Annotations: 1MTY

Domain Annotation: SCOP/SCOPe Classification SCOP-e Database Homepage

Chains	Domain Info	Class	Fold	Superfamily	Family	Domain	Species	Provenance Source (Version)
A [auth D]	d1mtyd_	All alpha proteins	Ferritin-like	Ferritin-like	Ribonucleotide reductase-like	Methane monooxygenase hydrolase alpha subunit	(Methylococcus capsulatus str. Bath ) [TaxId: 243233 ],	SCOPe (2.08)
B [auth E]	d1mtye_	All alpha proteins	Ferritin-like	Ferritin-like	Ribonucleotide reductase-like	Methane monooxygenase hydrolase alpha subunit	(Methylococcus capsulatus str. Bath ) [TaxId: 243233 ],	SCOPe (2.08)
C [auth B]	d1mtyb_	All alpha proteins	Ferritin-like	Ferritin-like	Ribonucleotide reductase-like	Methane monooxygenase hydrolase beta subunit	(Methylococcus capsulatus str. Bath ) [TaxId: 243233 ],	SCOPe (2.08)
D [auth C]	d1mtyc_	All alpha proteins	Ferritin-like	Ferritin-like	Ribonucleotide reductase-like	Methane monooxygenase hydrolase beta subunit	(Methylococcus capsulatus str. Bath ) [TaxId: 243233 ],	SCOPe (2.08)
E [auth G]	d1mtyg_	All alpha proteins	Open three-helical up-and-down bundle	Methane monooxygenase hydrolase, gamma subunit	Methane monooxygenase hydrolase, gamma subunit	Methane monooxygenase hydrolase, gamma subunit	(Methylococcus capsulatus str. Bath ) [TaxId: 243233 ],	SCOPe (2.08)
F [auth H]	d1mtyh_	All alpha proteins	Open three-helical up-and-down bundle	Methane monooxygenase hydrolase, gamma subunit	Methane monooxygenase hydrolase, gamma subunit	Methane monooxygenase hydrolase, gamma subunit	(Methylococcus capsulatus str. Bath ) [TaxId: 243233 ],	SCOPe (2.08)

Domain Annotation: SCOP2 Classification SCOP2 Database Homepage

Chains	Type	Family Name	Domain Identifier	Family Identifier	Provenance Source (Version)
A [auth D]	SCOP2 Family	Ribonucleotide reductase-like	8024637	4000846	SCOP2 (2022-06-29)
A [auth D]	SCOP2 Superfamily	Ferritin-like	8037016	3001658	SCOP2 (2022-06-29)
B [auth E]	SCOP2B Superfamily	Ferritin-like	8037016	3001658	SCOP2B (2022-06-29)
C [auth B]	SCOP2 Family	Ribonucleotide reductase-like	8024636	4000846	SCOP2 (2022-06-29)
C [auth B]	SCOP2 Superfamily	Ferritin-like	8037015	3001658	SCOP2 (2022-06-29)
D [auth C]	SCOP2B Superfamily	Ferritin-like	8037015	3001658	SCOP2B (2022-06-29)
E [auth G]	SCOP2 Family	Methane monooxygenase hydrolase, gamma subunit	8024464	4000804	SCOP2 (2022-06-29)
E [auth G]	SCOP2 Superfamily	Methane monooxygenase hydrolase, gamma subunit	8036843	3001468	SCOP2 (2022-06-29)
F [auth H]	SCOP2B Superfamily	Methane monooxygenase hydrolase, gamma subunit	8036843	3001468	SCOP2B (2022-06-29)

Domain Annotation: ECOD Classification ECOD Database Homepage

Chains	Family Name	Domain Identifier	Architecture	Possible Homology	Homology	Topology	Family	Provenance Source (Version)
A [auth D]	Phenol_Hydrox	e1mtyD1	A: alpha bundles	X: Ferritin/Heme oxygenase/4-helical cytokines	H: Ferritin/Heme oxygenase	T: Heme oxygenase/Ribonucleotide reductase	F: Phenol_Hydrox	ECOD (1.6)
B [auth E]	Phenol_Hydrox	e1mtyE1	A: alpha bundles	X: Ferritin/Heme oxygenase/4-helical cytokines	H: Ferritin/Heme oxygenase	T: Heme oxygenase/Ribonucleotide reductase	F: Phenol_Hydrox	ECOD (1.6)
C [auth B]	Phenol_Hydrox	e1mtyB1	A: alpha bundles	X: Ferritin/Heme oxygenase/4-helical cytokines	H: Ferritin/Heme oxygenase	T: Heme oxygenase/Ribonucleotide reductase	F: Phenol_Hydrox	ECOD (1.6)
D [auth C]	Phenol_Hydrox	e1mtyC1	A: alpha bundles	X: Ferritin/Heme oxygenase/4-helical cytokines	H: Ferritin/Heme oxygenase	T: Heme oxygenase/Ribonucleotide reductase	F: Phenol_Hydrox	ECOD (1.6)
E [auth G]	MeMO_Hyd_G	e1mtyG1	A: alpha arrays	X: Methane monooxygenase hydrolase gamma subunit-like	H: Methane monooxygenase hydrolase gamma subunit (From Topology)	T: Methane monooxygenase hydrolase gamma subunit	F: MeMO_Hyd_G	ECOD (1.6)
F [auth H]	MeMO_Hyd_G	e1mtyH1	A: alpha arrays	X: Methane monooxygenase hydrolase gamma subunit-like	H: Methane monooxygenase hydrolase gamma subunit (From Topology)	T: Methane monooxygenase hydrolase gamma subunit	F: MeMO_Hyd_G	ECOD (1.6)

Domain Annotation: CATH CATH Database Homepage

Chain	Domain	Class	Architecture	Topology	Homology	Provenance Source (Version)
A [auth D]	1.10.620.20	Mainly Alpha	Orthogonal Bundle	Ribonucleotide Reductase, subunit A	Ribonucleotide Reductase, subunit A	CATH (4.3.0)
B [auth E]	1.10.620.20	Mainly Alpha	Orthogonal Bundle	Ribonucleotide Reductase, subunit A	Ribonucleotide Reductase, subunit A	CATH (4.3.0)
C [auth B]	1.10.620.20	Mainly Alpha	Orthogonal Bundle	Ribonucleotide Reductase, subunit A	Ribonucleotide Reductase, subunit A	CATH (4.3.0)
D [auth C]	1.10.620.20	Mainly Alpha	Orthogonal Bundle	Ribonucleotide Reductase, subunit A	Ribonucleotide Reductase, subunit A	CATH (4.3.0)
E [auth G]	1.20.1280.10	Mainly Alpha	Up-down Bundle	Monooxygenase	Methane monooxygenase, gamma chain, domain 1	CATH (4.3.0)
E [auth G]	1.20.1280.30	Mainly Alpha	Up-down Bundle	Monooxygenase	Methane monooxygenase, gamma chain, domain 2	CATH (4.3.0)
F [auth H]	1.20.1280.10	Mainly Alpha	Up-down Bundle	Monooxygenase	Methane monooxygenase, gamma chain, domain 1	CATH (4.3.0)
F [auth H]	1.20.1280.30	Mainly Alpha	Up-down Bundle	Monooxygenase	Methane monooxygenase, gamma chain, domain 2	CATH (4.3.0)

Protein Family Annotation Pfam Database Homepage

Chains	Accession	Name	Description	Comments	Source
A [auth D], B [auth E]	PF02332	Methane/Phenol/Alkene Hydroxylase (Phenol_Hydrox)	Methane/Phenol/Alkene Hydroxylase	This protein family includes several components of multicomponent enzyme systems predominantly found in Proteobacteria and Actinobacteria, including subunits alpha and beta of a methane monooxygenase and an alkene monooxygenase system, small and larg ...	This protein family includes several components of multicomponent enzyme systems predominantly found in Proteobacteria and Actinobacteria, including subunits alpha and beta of a methane monooxygenase and an alkene monooxygenase system, small and large subunits of propane 2-monooxygenase system and P1 protein of phenol hydroxylase [1-4].	Domain
C [auth B], D [auth C]	PF02332	Methane/Phenol/Alkene Hydroxylase (Phenol_Hydrox)	Methane/Phenol/Alkene Hydroxylase	This protein family includes several components of multicomponent enzyme systems predominantly found in Proteobacteria and Actinobacteria, including subunits alpha and beta of a methane monooxygenase and an alkene monooxygenase system, small and larg ...	This protein family includes several components of multicomponent enzyme systems predominantly found in Proteobacteria and Actinobacteria, including subunits alpha and beta of a methane monooxygenase and an alkene monooxygenase system, small and large subunits of propane 2-monooxygenase system and P1 protein of phenol hydroxylase [1-4].	Domain
E [auth G], F [auth H]	PF02964	Methane monooxygenase, hydrolase gamma chain (MeMO_Hyd_G)	Methane monooxygenase, hydrolase gamma chain	-	Domain

Gene Ontology: Gene Product Annotation Gene Ontology Database Homepage

Chains	Polymer	Molecular Function	Biological Process	Cellular Component
A [auth D], B [auth E]	METHANE MONOOXYGENASE HYDROXYLASE	oxidoreductase activity monooxygenase activity oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen methane monooxygenase [NAD(P)H] activity oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen, NAD(P)H as one donor, and incorporation of one atom of oxygen catalytic activity cation binding ion binding binding metal ion binding small molecule binding	small molecule metabolic process metabolic process cellular process one-carbon metabolic process	-
C [auth B], D [auth C]	METHANE MONOOXYGENASE HYDROXYLASE	oxidoreductase activity monooxygenase activity oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen methane monooxygenase [NAD(P)H] activity oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen, NAD(P)H as one donor, and incorporation of one atom of oxygen catalytic activity	small molecule metabolic process metabolic process cellular process one-carbon metabolic process	-
E [auth G], F [auth H]	METHANE MONOOXYGENASE HYDROXYLASE	oxidoreductase activity monooxygenase activity oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen methane monooxygenase [NAD(P)H] activity oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen, NAD(P)H as one donor, and incorporation of one atom of oxygen catalytic activity	alkane metabolic process methane metabolic process metabolic process cellular process hydrocarbon metabolic process small molecule metabolic process one-carbon metabolic process	-

InterPro: Protein Family Classification InterPro Database Homepage

Chains	Accession	Name	Type
A [auth D], B [auth E]	IPR009078	Ferritin-like superfamily	Homologous Superfamily
A [auth D], B [auth E]	IPR003430	Propane/methane/phenol/toluene hydroxylase	Family
A [auth D], B [auth E]	IPR012348	Ribonucleotide reductase-like	Homologous Superfamily
C [auth B], D [auth C]	IPR054956	Methane monooxygenase component A beta chain	Family
C [auth B], D [auth C]	IPR009078	Ferritin-like superfamily	Homologous Superfamily
C [auth B], D [auth C]	IPR003430	Propane/methane/phenol/toluene hydroxylase	Family
C [auth B], D [auth C]	IPR012078	Methane/phenol monooxygenase, hydroxylase component	Family
C [auth B], D [auth C]	IPR012348	Ribonucleotide reductase-like	Homologous Superfamily
E [auth G], F [auth H]	IPR015952	Methane monooxygenase, gamma chain, domain 1	Homologous Superfamily
E [auth G], F [auth H]	IPR054953	Methane monooxygenase component A gamma chain	Family
E [auth G], F [auth H]	IPR015953	Methane monooxygenase, gamma chain, domain 2	Homologous Superfamily
E [auth G], F [auth H]	IPR036123	Methane monooxygenase, gamma chain superfamily	Homologous Superfamily
E [auth G], F [auth H]	IPR004222	Methane monooxygenase, gamma chain	Family

RCSB PDB Core Operations are funded by the U.S. National Science Foundation (DBI-2321666), the US Department of Energy (DE-SC0019749), and the National Cancer Institute, National Institute of Allergy and Infectious Diseases, and National Institute of General Medical Sciences of the National Institutes of Health under grant R01GM157729.