1NTV | pdb_00001ntv

Crystal Structure of the Disabled-1 (Dab1) PTB domain-ApoER2 peptide complex

External Resource: Annotation

Domain Annotation: SCOP/SCOPe Classification
Domain Annotation: SCOP2 Classification
Domain Annotation: ECOD Classification
Domain Annotation: CATH
Protein Family Annotation
Gene Ontology: Gene Product Annotation
InterPro: Protein Family Classification

Domain Annotation: SCOP/SCOPe Classification SCOP-e Database Homepage

Chains	Domain Info	Class	Fold	Superfamily	Family	Domain	Species	Provenance Source (Version)
A	d1ntva_	All beta proteins	PH domain-like barrel	PH domain-like	Phosphotyrosine-binding domain (PTB)	Disabled homolog 1 (Dab1)	house mouse (Mus musculus ) [TaxId: 10090 ],	SCOPe (2.08)

Domain Annotation: SCOP2 Classification SCOP2 Database Homepage

Chains	Type	Family Name	Domain Identifier	Family Identifier	Provenance Source (Version)
A	SCOP2 Family	Phosphotyrosine-binding domain (PTB)	8021227	4002427	SCOP2 (2022-06-29)
A	SCOP2 Superfamily	PH domain-like	8033607	3000134	SCOP2 (2022-06-29)

Domain Annotation: ECOD Classification ECOD Database Homepage

Chains	Family Name	Domain Identifier	Architecture	Possible Homology	Homology	Topology	Family	Provenance Source (Version)
A	PID	e1ntvA1	A: beta barrels	X: PH domain-like	H: PH domain-like (From Topology)	T: PH domain-like	F: PID	ECOD (1.6)

Domain Annotation: CATH CATH Database Homepage

Chain	Domain	Class	Architecture	Topology	Homology	Provenance Source (Version)
A	2.30.29.30	Mainly Beta	Roll	PH-domain like	Pleckstrin-homology domain (PH domain)/Phosphotyrosine-binding domain (PTB)	CATH (4.3.0)

Protein Family Annotation Pfam Database Homepage

Chains	Accession	Name	Description	Comments	Source
A	PF21792	Disabled homolog 2-like, sulfatide-binding motifs (DAB2_SBM)	Disabled homolog 2-like, sulfatide-binding motifs	-	Motif
A	PF00640	Phosphotyrosine interaction domain (PTB/PID) (PID)	Phosphotyrosine interaction domain (PTB/PID)		Domain

Gene Ontology: Gene Product Annotation Gene Ontology Database Homepage

Chains	Polymer	Molecular Function	Biological Process	Cellular Component
A	Disabled homolog 1	protein-macromolecule adaptor activity molecular adaptor activity signaling adaptor activity protein binding binding SH2 domain binding protein domain specific binding phospholipid binding lipid binding	multicellular organismal process regulation of cellular process cellular developmental process regulation of developmental process astrocyte differentiation negative regulation of biological process cell development regulation of neurogenesis regulation of cell differentiation regulation of gliogenesis regulation of astrocyte differentiation regulation of cell development regulation of nervous system development multicellular organism development neurogenesis multicellular organismal process regulation of cellular process cellular developmental process regulation of developmental process astrocyte differentiation negative regulation of biological process cell development regulation of neurogenesis regulation of cell differentiation regulation of gliogenesis regulation of astrocyte differentiation regulation of cell development regulation of nervous system development multicellular organism development neurogenesis negative regulation of neurogenesis gliogenesis cell differentiation anatomical structure development negative regulation of cellular process regulation of multicellular organismal process negative regulation of nervous system development negative regulation of cell differentiation system development developmental process regulation of multicellular organismal development regulation of biological process negative regulation of developmental process biological regulation regulation of glial cell differentiation nervous system development negative regulation of astrocyte differentiation negative regulation of gliogenesis negative regulation of cell development negative regulation of glial cell differentiation central nervous system development glial cell differentiation cellular process negative regulation of multicellular organismal process head development forebrain development animal organ development brain development pallium development telencephalon development hippocampus development limbic system development lateral motor column neuron migration neuron migration spinal cord motor neuron migration motor neuron migration generation of neurons cell migration cell motility cerebral cortex cell migration cerebral cortex development telencephalon cell migration forebrain cell migration neuron differentiation cerebral cortex radially oriented cell migration axonogenesis cell projection organization plasma membrane bounded cell projection morphogenesis neuron projection development cell morphogenesis cellular component organization cell projection morphogenesis neuron projection morphogenesis cellular component organization or biogenesis plasma membrane bounded cell projection organization axon development cell morphogenesis involved in neuron differentiation anatomical structure morphogenesis neuron development radial glia guided migration of Purkinje cell hindbrain radial glia guided cell migration hindbrain development cell migration in hindbrain cellular response to stimulus cell surface receptor signaling pathway via STAT response to stimulus signaling negative regulation of signaling regulation of signal transduction negative regulation of cell communication cell communication regulation of receptor signaling pathway via JAK-STAT signal transduction negative regulation of receptor signaling pathway via JAK-STAT regulation of signaling cell surface receptor signaling pathway negative regulation of response to stimulus negative regulation of signal transduction regulation of response to stimulus regulation of cell communication negative regulation of receptor signaling pathway via STAT regulation of receptor signaling pathway via STAT cell surface receptor signaling pathway via JAK-STAT cerebellum morphogenesis hindbrain morphogenesis cerebellum development metencephalon development cerebellum structural organization anatomical structure arrangement hindbrain structural organization regulation of cellular component organization developmental maturation synapse maturation regulation of synapse organization regulation of synapse maturation cell junction organization regulation of synapse structure or activity synapse organization regulation of biological quality glial cell migration telencephalon glial cell migration cell adhesion cell-cell adhesion cell-cell adhesion via plasma-membrane adhesion molecules neuronal-glial interaction involved in cerebral cortex radial glia guided migration cell-cell adhesion involved in neuronal-glial interactions involved in cerebral cortex radial glia guided migration cerebral cortex radial glia-guided migration dendrite development positive regulation of biological process positive regulation of neuron differentiation positive regulation of developmental process positive regulation of cell differentiation positive regulation of cellular process regulation of neuron differentiation spinal cord development ventral spinal cord development reelin-mediated signaling pathway Golgi localization localization organelle localization radial glia-guided pyramidal neuron migration negative regulation of cellular component organization regulation of cell projection organization negative regulation of axonogenesis regulation of neuron projection development regulation of axonogenesis negative regulation of cell projection organization regulation of anatomical structure morphogenesis negative regulation of neuron projection development regulation of plasma membrane bounded cell projection organization adult walking behavior adult locomotory behavior behavior adult behavior locomotory behavior walking behavior intracellular signal transduction small GTPase-mediated signal transduction intracellular signaling cassette regulation of cell adhesion negative regulation of cell adhesion	membrane-bounded organelle intracellular organelle cellular anatomical structure intracellular anatomical structure organelle intracellular membrane-bounded organelle cytoplasm synapse cell junction glutamatergic synapse perinuclear region of cytoplasm
B	Apolipoprotein E Receptor-2 peptide	-	-	-

InterPro: Protein Family Classification InterPro Database Homepage

Chains	Accession	Name	Type
A	IPR011993	PH-like domain superfamily	Homologous Superfamily
A	IPR006020	PTB/PI domain	Domain
A	IPR048561	Disabled, phosphotyrosine-binding domain	Domain
A	IPR048559	Disabled homolog 1/2, sulfatide-binding motif	Conserved Site

RCSB PDB Core Operations are funded by the U.S. National Science Foundation (DBI-2321666), the US Department of Energy (DE-SC0019749), and the National Cancer Institute, National Institute of Allergy and Infectious Diseases, and National Institute of General Medical Sciences of the National Institutes of Health under grant R01GM157729.