Domain Annotation: SCOP2 Classification SCOP2 Database Homepage

ChainsTypeFamily Name Domain Identifier Family IdentifierProvenance Source (Version)
ASCOP2B SuperfamilyNuclear receptor ligand-binding domain 8033332 3001442 SCOP2B (2022-06-29)
C [auth B]SCOP2B SuperfamilyNuclear receptor ligand-binding domain 8033332 3001442 SCOP2B (2022-06-29)
E [auth C]SCOP2B SuperfamilyNuclear receptor ligand-binding domain 8033332 3001442 SCOP2B (2022-06-29)
G [auth D]SCOP2B SuperfamilyNuclear receptor ligand-binding domain 8033332 3001442 SCOP2B (2022-06-29)

Domain Annotation: ECOD Classification ECOD Database Homepage

ChainsFamily NameDomain Identifier ArchitecturePossible HomologyHomologyTopologyFamilyProvenance Source (Version)
AHormone_recepe1p93A1 A: alpha arraysX: Nuclear receptor ligand-binding domain (From Topology)H: Nuclear receptor ligand-binding domain (From Topology)T: Nuclear receptor ligand-binding domainF: Hormone_recepECOD (1.6)
C [auth B]Hormone_recepe1p93B1 A: alpha arraysX: Nuclear receptor ligand-binding domain (From Topology)H: Nuclear receptor ligand-binding domain (From Topology)T: Nuclear receptor ligand-binding domainF: Hormone_recepECOD (1.6)
E [auth C]Hormone_recepe1p93C1 A: alpha arraysX: Nuclear receptor ligand-binding domain (From Topology)H: Nuclear receptor ligand-binding domain (From Topology)T: Nuclear receptor ligand-binding domainF: Hormone_recepECOD (1.6)
G [auth D]Hormone_recepe1p93D1 A: alpha arraysX: Nuclear receptor ligand-binding domain (From Topology)H: Nuclear receptor ligand-binding domain (From Topology)T: Nuclear receptor ligand-binding domainF: Hormone_recepECOD (1.6)

Domain Annotation: CATH CATH Database Homepage

Protein Family Annotation Pfam Database Homepage

ChainsAccessionNameDescriptionCommentsSource
A,
C [auth B],
E [auth C],
G [auth D]
PF00104Ligand-binding domain of nuclear hormone receptor (Hormone_recep)Ligand-binding domain of nuclear hormone receptorThis all helical domain is involved in binding the hormone in these receptors.Domain

Gene Ontology: Gene Product Annotation Gene Ontology Database Homepage

ChainsPolymerMolecular FunctionBiological ProcessCellular Component
A,
C [auth B],
E [auth C],
G [auth D]
Glucocorticoid receptor
B [auth E],
D [auth F],
F [auth G],
H
Nuclear receptor coactivator 2

InterPro: Protein Family Classification InterPro Database Homepage

ChainsAccessionNameType
A,
C [auth B],
E [auth C],
G [auth D]
IPR001628Zinc finger, nuclear hormone receptor-typeDomain
A,
C [auth B],
E [auth C],
G [auth D]
IPR050200Nuclear hormone receptor family NR3 subfamilyFamily
A,
C [auth B],
E [auth C],
G [auth D]
IPR013088Zinc finger, NHR/GATA-typeHomologous Superfamily
A,
C [auth B],
E [auth C],
G [auth D]
IPR001409Glucocorticoid receptorFamily
A,
C [auth B],
E [auth C],
G [auth D]
IPR001723Nuclear hormone receptorFamily
A,
C [auth B],
E [auth C],
G [auth D]
IPR000536Nuclear hormone receptor, ligand-binding domainDomain
A,
C [auth B],
E [auth C],
G [auth D]
IPR035500Nuclear hormone receptor-like domain superfamilyHomologous Superfamily
B [auth E],
D [auth F],
F [auth G],
H
IPR010011Nuclear receptor coactivator, DUF1518Domain
B [auth E],
D [auth F],
F [auth G],
H
IPR009110Nuclear receptor coactivator, interlockingHomologous Superfamily
B [auth E],
D [auth F],
F [auth G],
H
IPR037077Nuclear receptor coactivator, Ncoa-type, interlocking domain superfamilyHomologous Superfamily
B [auth E],
D [auth F],
F [auth G],
H
IPR017426Nuclear receptor coactivatorFamily
B [auth E],
D [auth F],
F [auth G],
H
IPR014935Nuclear receptor coactivator, receptor-binding domainDomain
B [auth E],
D [auth F],
F [auth G],
H
IPR013767PAS foldDomain
B [auth E],
D [auth F],
F [auth G],
H
IPR000014PAS domainDomain
B [auth E],
D [auth F],
F [auth G],
H
IPR011598Myc-type, basic helix-loop-helix (bHLH) domainDomain
B [auth E],
D [auth F],
F [auth G],
H
IPR014920Nuclear receptor coactivator, Ncoa-type, interlockingDomain
B [auth E],
D [auth F],
F [auth G],
H
IPR035965PAS domain superfamilyHomologous Superfamily
B [auth E],
D [auth F],
F [auth G],
H
IPR028822Nuclear receptor coactivator 2, basic helix-loop-helixDomain
B [auth E],
D [auth F],
F [auth G],
H
IPR032565Nuclear receptor coactivator 2/3, DUF4927Domain
B [auth E],
D [auth F],
F [auth G],
H
IPR036638Helix-loop-helix DNA-binding domain superfamilyHomologous Superfamily

Pharos: Disease Associations Pharos Homepage Annotation

ChainsDrug Target  Associated Disease
A,
C [auth B],
E [auth C],
G [auth D]
PharosP04150
B [auth E],
D [auth F],
F [auth G],
H
PharosQ15596