1NHL | pdb_00001nhl

SNAP-23N Structure

External Resource: Annotation

Domain Annotation: SCOP/SCOPe Classification
Domain Annotation: SCOP2 Classification
Domain Annotation: CATH
Gene Ontology: Gene Product Annotation
InterPro: Protein Family Classification
Pharos: Disease Associations

Domain Annotation: SCOP/SCOPe Classification SCOP-e Database Homepage

Chains	Domain Info	Class	Fold	Superfamily	Family	Domain	Species	Provenance Source (Version)
A	d1nhla_	Coiled coil proteins	Parallel coiled-coil	SNARE fusion complex	SNARE fusion complex	Synaptosomal-associated protein SNAP-23	human (Homo sapiens ) [TaxId: 9606 ],	SCOPe (2.08)

Domain Annotation: SCOP2 Classification SCOP2 Database Homepage

Chains	Type	Family Name	Domain Identifier	Family Identifier	Provenance Source (Version)
A	SCOP2 Family	SNARE fusion complex	8020950	4003812	SCOP2 (2022-06-29)
A	SCOP2 Superfamily	SNARE fusion complex	8033330	3001549	SCOP2 (2022-06-29)

Domain Annotation: CATH CATH Database Homepage

Chain	Domain	Class	Architecture	Topology	Homology	Provenance Source (Version)
A	1.20.5.110	Mainly Alpha	Up-down Bundle	Single alpha-helices involved in coiled-coils or other helix-helix interfaces		CATH (4.3.0)

Gene Ontology: Gene Product Annotation Gene Ontology Database Homepage

Chains	Polymer	Molecular Function	Biological Process	Cellular Component
A	Synaptosomal-associated protein 23	protein binding binding SNARE binding syntaxin binding syntaxin-1 binding SNAP receptor activity protein-macromolecule adaptor activity molecular adaptor activity	membrane organization cellular component organization membrane fusion cellular process cellular component organization or biogenesis localization post-Golgi vesicle-mediated transport transport establishment of localization Golgi vesicle transport vesicle-mediated transport protein localization establishment of protein localization cellular localization membrane organization cellular component organization membrane fusion cellular process cellular component organization or biogenesis localization post-Golgi vesicle-mediated transport transport establishment of localization Golgi vesicle transport vesicle-mediated transport protein localization establishment of protein localization cellular localization nitrogen compound transport protein transport cellular macromolecule localization macromolecule localization establishment of organelle localization multicellular organismal process regulated exocytosis response to stimulus cell activation involved in immune response leukocyte degranulation myeloid leukocyte activation myeloid leukocyte mediated immunity cell communication establishment of localization in cell leukocyte mediated immunity regulation of biological quality regulation of biological process immune response regulation of hormone levels histamine secretion by mast cell vacuolar localization mast cell degranulation immune effector process histamine secretion involved in inflammatory response exocytosis lysosome localization inflammatory response histamine production involved in inflammatory response signaling hormone secretion histamine secretion leukocyte activation secretion by cell organelle localization response to stress signal release leukocyte activation involved in immune response histamine transport mast cell activation mast cell mediated immunity production of molecular mediator involved in inflammatory response secretion defense response cell activation biological regulation export from cell cell-cell signaling myeloid cell activation involved in immune response mast cell activation involved in immune response immune system process exocytic process hormone transport organelle membrane fusion synaptic vesicle cycle synaptic vesicle exocytosis vesicle-mediated transport in synapse vesicle organization synaptic signaling endomembrane system organization vesicle fusion to plasma membrane trans-synaptic signaling neurotransmitter secretion synaptic vesicle fusion to presynaptic active zone membrane neurotransmitter transport chemical synaptic transmission organelle fusion signal release from synapse organelle organization anterograde trans-synaptic signaling synaptic vesicle membrane organization vesicle fusion synaptic vesicle priming cellular component biogenesis cellular component assembly protein-containing complex assembly protein-containing complex organization vesicle localization establishment of vesicle localization vesicle targeting	membrane-bounded organelle intracellular organelle cellular anatomical structure intracellular anatomical structure mitochondrion organelle cytoplasm intracellular membrane-bounded organelle tertiary granule membrane membrane intracellular vesicle endomembrane system tertiary granule cytoplasmic vesicle membrane membrane-bounded organelle intracellular organelle cellular anatomical structure intracellular anatomical structure mitochondrion organelle cytoplasm intracellular membrane-bounded organelle tertiary granule membrane membrane intracellular vesicle endomembrane system tertiary granule cytoplasmic vesicle membrane bounding membrane of organelle vesicle membrane cytoplasmic vesicle secretory granule secretory vesicle vesicle organelle membrane secretory granule membrane anchoring junction cell junction focal adhesion cell-substrate junction specific granule membrane specific granule extracellular exosome extracellular vesicle extracellular organelle extracellular region extracellular space extracellular membrane-bounded organelle SNARE complex protein-containing complex membrane protein complex cell periphery plasma membrane presynapse synapse nucleus membrane-enclosed lumen intracellular organelle lumen nucleoplasm organelle lumen nuclear lumen cell projection neuron projection plasma membrane bounded cell projection cell-cell junction adherens junction phagocytic vesicle phagocytic vesicle membrane endocytic vesicle membrane endocytic vesicle lytic vacuole azurophil granule vacuole primary lysosome lysosome synaptobrevin 2-SNAP-25-syntaxin-1a-complexin I complex

InterPro: Protein Family Classification InterPro Database Homepage

Chains	Accession	Name	Type
A	IPR000727	Target SNARE coiled-coil homology domain	Domain
A	IPR000928	SNAP-25 domain	Domain

Pharos: Disease Associations Pharos Homepage Annotation

Chains	Drug Target	Associated Disease
A	Pharos: O00161	Liver Cirrhosis, Experimental oligodendroglioma pancreatic intraductal papillary-mucinous carcinoma pilocytic astrocytoma Sjogren syndrome adenoma atypical teratoid rhabdoid tumor dermatomyositis Gaucher disease large cell medulloblastoma lymphoplasmacytic lymphoma myocardial ischemia osteosarcoma pancreatic intraductal papillary-mucinous neoplasm plasma cell myeloma Liver Cirrhosis, Experimental oligodendroglioma pancreatic intraductal papillary-mucinous carcinoma pilocytic astrocytoma Sjogren syndrome adenoma atypical teratoid rhabdoid tumor dermatomyositis Gaucher disease large cell medulloblastoma lymphoplasmacytic lymphoma myocardial ischemia osteosarcoma pancreatic intraductal papillary-mucinous neoplasm plasma cell myeloma subependymal giant cell astrocytoma amyotrophic lateral sclerosis bipolar disorder Down syndrome glioblastoma malignant ependymoma myopathy ovarian cancer pancreatic intraductal papillary-mucinous neoplasm with low grade dysplasia psoriasis astrocytic tumor coronary artery disease endogenous depression juvenile dermatomyositis lung carcinoma medulloblastoma

RCSB PDB Core Operations are funded by the U.S. National Science Foundation (DBI-2321666), the US Department of Energy (DE-SC0019749), and the National Cancer Institute, National Institute of Allergy and Infectious Diseases, and National Institute of General Medical Sciences of the National Institutes of Health under grant R01GM157729.