Download MendeleyChemical probes in the BAZ2A bromodomain
Cazzanelli, G., Dalle Vedove, A., D'Agostino, V.G., Caflisch, A., Lolli, G.To be published.
7BL9
BAZ2A bromodomain in complex with GSK2801 chemical probe
- PDB DOI: https://doi.org/10.2210/pdb7BL9/pdb
- Classification: TRANSCRIPTION
- Organism(s): Homo sapiens
- Expression System: Escherichia coli BL21(DE3)
- Mutation(s): No
- Deposited: 2021-01-18 Released: 2022-03-02
- Funding Organization(s): Italian Association for Cancer Research, Swiss National Science Foundation
Experimental Data Snapshot
- Method: X-RAY DIFFRACTION
- Resolution: 1.30 Å
- R-Value Free: 0.180
- R-Value Work: 0.156
- R-Value Observed: 0.157
Starting Model: experimental
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This is version 1.1 of the entry. See complete history.
Literature
To be published.
Macromolecules
Find similar proteins by:
(by identity cutoff) | 3D Structure
Entity ID: 1 | |||||
|---|---|---|---|---|---|
| Molecule | Chains | Sequence Length | Organism | Details | Image |
| Bromodomain adjacent to zinc finger domain protein 2A | 105 | Homo sapiens | Mutation(s): 0 Gene Names: BAZ2A, KIAA0314, TIP5 |  | |
UniProt & NIH Common Fund Data Resources | |||||
Find proteins for Q9UIF9 (Homo sapiens) Explore Q9UIF9 Go to UniProtKB: Q9UIF9 | |||||
PHAROS: Q9UIF9 GTEx: ENSG00000076108 | |||||
Entity Groups | |||||
| Sequence Clusters | 30% Identity50% Identity70% Identity90% Identity95% Identity100% Identity | ||||
| UniProt Group | Q9UIF9 | ||||
Sequence AnnotationsExpand | |||||
| |||||
Small Molecules
| Ligands 2 Unique | |||||
|---|---|---|---|---|---|
| ID | Chains | Name / Formula / InChI Key | 2D Diagram | 3D Interactions | |
| 3WQ (Subject of Investigation/LOI) Query on 3WQ | B [auth A] | 1-{1-[2-(methylsulfonyl)phenyl]-7-propoxyindolizin-3-yl}ethanone C20 H21 N O4 S KHWCPNJRJCNVRI-UHFFFAOYSA-N |  | ||
| EDO Query on EDO | C [auth A] | 1,2-ETHANEDIOL C2 H6 O2 LYCAIKOWRPUZTN-UHFFFAOYSA-N |  | ||
Experimental Data & Validation
Experimental Data
- Method: X-RAY DIFFRACTION
- Resolution: 1.30 Å
- R-Value Free: 0.180
- R-Value Work: 0.156
- R-Value Observed: 0.157
- Space Group: C 2 2 21
Unit Cell:
| Length ( Å ) | Angle ( ˚ ) |
|---|---|
| a = 44.271 | α = 90 |
| b = 56.802 | β = 90 |
| c = 76.623 | γ = 90 |
| Software Name | Purpose |
|---|---|
| PHENIX | refinement |
| XDS | data scaling |
| Aimless | data reduction |
| PHASER | phasing |
| PDB_EXTRACT | data extraction |
Entry History & Funding Information
Deposition Data
- Released Date: 2022-03-02 Deposition Author(s): Dalle Vedove, A., Cazzanelli, G., Caflisch, A., Lolli, G.
| Funding Organization | Location | Grant Number |
|---|---|---|
| Italian Association for Cancer Research | Italy | MFAG 2017 - ID. 19882 |
| Swiss National Science Foundation | Switzerland | SNSF grant 310030B-189363 |
Revision History (Full details and data files)
- Version 1.0: 2022-03-02
Type: Initial release - Version 1.1: 2024-01-31
Changes: Data collection, Refinement description
