RCSB PDB: Search

Warning You are using a web browser that we do not support. Our website will not work properly. Please update to a newer version or download a new web browser, such as Chrome or Firefox.

Help

Help

RCSB PDB

Deposit
- PDBx/mmCIF file
- pdb_extract
- SF-Tool
- Ligand Expo
- MAXIT
- Validation Server
- Validation API
- Information for Journals
- Validation Task Forces
- wwPDB OneDep System
- PDB-IHM
Search
Visualize
Analyze
Download
Learn
- Training Courses
- Guide to PDB Data
- Molecule of the Month
- Educational Resources
- Curricula
- Browse
- News
- SciArt Galleries
- Irving Geis
- David Goodsell
About
Careers
COVID-19

234,136 Structures from the PDB

1,068,577 Computed Structure Models (CSM)

	Include CSM
Advanced Search \| Browse Annotations		Help

Search
Query History
Browse Annotations
MyPDB

QUERY: PubMed ID = 30347148

MyPDB Login

Search API

Advanced Search Query Builder

Help

Full Text

Structure Attributes

Help

NOT

Count

Add Subquery

Chemical Attributes

Sequence Similarity

Sequence Motif

Structure Similarity

Structure Motif

Chemical Similarity

Return

grouped by

Include Computed Structure Models (CSM)

Count

Clear

Search Summary

This query matches 17 Structures.

Refinements

Structure Determination Methodology

experimental (17)

Scientific Name of Source Organism

	Schistosoma mansoni (16)
	Homo sapiens (1)

Taxonomy

Eukaryota (17)

Experimental Method

X-RAY DIFFRACTION (17)

Polymer Entity Type

Protein (17)

Refinement Resolution (Å)

	1.5 - 2.0 (13)
	2.0 - 2.5 (3)
	2.5 - 3.0 (1)

Release Date

2015 - 2019 (17)

Enzyme Classification Name

Hydrolases (17)

Symmetry Type

	Asymmetric (14)
	Cyclic (3)

SCOP Classification

Alpha and beta proteins (a/b) (1)

AllSelected

1 to 17 of 17 Structures

Page 1 of 1

Sort by

Explore in 3D

6HQY \| pdb_00006hqy	Download File View File

Crystal structure of Schistosoma mansoni HDAC8 complexed with PCI-34051

Marek, M., Shaik, T.B., Romier, C.

(2018) J Med Chem 61: 10000-10016

Released	2018-10-31
Method	X-RAY DIFFRACTION 2.501 Å
Organisms	Schistosoma mansoni
Macromolecule	Histone deacetylase (protein)
Unique Ligands	GKW, GOL, K, ZN

Explore in 3D

6HRQ \| pdb_00006hrq	Download File View File

Crystal structure of Schistosoma mansoni HDAC8 complexed with NCC-149

Shaik, T.B., Marek, M., Romier, C.

(2018) J Med Chem 61: 10000-10016

Released	2018-10-31
Method	X-RAY DIFFRACTION 1.845 Å
Organisms	Schistosoma mansoni
Macromolecule	Histone deacetylase (protein)
Unique Ligands	DMF, GM5, GOL, K, ZN

Explore in 3D

6HSF \| pdb_00006hsf	Download File View File

Crystal structure of Schistosoma mansoni HDAC8 mutant H292M complexed with PCI-34051

Shaik, T.B., Marek, M., Romier, C.

(2018) J Med Chem 61: 10000-10016

Released	2018-10-31
Method	X-RAY DIFFRACTION 1.899 Å
Organisms	Schistosoma mansoni
Macromolecule	Histone deacetylase (protein)
Unique Ligands	DMF, GKW, GOL, K, ZN

Explore in 3D

6HSG \| pdb_00006hsg	Download File View File

Crystal structure of Schistosoma mansoni HDAC8 H292M mutant complexed with NCC-149

Shaik, T.B., Marek, M., Romier, C.

(2018) J Med Chem 61: 10000-10016

Released	2018-10-31
Method	X-RAY DIFFRACTION 1.846 Å
Organisms	Schistosoma mansoni
Macromolecule	Histone deacetylase (protein)
Unique Ligands	DMF, GM5, GOL, K, ZN

Explore in 3D

6HSH \| pdb_00006hsh	Download File View File

Crystal structure of Schistosoma mansoni HDAC8 complexed with Quisinostat

Shaik, T.B., Marek, M., Romier, C.

(2018) J Med Chem 61: 10000-10016

Released	2018-10-31
Method	X-RAY DIFFRACTION 1.545 Å
Organisms	Schistosoma mansoni
Macromolecule	Histone deacetylase (protein)
Unique Ligands	DMF, GOK, GOL, K, ZN

Explore in 3D

6HSK \| pdb_00006hsk	Download File View File

Crystal structure of a human HDAC8 L6 loop mutant complexed with Quisinostat

Marek, M., Shaik, T.B., Ramos-Morales, E., Romier, C.

(2018) J Med Chem 61: 10000-10016

Released	2018-10-31
Method	X-RAY DIFFRACTION 2.096 Å
Organisms	Homo sapiens
Macromolecule	Histone deacetylase 8 (protein)
Unique Ligands	GOK, K, ZN

Explore in 3D

6HSZ \| pdb_00006hsz	Download File View File

Crystal structure of Schistosoma mansoni HDAC8 complexed with a benzohydroxamate inhibitor 2

Marek, M., Shaik, T.B., Romier, C.

(2018) J Med Chem 61: 10000-10016

Released	2018-10-31
Method	X-RAY DIFFRACTION 2.374 Å
Organisms	Schistosoma mansoni
Macromolecule	Histone deacetylase (protein)
Unique Ligands	GOL, GOW, K, ZN

Explore in 3D

6HT8 \| pdb_00006ht8	Download File View File

Crystal structure of Schistosoma mansoni HDAC8 complexed with a benzohydroxamate inhibitor 3

Marek, M., Shaik, T.B., Romier, C.

(2018) J Med Chem 61: 10000-10016

Released	2018-10-31
Method	X-RAY DIFFRACTION 2.497 Å
Organisms	Schistosoma mansoni
Macromolecule	Histone deacetylase (protein)
Unique Ligands	DMF, GOL, GQE, K, ZN

Explore in 3D

6HTG \| pdb_00006htg	Download File View File

Crystal structure of Schistosoma mansoni HDAC8 complexed with a benzohydroxamate inhibitor 4

Shaik, T.B., Marek, M., Romier, C.

(2018) J Med Chem 61: 10000-10016

Released	2018-10-31
Method	X-RAY DIFFRACTION 1.939 Å
Organisms	Schistosoma mansoni
Macromolecule	Histone deacetylase (protein)
Unique Ligands	DMF, GOL, K, T61, ZN

Explore in 3D

6HTH \| pdb_00006hth	Download File View File

Crystal structure of Schistosoma mansoni HDAC8 complexed with a benzohydroxamate inhibitor 5

Shaik, T.B., Marek, M., Romier, C.

(2018) J Med Chem 61: 10000-10016

Released	2018-10-31
Method	X-RAY DIFFRACTION 1.95 Å
Organisms	Schistosoma mansoni
Macromolecule	Histone deacetylase (protein)
Unique Ligands	DMF, GOL, GQN, K, ZN

Explore in 3D

6HTI \| pdb_00006hti	Download File View File

Crystal structure of Schistosoma mansoni HDAC8 complexed with a benzohydroxamate inhibitor 6

Shaik, T.B., Marek, M., Romier, C.

(2018) J Med Chem 61: 10000-10016

Released	2018-10-31
Method	X-RAY DIFFRACTION 1.693 Å
Organisms	Schistosoma mansoni
Macromolecule	Histone deacetylase (protein)
Unique Ligands	GOL, GQW, K, ZN

Explore in 3D

6HTT \| pdb_00006htt	Download File View File

Crystal structure of Schistosoma mansoni HDAC8 complexed with a benzohydroxamate inhibitor 7

Shaik, T.B., Marek, M., Romier, C.

(2018) J Med Chem 61: 10000-10016

Released	2018-10-31
Method	X-RAY DIFFRACTION 1.748 Å
Organisms	Schistosoma mansoni
Macromolecule	Histone deacetylase (protein)
Unique Ligands	DMF, GOL, GQZ, K, ZN

Explore in 3D

6HTZ \| pdb_00006htz	Download File View File

Crystal structure of Schistosoma mansoni HDAC8 complexed with a benzohydroxamate inhibitor 8

Shaik, T.B., Marek, M., Romier, C.

(2018) J Med Chem 61: 10000-10016

Released	2018-10-31
Method	X-RAY DIFFRACTION 1.841 Å
Organisms	Schistosoma mansoni
Macromolecule	Histone deacetylase (protein)
Unique Ligands	DMF, GOL, GRK, K, ZN

Explore in 3D

6HU0 \| pdb_00006hu0	Download File View File

Crystal structure of Schistosoma mansoni HDAC8 complexed with a benzohydroxamate inhibitor 9

Shaik, T.B., Marek, M., Romier, C.

(2018) J Med Chem 61: 10000-10016

Released	2018-10-31
Method	X-RAY DIFFRACTION 1.746 Å
Organisms	Schistosoma mansoni
Macromolecule	Histone deacetylase (protein)
Unique Ligands	DMF, GOL, K, T86, ZN

Explore in 3D

6HU1 \| pdb_00006hu1	Download File View File

Crystal structure of Schistosoma mansoni HDAC8 complexed with a benzohydroxamate inhibitor 10

Shaik, T.B., Marek, M., Romier, C.

(2018) J Med Chem 61: 10000-10016

Released	2018-10-31
Method	X-RAY DIFFRACTION 1.996 Å
Organisms	Schistosoma mansoni
Macromolecule	Histone deacetylase (protein)
Unique Ligands	DMF, GOL, GT2, K, ZN

Explore in 3D

6HU2 \| pdb_00006hu2	Download File View File

Crystal structure of Schistosoma mansoni HDAC8 complexed with a benzohydroxamate inhibitor 11

Shaik, T.B., Marek, M., Romier, C.

(2018) J Med Chem 61: 10000-10016

Released	2018-10-31
Method	X-RAY DIFFRACTION 1.986 Å
Organisms	Schistosoma mansoni
Macromolecule	Histone deacetylase (protein)
Unique Ligands	DMF, GOL, K, T34, ZN

Explore in 3D

6HU3 \| pdb_00006hu3	Download File View File

Crystal structure of Schistosoma mansoni HDAC8 complexed with a triazole hydroxamate inhibitor

Shaik, T.B., Marek, M., Romier, C.

(2018) J Med Chem 61: 10000-10016

Released	2018-10-31
Method	X-RAY DIFFRACTION 1.655 Å
Organisms	Schistosoma mansoni
Macromolecule	Histone deacetylase (protein)
Unique Ligands	DMF, GOL, GRZ, K, ZN

1 to 17 of 17 Structures

Page 1 of 1

Sort by

About
About Us
Citing Us
Publications
Team
Careers
Usage & Privacy

Support
Contact Us
Help
Website FAQ
Glossary
Service Status

RCSB PDB is hosted by

RCSB PDB is a member of the

RCSB Partners
Nucleic Acid Knowledgebase

wwPDB Partners
RCSB PDB
PDBe
PDBj
BMRB
EMDB

RCSB PDB Core Operations are funded by the U.S. National Science Foundation (DBI-2321666), the US Department of Energy (DE-SC0019749), and the National Cancer Institute, National Institute of Allergy and Infectious Diseases, and National Institute of General Medical Sciences of the National Institutes of Health under grant R01GM157729.

6HQY | pdb_00006hqy

Crystal structure of Schistosoma mansoni HDAC8 complexed with PCI-34051

6HRQ | pdb_00006hrq

Crystal structure of Schistosoma mansoni HDAC8 complexed with NCC-149

6HSF | pdb_00006hsf

Crystal structure of Schistosoma mansoni HDAC8 mutant H292M complexed with PCI-34051

6HSG | pdb_00006hsg

Crystal structure of Schistosoma mansoni HDAC8 H292M mutant complexed with NCC-149

6HSH | pdb_00006hsh

Crystal structure of Schistosoma mansoni HDAC8 complexed with Quisinostat

6HSK | pdb_00006hsk

Crystal structure of a human HDAC8 L6 loop mutant complexed with Quisinostat

6HSZ | pdb_00006hsz

Crystal structure of Schistosoma mansoni HDAC8 complexed with a benzohydroxamate inhibitor 2

6HT8 | pdb_00006ht8

Crystal structure of Schistosoma mansoni HDAC8 complexed with a benzohydroxamate inhibitor 3

6HTG | pdb_00006htg

Crystal structure of Schistosoma mansoni HDAC8 complexed with a benzohydroxamate inhibitor 4

6HTH | pdb_00006hth

Crystal structure of Schistosoma mansoni HDAC8 complexed with a benzohydroxamate inhibitor 5

6HTI | pdb_00006hti

Crystal structure of Schistosoma mansoni HDAC8 complexed with a benzohydroxamate inhibitor 6

6HTT | pdb_00006htt

Crystal structure of Schistosoma mansoni HDAC8 complexed with a benzohydroxamate inhibitor 7

6HTZ | pdb_00006htz

Crystal structure of Schistosoma mansoni HDAC8 complexed with a benzohydroxamate inhibitor 8

6HU0 | pdb_00006hu0

Crystal structure of Schistosoma mansoni HDAC8 complexed with a benzohydroxamate inhibitor 9

6HU1 | pdb_00006hu1

Crystal structure of Schistosoma mansoni HDAC8 complexed with a benzohydroxamate inhibitor 10

6HU2 | pdb_00006hu2

Crystal structure of Schistosoma mansoni HDAC8 complexed with a benzohydroxamate inhibitor 11

6HU3 | pdb_00006hu3

Crystal structure of Schistosoma mansoni HDAC8 complexed with a triazole hydroxamate inhibitor

Prepare Data

Validate Data

Deposit Data

Help and Resources

Structure Determination Methodology

Scientific Name of Source Organism

Taxonomy

Experimental Method

Polymer Entity Type

Refinement Resolution (Å)

Release Date

Enzyme Classification Name

Symmetry Type

SCOP Classification

6HQY | pdb_00006hqy

6HRQ | pdb_00006hrq

6HSF | pdb_00006hsf

6HSG | pdb_00006hsg

6HSH | pdb_00006hsh

6HSK | pdb_00006hsk

6HSZ | pdb_00006hsz

6HT8 | pdb_00006ht8

6HTG | pdb_00006htg

6HTH | pdb_00006hth

6HTI | pdb_00006hti

6HTT | pdb_00006htt

6HTZ | pdb_00006htz

6HU0 | pdb_00006hu0

6HU1 | pdb_00006hu1

6HU2 | pdb_00006hu2

6HU3 | pdb_00006hu3