1U0W
An Aldol Switch Discovered in Stilbene Synthases Mediates Cyclization Specificity of Type III Polyketide Synthases: 18xCHS+resveratrol Structure
Domain Annotation: SCOP/SCOPe Classification SCOP-e Database Homepage
Domain Annotation: SCOP2 Classification SCOP2 Database Homepage
Chains | Type | Family Name | Domain Identifier | Family Identifier | Provenance Source (Version) |
---|---|---|---|---|---|
A | SCOP2B Superfamily | Thiolase-like | 8033515 | 3000122 | SCOP2B (2022-06-29) |
A | SCOP2B Superfamily | Thiolase-like | 8033512 | 3000122 | SCOP2B (2022-06-29) |
B | SCOP2B Superfamily | Thiolase-like | 8033515 | 3000122 | SCOP2B (2022-06-29) |
B | SCOP2B Superfamily | Thiolase-like | 8033512 | 3000122 | SCOP2B (2022-06-29) |
D | SCOP2B Superfamily | Thiolase-like | 8033512 | 3000122 | SCOP2B (2022-06-29) |
D | SCOP2B Superfamily | Thiolase-like | 8033515 | 3000122 | SCOP2B (2022-06-29) |
C | SCOP2B Superfamily | Thiolase-like | 8033512 | 3000122 | SCOP2B (2022-06-29) |
C | SCOP2B Superfamily | Thiolase-like | 8033515 | 3000122 | SCOP2B (2022-06-29) |
Domain Annotation: ECOD Classification ECOD Database Homepage
Chains | Family Name | Domain Identifier | Architecture | Possible Homology | Homology | Topology | Family | Provenance Source (Version) |
---|---|---|---|---|---|---|---|---|
A | ACP_syn_III_C | e1u0wA2 | A: a/b three-layered sandwiches | X: Thiolase-like (From Topology) | H: Thiolase-like (From Topology) | T: Thiolase-like | F: ACP_syn_III_C | ECOD (1.6) |
A | Chal_sti_synt_N | e1u0wA1 | A: a/b three-layered sandwiches | X: Thiolase-like (From Topology) | H: Thiolase-like (From Topology) | T: Thiolase-like | F: Chal_sti_synt_N | ECOD (1.6) |
B | ACP_syn_III_C | e1u0wB2 | A: a/b three-layered sandwiches | X: Thiolase-like (From Topology) | H: Thiolase-like (From Topology) | T: Thiolase-like | F: ACP_syn_III_C | ECOD (1.6) |
B | Chal_sti_synt_N | e1u0wB1 | A: a/b three-layered sandwiches | X: Thiolase-like (From Topology) | H: Thiolase-like (From Topology) | T: Thiolase-like | F: Chal_sti_synt_N | ECOD (1.6) |
D | ACP_syn_III_C | e1u0wD2 | A: a/b three-layered sandwiches | X: Thiolase-like (From Topology) | H: Thiolase-like (From Topology) | T: Thiolase-like | F: ACP_syn_III_C | ECOD (1.6) |
D | Chal_sti_synt_N | e1u0wD1 | A: a/b three-layered sandwiches | X: Thiolase-like (From Topology) | H: Thiolase-like (From Topology) | T: Thiolase-like | F: Chal_sti_synt_N | ECOD (1.6) |
C | ACP_syn_III_C | e1u0wC2 | A: a/b three-layered sandwiches | X: Thiolase-like (From Topology) | H: Thiolase-like (From Topology) | T: Thiolase-like | F: ACP_syn_III_C | ECOD (1.6) |
C | Chal_sti_synt_N | e1u0wC1 | A: a/b three-layered sandwiches | X: Thiolase-like (From Topology) | H: Thiolase-like (From Topology) | T: Thiolase-like | F: Chal_sti_synt_N | ECOD (1.6) |
Domain Annotation: CATH CATH Database Homepage
Chain | Domain | Class | Architecture | Topology | Homology | Provenance Source (Version) |
---|---|---|---|---|---|---|
A | 3.40.47.10 | Alpha Beta | 3-Layer(aba) Sandwich | Peroxisomal Thiolase | Chain A, domain 1 | CATH (4.3.0) |
B | 3.40.47.10 | Alpha Beta | 3-Layer(aba) Sandwich | Peroxisomal Thiolase | Chain A, domain 1 | CATH (4.3.0) |
D | 3.40.47.10 | Alpha Beta | 3-Layer(aba) Sandwich | Peroxisomal Thiolase | Chain A, domain 1 | CATH (4.3.0) |
C | 3.40.47.10 | Alpha Beta | 3-Layer(aba) Sandwich | Peroxisomal Thiolase | Chain A, domain 1 | CATH (4.3.0) |
Protein Family Annotation Pfam Database Homepage
Chains | Accession | Name | Description | Comments | Source |
---|---|---|---|---|---|
PF00195 | Chalcone and stilbene synthases, N-terminal domain (Chal_sti_synt_N) | Chalcone and stilbene synthases, N-terminal domain | The C-terminal domain of Chalcone synthase is reported to be structurally similar to domains in thiolase and beta-ketoacyl synthase. The differences in activity are accounted for by differences in this N-terminal domain. | Domain | |
PF02797 | Chalcone and stilbene synthases, C-terminal domain (Chal_sti_synt_C) | Chalcone and stilbene synthases, C-terminal domain | This domain of chalcone synthase is reported to be structurally similar to domains in thiolase and beta-ketoacyl synthase. The differences in activity are accounted for by differences in the N-terminal domain. | Domain |
Gene Ontology: Gene Product Annotation Gene Ontology Database Homepage
InterPro: Protein Family Classification InterPro Database Homepage
Chains | Accession | Name | Type |
---|---|---|---|
IPR001099 | Chalcone/stilbene synthase, N-terminal | Domain | |
IPR016039 | Thiolase-like | Homologous Superfamily | |
IPR012328 | Chalcone/stilbene synthase, C-terminal | Domain | |
IPR011141 | Polyketide synthase, type III | Family | |
IPR018088 | Chalcone/stilbene synthase, active site | Active Site |