8OEQ

Crystal structure of the Candida albicans 80S ribosome in complex with Paromomycin (250uM)

  • Classification: RIBOSOME
  • Organism(s): Candida albicans
  • Mutation(s): No 

  • Deposited: 2023-03-12 Released: 2024-09-25 
  • Deposition Author(s): Kolosova, O., Zgadzay, Y., Yusupov, M.
  • Funding Organization(s): Foundation for Medical Research (France), Russian Science Foundation, National Institutes of Health/Eunice Kennedy Shriver National Institute of Child Health & Human Development (NIH/NICHD)

Experimental Data Snapshot

  • Method: X-RAY DIFFRACTION
  • Resolution: 3.30 Å
  • R-Value Free: 0.297 
  • R-Value Work: 0.254 
  • R-Value Observed: 0.254 

Starting Model: experimental
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wwPDB Validation   3D Report Full Report


Ligand Structure Quality Assessment 


This is version 1.0 of the entry. See complete history. 


Literature

Drug-induced rotational movement of the ribosome is a key factor for read-through enhancement

Kolosova, O., Zgadzay, Y., Stetsenko, A., Validov, S., Usachev, K., Jenner, L., Dmitriev, S., Guskov, A., Yusupov, M.

To be published.

Macromolecules

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Entity ID: 4
MoleculeChains Sequence LengthOrganismDetailsImage
60S ribosomal protein L2-BD [auth j],
EC [auth AW]		254Candida albicansMutation(s): 0 
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Entity ID: 5
MoleculeChains Sequence LengthOrganismDetailsImage
60S ribosomal protein L3E [auth k],
FC [auth AX]		389Candida albicansMutation(s): 0 
UniProt
Find proteins for Q59LS1 (Candida albicans (strain SC5314 / ATCC MYA-2876))
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Entity ID: 6
MoleculeChains Sequence LengthOrganismDetailsImage
60S ribosomal protein L4-BF [auth l],
GC [auth AY]		363Candida albicansMutation(s): 0 
UniProt
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Entity ID: 7
MoleculeChains Sequence LengthOrganismDetailsImage
Uncharacterized protein CaJ7.0206G [auth m],
HC [auth AZ]		298Candida albicansMutation(s): 0 
UniProt
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Entity ID: 8
MoleculeChains Sequence LengthOrganismDetailsImage
60S ribosomal protein L6H [auth n],
IC [auth BA]		176Candida albicansMutation(s): 0 
UniProt
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Entity ID: 9
MoleculeChains Sequence LengthOrganismDetailsImage
60S ribosomal protein L7-AI [auth o],
JC [auth BB]		241Candida albicansMutation(s): 0 
UniProt
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Entity ID: 10
MoleculeChains Sequence LengthOrganismDetailsImage
60S ribosomal protein L8J [auth p],
KC [auth BC]		262Candida albicansMutation(s): 0 
UniProt
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Entity ID: 11
MoleculeChains Sequence LengthOrganismDetailsImage
60S ribosomal protein L9-BK [auth q],
LC [auth BD]		191Candida albicansMutation(s): 0 
UniProt
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Entity ID: 12
MoleculeChains Sequence LengthOrganismDetailsImage
60S ribosomal protein L10L [auth r],
MC [auth BE]		220Candida albicansMutation(s): 0 
UniProt
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Entity ID: 13
MoleculeChains Sequence LengthOrganismDetailsImage
60S ribosomal protein L11-BM [auth s],
NC [auth BF]		174Candida albicansMutation(s): 0 
UniProt
Find proteins for A0A8H6F1S5 (Candida albicans)
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Entity ID: 14
MoleculeChains Sequence LengthOrganismDetailsImage
60S ribosomal protein L13N [auth t],
OC [auth BG]		202Candida albicansMutation(s): 0 
UniProt
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Entity ID: 15
MoleculeChains Sequence LengthOrganismDetailsImage
60S ribosomal protein L14-BO [auth u],
PC [auth BH]		131Candida albicansMutation(s): 0 
UniProt
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Entity ID: 16
MoleculeChains Sequence LengthOrganismDetailsImage
60S ribosomal protein L15-AP [auth v],
QC [auth BI]		204Candida albicansMutation(s): 0 
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Entity ID: 17
MoleculeChains Sequence LengthOrganismDetailsImage
Ribosomal protein L13Q [auth w],
RC [auth BJ]		200Candida albicansMutation(s): 0 
UniProt
Find proteins for A0A8H6BZ56 (Candida albicans)
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Entity ID: 18
MoleculeChains Sequence LengthOrganismDetailsImage
Ribosomal protein L22R [auth x],
SC [auth BK]		185Candida albicansMutation(s): 0 
UniProt
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Entity ID: 19
MoleculeChains Sequence LengthOrganismDetailsImage
60S ribosomal protein L18-AS [auth y],
TC [auth BL]		186Candida albicansMutation(s): 0 
UniProt
Find proteins for A0A8H6C4Y1 (Candida albicans)
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Entity ID: 20
MoleculeChains Sequence LengthOrganismDetailsImage
60S ribosomal protein L19-AT [auth z],
UC [auth BM]		190Candida albicansMutation(s): 0 
UniProt
Find proteins for A0A1D8PK40 (Candida albicans (strain SC5314 / ATCC MYA-2876))
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Entity ID: 21
MoleculeChains Sequence LengthOrganismDetailsImage
60S ribosomal protein L20U [auth 0],
VC [auth BN]		172Candida albicansMutation(s): 0 
UniProt
Find proteins for A0A8H6BZJ3 (Candida albicans)
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Entity ID: 22
MoleculeChains Sequence LengthOrganismDetailsImage
60S ribosomal protein L21-AV [auth 2],
WC [auth BO]		160Candida albicansMutation(s): 0 
UniProt
Find proteins for A0A8H6F1C8 (Candida albicans)
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Entity ID: 23
MoleculeChains Sequence LengthOrganismDetailsImage
60S ribosomal protein L22-BW [auth 5],
XC [auth BP]		124Candida albicansMutation(s): 0 
UniProt
Find proteins for A0A1D8PM41 (Candida albicans (strain SC5314 / ATCC MYA-2876))
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Entity ID: 24
MoleculeChains Sequence LengthOrganismDetailsImage
60S ribosomal protein L23-AX [auth 6],
YC [auth BQ]		137Candida albicansMutation(s): 0 
UniProt
Find proteins for A0A8H6C444 (Candida albicans)
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Entity ID: 25
MoleculeChains Sequence LengthOrganismDetailsImage
60S ribosomal protein L24-AY [auth 7],
ZC [auth BR]		155Candida albicansMutation(s): 0 
UniProt
Find proteins for A0A8H6C4U1 (Candida albicans)
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Entity ID: 26
MoleculeChains Sequence LengthOrganismDetailsImage
60S ribosomal protein L25AD [auth BS],
Z [auth 8]		142Candida albicansMutation(s): 0 
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Entity ID: 27
MoleculeChains Sequence LengthOrganismDetailsImage
Ribosomal protein L24AA [auth 9],
BD [auth BT]		127Candida albicansMutation(s): 0 
UniProt
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Entity ID: 28
MoleculeChains Sequence LengthOrganismDetailsImage
60S ribosomal protein L27BA [auth AA],
CD [auth BU]		136Candida albicansMutation(s): 0 
UniProt
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Entity ID: 29
MoleculeChains Sequence LengthOrganismDetailsImage
60S ribosomal protein L28CA [auth AB],
DD [auth BV]		149Candida albicansMutation(s): 0 
UniProt
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Entity ID: 30
MoleculeChains Sequence LengthOrganismDetailsImage
60S ribosomal protein L29DA [auth AC],
ED [auth BW]		63Candida albicansMutation(s): 0 
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Entity ID: 31
MoleculeChains Sequence LengthOrganismDetailsImage
60S ribosomal protein L30EA [auth AD],
FD [auth BX]		106Candida albicansMutation(s): 0 
UniProt
Find proteins for A0A1D8PM75 (Candida albicans (strain SC5314 / ATCC MYA-2876))
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Entity ID: 32
MoleculeChains Sequence LengthOrganismDetailsImage
60S ribosomal protein L31-BFA [auth AE],
GD [auth BY]		112Candida albicansMutation(s): 0 
UniProt
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Entity ID: 33
MoleculeChains Sequence LengthOrganismDetailsImage
60S ribosomal protein L32GA [auth AF],
HD [auth BZ]		131Candida albicansMutation(s): 0 
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Entity ID: 34
MoleculeChains Sequence LengthOrganismDetailsImage
60S ribosomal protein L33-AHA [auth AG],
ID [auth CA]		107Candida albicansMutation(s): 0 
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Entity ID: 35
MoleculeChains Sequence LengthOrganismDetailsImage
60S ribosomal protein L34-BIA [auth AH],
JD [auth CB]		113Candida albicansMutation(s): 0 
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Entity ID: 36
MoleculeChains Sequence LengthOrganismDetailsImage
Ribosomal protein L29JA [auth AI],
KD [auth CC]		120Candida albicansMutation(s): 0 
UniProt
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Entity ID: 37
MoleculeChains Sequence LengthOrganismDetailsImage
60S ribosomal protein L36KA [auth AJ],
LD [auth CD]		99Candida albicansMutation(s): 0 
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Entity ID: 38
MoleculeChains Sequence LengthOrganismDetailsImage
60S ribosomal protein L37-BLA [auth AK],
MD [auth CE]		90Candida albicansMutation(s): 0 
UniProt
Find proteins for A0A1D8PF45 (Candida albicans (strain SC5314 / ATCC MYA-2876))
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Entity ID: 39
MoleculeChains Sequence LengthOrganismDetailsImage
60S ribosomal protein L38MA [auth AL],
ND [auth CF]		78Candida albicansMutation(s): 0 
UniProt
Find proteins for A0A1D8PG16 (Candida albicans (strain SC5314 / ATCC MYA-2876))
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Entity ID: 40
MoleculeChains Sequence LengthOrganismDetailsImage
60S ribosomal protein L39NA [auth AM],
OD [auth CG]		51Candida albicansMutation(s): 0 
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Entity ID: 41
MoleculeChains Sequence LengthOrganismDetailsImage
60S ribosomal protein L40-BOA [auth AN],
PD [auth CH]		52Candida albicansMutation(s): 0 
UniProt
Find proteins for A0A1D8PL68 (Candida albicans (strain SC5314 / ATCC MYA-2876))
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Entity ID: 42
MoleculeChains Sequence LengthOrganismDetailsImage
60S ribosomal protein L41PA [auth AO],
QD [auth CI]		25Candida albicansMutation(s): 0 
UniProt
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Entity ID: 43
MoleculeChains Sequence LengthOrganismDetailsImage
60S ribosomal protein L42-BQA [auth AP],
RD [auth CJ]		106Candida albicansMutation(s): 0 
UniProt
Find proteins for A0A8H6BR69 (Candida albicans)
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Entity ID: 44
MoleculeChains Sequence LengthOrganismDetailsImage
60S ribosomal protein L43-ARA [auth AQ],
SD [auth CK]		92Candida albicansMutation(s): 0 
UniProt
Find proteins for A0A1D8PP14 (Candida albicans (strain SC5314 / ATCC MYA-2876))
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Entity ID: 45
MoleculeChains Sequence LengthOrganismDetailsImage
60S ribosomal protein CAALFM_C304810CADF [auth CL],
SA [auth i]		267Candida albicansMutation(s): 0 
UniProt
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Entity ID: 47
MoleculeChains Sequence LengthOrganismDetailsImage
40S ribosomal protein S0UA [auth C],
UD [auth CN]		261Candida albicansMutation(s): 0 
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Entity ID: 48
MoleculeChains Sequence LengthOrganismDetailsImage
40S ribosomal protein S1VA [auth D],
VD [auth CO]		256Candida albicansMutation(s): 0 
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Entity ID: 49
MoleculeChains Sequence LengthOrganismDetailsImage
Ribosomal protein S5WA [auth E],
WD [auth CP]		249Candida albicansMutation(s): 0 
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Entity ID: 50
MoleculeChains Sequence LengthOrganismDetailsImage
Ribosomal protein S3XA [auth F],
XD [auth CQ]		251Candida albicansMutation(s): 0 
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Entity ID: 51
MoleculeChains Sequence LengthOrganismDetailsImage
40S ribosomal protein S4YA [auth G],
YD [auth CR]		262Candida albicansMutation(s): 0 
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Entity ID: 52
MoleculeChains Sequence LengthOrganismDetailsImage
Ribosomal protein S7ZA [auth H],
ZD [auth CS]		225Candida albicansMutation(s): 0 
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Entity ID: 53
MoleculeChains Sequence LengthOrganismDetailsImage
40S ribosomal protein S6AB [auth I],
AE [auth CT]		236Candida albicansMutation(s): 0 
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Entity ID: 54
MoleculeChains Sequence LengthOrganismDetailsImage
40S ribosomal protein S7BB [auth J],
BE [auth CU]		186Candida albicansMutation(s): 0 
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Entity ID: 55
MoleculeChains Sequence LengthOrganismDetailsImage
40S ribosomal protein S8CB [auth K],
CE [auth CV]		206Candida albicansMutation(s): 0 
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Entity ID: 56
MoleculeChains Sequence LengthOrganismDetailsImage
Ribosomal protein S4DB [auth L],
DE [auth CW]		189Candida albicansMutation(s): 0 
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Entity ID: 57
MoleculeChains Sequence LengthOrganismDetailsImage
40S ribosomal protein S10-AEB [auth M],
EE [auth CX]		118Candida albicansMutation(s): 0 
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Entity ID: 58
MoleculeChains Sequence LengthOrganismDetailsImage
40S ribosomal protein S11AFB [auth N],
FE [auth CY]		155Candida albicansMutation(s): 0 
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Entity ID: 59
MoleculeChains Sequence LengthOrganismDetailsImage
40S ribosomal protein S12GB [auth O],
GE [auth CZ]		143Candida albicansMutation(s): 0 
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Entity ID: 60
MoleculeChains Sequence LengthOrganismDetailsImage
40S ribosomal protein S13HB [auth P],
HE [auth DA]		151Candida albicansMutation(s): 0 
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Entity ID: 61
MoleculeChains Sequence LengthOrganismDetailsImage
40S ribosomal protein S14-AIB [auth Q],
IE [auth DB]		132Candida albicansMutation(s): 0 
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Entity ID: 62
MoleculeChains Sequence LengthOrganismDetailsImage
40S ribosomal protein S15JB [auth R],
JE [auth DC]		142Candida albicansMutation(s): 0 
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Entity ID: 63
MoleculeChains Sequence LengthOrganismDetailsImage
40S ribosomal protein S16KB [auth S],
KE [auth DD]		142Candida albicansMutation(s): 0 
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Entity ID: 64
MoleculeChains Sequence LengthOrganismDetailsImage
40S ribosomal protein S17-BLB [auth T],
LE [auth DE]		137Candida albicansMutation(s): 0 
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Entity ID: 65
MoleculeChains Sequence LengthOrganismDetailsImage
40S ribosomal protein S18-BMB [auth U],
ME [auth DF]		145Candida albicansMutation(s): 0 
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Entity ID: 66
MoleculeChains Sequence LengthOrganismDetailsImage
40S ribosomal protein S19-ANB [auth V],
NE [auth DG]		145Candida albicansMutation(s): 0 
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Entity ID: 67
MoleculeChains Sequence LengthOrganismDetailsImage
Ribosomal protein S10OB [auth W],
OE [auth DH]		119Candida albicansMutation(s): 0 
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Entity ID: 68
MoleculeChains Sequence LengthOrganismDetailsImage
40S ribosomal protein S21PB [auth X],
PE [auth DI]		87Candida albicansMutation(s): 0 
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Entity ID: 69
MoleculeChains Sequence LengthOrganismDetailsImage
40S ribosomal protein S22-AQB [auth Y],
QE [auth DJ]		130Candida albicansMutation(s): 0 
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Entity ID: 70
MoleculeChains Sequence LengthOrganismDetailsImage
Ribosomal protein S23 (S12)RB [auth Z],
RE [auth DK]		145Candida albicansMutation(s): 0 
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Entity ID: 71
MoleculeChains Sequence LengthOrganismDetailsImage
40S ribosomal protein S24SB [auth a],
SE [auth DL]		135Candida albicansMutation(s): 0 
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Entity ID: 72
MoleculeChains Sequence LengthOrganismDetailsImage
40S ribosomal protein S25TB [auth b],
TE [auth DM]		105Candida albicansMutation(s): 0 
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Entity ID: 73
MoleculeChains Sequence LengthOrganismDetailsImage
40S ribosomal protein S26UB [auth c],
UE [auth DN]		119Candida albicansMutation(s): 0 
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Entity ID: 74
MoleculeChains Sequence LengthOrganismDetailsImage
40S ribosomal protein S27VB [auth d],
VE [auth DO]		82Candida albicansMutation(s): 0 
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Entity ID: 75
MoleculeChains Sequence LengthOrganismDetailsImage
40S ribosomal protein S28-BWB [auth e],
WE [auth DP]		67Candida albicansMutation(s): 0 
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Entity ID: 76
MoleculeChains Sequence LengthOrganismDetailsImage
40S ribosomal protein S29AXB [auth f],
XE [auth DQ]		56Candida albicansMutation(s): 0 
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Entity ID: 77
MoleculeChains Sequence LengthOrganismDetailsImage
40S ribosomal protein S30YB [auth g],
YE [auth DR]		63Candida albicansMutation(s): 0 
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Entity ID: 78
MoleculeChains Sequence LengthOrganismDetailsImage
Ubiquitin-40S ribosomal protein S31 fusion proteinZB [auth h],
ZE [auth DS]		193Candida albicansMutation(s): 0 
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Entity ID: 79
MoleculeChains Sequence LengthOrganismDetailsImage
Guanine nucleotide-binding protein subunit beta-like proteinAC [auth AR],
AF [auth DT]		317Candida albicansMutation(s): 0 
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Entity ID: 80
MoleculeChains Sequence LengthOrganismDetailsImage
Ribosomal proteinBF [auth L1],
CF [auth l1]		217Candida albicansMutation(s): 0 
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Entity ID: 1
MoleculeChains LengthOrganismImage
25S ribosomal RNAA [auth 1],
BC [auth AS]		3,359Candida albicans
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Entity ID: 2
MoleculeChains LengthOrganismImage
5S ribosomal RNAB [auth 3],
CC [auth AT]		121Candida albicans
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Entity ID: 3
MoleculeChains LengthOrganismImage
5.8S ribosomal RNAC [auth 4],
DC [auth AU]		158Candida albicans
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Entity ID: 46
MoleculeChains LengthOrganismImage
18S ribosomal RNATA [auth B],
TD [auth CM]		1,787Candida albicans
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Small Molecules
Ligands 4 Unique
IDChains Name / Formula / InChI Key2D Diagram3D Interactions
3K5
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HDB [auth CJ],
JF [auth 1]		3-O-acetyl-2-O-(3-O-acetyl-6-deoxy-beta-D-glucopyranosyl)-6-deoxy-1-O-{[(2R,2'S,3a'R,4''S,5''R,6'S,7a'S)-5''-methyl-4''-{[(2E)-3-phenylprop-2-enoyl]oxy}decahydrodispiro[oxirane-2,3'-[1]benzofuran-2',2''-pyran]-6'-yl]carbonyl}-beta-D-glucopyranose
C40 H52 O17
VOTNXJVGRXZYOA-XFJWYURVSA-N
PAR (Subject of Investigation/LOI)
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ABA [auth 1]
AJB [auth CM]
CBB [auth AS]
DBB [auth AS]
EBB [auth AS]
ABA [auth 1],
AJB [auth CM],
CBB [auth AS],
DBB [auth AS],
EBB [auth AS],
JLA [auth B],
YAA [auth 1],
ZAA [auth 1]
PAROMOMYCIN
C23 H45 N5 O14
UOZODPSAJZTQNH-LSWIJEOBSA-N
ZN
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BMA [auth f]
FDB [auth CB]
GDB [auth CE]
JDB [auth CK]
JEA [auth AH]
BMA [auth f],
FDB [auth CB],
GDB [auth CE],
JDB [auth CK],
JEA [auth AH],
NEA [auth AK],
OEA [auth AN],
PEA [auth AP],
TEA [auth AQ],
UJB [auth DQ],
ZLA [auth c]
ZINC ION
Zn
PTFCDOFLOPIGGS-UHFFFAOYSA-N
MG
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AAA [auth 1]
AAB [auth AS]
ABB [auth AS]
ACA [auth 4]
ACB [auth AW]
AAA [auth 1],
AAB [auth AS],
ABB [auth AS],
ACA [auth 4],
ACB [auth AW],
ADA [auth u],
ADB [auth BZ],
AEA [auth AC],
AEB [auth CM],
AFA [auth B],
AFB [auth CM],
AG [auth 1],
AGA [auth B],
AGB [auth CM],
AH [auth 1],
AHA [auth B],
AHB [auth CM],
AI [auth 1],
AIA [auth B],
AIB [auth CM],
AJ [auth 1],
AJA [auth B],
AK [auth 1],
AKA [auth B],
AL [auth 1],
ALA [auth B],
AM [auth 1],
AMA [auth c],
AN [auth 1],
ANA [auth AS],
AO [auth 1],
AOA [auth AS],
AP [auth 1],
APA [auth AS],
AQ [auth 1],
AQA [auth AS],
AR [auth 1],
ARA [auth AS],
AS [auth 1],
ASA [auth AS],
AT [auth 1],
ATA [auth AS],
AU [auth 1],
AUA [auth AS],
AV [auth 1],
AVA [auth AS],
AW [auth 1],
AWA [auth AS],
AX [auth 1],
AXA [auth AS],
AY [auth 1],
AYA [auth AS],
AZ [auth 1],
AZA [auth AS],
BAA [auth 1],
BAB [auth AS],
BBA [auth 3],
BBB [auth AS],
BCA [auth 4],
BCB [auth AW],
BDA [auth v],
BDB [auth BZ],
BEA [auth AD],
BEB [auth CM],
BFA [auth B],
BFB [auth CM],
BG [auth 1],
BGA [auth B],
BGB [auth CM],
BH [auth 1],
BHA [auth B],
BHB [auth CM],
BI [auth 1],
BIA [auth B],
BIB [auth CM],
BJ [auth 1],
BJA [auth B],
BJB [auth CN],
BK [auth 1],
BKA [auth B],
BL [auth 1],
BLA [auth B],
BM [auth 1],
BN [auth 1],
BNA [auth AS],
BO [auth 1],
BOA [auth AS],
BP [auth 1],
BPA [auth AS],
BQ [auth 1],
BQA [auth AS],
BR [auth 1],
BRA [auth AS],
BS [auth 1],
BSA [auth AS],
BT [auth 1],
BTA [auth AS],
BU [auth 1],
BUA [auth AS],
BV [auth 1],
BVA [auth AS],
BW [auth 1],
BWA [auth AS],
BX [auth 1],
BXA [auth AS],
BY [auth 1],
BYA [auth AS],
BZ [auth 1],
BZA [auth AS],
CAA [auth 1],
CAB [auth AS],
CBA [auth 3],
CCA [auth 4],
CCB [auth AX],
CDA [auth v],
CDB [auth BZ],
CEA [auth AD],
CEB [auth CM],
CFA [auth B],
CFB [auth CM],
CG [auth 1],
CGA [auth B],
CGB [auth CM],
CH [auth 1],
CHA [auth B],
CHB [auth CM],
CI [auth 1],
CIA [auth B],
CIB [auth CM],
CJ [auth 1],
CJA [auth B],
CJB [auth CP],
CK [auth 1],
CKA [auth B],
CL [auth 1],
CLA [auth B],
CM [auth 1],
CMA [auth f],
CN [auth 1],
CNA [auth AS],
CO [auth 1],
COA [auth AS],
CP [auth 1],
CPA [auth AS],
CQ [auth 1],
CQA [auth AS],
CR [auth 1],
CRA [auth AS],
CS [auth 1],
CSA [auth AS],
CT [auth 1],
CTA [auth AS],
CU [auth 1],
CUA [auth AS],
CV [auth 1],
CVA [auth AS],
CW [auth 1],
CWA [auth AS],
CX [auth 1],
CXA [auth AS],
CY [auth 1],
CYA [auth AS],
CZ [auth 1],
CZA [auth AS],
DAA [auth 1],
DAB [auth AS],
DBA [auth 3],
DCA [auth 4],
DCB [auth AX],
DDA [auth w],
DDB [auth BZ],
DEA [auth AF],
DEB [auth CM],
DFA [auth B],
DFB [auth CM],
DG [auth 1],
DGA [auth B],
DGB [auth CM],
DH [auth 1],
DHA [auth B],
DHB [auth CM],
DI [auth 1],
DIA [auth B],
DIB [auth CM],
DJ [auth 1],
DJA [auth B],
DJB [auth CP],
DK [auth 1],
DKA [auth B],
DL [auth 1],
DLA [auth B],
DM [auth 1],
DMA [auth g],
DN [auth 1],
DNA [auth AS],
DO [auth 1],
DOA [auth AS],
DP [auth 1],
DPA [auth AS],
DQ [auth 1],
DQA [auth AS],
DR [auth 1],
DRA [auth AS],
DS [auth 1],
DSA [auth AS],
DT [auth 1],
DTA [auth AS],
DU [auth 1],
DUA [auth AS],
DV [auth 1],
DVA [auth AS],
DW [auth 1],
DWA [auth AS],
DX [auth 1],
DXA [auth AS],
DY [auth 1],
DYA [auth AS],
DZ [auth 1],
DZA [auth AS],
EAA [auth 1],
EAB [auth AS],
EBA [auth 3],
ECA [auth 4],
ECB [auth AY],
EDA [auth w],
EDB [auth CA],
EEA [auth AF],
EEB [auth CM],
EF [auth 1],
EFA [auth B],
EFB [auth CM],
EG [auth 1],
EGA [auth B],
EGB [auth CM],
EH [auth 1],
EHA [auth B],
EHB [auth CM],
EI [auth 1],
EIA [auth B],
EIB [auth CM],
EJ [auth 1],
EJA [auth B],
EJB [auth CQ],
EK [auth 1],
EKA [auth B],
EL [auth 1],
ELA [auth B],
EM [auth 1],
EMA [auth AR],
EN [auth 1],
ENA [auth AS],
EO [auth 1],
EOA [auth AS],
EP [auth 1],
EPA [auth AS],
EQ [auth 1],
EQA [auth AS],
ER [auth 1],
ERA [auth AS],
ES [auth 1],
ESA [auth AS],
ET [auth 1],
ETA [auth AS],
EU [auth 1],
EUA [auth AS],
EV [auth 1],
EVA [auth AS],
EW [auth 1],
EWA [auth AS],
EX [auth 1],
EXA [auth AS],
EY [auth 1],
EYA [auth AS],
EZ [auth 1],
EZA [auth AS],
FAA [auth 1],
FAB [auth AS],
FBA [auth 3],
FBB [auth AT],
FCA [auth j],
FCB [auth BB],
FDA [auth w],
FEA [auth AF],
FEB [auth CM],
FF [auth 1],
FFA [auth B],
FFB [auth CM],
FG [auth 1],
FGA [auth B],
FGB [auth CM],
FH [auth 1],
FHA [auth B],
FHB [auth CM],
FI [auth 1],
FIA [auth B],
FIB [auth CM],
FJ [auth 1],
FJA [auth B],
FJB [auth CQ],
FK [auth 1],
FKA [auth B],
FL [auth 1],
FLA [auth B],
FM [auth 1],
FMA [auth AS],
FN [auth 1],
FNA [auth AS],
FO [auth 1],
FOA [auth AS],
FP [auth 1],
FPA [auth AS],
FQ [auth 1],
FQA [auth AS],
FR [auth 1],
FRA [auth AS],
FS [auth 1],
FSA [auth AS],
FT [auth 1],
FTA [auth AS],
FU [auth 1],
FUA [auth AS],
FV [auth 1],
FVA [auth AS],
FW [auth 1],
FWA [auth AS],
FX [auth 1],
FXA [auth AS],
FY [auth 1],
FYA [auth AS],
FZ [auth 1],
FZA [auth AS],
GAA [auth 1],
GAB [auth AS],
GBA [auth 3],
GBB [auth AT],
GCA [auth j],
GCB [auth BB],
GDA [auth x],
GEA [auth AF],
GEB [auth CM],
GF [auth 1],
GFA [auth B],
GFB [auth CM],
GG [auth 1],
GGA [auth B],
GGB [auth CM],
GH [auth 1],
GHA [auth B],
GHB [auth CM],
GI [auth 1],
GIA [auth B],
GIB [auth CM],
GJ [auth 1],
GJA [auth B],
GJB [auth CQ],
GK [auth 1],
GKA [auth B],
GL [auth 1],
GLA [auth B],
GM [auth 1],
GMA [auth AS],
GN [auth 1],
GNA [auth AS],
GO [auth 1],
GOA [auth AS],
GP [auth 1],
GPA [auth AS],
GQ [auth 1],
GQA [auth AS],
GR [auth 1],
GRA [auth AS],
GS [auth 1],
GSA [auth AS],
GT [auth 1],
GTA [auth AS],
GU [auth 1],
GUA [auth AS],
GV [auth 1],
GVA [auth AS],
GW [auth 1],
GWA [auth AS],
GX [auth 1],
GXA [auth AS],
GY [auth 1],
GYA [auth AS],
GZ [auth 1],
GZA [auth AS],
HAA [auth 1],
HAB [auth AS],
HBA [auth 3],
HBB [auth AT],
HCA [auth j],
HCB [auth BB],
HDA [auth x],
HEA [auth AG],
HEB [auth CM],
HF [auth 1],
HFA [auth B],
HFB [auth CM],
HG [auth 1],
HGA [auth B],
HGB [auth CM],
HH [auth 1],
HHA [auth B],
HHB [auth CM],
HI [auth 1],
HIA [auth B],
HIB [auth CM],
HJ [auth 1],
HJA [auth B],
HJB [auth CQ],
HK [auth 1],
HKA [auth B],
HL [auth 1],
HLA [auth B],
HM [auth 1],
HMA [auth AS],
HN [auth 1],
HNA [auth AS],
HO [auth 1],
HOA [auth AS],
HP [auth 1],
HPA [auth AS],
HQ [auth 1],
HQA [auth AS],
HR [auth 1],
HRA [auth AS],
HS [auth 1],
HSA [auth AS],
HT [auth 1],
HTA [auth AS],
HU [auth 1],
HUA [auth AS],
HV [auth 1],
HVA [auth AS],
HW [auth 1],
HWA [auth AS],
HX [auth 1],
HXA [auth AS],
HY [auth 1],
HYA [auth AS],
HZ [auth 1],
HZA [auth AS],
IAA [auth 1],
IAB [auth AS],
IBA [auth 3],
IBB [auth AT],
ICA [auth j],
ICB [auth BE],
IDA [auth x],
IDB [auth CJ],
IEA [auth AG],
IEB [auth CM],
IF [auth 1],
IFA [auth B],
IFB [auth CM],
IG [auth 1],
IGA [auth B],
IGB [auth CM],
IH [auth 1],
IHA [auth B],
IHB [auth CM],
II [auth 1],
IIA [auth B],
IIB [auth CM],
IJ [auth 1],
IJA [auth B],
IJB [auth CW],
IK [auth 1],
IKA [auth B],
IL [auth 1],
ILA [auth B],
IM [auth 1],
IMA [auth AS],
IN [auth 1],
INA [auth AS],
IO [auth 1],
IOA [auth AS],
IP [auth 1],
IPA [auth AS],
IQ [auth 1],
IQA [auth AS],
IR [auth 1],
IRA [auth AS],
IS [auth 1],
ISA [auth AS],
IT [auth 1],
ITA [auth AS],
IU [auth 1],
IUA [auth AS],
IV [auth 1],
IVA [auth AS],
IW [auth 1],
IWA [auth AS],
IX [auth 1],
IXA [auth AS],
IY [auth 1],
IYA [auth AS],
IZ [auth 1],
IZA [auth AS],
JAA [auth 1],
JAB [auth AS],
JBA [auth 3],
JBB [auth AT],
JCA [auth k],
JCB [auth BE],
JDA [auth x],
JEB [auth CM],
JFA [auth B],
JFB [auth CM],
JG [auth 1],
JGA [auth B],
JGB [auth CM],
JH [auth 1],
JHA [auth B],
JHB [auth CM],
JI [auth 1],
JIA [auth B],
JIB [auth CM],
JJ [auth 1],
JJA [auth B],
JJB [auth DA],
JK [auth 1],
JKA [auth B],
JL [auth 1],
JM [auth 1],
JMA [auth AS],
JN [auth 1],
JNA [auth AS],
JO [auth 1],
JOA [auth AS],
JP [auth 1],
JPA [auth AS],
JQ [auth 1],
JQA [auth AS],
JR [auth 1],
JRA [auth AS],
JS [auth 1],
JSA [auth AS],
JT [auth 1],
JTA [auth AS],
JU [auth 1],
JUA [auth AS],
JV [auth 1],
JVA [auth AS],
JW [auth 1],
JWA [auth AS],
JX [auth 1],
JXA [auth AS],
JY [auth 1],
JYA [auth AS],
JZ [auth 1],
JZA [auth AS],
KAA [auth 1],
KAB [auth AS],
KBA [auth 3],
KBB [auth AT],
KCA [auth k],
KCB [auth BF],
KDA [auth x],
KDB [auth CK],
KEA [auth AH],
KEB [auth CM],
KF [auth 1],
KFA [auth B],
KFB [auth CM],
KG [auth 1],
KGA [auth B],
KGB [auth CM],
KH [auth 1],
KHA [auth B],
KHB [auth CM],
KI [auth 1],
KIA [auth B],
KIB [auth CM],
KJ [auth 1],
KJA [auth B],
KJB [auth DA],
KK [auth 1],
KKA [auth B],
KL [auth 1],
KLA [auth D],
KM [auth 1],
KMA [auth AS],
KN [auth 1],
KNA [auth AS],
KO [auth 1],
KOA [auth AS],
KP [auth 1],
KPA [auth AS],
KQ [auth 1],
KQA [auth AS],
KR [auth 1],
KRA [auth AS],
KS [auth 1],
KSA [auth AS],
KT [auth 1],
KTA [auth AS],
KU [auth 1],
KUA [auth AS],
KV [auth 1],
KVA [auth AS],
KW [auth 1],
KWA [auth AS],
KX [auth 1],
KXA [auth AS],
KY [auth 1],
KYA [auth AS],
KZ [auth 1],
KZA [auth AS],
LAA [auth 1],
LAB [auth AS],
LBA [auth 3],
LBB [auth AT],
LCA [auth k],
LCB [auth BG],
LDA [auth y],
LDB [auth CM],
LEA [auth AH],
LEB [auth CM],
LF [auth 1],
LFA [auth B],
LFB [auth CM],
LG [auth 1],
LGA [auth B],
LGB [auth CM],
LH [auth 1],
LHA [auth B],
LHB [auth CM],
LI [auth 1],
LIA [auth B],
LIB [auth CM],
LJ [auth 1],
LJA [auth B],
LJB [auth DB],
LK [auth 1],
LKA [auth B],
LL [auth 1],
LLA [auth E],
LM [auth 1],
LMA [auth AS],
LN [auth 1],
LNA [auth AS],
LO [auth 1],
LOA [auth AS],
LP [auth 1],
LPA [auth AS],
LQ [auth 1],
LQA [auth AS],
LR [auth 1],
LRA [auth AS],
LS [auth 1],
LSA [auth AS],
LT [auth 1],
LTA [auth AS],
LU [auth 1],
LUA [auth AS],
LV [auth 1],
LVA [auth AS],
LW [auth 1],
LWA [auth AS],
LX [auth 1],
LXA [auth AS],
LY [auth 1],
LYA [auth AS],
LZ [auth 1],
LZA [auth AS],
MAA [auth 1],
MAB [auth AS],
MBA [auth 3],
MBB [auth AT],
MCA [auth k],
MCB [auth BG],
MDA [auth y],
MDB [auth CM],
MEA [auth AI],
MEB [auth CM],
MF [auth 1],
MFA [auth B],
MFB [auth CM],
MG [auth 1],
MGA [auth B],
MGB [auth CM],
MH [auth 1],
MHA [auth B],
MHB [auth CM],
MI [auth 1],
MIA [auth B],
MIB [auth CM],
MJ [auth 1],
MJA [auth B],
MJB [auth DB],
MK [auth 1],
MKA [auth B],
ML [auth 1],
MLA [auth E],
MM [auth 1],
MMA [auth AS],
MN [auth 1],
MNA [auth AS],
MO [auth 1],
MOA [auth AS],
MP [auth 1],
MPA [auth AS],
MQ [auth 1],
MQA [auth AS],
MR [auth 1],
MRA [auth AS],
MS [auth 1],
MSA [auth AS],
MT [auth 1],
MTA [auth AS],
MU [auth 1],
MUA [auth AS],
MV [auth 1],
MVA [auth AS],
MW [auth 1],
MWA [auth AS],
MX [auth 1],
MXA [auth AS],
MY [auth 1],
MYA [auth AS],
MZ [auth 1],
MZA [auth AS],
NAA [auth 1],
NAB [auth AS],
NBA [auth 3],
NBB [auth AT],
NCA [auth k],
NCB [auth BH],
NDA [auth z],
NDB [auth CM],
NEB [auth CM],
NF [auth 1],
NFA [auth B],
NFB [auth CM],
NG [auth 1],
NGA [auth B],
NGB [auth CM],
NH [auth 1],
NHA [auth B],
NHB [auth CM],
NI [auth 1],
NIA [auth B],
NIB [auth CM],
NJ [auth 1],
NJA [auth B],
NJB [auth DB],
NK [auth 1],
NKA [auth B],
NL [auth 1],
NLA [auth F],
NM [auth 1],
NMA [auth AS],
NN [auth 1],
NNA [auth AS],
NO [auth 1],
NOA [auth AS],
NP [auth 1],
NPA [auth AS],
NQ [auth 1],
NQA [auth AS],
NR [auth 1],
NRA [auth AS],
NS [auth 1],
NSA [auth AS],
NT [auth 1],
NTA [auth AS],
NU [auth 1],
NUA [auth AS],
NV [auth 1],
NVA [auth AS],
NW [auth 1],
NWA [auth AS],
NX [auth 1],
NXA [auth AS],
NY [auth 1],
NYA [auth AS],
NZ [auth 1],
NZA [auth AS],
OAA [auth 1],
OAB [auth AS],
OBA [auth 3],
OBB [auth AT],
OCA [auth l],
OCB [auth BI],
ODA [auth 0],
ODB [auth CM],
OEB [auth CM],
OF [auth 1],
OFA [auth B],
OFB [auth CM],
OG [auth 1],
OGA [auth B],
OGB [auth CM],
OH [auth 1],
OHA [auth B],
OHB [auth CM],
OI [auth 1],
OIA [auth B],
OIB [auth CM],
OJ [auth 1],
OJA [auth B],
OJB [auth DB],
OK [auth 1],
OKA [auth B],
OL [auth 1],
OLA [auth G],
OM [auth 1],
OMA [auth AS],
ON [auth 1],
ONA [auth AS],
OO [auth 1],
OOA [auth AS],
OP [auth 1],
OPA [auth AS],
OQ [auth 1],
OQA [auth AS],
OR [auth 1],
ORA [auth AS],
OS [auth 1],
OSA [auth AS],
OT [auth 1],
OTA [auth AS],
OU [auth 1],
OUA [auth AS],
OV [auth 1],
OVA [auth AS],
OW [auth 1],
OWA [auth AS],
OX [auth 1],
OXA [auth AS],
OY [auth 1],
OYA [auth AS],
OZ [auth 1],
OZA [auth AS],
PAA [auth 1],
PAB [auth AS],
PBA [auth 4],
PBB [auth AT],
PCA [auth l],
PCB [auth BJ],
PDA [auth 0],
PDB [auth CM],
PEB [auth CM],
PF [auth 1],
PFA [auth B],
PFB [auth CM],
PG [auth 1],
PGA [auth B],
PGB [auth CM],
PH [auth 1],
PHA [auth B],
PHB [auth CM],
PI [auth 1],
PIA [auth B],
PIB [auth CM],
PJ [auth 1],
PJA [auth B],
PJB [auth DC],
PK [auth 1],
PKA [auth B],
PL [auth 1],
PLA [auth H],
PM [auth 1],
PMA [auth AS],
PN [auth 1],
PNA [auth AS],
PO [auth 1],
POA [auth AS],
PP [auth 1],
PPA [auth AS],
PQ [auth 1],
PQA [auth AS],
PR [auth 1],
PRA [auth AS],
PS [auth 1],
PSA [auth AS],
PT [auth 1],
PTA [auth AS],
PU [auth 1],
PUA [auth AS],
PV [auth 1],
PVA [auth AS],
PW [auth 1],
PWA [auth AS],
PX [auth 1],
PXA [auth AS],
PY [auth 1],
PYA [auth AS],
PZ [auth 1],
PZA [auth AS],
QAA [auth 1],
QAB [auth AS],
QBA [auth 4],
QBB [auth AT],
QCA [auth m],
QCB [auth BJ],
QDA [auth 0],
QDB [auth CM],
QEA [auth AP],
QEB [auth CM],
QF [auth 1],
QFA [auth B],
QFB [auth CM],
QG [auth 1],
QGA [auth B],
QGB [auth CM],
QH [auth 1],
QHA [auth B],
QHB [auth CM],
QI [auth 1],
QIA [auth B],
QIB [auth CM],
QJ [auth 1],
QJA [auth B],
QJB [auth DG],
QK [auth 1],
QKA [auth B],
QL [auth 1],
QLA [auth I],
QM [auth 1],
QMA [auth AS],
QN [auth 1],
QNA [auth AS],
QO [auth 1],
QOA [auth AS],
QP [auth 1],
QPA [auth AS],
QQ [auth 1],
QQA [auth AS],
QR [auth 1],
QRA [auth AS],
QS [auth 1],
QSA [auth AS],
QT [auth 1],
QTA [auth AS],
QU [auth 1],
QUA [auth AS],
QV [auth 1],
QVA [auth AS],
QW [auth 1],
QWA [auth AS],
QX [auth 1],
QXA [auth AS],
QY [auth 1],
QYA [auth AS],
QZ [auth 1],
QZA [auth AS],
RAA [auth 1],
RAB [auth AS],
RBA [auth 4],
RBB [auth AT],
RCA [auth o],
RCB [auth BJ],
RDA [auth 2],
RDB [auth CM],
REA [auth AP],
REB [auth CM],
RF [auth 1],
RFA [auth B],
RFB [auth CM],
RG [auth 1],
RGA [auth B],
RGB [auth CM],
RH [auth 1],
RHA [auth B],
RHB [auth CM],
RI [auth 1],
RIA [auth B],
RIB [auth CM],
RJ [auth 1],
RJA [auth B],
RJB [auth DJ],
RK [auth 1],
RKA [auth B],
RL [auth 1],
RLA [auth K],
RM [auth 1],
RMA [auth AS],
RN [auth 1],
RNA [auth AS],
RO [auth 1],
ROA [auth AS],
RP [auth 1],
RPA [auth AS],
RQ [auth 1],
RQA [auth AS],
RR [auth 1],
RRA [auth AS],
RS [auth 1],
RSA [auth AS],
RT [auth 1],
RTA [auth AS],
RU [auth 1],
RUA [auth AS],
RV [auth 1],
RVA [auth AS],
RW [auth 1],
RWA [auth AS],
RX [auth 1],
RXA [auth AS],
RY [auth 1],
RYA [auth AS],
RZ [auth 1],
RZA [auth AS],
SAA [auth 1],
SAB [auth AS],
SBA [auth 4],
SBB [auth AU],
SCA [auth o],
SCB [auth BJ],
SDA [auth 5],
SDB [auth CM],
SEA [auth AP],
SEB [auth CM],
SF [auth 1],
SFA [auth B],
SFB [auth CM],
SG [auth 1],
SGA [auth B],
SGB [auth CM],
SH [auth 1],
SHA [auth B],
SHB [auth CM],
SI [auth 1],
SIA [auth B],
SIB [auth CM],
SJ [auth 1],
SJA [auth B],
SJB [auth DJ],
SK [auth 1],
SKA [auth B],
SL [auth 1],
SLA [auth Q],
SM [auth 1],
SMA [auth AS],
SN [auth 1],
SNA [auth AS],
SO [auth 1],
SOA [auth AS],
SP [auth 1],
SPA [auth AS],
SQ [auth 1],
SQA [auth AS],
SR [auth 1],
SRA [auth AS],
SS [auth 1],
SSA [auth AS],
ST [auth 1],
STA [auth AS],
SU [auth 1],
SUA [auth AS],
SV [auth 1],
SVA [auth AS],
SW [auth 1],
SWA [auth AS],
SX [auth 1],
SXA [auth AS],
SY [auth 1],
SYA [auth AS],
SZ [auth 1],
SZA [auth AS],
TAA [auth 1],
TAB [auth AS],
TBA [auth 4],
TBB [auth AU],
TCA [auth o],
TCB [auth BK],
TDA [auth 6],
TDB [auth CM],
TEB [auth CM],
TF [auth 1],
TFA [auth B],
TFB [auth CM],
TG [auth 1],
TGA [auth B],
TGB [auth CM],
TH [auth 1],
THA [auth B],
THB [auth CM],
TI [auth 1],
TIA [auth B],
TIB [auth CM],
TJ [auth 1],
TJA [auth B],
TJB [auth DQ],
TK [auth 1],
TKA [auth B],
TL [auth 1],
TLA [auth Q],
TM [auth 1],
TMA [auth AS],
TN [auth 1],
TNA [auth AS],
TO [auth 1],
TOA [auth AS],
TP [auth 1],
TPA [auth AS],
TQ [auth 1],
TQA [auth AS],
TR [auth 1],
TRA [auth AS],
TS [auth 1],
TSA [auth AS],
TT [auth 1],
TTA [auth AS],
TU [auth 1],
TUA [auth AS],
TV [auth 1],
TVA [auth AS],
TW [auth 1],
TWA [auth AS],
TX [auth 1],
TXA [auth AS],
TY [auth 1],
TYA [auth AS],
TZ [auth 1],
TZA [auth AS],
UAA [auth 1],
UAB [auth AS],
UBA [auth 4],
UBB [auth AU],
UCA [auth o],
UCB [auth BK],
UDA [auth 6],
UDB [auth CM],
UEA [auth AQ],
UEB [auth CM],
UF [auth 1],
UFA [auth B],
UFB [auth CM],
UG [auth 1],
UGA [auth B],
UGB [auth CM],
UH [auth 1],
UHA [auth B],
UHB [auth CM],
UI [auth 1],
UIA [auth B],
UIB [auth CM],
UJ [auth 1],
UJA [auth B],
UK [auth 1],
UKA [auth B],
UL [auth 1],
ULA [auth V],
UM [auth 1],
UMA [auth AS],
UN [auth 1],
UNA [auth AS],
UO [auth 1],
UOA [auth AS],
UP [auth 1],
UPA [auth AS],
UQ [auth 1],
UQA [auth AS],
UR [auth 1],
URA [auth AS],
US [auth 1],
USA [auth AS],
UT [auth 1],
UTA [auth AS],
UU [auth 1],
UUA [auth AS],
UV [auth 1],
UVA [auth AS],
UW [auth 1],
UWA [auth AS],
UX [auth 1],
UXA [auth AS],
UY [auth 1],
UYA [auth AS],
UZ [auth 1],
UZA [auth AS],
VAA [auth 1],
VAB [auth AS],
VBA [auth 4],
VBB [auth AU],
VCA [auth r],
VCB [auth BN],
VDA [auth 8],
VDB [auth CM],
VEA [auth i],
VEB [auth CM],
VF [auth 1],
VFA [auth B],
VFB [auth CM],
VG [auth 1],
VGA [auth B],
VGB [auth CM],
VH [auth 1],
VHA [auth B],
VHB [auth CM],
VI [auth 1],
VIA [auth B],
VIB [auth CM],
VJ [auth 1],
VJA [auth B],
VJB [auth CL],
VK [auth 1],
VKA [auth B],
VL [auth 1],
VLA [auth Y],
VM [auth 1],
VMA [auth AS],
VN [auth 1],
VNA [auth AS],
VO [auth 1],
VOA [auth AS],
VP [auth 1],
VPA [auth AS],
VQ [auth 1],
VQA [auth AS],
VR [auth 1],
VRA [auth AS],
VS [auth 1],
VSA [auth AS],
VT [auth 1],
VTA [auth AS],
VU [auth 1],
VUA [auth AS],
VV [auth 1],
VVA [auth AS],
VW [auth 1],
VWA [auth AS],
VX [auth 1],
VXA [auth AS],
VY [auth 1],
VYA [auth AS],
VZ [auth 1],
VZA [auth AS],
WAA [auth 1],
WAB [auth AS],
WBA [auth 4],
WBB [auth AU],
WCA [auth r],
WCB [auth BN],
WDA [auth 8],
WDB [auth CM],
WEA [auth B],
WEB [auth CM],
WF [auth 1],
WFA [auth B],
WFB [auth CM],
WG [auth 1],
WGA [auth B],
WGB [auth CM],
WH [auth 1],
WHA [auth B],
WHB [auth CM],
WI [auth 1],
WIA [auth B],
WIB [auth CM],
WJ [auth 1],
WJA [auth B],
WJB [auth CL],
WK [auth 1],
WKA [auth B],
WL [auth 1],
WLA [auth Z],
WM [auth 1],
WMA [auth AS],
WN [auth 1],
WNA [auth AS],
WO [auth 1],
WOA [auth AS],
WP [auth 1],
WPA [auth AS],
WQ [auth 1],
WQA [auth AS],
WR [auth 1],
WRA [auth AS],
WS [auth 1],
WSA [auth AS],
WT [auth 1],
WTA [auth AS],
WU [auth 1],
WUA [auth AS],
WV [auth 1],
WVA [auth AS],
WW [auth 1],
WWA [auth AS],
WX [auth 1],
WXA [auth AS],
WY [auth 1],
WYA [auth AS],
WZ [auth 1],
WZA [auth AS],
XAA [auth 1],
XAB [auth AS],
XBA [auth 4],
XBB [auth AU],
XCA [auth r],
XCB [auth BO],
XDA [auth 9],
XDB [auth CM],
XEA [auth B],
XEB [auth CM],
XF [auth 1],
XFA [auth B],
XFB [auth CM],
XG [auth 1],
XGA [auth B],
XGB [auth CM],
XH [auth 1],
XHA [auth B],
XHB [auth CM],
XI [auth 1],
XIA [auth B],
XIB [auth CM],
XJ [auth 1],
XJA [auth B],
XJB [auth CL],
XK [auth 1],
XKA [auth B],
XL [auth 1],
XLA [auth Z],
XM [auth 1],
XMA [auth AS],
XN [auth 1],
XNA [auth AS],
XO [auth 1],
XOA [auth AS],
XP [auth 1],
XPA [auth AS],
XQ [auth 1],
XQA [auth AS],
XR [auth 1],
XRA [auth AS],
XS [auth 1],
XSA [auth AS],
XT [auth 1],
XTA [auth AS],
XU [auth 1],
XUA [auth AS],
XV [auth 1],
XVA [auth AS],
XW [auth 1],
XWA [auth AS],
XX [auth 1],
XXA [auth AS],
XY [auth 1],
XYA [auth AS],
XZ [auth 1],
XZA [auth AS],
YAB [auth AS],
YBA [auth 4],
YBB [auth AU],
YCA [auth s],
YCB [auth BS],
YDA [auth 9],
YDB [auth CM],
YEA [auth B],
YEB [auth CM],
YF [auth 1],
YFA [auth B],
YFB [auth CM],
YG [auth 1],
YGA [auth B],
YGB [auth CM],
YH [auth 1],
YHA [auth B],
YHB [auth CM],
YI [auth 1],
YIA [auth B],
YIB [auth CM],
YJ [auth 1],
YJA [auth B],
YK [auth 1],
YKA [auth B],
YL [auth 1],
YLA [auth Z],
YM [auth 1],
YMA [auth AS],
YN [auth 1],
YNA [auth AS],
YO [auth 1],
YOA [auth AS],
YP [auth 1],
YPA [auth AS],
YQ [auth 1],
YQA [auth AS],
YR [auth 1],
YRA [auth AS],
YS [auth 1],
YSA [auth AS],
YT [auth 1],
YTA [auth AS],
YU [auth 1],
YUA [auth AS],
YV [auth 1],
YVA [auth AS],
YW [auth 1],
YWA [auth AS],
YX [auth 1],
YXA [auth AS],
YY [auth 1],
YYA [auth AS],
YZ [auth 1],
YZA [auth AS],
ZAB [auth AS],
ZBA [auth 4],
ZBB [auth AW],
ZCA [auth u],
ZCB [auth BV],
ZDA [auth AB],
ZDB [auth CM],
ZEA [auth B],
ZEB [auth CM],
ZF [auth 1],
ZFA [auth B],
ZFB [auth CM],
ZG [auth 1],
ZGA [auth B],
ZGB [auth CM],
ZH [auth 1],
ZHA [auth B],
ZHB [auth CM],
ZI [auth 1],
ZIA [auth B],
ZIB [auth CM],
ZJ [auth 1],
ZJA [auth B],
ZK [auth 1],
ZKA [auth B],
ZL [auth 1],
ZM [auth 1],
ZMA [auth AS],
ZN [auth 1],
ZNA [auth AS],
ZO [auth 1],
ZOA [auth AS],
ZP [auth 1],
ZPA [auth AS],
ZQ [auth 1],
ZQA [auth AS],
ZR [auth 1],
ZRA [auth AS],
ZS [auth 1],
ZSA [auth AS],
ZT [auth 1],
ZTA [auth AS],
ZU [auth 1],
ZUA [auth AS],
ZV [auth 1],
ZVA [auth AS],
ZW [auth 1],
ZWA [auth AS],
ZX [auth 1],
ZXA [auth AS],
ZY [auth 1],
ZYA [auth AS],
ZZ [auth 1],
ZZA [auth AS]
MAGNESIUM ION
Mg
JLVVSXFLKOJNIY-UHFFFAOYSA-N
Experimental Data & Validation

Experimental Data

  • Method: X-RAY DIFFRACTION
  • Resolution: 3.30 Å
  • R-Value Free: 0.297 
  • R-Value Work: 0.254 
  • R-Value Observed: 0.254 
  • Space Group: P 1 21 1
Unit Cell:
Length ( Å )Angle ( ˚ )
a = 298.32α = 90
b = 293.37β = 100.16
c = 451.08γ = 90
Software Package:
Software NamePurpose
PHENIXrefinement
XSCALEdata scaling
XDSdata reduction
PHENIXphasing

Structure Validation

View Full Validation Report



Ligand Structure Quality Assessment 


View more in-depth experimental data
Entry History & Funding Information

Deposition Data

Funding OrganizationLocationGrant Number
Foundation for Medical Research (France)FranceDEQ20181039600
Foundation for Medical Research (France)FranceDBF20160635745
Foundation for Medical Research (France)FranceFDT202204014886
Russian Science FoundationRussian Federation20-65-47031
National Institutes of Health/Eunice Kennedy Shriver National Institute of Child Health & Human Development (NIH/NICHD)United States21 AI138158

Revision History  (Full details and data files)

  • Version 1.0: 2024-09-25
    Type: Initial release