1HKX

Crystal structure of calcium/calmodulin-dependent protein kinase

External Resource: Annotation

Domain Annotation: SCOP/SCOPe Classification
Domain Annotation: SCOP2 Classification
Domain Annotation: ECOD Classification
Domain Annotation: CATH
Protein Family Annotation
Gene Ontology: Gene Product Annotation
InterPro: Protein Family Classification

Domain Annotation: SCOP/SCOPe Classification SCOP-e Database Homepage

Chains	Domain Info	Class	Fold	Superfamily	Family	Domain	Species	Provenance Source (Version)
A	d1hkxa_	Alpha and beta proteins (a+b)	Cystatin-like	NTF2-like	Association domain of calcium/calmodulin-dependent protein kinase type II alpha subunit, CAMK2A	Association domain of calcium/calmodulin-dependent protein kinase type II alpha subunit, CAMK2A	MOUSE (Mus musculus ) [TaxId: 10090 ],	SCOPe (2.08)
B	d1hkxb_	Alpha and beta proteins (a+b)	Cystatin-like	NTF2-like	Association domain of calcium/calmodulin-dependent protein kinase type II alpha subunit, CAMK2A	Association domain of calcium/calmodulin-dependent protein kinase type II alpha subunit, CAMK2A	MOUSE (Mus musculus ) [TaxId: 10090 ],	SCOPe (2.08)
C	d1hkxc_	Alpha and beta proteins (a+b)	Cystatin-like	NTF2-like	Association domain of calcium/calmodulin-dependent protein kinase type II alpha subunit, CAMK2A	Association domain of calcium/calmodulin-dependent protein kinase type II alpha subunit, CAMK2A	MOUSE (Mus musculus ) [TaxId: 10090 ],	SCOPe (2.08)
G	d1hkxg_	Alpha and beta proteins (a+b)	Cystatin-like	NTF2-like	Association domain of calcium/calmodulin-dependent protein kinase type II alpha subunit, CAMK2A	Association domain of calcium/calmodulin-dependent protein kinase type II alpha subunit, CAMK2A	MOUSE (Mus musculus ) [TaxId: 10090 ],	SCOPe (2.08)
I	d1hkxi_	Alpha and beta proteins (a+b)	Cystatin-like	NTF2-like	Association domain of calcium/calmodulin-dependent protein kinase type II alpha subunit, CAMK2A	Association domain of calcium/calmodulin-dependent protein kinase type II alpha subunit, CAMK2A	MOUSE (Mus musculus ) [TaxId: 10090 ],	SCOPe (2.08)
K	d1hkxk_	Alpha and beta proteins (a+b)	Cystatin-like	NTF2-like	Association domain of calcium/calmodulin-dependent protein kinase type II alpha subunit, CAMK2A	Association domain of calcium/calmodulin-dependent protein kinase type II alpha subunit, CAMK2A	MOUSE (Mus musculus ) [TaxId: 10090 ],	SCOPe (2.08)
L	d1hkxl_	Alpha and beta proteins (a+b)	Cystatin-like	NTF2-like	Association domain of calcium/calmodulin-dependent protein kinase type II alpha subunit, CAMK2A	Association domain of calcium/calmodulin-dependent protein kinase type II alpha subunit, CAMK2A	MOUSE (Mus musculus ) [TaxId: 10090 ],	SCOPe (2.08)
M	d1hkxm_	Alpha and beta proteins (a+b)	Cystatin-like	NTF2-like	Association domain of calcium/calmodulin-dependent protein kinase type II alpha subunit, CAMK2A	Association domain of calcium/calmodulin-dependent protein kinase type II alpha subunit, CAMK2A	MOUSE (Mus musculus ) [TaxId: 10090 ],	SCOPe (2.08)
N	d1hkxn_	Alpha and beta proteins (a+b)	Cystatin-like	NTF2-like	Association domain of calcium/calmodulin-dependent protein kinase type II alpha subunit, CAMK2A	Association domain of calcium/calmodulin-dependent protein kinase type II alpha subunit, CAMK2A	MOUSE (Mus musculus ) [TaxId: 10090 ],	SCOPe (2.08)
D	d1hkxd_	Alpha and beta proteins (a+b)	Cystatin-like	NTF2-like	Association domain of calcium/calmodulin-dependent protein kinase type II alpha subunit, CAMK2A	Association domain of calcium/calmodulin-dependent protein kinase type II alpha subunit, CAMK2A	MOUSE (Mus musculus ) [TaxId: 10090 ],	SCOPe (2.08)
E	d1hkxe_	Alpha and beta proteins (a+b)	Cystatin-like	NTF2-like	Association domain of calcium/calmodulin-dependent protein kinase type II alpha subunit, CAMK2A	Association domain of calcium/calmodulin-dependent protein kinase type II alpha subunit, CAMK2A	MOUSE (Mus musculus ) [TaxId: 10090 ],	SCOPe (2.08)
F	d1hkxf_	Alpha and beta proteins (a+b)	Cystatin-like	NTF2-like	Association domain of calcium/calmodulin-dependent protein kinase type II alpha subunit, CAMK2A	Association domain of calcium/calmodulin-dependent protein kinase type II alpha subunit, CAMK2A	MOUSE (Mus musculus ) [TaxId: 10090 ],	SCOPe (2.08)
H	d1hkxh_	Alpha and beta proteins (a+b)	Cystatin-like	NTF2-like	Association domain of calcium/calmodulin-dependent protein kinase type II alpha subunit, CAMK2A	Association domain of calcium/calmodulin-dependent protein kinase type II alpha subunit, CAMK2A	MOUSE (Mus musculus ) [TaxId: 10090 ],	SCOPe (2.08)
J	d1hkxj_	Alpha and beta proteins (a+b)	Cystatin-like	NTF2-like	Association domain of calcium/calmodulin-dependent protein kinase type II alpha subunit, CAMK2A	Association domain of calcium/calmodulin-dependent protein kinase type II alpha subunit, CAMK2A	MOUSE (Mus musculus ) [TaxId: 10090 ],	SCOPe (2.08)

Domain Annotation: SCOP2 Classification SCOP2 Database Homepage

Chains	Type	Family Name	Domain Identifier	Family Identifier	Provenance Source (Version)
A	SCOP2 Family	Association domain of calcium/calmodulin-dependent protein kinase type II alpha subunit, CAMK2A	8032145	4000593	SCOP2 (2022-06-29)
A	SCOP2 Superfamily	NTF2-like	8044523	3000472	SCOP2 (2022-06-29)
B	SCOP2B Superfamily	NTF2-like	8044523	3000472	SCOP2B (2022-06-29)
C	SCOP2B Superfamily	NTF2-like	8044523	3000472	SCOP2B (2022-06-29)
G	SCOP2B Superfamily	NTF2-like	8044523	3000472	SCOP2B (2022-06-29)
I	SCOP2B Superfamily	NTF2-like	8044523	3000472	SCOP2B (2022-06-29)
K	SCOP2B Superfamily	NTF2-like	8044523	3000472	SCOP2B (2022-06-29)
L	SCOP2B Superfamily	NTF2-like	8044523	3000472	SCOP2B (2022-06-29)
M	SCOP2B Superfamily	NTF2-like	8044523	3000472	SCOP2B (2022-06-29)
N	SCOP2B Superfamily	NTF2-like	8044523	3000472	SCOP2B (2022-06-29)
D	SCOP2B Superfamily	NTF2-like	8044523	3000472	SCOP2B (2022-06-29)
E	SCOP2B Superfamily	NTF2-like	8044523	3000472	SCOP2B (2022-06-29)
F	SCOP2B Superfamily	NTF2-like	8044523	3000472	SCOP2B (2022-06-29)
H	SCOP2B Superfamily	NTF2-like	8044523	3000472	SCOP2B (2022-06-29)
J	SCOP2B Superfamily	NTF2-like	8044523	3000472	SCOP2B (2022-06-29)

Domain Annotation: ECOD Classification ECOD Database Homepage

Chains	Family Name	Domain Identifier	Architecture	Possible Homology	Homology	Topology	Family	Provenance Source (Version)
A	DUF4440	e1hkxA1	A: a+b two layers	X: Cystatin-like	H: NTF2-like (From Topology)	T: NTF2-like	F: DUF4440	ECOD (1.6)
B	DUF4440	e1hkxB1	A: a+b two layers	X: Cystatin-like	H: NTF2-like (From Topology)	T: NTF2-like	F: DUF4440	ECOD (1.6)
C	DUF4440	e1hkxC1	A: a+b two layers	X: Cystatin-like	H: NTF2-like (From Topology)	T: NTF2-like	F: DUF4440	ECOD (1.6)
G	DUF4440	e1hkxG1	A: a+b two layers	X: Cystatin-like	H: NTF2-like (From Topology)	T: NTF2-like	F: DUF4440	ECOD (1.6)
I	DUF4440	e1hkxI1	A: a+b two layers	X: Cystatin-like	H: NTF2-like (From Topology)	T: NTF2-like	F: DUF4440	ECOD (1.6)
K	DUF4440	e1hkxK1	A: a+b two layers	X: Cystatin-like	H: NTF2-like (From Topology)	T: NTF2-like	F: DUF4440	ECOD (1.6)
L	DUF4440	e1hkxL1	A: a+b two layers	X: Cystatin-like	H: NTF2-like (From Topology)	T: NTF2-like	F: DUF4440	ECOD (1.6)
M	DUF4440	e1hkxM1	A: a+b two layers	X: Cystatin-like	H: NTF2-like (From Topology)	T: NTF2-like	F: DUF4440	ECOD (1.6)
N	DUF4440	e1hkxN1	A: a+b two layers	X: Cystatin-like	H: NTF2-like (From Topology)	T: NTF2-like	F: DUF4440	ECOD (1.6)
D	DUF4440	e1hkxD1	A: a+b two layers	X: Cystatin-like	H: NTF2-like (From Topology)	T: NTF2-like	F: DUF4440	ECOD (1.6)
E	DUF4440	e1hkxE1	A: a+b two layers	X: Cystatin-like	H: NTF2-like (From Topology)	T: NTF2-like	F: DUF4440	ECOD (1.6)
F	DUF4440	e1hkxF1	A: a+b two layers	X: Cystatin-like	H: NTF2-like (From Topology)	T: NTF2-like	F: DUF4440	ECOD (1.6)
H	DUF4440	e1hkxH1	A: a+b two layers	X: Cystatin-like	H: NTF2-like (From Topology)	T: NTF2-like	F: DUF4440	ECOD (1.6)
J	DUF4440	e1hkxJ1	A: a+b two layers	X: Cystatin-like	H: NTF2-like (From Topology)	T: NTF2-like	F: DUF4440	ECOD (1.6)

Domain Annotation: CATH CATH Database Homepage

Chain	Domain	Class	Architecture	Topology	Homology	Provenance Source (Version)
A	3.10.450.50	Alpha Beta	Roll	Nuclear Transport Factor 2	Chain: A,	CATH (4.3.0)
B	3.10.450.50	Alpha Beta	Roll	Nuclear Transport Factor 2	Chain: A,	CATH (4.3.0)
C	3.10.450.50	Alpha Beta	Roll	Nuclear Transport Factor 2	Chain: A,	CATH (4.3.0)
G	3.10.450.50	Alpha Beta	Roll	Nuclear Transport Factor 2	Chain: A,	CATH (4.3.0)
I	3.10.450.50	Alpha Beta	Roll	Nuclear Transport Factor 2	Chain: A,	CATH (4.3.0)
K	3.10.450.50	Alpha Beta	Roll	Nuclear Transport Factor 2	Chain: A,	CATH (4.3.0)
L	3.10.450.50	Alpha Beta	Roll	Nuclear Transport Factor 2	Chain: A,	CATH (4.3.0)
M	3.10.450.50	Alpha Beta	Roll	Nuclear Transport Factor 2	Chain: A,	CATH (4.3.0)
N	3.10.450.50	Alpha Beta	Roll	Nuclear Transport Factor 2	Chain: A,	CATH (4.3.0)
D	3.10.450.50	Alpha Beta	Roll	Nuclear Transport Factor 2	Chain: A,	CATH (4.3.0)
E	3.10.450.50	Alpha Beta	Roll	Nuclear Transport Factor 2	Chain: A,	CATH (4.3.0)
F	3.10.450.50	Alpha Beta	Roll	Nuclear Transport Factor 2	Chain: A,	CATH (4.3.0)
H	3.10.450.50	Alpha Beta	Roll	Nuclear Transport Factor 2	Chain: A,	CATH (4.3.0)
J	3.10.450.50	Alpha Beta	Roll	Nuclear Transport Factor 2	Chain: A,	CATH (4.3.0)

Protein Family Annotation Pfam Database Homepage

Chains	Accession	Name	Description	Comments	Source
A, B, C, D, E A, B, C, D, E, F, G, H, I, J, K, L, M, N	PF08332	Calcium/calmodulin dependent protein kinase II association domain (CaMKII_AD)	Calcium/calmodulin dependent protein kinase II association domain	This domain is found at the C-terminus of the Calcium/calmodulin dependent protein kinases II (CaMKII). These proteins also have a Ser/Thr protein kinase domain (Pfam:PF00069) at their N-terminus [1]. The function of the CaMKII association domain i ...	This domain is found at the C-terminus of the Calcium/calmodulin dependent protein kinases II (CaMKII). These proteins also have a Ser/Thr protein kinase domain (Pfam:PF00069) at their N-terminus [1]. The function of the CaMKII association domain is the assembly of the single proteins into large (8 to 14 subunits) multimers [2].	Domain

Gene Ontology: Gene Product Annotation Gene Ontology Database Homepage

Chains	Polymer	Molecular Function	Biological Process	Cellular Component
A, B, C, D, E A, B, C, D, E, F, G, H, I, J, K, L, M, N	CALCIUM/CALMODULIN-DEPENDENT PROTEIN KINASE TYPE II ALPHA CHAIN	protein serine/threonine kinase activity catalytic activity, acting on a protein kinase activity protein kinase activity calcium/calmodulin-dependent protein kinase activity transferase activity catalytic activity phosphotransferase activity, alcohol group as acceptor transferase activity, transferring phosphorus-containing groups protein binding binding signaling receptor binding glutamate receptor binding protein serine kinase activity protein serine/threonine kinase activity catalytic activity, acting on a protein kinase activity protein kinase activity calcium/calmodulin-dependent protein kinase activity transferase activity catalytic activity phosphotransferase activity, alcohol group as acceptor transferase activity, transferring phosphorus-containing groups protein binding binding signaling receptor binding glutamate receptor binding protein serine kinase activity adenyl ribonucleotide binding nucleotide binding purine ribonucleotide binding purine ribonucleoside triphosphate binding nucleoside phosphate binding ion binding purine nucleotide binding organic cyclic compound binding anion binding adenyl nucleotide binding ATP binding heterocyclic compound binding carbohydrate derivative binding ribonucleotide binding small molecule binding calmodulin binding cation binding metal ion binding	membrane organization transport apoptotic mitochondrial changes biological regulation cell death establishment of localization cellular component organization mitochondrial membrane organization localization organelle organization cellular process regulation of membrane permeability regulation of mitochondrial membrane permeability involved in apoptotic process apoptotic process membrane organization transport apoptotic mitochondrial changes biological regulation cell death establishment of localization cellular component organization mitochondrial membrane organization localization organelle organization cellular process regulation of membrane permeability regulation of mitochondrial membrane permeability involved in apoptotic process apoptotic process cellular component organization or biogenesis regulation of biological quality regulation of mitochondrial membrane permeability programmed cell death mitochondrion organization mitochondrial transport response to stimulus response to stress response to ischemia multicellular organismal process cellular developmental process cell projection organization plasma membrane bounded cell projection morphogenesis cell development neuron projection development cell morphogenesis neurogenesis multicellular organism development cell projection morphogenesis neuron differentiation neuron projection morphogenesis dendrite development cell differentiation anatomical structure development system development developmental process plasma membrane bounded cell projection organization dendrite morphogenesis nervous system development cell morphogenesis involved in neuron differentiation generation of neurons anatomical structure morphogenesis neuron development regulation of biological process regulation of cell motility regulation of cellular process neuron migration regulation of neuron migration regulation of locomotion regulation of cell migration cell migration cell motility locomotion cellular response to interferon-beta response to peptide response to interferon-beta response to chemical response to cytokine cellular response to cytokine stimulus cellular response to stimulus regulation of signaling signaling cannabinoid signaling pathway regulation of signal transduction cell communication endocannabinoid signaling pathway regulation of response to stimulus regulation of cell communication G protein-coupled receptor signaling pathway signal transduction regulation of G protein-coupled receptor signaling pathway regulation of endocannabinoid signaling pathway positive regulation of cardiac muscle cell apoptotic process positive regulation of programmed cell death muscle cell apoptotic process positive regulation of striated muscle cell apoptotic process regulation of apoptotic process positive regulation of biological process regulation of cardiac muscle cell apoptotic process regulation of muscle cell apoptotic process regulation of programmed cell death positive regulation of apoptotic process cardiac muscle cell apoptotic process positive regulation of muscle cell apoptotic process regulation of striated muscle cell apoptotic process striated muscle cell apoptotic process positive regulation of cellular process regulation of localization cellular localization modulation of chemical synaptic transmission synaptic signaling regulation of secretion by cell secretion by cell signal release establishment of localization in cell trans-synaptic signaling neurotransmitter secretion regulation of transport secretion regulation of neurotransmitter transport export from cell cell-cell signaling neurotransmitter transport regulation of secretion chemical synaptic transmission signal release from synapse regulation of trans-synaptic signaling regulation of neurotransmitter secretion anterograde trans-synaptic signaling protein phosphorylation protein autophosphorylation phosphorylation primary metabolic process peptidyl-threonine autophosphorylation macromolecule modification phosphate-containing compound metabolic process peptidyl-amino acid modification metabolic process protein metabolic process macromolecule metabolic process peptidyl-threonine modification protein modification process phosphorus metabolic process peptidyl-threonine phosphorylation regulation of neuronal synaptic plasticity regulation of synaptic plasticity regulated exocytosis synaptic vesicle cycle synaptic vesicle exocytosis membrane docking vesicle-mediated transport vesicle-mediated transport in synapse organelle localization by membrane tethering organelle localization vesicle docking involved in exocytosis regulation of synaptic vesicle docking synaptic vesicle docking exocytosis vesicle docking exocytic process regulation of vesicle docking dendritic spine development regulation of calcium ion transport positive regulation of calcium ion transport regulation of monoatomic ion transport calcium ion transport metal ion transport positive regulation of transport positive regulation of monoatomic ion transport monoatomic ion transport monoatomic cation transport regulation of metal ion transport mitotic cell cycle process cell cycle phase transition cell cycle G1/S transition of mitotic cell cycle cell cycle G1/S phase transition mitotic cell cycle mitotic cell cycle phase transition cell cycle process positive regulation of cell communication cell surface receptor signaling pathway via STAT positive regulation of signal transduction positive regulation of receptor signaling pathway via STAT positive regulation of receptor signaling pathway via JAK-STAT positive regulation of response to stimulus regulation of receptor signaling pathway via JAK-STAT cell surface receptor signaling pathway regulation of receptor signaling pathway via STAT cell surface receptor signaling pathway via JAK-STAT positive regulation of signaling negative regulation of hydrolase activity regulation of molecular function regulation of catalytic activity regulation of hydrolase activity negative regulation of molecular function negative regulation of catalytic activity	membrane-bounded organelle intracellular organelle cellular anatomical structure intracellular anatomical structure mitochondrion organelle cytoplasm intracellular membrane-bounded organelle protein-containing complex catalytic complex calcium- and calmodulin-dependent protein kinase complex intracellular protein-containing complex synapse cell junction membrane-bounded organelle intracellular organelle cellular anatomical structure intracellular anatomical structure mitochondrion organelle cytoplasm intracellular membrane-bounded organelle protein-containing complex catalytic complex calcium- and calmodulin-dependent protein kinase complex intracellular protein-containing complex synapse cell junction neuron spine neuron projection dendritic spine plasma membrane bounded cell projection somatodendritic compartment cell projection postsynapse dendrite dendritic tree postsynaptic density neuron to neuron synapse postsynaptic specialization asymmetric synapse Schaffer collateral - CA1 synapse

InterPro: Protein Family Classification InterPro Database Homepage

Chains	Accession	Name	Type
A, B, C, D, E A, B, C, D, E, F, G, H, I, J, K, L, M, N	IPR032710	NTF2-like domain superfamily	Homologous Superfamily
A, B, C, D, E A, B, C, D, E, F, G, H, I, J, K, L, M, N	IPR017441	Protein kinase, ATP binding site	Binding Site
A, B, C, D, E A, B, C, D, E, F, G, H, I, J, K, L, M, N	IPR013543	Calcium/calmodulin-dependent protein kinase II, association-domain	Domain
A, B, C, D, E A, B, C, D, E, F, G, H, I, J, K, L, M, N	IPR000719	Protein kinase domain	Domain
A, B, C, D, E A, B, C, D, E, F, G, H, I, J, K, L, M, N	IPR011009	Protein kinase-like domain superfamily	Homologous Superfamily
A, B, C, D, E A, B, C, D, E, F, G, H, I, J, K, L, M, N	IPR008271	Serine/threonine-protein kinase, active site	Active Site

RCSB PDB Core Operations are funded by the U.S. National Science Foundation (DBI-2321666), the US Department of Energy (DE-SC0019749), and the National Cancer Institute, National Institute of Allergy and Infectious Diseases, and National Institute of General Medical Sciences of the National Institutes of Health under grant R01GM157729.