Download MendeleyThe Crystal Structure of Human AD-003 protein in complex with S-adenosyl-L-homocysteine
Min, J., Wu, H., Zeng, H., Loppnau, P., Sundstrom, M., Arrowsmith, C.H., Edwards, A.M., Bochkarev, A., Plotnikov, A.N.To be published.
2EX4 | pdb_00002ex4
Crystal Structure of Human methyltransferase AD-003 in complex with S-adenosyl-L-homocysteine
- PDB DOI: https://doi.org/10.2210/pdb2EX4/pdb
- Classification: TRANSFERASE
- Organism(s): Homo sapiens
- Expression System: Escherichia coli
- Mutation(s): No
- Deposited: 2005-11-07 Released: 2005-11-15
Experimental Data Snapshot
- Method: X-RAY DIFFRACTION
- Resolution: 1.75 Å
- R-Value Free: 0.258 (Depositor), 0.200 (DCC)
- R-Value Work: 0.194 (Depositor), 0.200 (DCC)
- R-Value Observed: 0.197 (Depositor)
Starting Model: experimental
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This is version 1.3 of the entry. See complete history.
Literature
To be published.
Macromolecules
Find similar proteins by:
(by identity cutoff) | 3D Structure
Entity ID: 1 | |||||
|---|---|---|---|---|---|
| Molecule | Chains | Sequence Length | Organism | Details | Image |
| adrenal gland protein AD-003 | 241 | Homo sapiens | Mutation(s): 0 EC: 2.1.1.244 |  | |
UniProt & NIH Common Fund Data Resources | |||||
Find proteins for Q9BV86 (Homo sapiens) Explore Q9BV86 Go to UniProtKB: Q9BV86 | |||||
PHAROS: Q9BV86 GTEx: ENSG00000148335 | |||||
Entity Groups | |||||
| Sequence Clusters | 30% Identity50% Identity70% Identity90% Identity95% Identity100% Identity | ||||
| UniProt Group | Q9BV86 | ||||
Sequence AnnotationsExpand | |||||
| |||||
Small Molecules
| Ligands 1 Unique | |||||
|---|---|---|---|---|---|
| ID | Chains | Name / Formula / InChI Key | 2D Diagram | 3D Interactions | |
| SAH Query on SAH | C [auth A], D [auth B] | S-ADENOSYL-L-HOMOCYSTEINE C14 H20 N6 O5 S ZJUKTBDSGOFHSH-WFMPWKQPSA-N |  | ||
Experimental Data & Validation
Experimental Data
- Method: X-RAY DIFFRACTION
- Resolution: 1.75 Å
- R-Value Free: 0.258 (Depositor), 0.200 (DCC)
- R-Value Work: 0.194 (Depositor), 0.200 (DCC)
- R-Value Observed: 0.197 (Depositor)
Space Group: P 1
Unit Cell:
| Length ( Å ) | Angle ( ˚ ) |
|---|---|
| a = 43.922 | α = 105.72 |
| b = 47.367 | β = 88.18 |
| c = 64.734 | γ = 115.97 |
| Software Name | Purpose |
|---|---|
| REFMAC | refinement |
| HKL-2000 | data reduction |
| SCALEPACK | data scaling |
| MOLREP | phasing |
Entry History
Deposition Data
- Released Date: 2005-11-15 Deposition Author(s): Min, J.R., Wu, H., Zeng, H., Loppnau, P., Sundstrom, M., Arrowsmith, C.H., Edwards, A.M., Bochkarev, A., Plotnikov, A.N., Structural Genomics Consortium (SGC)
Revision History (Full details and data files)
- Version 1.0: 2005-11-15
Type: Initial release - Version 1.1: 2008-05-01
Changes: Version format compliance - Version 1.2: 2011-07-13
Changes: Version format compliance - Version 1.3: 2023-08-23
Changes: Data collection, Database references, Derived calculations, Refinement description
