1EMS

CRYSTAL STRUCTURE OF THE C. ELEGANS NITFHIT PROTEIN

External Resource: Annotation

Domain Annotation: SCOP/SCOPe Classification
Domain Annotation: SCOP2 Classification
Domain Annotation: ECOD Classification
Domain Annotation: CATH
Protein Family Annotation
Gene Ontology: Gene Product Annotation
InterPro: Protein Family Classification

Domain Annotation: SCOP/SCOPe Classification SCOP-e Database Homepage

Chains	Domain Info	Class	Fold	Superfamily	Family	Domain	Species	Provenance Source (Version)
B	d1emsb1	Alpha and beta proteins (a+b)	HIT-like	HIT-like	HIT (HINT, histidine triad) family of protein kinase-interacting proteins	NIT-FHIT fusion protein, C-terminal domain	(Caenorhabditis elegans ) [TaxId: 6239 ],	SCOPe (2.08)
B	d1emsb2	Alpha and beta proteins (a+b)	Carbon-nitrogen hydrolase	Carbon-nitrogen hydrolase	Nitrilase	NIT-FHIT fusion protein, N-terminal domain	(Caenorhabditis elegans ) [TaxId: 6239 ],	SCOPe (2.08)
A	d1emsa1	Alpha and beta proteins (a+b)	HIT-like	HIT-like	HIT (HINT, histidine triad) family of protein kinase-interacting proteins	NIT-FHIT fusion protein, C-terminal domain	(Caenorhabditis elegans ) [TaxId: 6239 ],	SCOPe (2.08)
A	d1emsa2	Alpha and beta proteins (a+b)	Carbon-nitrogen hydrolase	Carbon-nitrogen hydrolase	Nitrilase	NIT-FHIT fusion protein, N-terminal domain	(Caenorhabditis elegans ) [TaxId: 6239 ],	SCOPe (2.08)

Domain Annotation: SCOP2 Classification SCOP2 Database Homepage

Chains	Type	Family Name	Domain Identifier	Family Identifier	Provenance Source (Version)
B	SCOP2B Superfamily	Carbon-nitrogen hydrolases	8036897	3001086	SCOP2B (2022-06-29)
B	SCOP2B Superfamily	HIT-like	8034399	3000223	SCOP2B (2022-06-29)
A	SCOP2 Family	HIT domain-like	8022019	4000950	SCOP2 (2022-06-29)
A	SCOP2 Family	Carbon-nitrogen hydrolases-like	8024518	4002312	SCOP2 (2022-06-29)
A	SCOP2 Superfamily	HIT-like	8034399	3000223	SCOP2 (2022-06-29)
A	SCOP2 Superfamily	Carbon-nitrogen hydrolases	8036897	3001086	SCOP2 (2022-06-29)

Domain Annotation: ECOD Classification ECOD Database Homepage

Chains	Family Name	Domain Identifier	Architecture	Possible Homology	Homology	Topology	Family	Provenance Source (Version)
B	HIT	e1emsB1	A: a+b three layers	X: HIT-like	H: HIT-related (From Topology)	T: HIT-related	F: HIT	ECOD (1.6)
B	CN_hydrolase	e1emsB2	A: a+b four layers	X: Carbon-nitrogen hydrolase-like	H: Carbon-nitrogen hydrolase (From Topology)	T: Carbon-nitrogen hydrolase	F: CN_hydrolase	ECOD (1.6)
A	HIT	e1emsA1	A: a+b three layers	X: HIT-like	H: HIT-related (From Topology)	T: HIT-related	F: HIT	ECOD (1.6)
A	CN_hydrolase	e1emsA2	A: a+b four layers	X: Carbon-nitrogen hydrolase-like	H: Carbon-nitrogen hydrolase (From Topology)	T: Carbon-nitrogen hydrolase	F: CN_hydrolase	ECOD (1.6)

Domain Annotation: CATH CATH Database Homepage

Chain	Domain	Class	Architecture	Topology	Homology	Provenance Source (Version)
B	3.60.110.10	Alpha Beta	4-Layer Sandwich	Nitrilase/N-carbamoyl-D-aminoacid amidohydrolase	Carbon-nitrogen hydrolase	CATH (4.3.0)
B	3.30.428.10	Alpha Beta	2-Layer Sandwich	HIT family, subunit A	HIT-like	CATH (4.3.0)
A	3.60.110.10	Alpha Beta	4-Layer Sandwich	Nitrilase/N-carbamoyl-D-aminoacid amidohydrolase	Carbon-nitrogen hydrolase	CATH (4.3.0)
A	3.30.428.10	Alpha Beta	2-Layer Sandwich	HIT family, subunit A	HIT-like	CATH (4.3.0)

Protein Family Annotation Pfam Database Homepage

Chains	Accession	Name	Description	Comments	Source
A, B	PF01230	HIT domain (HIT)	HIT domain	-	Domain
A, B	PF00795	Carbon-nitrogen hydrolase (CN_hydrolase)	Carbon-nitrogen hydrolase	-	Family

Gene Ontology: Gene Product Annotation Gene Ontology Database Homepage

Chains	Polymer	Molecular Function	Biological Process	Cellular Component
A, B	NIT-FRAGILE HISTIDINE TRIAD FUSION PROTEIN	pyrophosphatase activity bis(5'-adenosyl)-triphosphatase activity hydrolase activity, acting on acid anhydrides, in phosphorus-containing anhydrides hydrolase activity hydrolase activity, acting on acid anhydrides catalytic activity hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds, in linear amides deaminated glutathione amidase activity hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds binding nucleoside phosphate binding organic cyclic compound binding nucleotide binding heterocyclic compound binding pyrophosphatase activity bis(5'-adenosyl)-triphosphatase activity hydrolase activity, acting on acid anhydrides, in phosphorus-containing anhydrides hydrolase activity hydrolase activity, acting on acid anhydrides catalytic activity hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds, in linear amides deaminated glutathione amidase activity hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds binding nucleoside phosphate binding organic cyclic compound binding nucleotide binding heterocyclic compound binding small molecule binding	catabolic process amide catabolic process metabolic process cellular process amide metabolic process nucleobase-containing compound metabolic process primary metabolic process	-

InterPro: Protein Family Classification InterPro Database Homepage

Chains	Accession	Name	Type
A, B	IPR011146	HIT-like domain	Domain
A, B	IPR003010	Carbon-nitrogen hydrolase	Domain
A, B	IPR001110	Uncharacterised protein family UPF0012, conserved site	Conserved Site
A, B	IPR036526	Carbon-nitrogen hydrolase superfamily	Homologous Superfamily
A, B	IPR036265	HIT-like superfamily	Homologous Superfamily
A, B	IPR039383	FHIT family	Family
A, B	IPR045254	Nit1/2, carbon-nitrogen hydrolase domain	Domain
A, B	IPR019808	Histidine triad, conserved site	Conserved Site

RCSB PDB Core Operations are funded by the U.S. National Science Foundation (DBI-2321666), the US Department of Energy (DE-SC0019749), and the National Cancer Institute, National Institute of Allergy and Infectious Diseases, and National Institute of General Medical Sciences of the National Institutes of Health under grant R01GM157729.