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234,440 Structures from the PDB

1,068,577 Computed Structure Models (CSM)

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QUERY: PubMed ID = 27685665

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Search Summary

This query matches 10 Structures.

Refinements

Structure Determination Methodology

experimental (10)

Scientific Name of Source Organism

Rattus norvegicus (10)

Taxonomy

Eukaryota (10)

Experimental Method

X-RAY DIFFRACTION (10)

Polymer Entity Type

Protein (10)

Refinement Resolution (Å)

	1.5 - 2.0 (6)
	2.0 - 2.5 (3)
	2.5 - 3.0 (1)

Release Date

2015 - 2019 (10)

Enzyme Classification Name

Transferases (10)

Symmetry Type

Asymmetric (10)

SCOP Classification

	Alpha and beta proteins (a/b) (10)
	Artifacts (2)

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1 to 10 of 10 Structures

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Explore in 3D

5K03 \| pdb_00005k03	Download File View File

Crystal Structure of COMT in complex with 2,6-dimethyl-3-(1H-pyrazol-3-yl)imidazo[1,2-a]pyridine

Ehler, A., Rodriguez-Sarmiento, R.M., Rudolph, M.G.

(2016) J Med Chem 59: 10163-10175

Released	2016-09-07
Method	X-RAY DIFFRACTION 1.81 Å
Organisms	Rattus norvegicus
Macromolecule	Catechol O-methyltransferase (protein)
Unique Ligands	6P4, K

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5K05 \| pdb_00005k05	Download File View File

Crystal Structure of COMT in complex with 4-methyl-2-(4-methylphenyl)-5-(1H-pyrazol-5-yl)-1,3-thiazole

Ehler, A., Rodriguez-Sarmiento, R.M., Rudolph, M.G.

(2016) J Med Chem 59: 10163-10175

Released	2016-09-07
Method	X-RAY DIFFRACTION 2.14 Å
Organisms	Rattus norvegicus
Macromolecule	Catechol O-methyltransferase (protein)
Unique Ligands	6P5, SO4

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5K09 \| pdb_00005k09	Download File View File

Crystal Structure of COMT in complex with a thiazole ligand

Ehler, A., Rodriguez-Sarmiento, R.M., Rudolph, M.G.

(2016) J Med Chem 59: 10163-10175

Released	2016-09-07
Method	X-RAY DIFFRACTION 2.7 Å
Organisms	Rattus norvegicus
Macromolecule	Catechol O-methyltransferase (protein)
Unique Ligands	6PQ, K, PO4

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5K0B \| pdb_00005k0b	Download File View File

Crystal Structure of COMT in complex with 2,4-dimethyl-5-[3-(1-phenylethyl)-1H-pyrazol-5-yl]-1,3-thiazole

Ehler, A., Rodriguez-Sarmiento, R.M., Rudolph, M.G.

(2016) J Med Chem 59: 10163-10175

Released	2016-09-07
Method	X-RAY DIFFRACTION 2.36 Å
Organisms	Rattus norvegicus
Macromolecule	Catechol O-methyltransferase (protein)
Unique Ligands	6PS, CL, CXS, EDO, K, PO4

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5K0C \| pdb_00005k0c	Download File View File

Crystal Structure of COMT in complex with 2,4-dimethyl-5-[3-(2-phenylpropan-2-yl)-1H-pyrazol-5-yl]-1,3-thiazole

Ehler, A., Rodriguez-Sarmiento, R.M., Rudolph, M.G.

(2016) J Med Chem 59: 10163-10175

Released	2016-09-07
Method	X-RAY DIFFRACTION 1.95 Å
Organisms	Rattus norvegicus
Macromolecule	Catechol O-methyltransferase (protein)
Unique Ligands	6OZ, EDO, NA, NHE

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5K0F \| pdb_00005k0f	Download File View File

Crystal Structure of COMT in complex with 5-[5-[1-(4-methoxyphenyl)ethyl]-1H-pyrazol-3-yl]-2,4-dimethyl-1,3-thiazole

Ehler, A., Rodriguez-Sarmiento, R.M., Rudolph, M.G.

(2016) J Med Chem 59: 10163-10175

Released	2016-09-07
Method	X-RAY DIFFRACTION 1.81 Å
Organisms	Rattus norvegicus
Macromolecule	Catechol O-methyltransferase (protein)
Unique Ligands	6P1, NA, NHE

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5K0G \| pdb_00005k0g	Download File View File

Crystal Structure of COMT in complex with 4-[5-[1-(4-methoxyphenyl)ethyl]-1H-pyrazol-3-yl]-1,3-dimethylpyrazole

Ehler, A., rodriguez-Sarmiento, R.M., Rudolph, M.G.

(2016) J Med Chem 59: 10163-10175

Released	2016-09-07
Method	X-RAY DIFFRACTION 1.89 Å
Organisms	Rattus norvegicus
Macromolecule	Catechol O-methyltransferase (protein)
Unique Ligands	6PM, NA, NHE

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5K0J \| pdb_00005k0j	Download File View File

Crystal Structure of COMT in complex with 5-[5-[1-(4-methoxyphenyl)cyclopropyl]-1H-pyrazol-3-yl]-2,4-dimethyl-1,3-thiazole

Ehler, A., Rodriguez-Sarmiento, R.M., Rudolph, M.G.

(2016) J Med Chem 59: 10163-10175

Released	2016-09-07
Method	X-RAY DIFFRACTION 1.94 Å
Organisms	Rattus norvegicus
Macromolecule	Catechol O-methyltransferase (protein)
Unique Ligands	6P2, NA, NHE

Explore in 3D

5K0L \| pdb_00005k0l	Download File View File

Crystal Structure of COMT in complex with 5-[5-[1-(4-methoxyphenyl)cyclopropyl]-1H-pyrazol-3-yl]-2,4-dimethyl-1,3-thiazole

Ehler, A., Rodriguez-Sarmiento, R.M., Rudolph, M.G.

(2016) J Med Chem 59: 10163-10175

Released	2016-09-07
Method	X-RAY DIFFRACTION 2.02 Å
Organisms	Rattus norvegicus
Macromolecule	Catechol O-methyltransferase (protein)
Unique Ligands	6P2, K, MG, NHE

Explore in 3D

5K0N \| pdb_00005k0n	Download File View File

Crystal Structure of COMT in complex with 4-[5-[1-(4-methoxyphenyl)cyclopropyl]-1H-pyrazol-3-yl]-1,3-dimethylpyrazole

Ehler, A., Rodriguez-Sarmiento, R.M.

(2016) J Med Chem 59: 10163-10175

Released	2016-09-07
Method	X-RAY DIFFRACTION 1.99 Å
Organisms	Rattus norvegicus
Macromolecule	Catechol O-methyltransferase (protein)
Unique Ligands	6P0, EDO, K, MG, NHE

1 to 10 of 10 Structures

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RCSB PDB Core Operations are funded by the U.S. National Science Foundation (DBI-2321666), the US Department of Energy (DE-SC0019749), and the National Cancer Institute, National Institute of Allergy and Infectious Diseases, and National Institute of General Medical Sciences of the National Institutes of Health under grant R01GM157729.

5K03 | pdb_00005k03

Crystal Structure of COMT in complex with 2,6-dimethyl-3-(1H-pyrazol-3-yl)imidazo[1,2-a]pyridine

5K05 | pdb_00005k05

Crystal Structure of COMT in complex with 4-methyl-2-(4-methylphenyl)-5-(1H-pyrazol-5-yl)-1,3-thiazole

5K09 | pdb_00005k09

Crystal Structure of COMT in complex with a thiazole ligand

5K0B | pdb_00005k0b

Crystal Structure of COMT in complex with 2,4-dimethyl-5-[3-(1-phenylethyl)-1H-pyrazol-5-yl]-1,3-thiazole

5K0C | pdb_00005k0c

Crystal Structure of COMT in complex with 2,4-dimethyl-5-[3-(2-phenylpropan-2-yl)-1H-pyrazol-5-yl]-1,3-thiazole

5K0F | pdb_00005k0f

Crystal Structure of COMT in complex with 5-[5-[1-(4-methoxyphenyl)ethyl]-1H-pyrazol-3-yl]-2,4-dimethyl-1,3-thiazole

5K0G | pdb_00005k0g

Crystal Structure of COMT in complex with 4-[5-[1-(4-methoxyphenyl)ethyl]-1H-pyrazol-3-yl]-1,3-dimethylpyrazole

5K0J | pdb_00005k0j

Crystal Structure of COMT in complex with 5-[5-[1-(4-methoxyphenyl)cyclopropyl]-1H-pyrazol-3-yl]-2,4-dimethyl-1,3-thiazole

5K0L | pdb_00005k0l

Crystal Structure of COMT in complex with 5-[5-[1-(4-methoxyphenyl)cyclopropyl]-1H-pyrazol-3-yl]-2,4-dimethyl-1,3-thiazole

5K0N | pdb_00005k0n

Crystal Structure of COMT in complex with 4-[5-[1-(4-methoxyphenyl)cyclopropyl]-1H-pyrazol-3-yl]-1,3-dimethylpyrazole

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Structure Determination Methodology

Scientific Name of Source Organism

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Experimental Method

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Symmetry Type

SCOP Classification

5K03 | pdb_00005k03

5K05 | pdb_00005k05

5K09 | pdb_00005k09

5K0B | pdb_00005k0b

5K0C | pdb_00005k0c

5K0F | pdb_00005k0f

5K0G | pdb_00005k0g

5K0J | pdb_00005k0j

5K0L | pdb_00005k0l

5K0N | pdb_00005k0n