1O8B

Structure of Escherichia coli ribose-5-phosphate isomerase, RpiA, complexed with arabinose-5-phosphate.

External Resource: Annotation

Domain Annotation: SCOP/SCOPe Classification
Domain Annotation: SCOP2 Classification
Domain Annotation: ECOD Classification
Domain Annotation: CATH
Protein Family Annotation
Gene Ontology: Gene Product Annotation
InterPro: Protein Family Classification

Domain Annotation: SCOP/SCOPe Classification SCOP-e Database Homepage

Chains	Domain Info	Class	Fold	Superfamily	Family	Domain	Species	Provenance Source (Version)
B	d1o8bb1	Alpha and beta proteins (a/b)	NagB/RpiA/CoA transferase-like	NagB/RpiA/CoA transferase-like	D-ribose-5-phosphate isomerase (RpiA), catalytic domain	D-ribose-5-phosphate isomerase (RpiA), catalytic domain	(Escherichia coli ) [TaxId: 562 ],	SCOPe (2.08)
B	d1o8bb2	Alpha and beta proteins (a+b)	Ferredoxin-like	D-ribose-5-phosphate isomerase (RpiA), lid domain	D-ribose-5-phosphate isomerase (RpiA), lid domain	D-ribose-5-phosphate isomerase (RpiA), lid domain	(Escherichia coli ) [TaxId: 562 ],	SCOPe (2.08)
A	d1o8ba1	Alpha and beta proteins (a/b)	NagB/RpiA/CoA transferase-like	NagB/RpiA/CoA transferase-like	D-ribose-5-phosphate isomerase (RpiA), catalytic domain	D-ribose-5-phosphate isomerase (RpiA), catalytic domain	(Escherichia coli ) [TaxId: 562 ],	SCOPe (2.08)
A	d1o8ba2	Alpha and beta proteins (a+b)	Ferredoxin-like	D-ribose-5-phosphate isomerase (RpiA), lid domain	D-ribose-5-phosphate isomerase (RpiA), lid domain	D-ribose-5-phosphate isomerase (RpiA), lid domain	(Escherichia coli ) [TaxId: 562 ],	SCOPe (2.08)

Domain Annotation: SCOP2 Classification SCOP2 Database Homepage

Chains	Type	Family Name	Domain Identifier	Family Identifier	Provenance Source (Version)
B	SCOP2B Superfamily	D-ribose-5-phosphate isomerase (RpiA), lid domain	8040600	3001555	SCOP2B (2022-06-29)
B	SCOP2B Superfamily	NagB/RpiA/CoA transferase-like	8040597	3000693	SCOP2B (2022-06-29)
B	SCOP2B Superfamily	NagB/RpiA/CoA transferase-like	8040597	3000693	SCOP2B (2022-06-29)
A	SCOP2B Superfamily	NagB/RpiA/CoA transferase-like	8040597	3000693	SCOP2B (2022-06-29)
A	SCOP2B Superfamily	D-ribose-5-phosphate isomerase (RpiA), lid domain	8040600	3001555	SCOP2B (2022-06-29)

Domain Annotation: ECOD Classification ECOD Database Homepage

Chains	Family Name	Domain Identifier	Architecture	Possible Homology	Homology	Topology	Family	Provenance Source (Version)
B	Rib_5-P_isom_A_C	e1o8bB1	A: a+b two layers	X: Alpha-beta plaits	H: D-ribose-5-phosphate isomerase (RpiA), lid domain (From Topology)	T: D-ribose-5-phosphate isomerase (RpiA), lid domain	F: Rib_5-P_isom_A_C	ECOD (1.6)
B	Rib_5-P_isom_A_N	e1o8bB2	A: a/b three-layered sandwiches	X: Rossmann-like	H: Rossmann-related	T: NagB/RpiA/CoA transferase-like	F: Rib_5-P_isom_A_N	ECOD (1.6)
A	Rib_5-P_isom_A_C	e1o8bA1	A: a+b two layers	X: Alpha-beta plaits	H: D-ribose-5-phosphate isomerase (RpiA), lid domain (From Topology)	T: D-ribose-5-phosphate isomerase (RpiA), lid domain	F: Rib_5-P_isom_A_C	ECOD (1.6)
A	Rib_5-P_isom_A_N	e1o8bA2	A: a/b three-layered sandwiches	X: Rossmann-like	H: Rossmann-related	T: NagB/RpiA/CoA transferase-like	F: Rib_5-P_isom_A_N	ECOD (1.6)

Domain Annotation: CATH CATH Database Homepage

Chain	Domain	Class	Architecture	Topology	Homology	Provenance Source (Version)
B	3.40.50.1360	Alpha Beta	3-Layer(aba) Sandwich	Rossmann fold		CATH (4.3.0)
B	3.30.70.260	Alpha Beta	2-Layer Sandwich	Alpha-Beta Plaits	ACT domain	CATH (4.3.0)
A	3.40.50.1360	Alpha Beta	3-Layer(aba) Sandwich	Rossmann fold		CATH (4.3.0)
A	3.30.70.260	Alpha Beta	2-Layer Sandwich	Alpha-Beta Plaits	ACT domain	CATH (4.3.0)

Protein Family Annotation Pfam Database Homepage

Chains	Accession	Name	Description	Comments	Source
A, B	PF06026	Ribose 5-phosphate isomerase A (phosphoriboisomerase A) (Rib_5-P_isom_A)	Ribose 5-phosphate isomerase A (phosphoriboisomerase A)	-	Family

Gene Ontology: Gene Product Annotation Gene Ontology Database Homepage

Chains	Polymer	Molecular Function	Biological Process	Cellular Component
A, B	RIBOSE 5-PHOSPHATE ISOMERASE	isomerase activity intramolecular oxidoreductase activity, interconverting aldoses and ketoses intramolecular oxidoreductase activity ribose-5-phosphate isomerase activity catalytic activity identical protein binding protein binding binding protein homodimerization activity protein dimerization activity	monosaccharide metabolic process carbohydrate metabolic process small molecule metabolic process metabolic process cellular process primary metabolic process pentose metabolic process D-ribose metabolic process carbohydrate derivative metabolic process glyceraldehyde-3-phosphate metabolic process glucose 6-phosphate metabolic process nucleobase-containing compound metabolic process purine nucleotide metabolic process nucleobase-containing small molecule metabolic process monosaccharide metabolic process carbohydrate metabolic process small molecule metabolic process metabolic process cellular process primary metabolic process pentose metabolic process D-ribose metabolic process carbohydrate derivative metabolic process glyceraldehyde-3-phosphate metabolic process glucose 6-phosphate metabolic process nucleobase-containing compound metabolic process purine nucleotide metabolic process nucleobase-containing small molecule metabolic process pentose-phosphate shunt phosphate-containing compound metabolic process pyridine-containing compound metabolic process phosphorus metabolic process pyridine nucleotide metabolic process nucleoside phosphate metabolic process nicotinamide nucleotide metabolic process generation of precursor metabolites and energy nucleotide metabolic process aldehyde metabolic process purine-containing compound metabolic process NADP metabolic process NADPH regeneration organophosphate metabolic process pentose-phosphate shunt, non-oxidative branch	cellular anatomical structure intracellular anatomical structure cytoplasm cytosol

InterPro: Protein Family Classification InterPro Database Homepage

Chains	Accession	Name	Type
A, B	IPR037171	NagB/RpiA transferase-like	Homologous Superfamily
A, B	IPR020672	Ribose-5-phosphate isomerase, type A, subgroup	Family
A, B	IPR004788	Ribose 5-phosphate isomerase, type A	Family

RCSB PDB Core Operations are funded by the U.S. National Science Foundation (DBI-2321666), the US Department of Energy (DE-SC0019749), and the National Cancer Institute, National Institute of Allergy and Infectious Diseases, and National Institute of General Medical Sciences of the National Institutes of Health under grant R01GM157729.