Annotations: 1M6K


Domain Annotation: SCOP2 Classification SCOP2 Database Homepage

ChainsTypeFamily Name Domain Identifier Family IdentifierProvenance Source (Version)
ASCOP2 Familybeta-Lactamase/D-ala carboxypeptidase 8030944 4002685 SCOP2 (2022-06-29)
ASCOP2 Superfamilybeta-lactamase/transpeptidase-like 8043323 3001604 SCOP2 (2022-06-29)
BSCOP2B Superfamilybeta-lactamase/transpeptidase-like 8043323 3001604 SCOP2B (2022-06-29)

Domain Annotation: ECOD Classification ECOD Database Homepage

ChainsFamily NameDomain Identifier ArchitecturePossible HomologyHomologyTopologyFamilyProvenance Source (Version)
ATranspeptidase_1ste1m6kA1 A: alpha complex topologyX: alpha-helical domain in beta-lactamase/transpeptidase-like proteins (From Topology)H: alpha-helical domain in beta-lactamase/transpeptidase-like proteins (From Topology)T: alpha-helical domain in beta-lactamase/transpeptidase-like proteinsF: Transpeptidase_1stECOD (1.6)
ATranspeptidase_2nd_1e1m6kA2 A: a+b three layersX: Profilin-likeH: a+b domain in beta-lactamase/transpeptidase-like proteins (From Topology)T: a+b domain in beta-lactamase/transpeptidase-like proteinsF: Transpeptidase_2nd_1ECOD (1.6)
BTranspeptidase_1ste1m6kB1 A: alpha complex topologyX: alpha-helical domain in beta-lactamase/transpeptidase-like proteins (From Topology)H: alpha-helical domain in beta-lactamase/transpeptidase-like proteins (From Topology)T: alpha-helical domain in beta-lactamase/transpeptidase-like proteinsF: Transpeptidase_1stECOD (1.6)
BTranspeptidase_2nd_1e1m6kB2 A: a+b three layersX: Profilin-likeH: a+b domain in beta-lactamase/transpeptidase-like proteins (From Topology)T: a+b domain in beta-lactamase/transpeptidase-like proteinsF: Transpeptidase_2nd_1ECOD (1.6)

Domain Annotation: CATH CATH Database Homepage

ChainDomainClassArchitectureTopologyHomologyProvenance Source (Version)
A3.40.710.10 Alpha Beta 3-Layer(aba) Sandwich Beta-lactamase DD-peptidase/beta-lactamase superfamilyCATH (4.3.0)
B3.40.710.10 Alpha Beta 3-Layer(aba) Sandwich Beta-lactamase DD-peptidase/beta-lactamase superfamilyCATH (4.3.0)

AMR Gene: CARD Annotation CARD Database Homepage

ChainsAccessionShort NameDescriptionProvenance Source (Version)
A, B
ARO:3001396OXA-1OXA-1 is a beta-lactamase found in E. coli.CARD (3.3.0)

AMR Gene Family: CARD Annotation CARD Database Homepage

ChainsAccessionGene FamilyDrug Class Resistance MachanismProvenance Source (Version)
A, B
ARO:3007696OXA-1-like beta-lactamasecephalosporin, penamantibiotic inactivationCARD (3.3.0)

Protein Family Annotation Pfam Database Homepage

ChainsAccessionNameDescriptionCommentsSource
A, B
PF00905Penicillin binding protein transpeptidase domain (Transpeptidase)Penicillin binding protein transpeptidase domainThe active site serine (residue 337 in Swiss:P14677) is conserved in all members of this family.Domain

Structure Motif Annotation: Mechanism and Catalytic Site Atlas M-CSA Database Homepage

ChainsEnzyme NameDescriptionCatalytic Residues
beta-lactamase (Class D)  M-CSA #210

Class D beta lactamases are able to break down oxacillin and cloxacillin thus playing a vital role in antibiotic resistance in bacteria as they can prevent these compounds from inhibiting the DD peptidases involved in bacterial cell wall synthesis. As part of the family of serine beta lactamases, which also includes classes A B and C of the beta lactamases, they share significant homology with the DD peptidases, indicating that they diverged from a common ancestor. However, they are able to hydrolyse the acyl enzyme intermediate that forms through initial nucleophilic attack on the beta-lactam ring much more quickly, thus do not become inhibited by the beta lactams in the same way.

Defined by 6 residues: SER:A-46 [auth A-67]LYS:A-49 [auth A-70]SER:A-93 [auth A-115]SER:A-98 [auth A-120]TRP:A-138 [auth A-160]ALA:A-193 [auth A-215]
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