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234,136 Structures from the PDB

1,068,577 Computed Structure Models (CSM)

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QUERY: Structure Keywords HAS EXACT PHRASE "SIGNALING PROTEIN, Transferase/Inhibitor"

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Search Summary

This query matches 24 Structures.

Refinements

Structure Determination Methodology

experimental (24)

Scientific Name of Source Organism

	Homo sapiens (22)
	Bos taurus (1)
	Gallus gallus (1)
	Oryctolagus cuniculus (1)
	Rattus (1)

Taxonomy

	Eukaryota (24)
	Eukaryota (eukaryotes) (1)

Experimental Method

	X-RAY DIFFRACTION (23)
	SOLUTION NMR (1)

Polymer Entity Type

Protein (24)

Refinement Resolution (Å)

	1.5 - 2.0 (2)
	2.0 - 2.5 (10)
	2.5 - 3.0 (9)
	3.0 - 3.5 (1)
	3.5 - 4.0 (1)

Release Date

	2000 - 2004 (1)
	2005 - 2009 (2)
	2010 - 2014 (4)
	2015 - 2019 (1)
	2020 - 2024 (16)

Enzyme Classification Name

Transferases (24)

Symmetry Type

	Asymmetric (20)
	Cyclic (4)

SCOP Classification

	Alpha and beta proteins (a+b) (6)
	All alpha proteins (2)
	All beta proteins (2)
	Artifacts (1)

AllSelected

1 to 24 of 24 Structures

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1SMH \| pdb_00001smh	Download File View File

Protein kinase A variant complex with completely ordered N-terminal helix

Breitenlechner, C., Engh, R.A., Huber, R., Kinzel, V., Bossemeyer, D., Gassel, M.

(2004) Biochemistry 43: 7743-7749

Released	2004-07-06
Method	X-RAY DIFFRACTION 2.044 Å
Organisms	Bos taurus Oryctolagus cuniculus
Macromolecule	cAMP-Dependent Protein Kinase, alpha-catalytic subunit (protein) cAMP-dependent protein kinase inhibitor, alpha form (protein)
Unique Ligands	BU3, MG8

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2GU8 \| pdb_00002gu8	Download File View File

Discovery of 2-Pyrimidyl-5-Amidothiophenes as Novel and Potent Inhibitors for AKT: Synthesis and SAR Studies

Murray, J.M.

(2006) Bioorg Med Chem Lett 16: 4163-4168

Released	2007-05-01
Method	X-RAY DIFFRACTION 2.2 Å
Organisms	Homo sapiens
Macromolecule	CAMP-dependent protein kinase, alpha-catalytic subunit (protein) inhibitor of CAMP-dependent protein kinase (protein)
Unique Ligands	796

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2OJ2 \| pdb_00002oj2	Download File View File

NMR Structure Analysis of the Hematopoetic Cell Kinase SH3 Domain complexed with an artificial high affinity ligand (PD1)

Schmidt, H., Hoffmann, S., Tran, T., Stoldt, M., Stangler, T., Wiesehan, K., Willbold, D.

(2007) J Mol Biology 365: 1517-1532

Released	2007-01-30
Method	SOLUTION NMR
Organisms	Homo sapiens
Macromolecule	Hematopoetic Cell Kinase, SH3 domain (protein) artificial peptide PD1 (protein)

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4FZF \| pdb_00004fzf	Download File View File

Crystal structure of MST4-MO25 complex with DKI

Shi, Z.B., Zhou, Z.C.

(2013) Structure 21: 449-461

Released	2013-03-06
Method	X-RAY DIFFRACTION 3.64 Å
Organisms	Homo sapiens
Macromolecule	Calcium-binding protein 39 (protein) Serine/threonine-protein kinase MST4 (protein)
Unique Ligands	DKI

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4L1B \| pdb_00004l1b	Download File View File

Crystal Structure of p110alpha complexed with niSH2 of p85alpha

Zhang, J., Zhao, Y.L., Chen, Y.Y., Huang, M., Jiang, F.

(2014) ACS Med Chem Lett 5: 138-142

Released	2014-01-01
Method	X-RAY DIFFRACTION 2.586 Å
Organisms	Homo sapiens
Macromolecule	Phosphatidylinositol 3-kinase regulatory subunit alpha (protein) Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit alpha isoform (protein)
Unique Ligands	SO4

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4L23 \| pdb_00004l23	Download File View File

Crystal Structure of p110alpha complexed with niSH2 of p85alpha and PI-103

Zhang, J., Zhao, Y.L., Chen, Y.Y., Huang, M., Jiang, F.

(2014) ACS Med Chem Lett 5: 138-142

Released	2014-01-01
Method	X-RAY DIFFRACTION 2.501 Å
Organisms	Homo sapiens
Macromolecule	Phosphatidylinositol 3-kinase regulatory subunit alpha (protein) Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit alpha isoform (protein)
Unique Ligands	GOL, SO4, X6K

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4L2Y \| pdb_00004l2y	Download File View File

Crystal Structure of p110alpha complexed with niSH2 of p85alpha and compound 9d

Zhang, J., Zhao, Y.L., Chen, Y.Y., Huang, M., Jiang, F.

(2014) ACS Med Chem Lett 5: 138-142

Released	2014-01-01
Method	X-RAY DIFFRACTION 2.8 Å
Organisms	Homo sapiens
Macromolecule	Phosphatidylinositol 3-kinase regulatory subunit alpha (protein) Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit alpha isoform (protein)
Unique Ligands	GOL, SO4, XXK

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6C7Y \| pdb_00006c7y	Download File View File

Crystal structure of inhibitory protein SOCS1 in complex with JAK1 kinase domain

Liau, N.P.D., Laktyushin, A., Lucet, I.S., Murphy, J.M., Yao, S., Callaghan, K., Nicola, N.A., Kershaw, N.J., Babon, J.J.

(2018) Nat Commun 9: 1558-1558

Released	2018-05-02
Method	X-RAY DIFFRACTION 2.499 Å
Organisms	Gallus gallus Homo sapiens
Macromolecule	Suppressor of cytokine signaling 1 (protein) Tyrosine-protein kinase JAK1 (protein)
Unique Ligands	ACT, ADP, EDO, MG

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7K7L \| pdb_00007k7l	Download File View File

Structure of a hit for G Protein Coupled Receptor Kinase 2 (GRK2) Inhibitor for the Potential Treatment of Heart Failure

Spurlino, J.C., Milligan, C.

(2020) Bioorg Med Chem Lett 30: 127602-127602

Released	2020-10-28
Method	X-RAY DIFFRACTION 2.539 Å
Organisms	Homo sapiens
Macromolecule	Beta-adrenergic receptor kinase 1 (protein) Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-2 (protein) Guanine nucleotide-binding protein G(I)/G(S)/G(T) subunit beta-1 (protein)
Unique Ligands	MG, W4D

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7K7Z \| pdb_00007k7z	Download File View File

Structure of a hit for G Protein Coupled Receptor Kinase 2 (GRK2) Inhibitor for the Potential Treatment of Heart Failure

Spurlino, J.C., Milligan, C.

(2020) Bioorg Med Chem Lett 30: 127602-127602

Released	2020-10-28
Method	X-RAY DIFFRACTION 2.60608692764 Å
Organisms	Homo sapiens
Macromolecule	Beta-adrenergic receptor kinase 1 (protein) Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-2 (protein) Guanine nucleotide-binding protein G(I)/G(S)/G(T) subunit beta-1 (protein)
Unique Ligands	W4G

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7M2F \| pdb_00007m2f	Download File View File

CDK2 with compound 14 inhibitor with carboxylate

Longenecker, K.L., Qiu, W., Korepanova, A., Tong, Y.

(2021) ACS Med Chem Lett 12: 1108-1115

Released	2021-07-07
Method	X-RAY DIFFRACTION 1.632 Å
Organisms	Homo sapiens
Macromolecule	Cyclin-dependent kinase 2 (protein)
Unique Ligands	YOS

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8D6C \| pdb_00008d6c	Download File View File

Crystal Structure of Human Myt1 Kinase domain Bounded with compound 28

Pau, V.P.T., Mao, D.Y.L., Mader, P., Orlicky, S., Sicheri, F.

(2022) J Med Chem 65: 10251-10284

Released	2022-07-27
Method	X-RAY DIFFRACTION 2.2 Å
Organisms	Homo sapiens
Macromolecule	Membrane-associated tyrosine- and threonine-specific cdc2-inhibitory kinase (protein)
Unique Ligands	EDO, GOL, QGR, SO4

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8D6D \| pdb_00008d6d	Download File View File

Crystal Structure of Human Myt1 Kinase domain Bounded with compound 39

Pau, V.P.T., Mao, D.Y.L., Mader, P., Orlicky, S., Sicheri, F.

(2022) J Med Chem 65: 10251-10284

Released	2022-07-27
Method	X-RAY DIFFRACTION 2.35 Å
Organisms	Homo sapiens
Macromolecule	Membrane-associated tyrosine- and threonine-specific cdc2-inhibitory kinase (protein)
Unique Ligands	EDO, QGY, SO4

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8D6E \| pdb_00008d6e	Download File View File

Crystal Structure of Human Myt1 Kinase domain Bounded with RP-6306

Pau, V.P.T., Mao, D.Y.L., Mader, P., Orlicky, S., Sicheri, F.

(2022) J Med Chem 65: 10251-10284

Released	2022-07-27
Method	X-RAY DIFFRACTION 2.15 Å
Organisms	Homo sapiens
Macromolecule	Membrane-associated tyrosine- and threonine-specific cdc2-inhibitory kinase (protein)
Unique Ligands	EDO, GOL, QGI, SO4

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8D6F \| pdb_00008d6f	Download File View File

Crystal Structure of Human Myt1 Kinase domain Bounded with Eph receptor inhibitor / compound 41

Pau, V.P.T., Mao, D.Y.L., Mader, P., Orlicky, S., Sicheri, F.

(2022) J Med Chem 65: 10251-10284

Released	2022-07-27
Method	X-RAY DIFFRACTION 2.49 Å
Organisms	Homo sapiens
Macromolecule	Membrane-associated tyrosine- and threonine-specific cdc2-inhibitory kinase (protein)
Unique Ligands	QG5, SO4

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8DEG \| pdb_00008deg	Download File View File

Crystal structure of DLK in complex with inhibitor DN0011197

Srivastava, A., Lexa, K., de Vicente, J.

(2022) J Med Chem 65: 16290-16312

Released	2022-12-14
Method	X-RAY DIFFRACTION 2.79 Å
Organisms	Homo sapiens
Macromolecule	Mitogen-activated protein kinase kinase kinase 12 (protein)
Unique Ligands	SIQ

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8F4Q \| pdb_00008f4q	Download File View File

rat branched chain ketoacid dehydrogenase kinase in complex with inhibtors

Liu, S.

To be published

Released	2023-12-13
Method	X-RAY DIFFRACTION 2.151 Å
Organisms	Rattus
Macromolecule	[3-methyl-2-oxobutanoate dehydrogenase [lipoamide]] kinase, mitochondrial (protein)
Unique Ligands	ADP, SO4, XER

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8F5F \| pdb_00008f5f	Download File View File

human branched chain ketoacid dehydrogenase kinase in complex with inhibitors

Liu, S., Roth Flach, R., Bollinger, E., Filipski, K.

(2023) Nat Commun 14: 4812-4812

Released	2023-07-05
Method	X-RAY DIFFRACTION 3.149 Å
Organisms	Homo sapiens
Macromolecule	[3-methyl-2-oxobutanoate dehydrogenase [lipoamide]] kinase, mitochondrial (protein)
Unique Ligands	ADP, MG, SO4, XGG

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8F5J \| pdb_00008f5j	Download File View File

human branched chain ketoacid dehydrogenase kinase in complex with inhibitors

Liu, S., Roth Flach, R., Bollinger, E., Filipski, K.

(2023) Nat Commun 14: 4812-4812

Released	2023-07-05
Method	X-RAY DIFFRACTION 2.545 Å
Organisms	Homo sapiens
Macromolecule	[3-methyl-2-oxobutanoate dehydrogenase [lipoamide]] kinase, mitochondrial (protein)
Unique Ligands	ADP, K, MG, XER

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8F5S \| pdb_00008f5s	Download File View File

human branched chain ketoacid dehydrogenase kinase in complex with inhibitors

Liu, S., Roth Flach, R., Bollinger, E., Filipski, K.

(2023) Nat Commun 14: 4812-4812

Released	2023-07-05
Method	X-RAY DIFFRACTION 2.793 Å
Organisms	Homo sapiens
Macromolecule	[3-methyl-2-oxobutanoate dehydrogenase [lipoamide]] kinase, mitochondrial (protein)
Unique Ligands	ADP, K, MG, SO4, XGT

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8TSD \| pdb_00008tsd	Download File View File

Human PI3K p85alpha/p110alpha bound to RLY-2608

Holliday, M., Tang, Y., Bulku, A., Wilbur, J., Fraser, J.

(2024) Cancer Discov 14: 240-257

Released	2023-11-22
Method	X-RAY DIFFRACTION 2.7 Å
Organisms	Homo sapiens
Macromolecule	Phosphatidylinositol 3-kinase regulatory subunit alpha (protein) Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit alpha isoform (protein)
Unique Ligands	XUZ

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8U8J \| pdb_00008u8j	Download File View File

Co-crystal structure of phosphorylated ERK2 in complex with ERK1/2 inhibitor #16

Anderson, J.W., Vigers, G.P.

(2024) Elife 12:

Released	2024-03-27
Method	X-RAY DIFFRACTION 2.1 Å
Organisms	Homo sapiens
Macromolecule	Mitogen-activated protein kinase 1 (protein)
Unique Ligands	WAL

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8U8K \| pdb_00008u8k	Download File View File

Co-crystal structure of phosphorylated ERK2 in complex with ERK1/2 inhibitor #8

Anderson, J.W., Vigers, G.P.

(2024) Elife 12:

Released	2024-03-27
Method	X-RAY DIFFRACTION 2.1 Å
Organisms	Homo sapiens
Macromolecule	Mitogen-activated protein kinase 1 (protein)
Unique Ligands	W8U

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8U8X \| pdb_00008u8x	Download File View File

crystal structure of the receptor tyrosine kinase Human HER2 (ERBB2) YVMA mutant kinase domain in complex with inhibitor compound 27

Wang, J., Mou, T.C.

(2024) J Med Chem 67: 9759-9771

Released	2024-06-12
Method	X-RAY DIFFRACTION 1.69 Å
Organisms	Homo sapiens
Macromolecule	Receptor tyrosine-protein kinase erbB-2 (protein)
Unique Ligands	CL, PEG, W9N

1 to 24 of 24 Structures

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Structure Determination Methodology

Scientific Name of Source Organism

Taxonomy

Experimental Method

Polymer Entity Type

Refinement Resolution (Å)

Release Date

Enzyme Classification Name

Symmetry Type

SCOP Classification

1SMH | pdb_00001smh

2GU8 | pdb_00002gu8

2OJ2 | pdb_00002oj2

4FZF | pdb_00004fzf

4L1B | pdb_00004l1b

4L23 | pdb_00004l23

4L2Y | pdb_00004l2y

6C7Y | pdb_00006c7y

7K7L | pdb_00007k7l

7K7Z | pdb_00007k7z

7M2F | pdb_00007m2f

8D6C | pdb_00008d6c

8D6D | pdb_00008d6d

8D6E | pdb_00008d6e

8D6F | pdb_00008d6f

8DEG | pdb_00008deg

8F4Q | pdb_00008f4q

8F5F | pdb_00008f5f

8F5J | pdb_00008f5j

8F5S | pdb_00008f5s

8TSD | pdb_00008tsd

8U8J | pdb_00008u8j

8U8K | pdb_00008u8k

8U8X | pdb_00008u8x