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234,136 Structures from the PDB

1,068,577 Computed Structure Models (CSM)

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QUERY: Enzyme Classification Number = 1.3.1.9

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Search Summary

This query matches 312 Structures.

Refinements

Structure Determination Methodology

experimental (312)

Scientific Name of Source Organism

	Mycobacterium tuberculosis H37Rv (57)
	Mycobacterium tuberculosis (49)
	Saccharomyces cerevisiae (25)
	Plasmodium falciparum (22)
	Escherichia coli (13)
	Burkholderia pseudomallei (11)
	Homo sapiens (9)
	Escherichia coli K-12 (8)
	Mycobacterium tuberculosis CDC1551 (8)
	Bacillus cereus ATCC 14579 (6)

More...

Taxonomy

	Bacteria (244)
	Eukaryota (77)

Experimental Method

	X-RAY DIFFRACTION (286)
	ELECTRON MICROSCOPY (26)

Polymer Entity Type

Protein (312)

Refinement Resolution (Å)

	1.0 - 1.5 (4)
	1.5 - 2.0 (103)
	2.0 - 2.5 (99)
	2.5 - 3.0 (83)
	3.0 - 3.5 (12)
	3.5 - 4.0 (3)
	4.0 - 4.5 (4)
	> 4.5 (4)

Release Date

	1995 - 1999 (14)
	2000 - 2004 (14)
	2005 - 2009 (56)
	2010 - 2014 (77)
	2015 - 2019 (91)
	2020 - 2024 (60)

Enzyme Classification Name

	Oxidoreductases (312)
	Transferases (32)
	Hydrolases (32)
	Lyases (32)

Symmetry Type

	Dihedral (245)
	Asymmetric (46)
	Cyclic (45)

SCOP Classification

	Alpha and beta proteins (a/b) (196)
	Artifacts (15)
	All alpha proteins (1)

AllSelected

1 to 25 of 312 Structures

Page 1 of 13

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1BVR \| pdb_00001bvr	Download File View File

M.TB. ENOYL-ACP REDUCTASE (INHA) IN COMPLEX WITH NAD+ AND C16-FATTY-ACYL-SUBSTRATE

Rozwarski, D.A., Vilcheze, C., Sugantino, M., Bittman, R., Jacobs, W., TB Structural Genomics Consortium (TBSGC)

(1999) J Biological Chem 274: 15582-15589

Released	1999-09-17
Method	X-RAY DIFFRACTION 2.8 Å
Organisms	Mycobacterium tuberculosis
Macromolecule	PROTEIN (ENOYL-ACYL CARRIER PROTEIN (ACP) REDUCTASE) (protein)
Unique Ligands	NAD, THT

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1C14 \| pdb_00001c14	Download File View File

CRYSTAL STRUCTURE OF E COLI ENOYL REDUCTASE-NAD+-TRICLOSAN COMPLEX

Qiu, X., Janson, C., Court, R., Smyth, M., Payne, D., Abdel-Meguid, S.

(1999) Protein Sci 8: 2529-2532

Released	2000-07-20
Method	X-RAY DIFFRACTION 2 Å
Organisms	Escherichia coli
Macromolecule	ENOYL REDUCTASE (protein)
Unique Ligands	NAD, TCL

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1CWU \| pdb_00001cwu	Download File View File

BRASSICA NAPUS ENOYL ACP REDUCTASE A138G MUTANT COMPLEXED WITH NAD+ AND THIENODIAZABORINE

Roujeinikova, A., Rafferty, J.B., Rice, D.W.

(1999) J Biological Chem 274: 30811-30817

Released	1999-09-02
Method	X-RAY DIFFRACTION 2.5 Å
Organisms	Brassica napus
Macromolecule	ENOYL ACP REDUCTASE (protein)
Unique Ligands	NAD, TDB

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1D7O \| pdb_00001d7o	Download File View File

CRYSTAL STRUCTURE OF BRASSICA NAPUS ENOYL ACYL CARRIER PROTEIN REDUCTASE COMPLEXED WITH NAD AND TRICLOSAN

Roujeinikova, A., Levy, C., Rowsell, S., Sedelnikova, S., Baker, P.J., Minshull, C.A., Mistry, A., Colls, J.G., Camble, R., Stuitje, A.R., Slabas, A.R., Rafferty, J.B., Pauptit, R.A., Viner, R., Rice, D.W.

(1999) J Mol Biology 294: 527-535

Released	1999-11-08
Method	X-RAY DIFFRACTION 1.9 Å
Organisms	Brassica napus
Macromolecule	ENOYL-[ACYL-CARRIER PROTEIN] REDUCTASE (NADH) PRECURSOR (protein)
Unique Ligands	NAD, TCL

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1D8A \| pdb_00001d8a	Download File View File

E. COLI ENOYL REDUCTASE/NAD+/TRICLOSAN COMPLEX

Levy, C.W., Roujeinikova, A., Sedelnikova, S., Baker, P.J., Stuitje, A.R., Slabas, A.R., Rice, D.W., Rafferty, J.B.

(1999) Nature 398: 383-384

Released	1999-10-28
Method	X-RAY DIFFRACTION 2.2 Å
Organisms	Escherichia coli
Macromolecule	ENOYL-[ACYL-CARRIER-PROTEIN] REDUCTASE (protein)
Unique Ligands	NAD, TCL

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1DFG \| pdb_00001dfg	Download File View File

X-RAY STRUCTURE OF ESCHERICHIA COLI ENOYL REDUCTASE WITH BOUND NAD AND BENZO-DIAZABORINE

Baldock, C., Rafferty, J.B., Rice, D.W.

(1996) Science 274: 2107-2110

Released	1998-01-28
Method	X-RAY DIFFRACTION 2.5 Å
Organisms	Escherichia coli
Macromolecule	ENOYL ACYL CARRIER PROTEIN REDUCTASE (protein)
Unique Ligands	NAD, NDT

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1DFH \| pdb_00001dfh	Download File View File

X-RAY STRUCTURE OF ESCHERICHIA COLI ENOYL REDUCTASE WITH BOUND NAD AND THIENO-DIAZABORINE

Baldock, C., Rafferty, J.B., Rice, D.W.

(1996) Science 274: 2107-2110

Released	1998-01-28
Method	X-RAY DIFFRACTION 2.2 Å
Organisms	Escherichia coli
Macromolecule	ENOYL ACYL CARRIER PROTEIN REDUCTASE (protein)
Unique Ligands	NAD, TDB

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1DFI \| pdb_00001dfi	Download File View File

X-RAY STRUCTURE OF ESCHERICHIA COLI ENOYL REDUCTASE WITH BOUND NAD

Baldock, C., Rafferty, J.B., Rice, D.W.

(1996) Science 274: 2107-2110

Released	1998-01-28
Method	X-RAY DIFFRACTION 2.09 Å
Organisms	Escherichia coli
Macromolecule	ENOYL ACYL CARRIER PROTEIN REDUCTASE (protein)
Unique Ligands	NAD

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1ENO \| pdb_00001eno	Download File View File

BRASSICA NAPUS ENOYL ACP REDUCTASE/NAD BINARY COMPLEX AT PH 8.0 AND ROOM TEMPERATURE

Rafferty, J.B., Rice, D.W.

(1995) Structure 3: 927-938

Released	1996-10-14
Method	X-RAY DIFFRACTION 1.9 Å
Organisms	Brassica napus
Macromolecule	ENOYL ACYL CARRIER PROTEIN REDUCTASE (protein)
Unique Ligands	NAD

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1ENP \| pdb_00001enp	Download File View File

BRASSICA NAPUS ENOYL ACP REDUCTASE/NADH BINARY COMPLEX AT PH 8.0 AND ROOM TEMPERATURE

Rafferty, J.B., Rice, D.W.

(1995) Structure 3: 927-938

Released	1996-10-14
Method	X-RAY DIFFRACTION 2.6 Å
Organisms	Brassica napus
Macromolecule	ENOYL ACYL CARRIER PROTEIN REDUCTASE (protein)
Unique Ligands	NAD

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1ENY \| pdb_00001eny	Download File View File

CRYSTAL STRUCTURE AND FUNCTION OF THE ISONIAZID TARGET OF MYCOBACTERIUM TUBERCULOSIS

Dessen, A., Quemard, A., Blanchard, J.S., Jacobs Jr., W.R., Sacchettini, J.C., TB Structural Genomics Consortium (TBSGC)

(1995) Science 267: 1638-1641

Released	1996-01-29
Method	X-RAY DIFFRACTION 2.2 Å
Organisms	Mycobacterium tuberculosis
Macromolecule	ENOYL-ACYL CARRIER PROTEIN (ACP) REDUCTASE (protein)
Unique Ligands	NAD

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1ENZ \| pdb_00001enz	Download File View File

CRYSTAL STRUCTURE AND FUNCTION OF THE ISONIAZID TARGET OF MYCOBACTERIUM TUBERCULOSIS

Dessen, A., Quemard, A., Blanchard, J.S., Jacobs Jr., W.R., Sacchettini, J.C., TB Structural Genomics Consortium (TBSGC)

(1995) Science 267: 1638-1641

Released	1996-01-29
Method	X-RAY DIFFRACTION 2.7 Å
Organisms	Mycobacterium tuberculosis
Macromolecule	ENOYL-ACYL CARRIER PROTEIN (ACP) REDUCTASE (protein)
Unique Ligands	NAD

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1I2Z \| pdb_00001i2z	Download File View File

E. COLI ENOYL REDUCTASE IN COMPLEX WITH NAD AND BRL-12654

Heerding, D.A., Miller, W.H., Payne, D.J., Janson, C.A., Qiu, X.

(2001) Bioorg Med Chem Lett 11: 2061-2065

Released	2002-02-12
Method	X-RAY DIFFRACTION 2.8 Å
Organisms	Escherichia coli
Macromolecule	ENOYL-[ACYL-CARRIER-PROTEIN] REDUCTASE [NADH] (protein)
Unique Ligands	654, NAD

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1I30 \| pdb_00001i30	Download File View File

E. Coli Enoyl Reductase +NAD+SB385826

Seefeld, M.A., Miller, W.H., Payne, D.J., Janson, C.A., Qiu, X.

(2001) Bioorg Med Chem Lett 11: 2241-2244

Released	2002-02-12
Method	X-RAY DIFFRACTION 2.4 Å
Organisms	Escherichia coli
Macromolecule	ENOYL-[ACYL-CARRIER-PROTEIN] REDUCTASE [NADH] (protein)
Unique Ligands	826, NAD

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1LX6 \| pdb_00001lx6	Download File View File

Crystal Structure of E. Coli Enoyl Reductase-NAD+ with a Bound Benzamide Inhibitor

Smith, W.W., Qiu, X., Janson, C.A.

(2002) J Med Chem 45: 3246-3256

Released	2002-09-04
Method	X-RAY DIFFRACTION 2.4 Å
Organisms	Escherichia coli
Macromolecule	Enoyl-[acyl-carrier-protein] reductase [NADH] (protein)
Unique Ligands	NAD, ZAM

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1LXC \| pdb_00001lxc	Download File View File

Crystal Structure of E. Coli Enoyl Reductase-NAD+ with a Bound Acrylamide Inhibitor

Miller, W.H., Seefeld, M.A., Newlander, K.A., Uzinskas, I.N., Burgess, W.J., Heerding, D.A., Yuan, C.C.K., Head, M.S., Payne, D.J., Rittenhouse, S.F., Moore, T.D., Pearson, S.C., Dewolf, V., Berry, W.E., Keller, P.M., Polizzi, B.J., Qiu, X., Janson, C.A., Huffman, W.F.

(2002) J Med Chem 45: 3246-3256

Released	2002-09-04
Method	X-RAY DIFFRACTION 2.4 Å
Organisms	Escherichia coli
Macromolecule	ENOYL-[ACYL-CARRIER-PROTEIN] REDUCTASE [NADH] (protein)
Unique Ligands	AYM, NAD

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1MFP \| pdb_00001mfp	Download File View File

E. coli Enoyl Reductase in complex with NAD and SB611113

Seefeld, M.A., Miller, W.H., Newlander, K.A., Burgess, W.J., DeWolf Jr., W.E., Elkins, P.A., Head, M.S., Jakas, D.R., Janson, C.A., Keller, P.M., Manley, P.J., Moore, T.D., Payne, D.J., Pearson, S., Polizzi, B.J., Qiu, X., Rittenhouse, S.F., Uzinskas, I.N., Wallis, N.G., Huffman, W.F.

(2003) J Med Chem 46: 1627-1635

Released	2003-05-06
Method	X-RAY DIFFRACTION 2.33 Å
Organisms	Escherichia coli
Macromolecule	enoyl-[acyl-carrier-protein] reductase [Nadh] (protein)
Unique Ligands	IDN, NAD, SO4

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1NHG \| pdb_00001nhg	Download File View File

CRYSTAL STRUCTURE ANALYSIS OF PLASMODIUM FALCIPARUM ENOYL-ACYL-CARRIER-PROTEIN REDUCTASE WITH TRICLOSAN

Perozzo, R., Kuo, M., Sidhu, A.S., Valiyaveettil, J.T., Bittman, R., Jacobs Jr., W.R., Fidock, D.A., Sacchettini, J.C.

(2002) J Biological Chem 277: 13106-13114

Released	2003-02-25
Method	X-RAY DIFFRACTION 2.43 Å
Organisms	Plasmodium falciparum
Macromolecule	enoyl-acyl carrier reductase (protein)
Unique Ligands	NAD, TCL

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1NHW \| pdb_00001nhw	Download File View File

Crystal Structure Analysis of Plasmodium falciparum enoyl-acyl-carrier-protein reductase

Perozzo, R., Kuo, M., Sidhu, A.S., Valiyaveettil, J.T., Bittman, R., Jacobs Jr., W.R., Fidock, D.A., Sacchettini, J.C.

(2002) J Biological Chem 277: 13106-13114

Released	2003-02-25
Method	X-RAY DIFFRACTION 2.35 Å
Organisms	Plasmodium falciparum
Macromolecule	enoyl-acyl carrier reductase (protein)
Unique Ligands	NAD, TCC

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1NNU \| pdb_00001nnu	Download File View File

Crystal Structure Analysis of Plasmodium falciparum enoyl-acyl-carrier-protein reductase with Triclosan Analog

Perozzo, R., Kuo, M., Sidhu, A.S., Valiyaveettil, J.T., Bittman, R., Jacobs Jr., W.R., Fidock, D.A., Sacchettini, J.C.

(2002) J Biological Chem 277: 13106-13114

Released	2003-02-25
Method	X-RAY DIFFRACTION 2.5 Å
Organisms	Plasmodium falciparum
Macromolecule	enoyl-acyl carrier reductase (protein)
Unique Ligands	NAD, TCT

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1P44 \| pdb_00001p44	Download File View File

Targeting tuberculosis and malaria through inhibition of enoyl reductase: compound activity and structural data

Kuo, M.R., Morbidoni, H.R., Alland, D., Sneddon, S.F., Gourlie, B.B., Staveski, M.M., Leonard, M., Gregory, J.S., Janjigian, A.D., Yee, C., Musser, J.M., Kreiswirth, B., Iwamoto, H., Perozzo, R., Jacobs Jr, W.R., Sacchettini, J.C., Fidock, D.A., TB Structural Genomics Consortium (TBSGC)

(2003) J Biological Chem 278: 20851-20859

Released	2003-09-16
Method	X-RAY DIFFRACTION 2.7 Å
Organisms	Mycobacterium tuberculosis
Macromolecule	Enoyl-[acyl-carrier-protein] reductase [NADH] (protein)
Unique Ligands	GEQ, NAD

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1P45 \| pdb_00001p45	Download File View File

Targeting tuberculosis and malaria through inhibition of enoyl reductase: compound activity and structural data

Kuo, M.R., Morbidoni, H.R., Alland, D., Sneddon, S.F., Gourlie, B.B., Staveski, M.M., Leonard, M., Gregory, J.S., Janjigian, A.D., Yee, C., Musser, J.M., Kreiswirth, B.N., Iwamoto, H., Perozzo, R., Jacobs Jr., W.R., Sacchettini, J.C., Fidock, D.A., TB Structural Genomics Consortium (TBSGC)

(2003) J Biological Chem 278: 20851-20859

Released	2003-09-16
Method	X-RAY DIFFRACTION 2.6 Å
Organisms	Mycobacterium tuberculosis
Macromolecule	Enoyl-[acyl-carrier-protein] reductase [NADH] (protein)
Unique Ligands	NAD, TCL

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1QG6 \| pdb_00001qg6	Download File View File

CRYSTAL STRUCTURE OF E. COLI ENOYL ACYL CARRIER PROTEIN REDUCTASE IN COMPLEX WITH NAD AND TRICLOSAN

Rowsell, S., Pauptit, R.A.

(1999) Biochemistry 38: 12514-12525

Released	1999-09-21
Method	X-RAY DIFFRACTION 1.9 Å
Organisms	Escherichia coli
Macromolecule	PROTEIN (ENOYL-[ACYL-CARRIER PROTEIN] REDUCTASE) (protein)
Unique Ligands	NAD, TCL

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1QSG \| pdb_00001qsg	Download File View File

CRYSTAL STRUCTURE OF ENOYL REDUCTASE INHIBITION BY TRICLOSAN

Stewart, M.J., Parikh, S., Xiao, G., Tonge, P.J., Kisker, C.

(1999) J Mol Biology 290: 859-865

Released	1999-07-21
Method	X-RAY DIFFRACTION 1.75 Å
Organisms	Escherichia coli
Macromolecule	ENOYL-[ACYL-CARRIER-PROTEIN] REDUCTASE (protein)
Unique Ligands	GLC, NAD, TCL