1HPU

5'-NUCLEOTIDASE (CLOSED FORM), COMPLEX WITH AMPCP

External Resource: Annotation

Domain Annotation: SCOP/SCOPe Classification
Domain Annotation: SCOP2 Classification
Domain Annotation: ECOD Classification
Domain Annotation: CATH
Protein Family Annotation
Gene Ontology: Gene Product Annotation
InterPro: Protein Family Classification

Domain Annotation: SCOP/SCOPe Classification SCOP-e Database Homepage

Chains	Domain Info	Class	Fold	Superfamily	Family	Domain	Species	Provenance Source (Version)
B	d1hpub1	Alpha and beta proteins (a+b)	5'-nucleotidase (syn. UDP-sugar hydrolase), C-terminal domain	5'-nucleotidase (syn. UDP-sugar hydrolase), C-terminal domain	5'-nucleotidase (syn. UDP-sugar hydrolase), C-terminal domain	5'-nucleotidase (syn. UDP-sugar hydrolase), C-terminal domain	(Escherichia coli ) [TaxId: 562 ],	SCOPe (2.08)
B	d1hpub2	Alpha and beta proteins (a+b)	Metallo-dependent phosphatases	Metallo-dependent phosphatases	5'-nucleotidase (syn. UDP-sugar hydrolase), N-terminal domain	5'-nucleotidase (syn. UDP-sugar hydrolase), N-terminal domain	(Escherichia coli ) [TaxId: 562 ],	SCOPe (2.08)
C	d1hpuc1	Alpha and beta proteins (a+b)	5'-nucleotidase (syn. UDP-sugar hydrolase), C-terminal domain	5'-nucleotidase (syn. UDP-sugar hydrolase), C-terminal domain	5'-nucleotidase (syn. UDP-sugar hydrolase), C-terminal domain	5'-nucleotidase (syn. UDP-sugar hydrolase), C-terminal domain	(Escherichia coli ) [TaxId: 562 ],	SCOPe (2.08)
C	d1hpuc2	Alpha and beta proteins (a+b)	Metallo-dependent phosphatases	Metallo-dependent phosphatases	5'-nucleotidase (syn. UDP-sugar hydrolase), N-terminal domain	5'-nucleotidase (syn. UDP-sugar hydrolase), N-terminal domain	(Escherichia coli ) [TaxId: 562 ],	SCOPe (2.08)
A	d1hpua1	Alpha and beta proteins (a+b)	5'-nucleotidase (syn. UDP-sugar hydrolase), C-terminal domain	5'-nucleotidase (syn. UDP-sugar hydrolase), C-terminal domain	5'-nucleotidase (syn. UDP-sugar hydrolase), C-terminal domain	5'-nucleotidase (syn. UDP-sugar hydrolase), C-terminal domain	(Escherichia coli ) [TaxId: 562 ],	SCOPe (2.08)
A	d1hpua2	Alpha and beta proteins (a+b)	Metallo-dependent phosphatases	Metallo-dependent phosphatases	5'-nucleotidase (syn. UDP-sugar hydrolase), N-terminal domain	5'-nucleotidase (syn. UDP-sugar hydrolase), N-terminal domain	(Escherichia coli ) [TaxId: 562 ],	SCOPe (2.08)
D	d1hpud1	Alpha and beta proteins (a+b)	5'-nucleotidase (syn. UDP-sugar hydrolase), C-terminal domain	5'-nucleotidase (syn. UDP-sugar hydrolase), C-terminal domain	5'-nucleotidase (syn. UDP-sugar hydrolase), C-terminal domain	5'-nucleotidase (syn. UDP-sugar hydrolase), C-terminal domain	(Escherichia coli ) [TaxId: 562 ],	SCOPe (2.08)
D	d1hpud2	Alpha and beta proteins (a+b)	Metallo-dependent phosphatases	Metallo-dependent phosphatases	5'-nucleotidase (syn. UDP-sugar hydrolase), N-terminal domain	5'-nucleotidase (syn. UDP-sugar hydrolase), N-terminal domain	(Escherichia coli ) [TaxId: 562 ],	SCOPe (2.08)

Domain Annotation: SCOP2 Classification SCOP2 Database Homepage

Chains	Type	Family Name	Domain Identifier	Family Identifier	Provenance Source (Version)
B	SCOP2B Superfamily	Metallo-dependent phosphatases	8039498	3001067	SCOP2B (2022-06-29)
B	SCOP2B Superfamily	5'-nucleotidase (syn. UDP-sugar hydrolase), C-terminal domain	8039497	3000515	SCOP2B (2022-06-29)
C	SCOP2B Superfamily	Metallo-dependent phosphatases	8039498	3001067	SCOP2B (2022-06-29)
C	SCOP2B Superfamily	5'-nucleotidase (syn. UDP-sugar hydrolase), C-terminal domain	8039497	3000515	SCOP2B (2022-06-29)
A	SCOP2 Family	5'-nucleotidase (syn. UDP-sugar hydrolase), C-terminal domain	8027118	4001892	SCOP2 (2022-06-29)
A	SCOP2 Family	5'-nucleotidase (syn. UDP-sugar hydrolase), N-terminal domain	8027119	4002300	SCOP2 (2022-06-29)
A	SCOP2 Superfamily	5'-nucleotidase (syn. UDP-sugar hydrolase), C-terminal domain	8039497	3000515	SCOP2 (2022-06-29)
A	SCOP2 Superfamily	Metallo-dependent phosphatases	8039498	3001067	SCOP2 (2022-06-29)
D	SCOP2B Superfamily	Metallo-dependent phosphatases	8039498	3001067	SCOP2B (2022-06-29)
D	SCOP2B Superfamily	5'-nucleotidase (syn. UDP-sugar hydrolase), C-terminal domain	8039497	3000515	SCOP2B (2022-06-29)

Domain Annotation: ECOD Classification ECOD Database Homepage

Chains	Family Name	Domain Identifier	Architecture	Possible Homology	Homology	Topology	Family	Provenance Source (Version)
B	Metallophos_2_1	e1hpuB2	A: a+b four layers	X: Carbon-nitrogen hydrolase-like	H: Metallo-dependent phosphatases (From Topology)	T: Metallo-dependent phosphatases	F: Metallophos_2_1	ECOD (1.6)
B	5_nucleotid_C	e1hpuB1	A: a+b complex topology	X: 5'-nucleotidase (syn. UDP-sugar hydrolase), C-terminal domain (From Topology)	H: 5'-nucleotidase (syn. UDP-sugar hydrolase), C-terminal domain (From Topology)	T: 5'-nucleotidase (syn. UDP-sugar hydrolase), C-terminal domain	F: 5_nucleotid_C	ECOD (1.6)
C	Metallophos_2_1	e1hpuC2	A: a+b four layers	X: Carbon-nitrogen hydrolase-like	H: Metallo-dependent phosphatases (From Topology)	T: Metallo-dependent phosphatases	F: Metallophos_2_1	ECOD (1.6)
C	5_nucleotid_C	e1hpuC1	A: a+b complex topology	X: 5'-nucleotidase (syn. UDP-sugar hydrolase), C-terminal domain (From Topology)	H: 5'-nucleotidase (syn. UDP-sugar hydrolase), C-terminal domain (From Topology)	T: 5'-nucleotidase (syn. UDP-sugar hydrolase), C-terminal domain	F: 5_nucleotid_C	ECOD (1.6)
A	Metallophos_2_1	e1hpuA2	A: a+b four layers	X: Carbon-nitrogen hydrolase-like	H: Metallo-dependent phosphatases (From Topology)	T: Metallo-dependent phosphatases	F: Metallophos_2_1	ECOD (1.6)
A	5_nucleotid_C	e1hpuA1	A: a+b complex topology	X: 5'-nucleotidase (syn. UDP-sugar hydrolase), C-terminal domain (From Topology)	H: 5'-nucleotidase (syn. UDP-sugar hydrolase), C-terminal domain (From Topology)	T: 5'-nucleotidase (syn. UDP-sugar hydrolase), C-terminal domain	F: 5_nucleotid_C	ECOD (1.6)
D	Metallophos_2_1	e1hpuD2	A: a+b four layers	X: Carbon-nitrogen hydrolase-like	H: Metallo-dependent phosphatases (From Topology)	T: Metallo-dependent phosphatases	F: Metallophos_2_1	ECOD (1.6)
D	5_nucleotid_C	e1hpuD1	A: a+b complex topology	X: 5'-nucleotidase (syn. UDP-sugar hydrolase), C-terminal domain (From Topology)	H: 5'-nucleotidase (syn. UDP-sugar hydrolase), C-terminal domain (From Topology)	T: 5'-nucleotidase (syn. UDP-sugar hydrolase), C-terminal domain	F: 5_nucleotid_C	ECOD (1.6)

Domain Annotation: CATH CATH Database Homepage

Chain	Domain	Class	Architecture	Topology	Homology	Provenance Source (Version)
B	3.60.21.10	Alpha Beta	4-Layer Sandwich	Purple Acid Phosphatase	chain A, domain 2	CATH (4.3.0)
B	3.90.780.10	Alpha Beta	Alpha-Beta Complex	5'-nucleotidase	domain 2	CATH (4.3.0)
C	3.60.21.10	Alpha Beta	4-Layer Sandwich	Purple Acid Phosphatase	chain A, domain 2	CATH (4.3.0)
C	3.90.780.10	Alpha Beta	Alpha-Beta Complex	5'-nucleotidase	domain 2	CATH (4.3.0)
A	3.60.21.10	Alpha Beta	4-Layer Sandwich	Purple Acid Phosphatase	chain A, domain 2	CATH (4.3.0)
A	3.90.780.10	Alpha Beta	Alpha-Beta Complex	5'-nucleotidase	domain 2	CATH (4.3.0)
D	3.60.21.10	Alpha Beta	4-Layer Sandwich	Purple Acid Phosphatase	chain A, domain 2	CATH (4.3.0)
D	3.90.780.10	Alpha Beta	Alpha-Beta Complex	5'-nucleotidase	domain 2	CATH (4.3.0)

Protein Family Annotation Pfam Database Homepage

Chains	Accession	Name	Description	Comments	Source
A, B, C, D	PF00149	Calcineurin-like phosphoesterase (Metallophos)	Calcineurin-like phosphoesterase	This family includes a diverse range of phosphoesterases [1], including protein phosphoserine phosphatases, nucleotidases, sphingomyelin phosphodiesterases and 2'-3' cAMP phosphodiesterases as well as nucleases such as bacterial SbcD Swiss:P13457 or ...	This family includes a diverse range of phosphoesterases [1], including protein phosphoserine phosphatases, nucleotidases, sphingomyelin phosphodiesterases and 2'-3' cAMP phosphodiesterases as well as nucleases such as bacterial SbcD Swiss:P13457 or yeast MRE11 Swiss:P32829. The most conserved regions in this superfamily centre around the metal chelating residues.	Domain
A, B, C, D	PF02872	5'-nucleotidase, C-terminal domain (5_nucleotid_C)	5'-nucleotidase, C-terminal domain	-	Domain

Gene Ontology: Gene Product Annotation Gene Ontology Database Homepage

Chains	Polymer	Molecular Function	Biological Process	Cellular Component
A, B, C, D	5'-NUCLEOTIDASE	phosphoric ester hydrolase activity nucleotidase activity hydrolase activity, acting on ester bonds XMP 5'-nucleosidase activity phosphatase activity hydrolase activity 5'-nucleotidase activity catalytic activity pyrophosphatase activity UDP-sugar diphosphatase activity hydrolase activity, acting on acid anhydrides, in phosphorus-containing anhydrides hydrolase activity, acting on acid anhydrides binding nucleoside phosphate binding phosphoric ester hydrolase activity nucleotidase activity hydrolase activity, acting on ester bonds XMP 5'-nucleosidase activity phosphatase activity hydrolase activity 5'-nucleotidase activity catalytic activity pyrophosphatase activity UDP-sugar diphosphatase activity hydrolase activity, acting on acid anhydrides, in phosphorus-containing anhydrides hydrolase activity, acting on acid anhydrides binding nucleoside phosphate binding organic cyclic compound binding nucleotide binding heterocyclic compound binding small molecule binding cation binding ion binding metal ion binding	nucleoside phosphate metabolic process catabolic process organophosphate catabolic process primary metabolic process nucleoside phosphate catabolic process nucleotide metabolic process nucleobase-containing compound catabolic process nucleobase-containing compound metabolic process organophosphate metabolic process nucleobase-containing small molecule metabolic process phosphate-containing compound metabolic process metabolic process cellular process small molecule metabolic process nucleoside phosphate metabolic process catabolic process organophosphate catabolic process primary metabolic process nucleoside phosphate catabolic process nucleotide metabolic process nucleobase-containing compound catabolic process nucleobase-containing compound metabolic process organophosphate metabolic process nucleobase-containing small molecule metabolic process phosphate-containing compound metabolic process metabolic process cellular process small molecule metabolic process phosphorus metabolic process nucleotide catabolic process	cellular anatomical structure outer membrane-bounded periplasmic space cell envelope periplasmic space

InterPro: Protein Family Classification InterPro Database Homepage

Chains	Accession	Name	Type
A, B, C, D	IPR004843	Calcineurin-like phosphoesterase domain, ApaH type	Domain
A, B, C, D	IPR029052	Metallo-dependent phosphatase-like	Homologous Superfamily
A, B, C, D	IPR008334	5'-Nucleotidase, C-terminal	Domain
A, B, C, D	IPR036907	5'-Nucleotidase, C-terminal domain superfamily	Homologous Superfamily
A, B, C, D	IPR006146	5'-Nucleotidase, conserved site	Conserved Site
A, B, C, D	IPR006179	5'-Nucleotidase/apyrase	Family

RCSB PDB Core Operations are funded by the U.S. National Science Foundation (DBI-2321666), the US Department of Energy (DE-SC0019749), and the National Cancer Institute, National Institute of Allergy and Infectious Diseases, and National Institute of General Medical Sciences of the National Institutes of Health under grant R01GM157729.