Comments | Source |
---|---|---|---|---|---|
PF13589 | Histidine kinase-, DNA gyrase B-, and HSP90-like ATPase (HATPase_c_3) | Histidine kinase-, DNA gyrase B-, and HSP90-like ATPase | This family represents, additionally, the structurally related ATPase domains of histidine kinase, DNA gyrase B and HSP90. | Domain |
Gene Ontology: Gene Product Annotation Gene Ontology Database Homepage
InterPro: Protein Family Classification InterPro Database Homepage
Chains | Accession | Name | Type |
---|---|---|---|
IPR020568 | Ribosomal protein uS5 domain 2-type superfamily | Homologous Superfamily | |
IPR001404 | Heat shock protein Hsp90 family | Family | |
IPR020575 | Heat shock protein Hsp90, N-terminal | Domain | |
IPR003594 | Histidine kinase/HSP90-like ATPase domain | Domain | |
IPR019805 | Heat shock protein Hsp90, conserved site | Conserved Site | |
IPR036890 | Histidine kinase/HSP90-like ATPase superfamily | Homologous Superfamily | |
IPR037196 | HSP90, C-terminal domain | Homologous Superfamily |
Pharos: Disease Associations Pharos Homepage Annotation
Chains | Drug Target | Associated Disease |
---|---|---|
P07900 | :