1NYC | pdb_00001nyc

Staphostatins resemble lipocalins, not cystatins in fold.

External Resource: Annotation

Domain Annotation: SCOP/SCOPe Classification
Domain Annotation: SCOP2 Classification
Domain Annotation: ECOD Classification
Domain Annotation: CATH
Protein Family Annotation
Gene Ontology: Gene Product Annotation
InterPro: Protein Family Classification

Domain Annotation: SCOP/SCOPe Classification SCOP-e Database Homepage

Chains	Domain Info	Class	Fold	Superfamily	Family	Domain	Species	Provenance Source (Version)
A	d1nyca1	All beta proteins	Streptavidin-like	beta-Barrel protease inhibitors	Staphostatin	Staphostatin B (SspC)	(Staphylococcus aureus subsp. aureus MW2 ) [TaxId: 196620 ],	SCOPe (2.08)
A	d1nyca2	Artifacts	Tags	Tags	Tags	N-terminal Tags	(Staphylococcus aureus subsp. aureus MW2 ) [TaxId: 196620 ],	SCOPe (2.08)
B	d1nycb1	All beta proteins	Streptavidin-like	beta-Barrel protease inhibitors	Staphostatin	Staphostatin B (SspC)	(Staphylococcus aureus subsp. aureus MW2 ) [TaxId: 196620 ],	SCOPe (2.08)
B	d1nycb2	Artifacts	Tags	Tags	Tags	N-terminal Tags	(Staphylococcus aureus subsp. aureus MW2 ) [TaxId: 196620 ],	SCOPe (2.08)

Domain Annotation: SCOP2 Classification SCOP2 Database Homepage

Chains	Type	Family Name	Domain Identifier	Family Identifier	Provenance Source (Version)
A	SCOP2 Family	Staphostatin	8024711	4000917	SCOP2 (2022-06-29)
A	SCOP2 Superfamily	beta-Barrel protease inhibitors	8037090	3001476	SCOP2 (2022-06-29)
B	SCOP2B Superfamily	beta-Barrel protease inhibitors	8037090	3001476	SCOP2B (2022-06-29)

Domain Annotation: ECOD Classification ECOD Database Homepage

Chains	Family Name	Domain Identifier	Architecture	Possible Homology	Homology	Topology	Family	Provenance Source (Version)
A	Staphostatin_B	e1nycA1	A: beta barrels	X: Lipocalins/Streptavidin	H: Staphostatin (From Topology)	T: Staphostatin	F: Staphostatin_B	ECOD (1.6)
B	Staphostatin_B	e1nycB1	A: beta barrels	X: Lipocalins/Streptavidin	H: Staphostatin (From Topology)	T: Staphostatin	F: Staphostatin_B	ECOD (1.6)

Domain Annotation: CATH CATH Database Homepage

Chain	Domain	Class	Architecture	Topology	Homology	Provenance Source (Version)
A	2.40.310.10	Mainly Beta	Beta Barrel	Staphostatins	beta-Barrel protease inhibitors	CATH (4.3.0)
B	2.40.310.10	Mainly Beta	Beta Barrel	Staphostatins	beta-Barrel protease inhibitors	CATH (4.3.0)

Protein Family Annotation Pfam Database Homepage

Chains	Accession	Name	Description	Comments	Source
A, B	PF09023	Staphostatin B (Staphostatin_B)	Staphostatin B	Staphostatin B inhibits the cysteine protease Staphopain B, produced by Staphylococcus aureus, by blocking the active site of the enzyme. The domain adopts an eight-stranded mixed beta-barrel structure, with a deviation from the up-down topology of c ...	Staphostatin B inhibits the cysteine protease Staphopain B, produced by Staphylococcus aureus, by blocking the active site of the enzyme. The domain adopts an eight-stranded mixed beta-barrel structure, with a deviation from the up-down topology of canonical beta-barrels in the amino-terminal part of the molecule [1].	Domain

Gene Ontology: Gene Product Annotation Gene Ontology Database Homepage

Chains	Polymer	Molecular Function	Biological Process	Cellular Component
A, B	cysteine protease inhibitor	enzyme regulator activity peptidase activity peptidase regulator activity catalytic activity, acting on a protein hydrolase activity enzyme inhibitor activity cysteine-type endopeptidase inhibitor activity peptidase inhibitor activity endopeptidase regulator activity endopeptidase inhibitor activity cysteine-type peptidase activity molecular function inhibitor activity molecular function regulator activity cysteine-type endopeptidase activity catalytic activity enzyme regulator activity peptidase activity peptidase regulator activity catalytic activity, acting on a protein hydrolase activity enzyme inhibitor activity cysteine-type endopeptidase inhibitor activity peptidase inhibitor activity endopeptidase regulator activity endopeptidase inhibitor activity cysteine-type peptidase activity molecular function inhibitor activity molecular function regulator activity cysteine-type endopeptidase activity catalytic activity endopeptidase activity	-	cellular anatomical structure intracellular anatomical structure cytoplasm

InterPro: Protein Family Classification InterPro Database Homepage

Chains	Accession	Name	Type
A, B	IPR016085	Protease inhibitor, beta-barrel domain	Homologous Superfamily
A, B	IPR015113	Staphostatin B	Domain
A, B	IPR037296	Staphostatin A/B	Homologous Superfamily

RCSB PDB Core Operations are funded by the U.S. National Science Foundation (DBI-2321666), the US Department of Energy (DE-SC0019749), and the National Cancer Institute, National Institute of Allergy and Infectious Diseases, and National Institute of General Medical Sciences of the National Institutes of Health under grant R01GM157729.