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234,136 Structures from the PDB

1,068,577 Computed Structure Models (CSM)

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QUERY: Gene Name = "PKMYT1"

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Search Summary

This query matches 18 Structures.

Refinements

Structure Determination Methodology

experimental (18)

Scientific Name of Source Organism

Homo sapiens (18)

Taxonomy

Eukaryota (18)

Experimental Method

X-RAY DIFFRACTION (18)

Polymer Entity Type

Protein (18)

Refinement Resolution (Å)

	1.5 - 2.0 (11)
	2.0 - 2.5 (6)
	2.5 - 3.0 (1)

Release Date

	2010 - 2014 (1)
	2015 - 2019 (8)
	2020 - 2024 (9)

Enzyme Classification Name

Transferases (18)

Symmetry Type

Asymmetric (18)

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1 to 18 of 18 Structures

Page 1 of 1

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Explore in 3D

3P1A \| pdb_00003p1a	Download File View File

Structure of human Membrane-associated Tyrosine- and Threonine-specific cdc2-inhibitory kinase MYT1 (PKMYT1)

Chaikuad, A., Eswaran, J., Fedorov, O., Cooper, C.D.O., Kroeler, T., Vollmar, M., Krojer, T., Berridge, G., Muniz, J.R.C., Pike, A.C.W., von Delft, F., Weigelt, J., Arrowsmith, C.H., Edwards, A.M., Bountra, C., Knapp, S., Structural Genomics Consortium (SGC)

To be published

Released	2010-11-03
Method	X-RAY DIFFRACTION 1.7 Å
Organisms	Homo sapiens
Macromolecule	Membrane-associated tyrosine- and threonine-specific cdc2-inhibitory kinase (protein)
Unique Ligands	DMS, EDO

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5VCV \| pdb_00005vcv	Download File View File

CRYSTAL STRUCTURE OF HUMAN MYT1 KINASE DOMAIN IN COMPLEX WITH Dasatinib

Zhu, J.-Y., Martin, M.P., Schonbrunn, E.

(2017) J Med Chem 60: 7863-7875

Released	2017-08-23
Method	X-RAY DIFFRACTION 1.92 Å
Organisms	Homo sapiens
Macromolecule	Membrane-associated tyrosine- and threonine-specific cdc2-inhibitory kinase (protein)
Unique Ligands	1N1, CL, EDO

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5VCW \| pdb_00005vcw	Download File View File

CRYSTAL STRUCTURE OF HUMAN MYT1 KINASE DOMAIN IN COMPLEX WITH Pelitinib

Zhu, J.-Y., Schonbrunn, E.

(2017) J Med Chem 60: 7863-7875

Released	2017-08-23
Method	X-RAY DIFFRACTION 2.25 Å
Organisms	Homo sapiens
Macromolecule	Membrane-associated tyrosine- and threonine-specific cdc2-inhibitory kinase (protein)
Unique Ligands	93J, EDO, SO4

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5VCX \| pdb_00005vcx	Download File View File

CRYSTAL STRUCTURE OF HUMAN MYT1 KINASE DOMAIN (UNTREATED) IN COMPLEX WITH SARACATINIB

Zhu, J.-Y., Schonbrunn, E.

(2017) J Med Chem 60: 7863-7875

Released	2017-08-23
Method	X-RAY DIFFRACTION 2.7 Å
Organisms	Homo sapiens
Macromolecule	Membrane-associated tyrosine- and threonine-specific cdc2-inhibitory kinase (protein)
Unique Ligands	EDO, H8H

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5VCY \| pdb_00005vcy	Download File View File

CRYSTAL STRUCTURE OF HUMAN MYT1 KINASE DOMAIN IN COMPLEX WITH BOSUTINIB

Zhu, J.-Y., Schonbrunn, E.

(2017) J Med Chem 60: 7863-7875

Released	2017-08-23
Method	X-RAY DIFFRACTION 1.56 Å
Organisms	Homo sapiens
Macromolecule	Membrane-associated tyrosine- and threonine-specific cdc2-inhibitory kinase (protein)
Unique Ligands	DB8, DMS, EDO, PEG

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5VCZ \| pdb_00005vcz	Download File View File

CRYSTAL STRUCTURE OF HUMAN MYT1 KINASE DOMAIN IN COMPLEX WITH Bosutinib isomer

Zhu, J.-Y., Schonbrunn, E.

(2017) J Med Chem 60: 7863-7875

Released	2017-08-23
Method	X-RAY DIFFRACTION 1.5 Å
Organisms	Homo sapiens
Macromolecule	Membrane-associated tyrosine- and threonine-specific cdc2-inhibitory kinase (protein)
Unique Ligands	EDO, PEG, XZN

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5VD0 \| pdb_00005vd0	Download File View File

CRYSTAL STRUCTURE OF HUMAN MYT1 KINASE DOMAIN IN COMPLEX WITH MK1775

Zhu, J.-Y., Schonbrunn, E.

(2017) J Med Chem 60: 7863-7875

Released	2017-08-23
Method	X-RAY DIFFRACTION 2.13 Å
Organisms	Homo sapiens
Macromolecule	Membrane-associated tyrosine- and threonine-specific cdc2-inhibitory kinase (protein)
Unique Ligands	8X7, PEG

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5VD1 \| pdb_00005vd1	Download File View File

CRYSTAL STRUCTURE OF HUMAN MYT1 KINASE DOMAIN IN COMPLEX WITH PHA-848125

Zhu, J.-Y., Schonbrunn, E.

(2017) J Med Chem 60: 7863-7875

Released	2017-08-23
Method	X-RAY DIFFRACTION 1.7 Å
Organisms	Homo sapiens
Macromolecule	Membrane-associated tyrosine- and threonine-specific cdc2-inhibitory kinase (protein)
Unique Ligands	P48, PEG

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5VD3 \| pdb_00005vd3	Download File View File

CRYSTAL STRUCTURE OF HUMAN MYT1 KINASE DOMAIN (de-phosphorylated) IN COMPLEX WITH SARACATINIB

Zhu, J.-Y., Schonbrunn, E.

(2017) J Med Chem 60: 7863-7875

Released	2017-08-23
Method	X-RAY DIFFRACTION 1.8 Å
Organisms	Homo sapiens
Macromolecule	Membrane-associated tyrosine- and threonine-specific cdc2-inhibitory kinase (protein)
Unique Ligands	EDO, H8H, PEG

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8D6C \| pdb_00008d6c	Download File View File

Crystal Structure of Human Myt1 Kinase domain Bounded with compound 28

Pau, V.P.T., Mao, D.Y.L., Mader, P., Orlicky, S., Sicheri, F.

(2022) J Med Chem 65: 10251-10284

Released	2022-07-27
Method	X-RAY DIFFRACTION 2.2 Å
Organisms	Homo sapiens
Macromolecule	Membrane-associated tyrosine- and threonine-specific cdc2-inhibitory kinase (protein)
Unique Ligands	EDO, GOL, QGR, SO4

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8D6D \| pdb_00008d6d	Download File View File

Crystal Structure of Human Myt1 Kinase domain Bounded with compound 39

Pau, V.P.T., Mao, D.Y.L., Mader, P., Orlicky, S., Sicheri, F.

(2022) J Med Chem 65: 10251-10284

Released	2022-07-27
Method	X-RAY DIFFRACTION 2.35 Å
Organisms	Homo sapiens
Macromolecule	Membrane-associated tyrosine- and threonine-specific cdc2-inhibitory kinase (protein)
Unique Ligands	EDO, QGY, SO4

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8D6E \| pdb_00008d6e	Download File View File

Crystal Structure of Human Myt1 Kinase domain Bounded with RP-6306

Pau, V.P.T., Mao, D.Y.L., Mader, P., Orlicky, S., Sicheri, F.

(2022) J Med Chem 65: 10251-10284

Released	2022-07-27
Method	X-RAY DIFFRACTION 2.15 Å
Organisms	Homo sapiens
Macromolecule	Membrane-associated tyrosine- and threonine-specific cdc2-inhibitory kinase (protein)
Unique Ligands	EDO, GOL, QGI, SO4

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8D6F \| pdb_00008d6f	Download File View File

Crystal Structure of Human Myt1 Kinase domain Bounded with Eph receptor inhibitor / compound 41

Pau, V.P.T., Mao, D.Y.L., Mader, P., Orlicky, S., Sicheri, F.

(2022) J Med Chem 65: 10251-10284

Released	2022-07-27
Method	X-RAY DIFFRACTION 2.49 Å
Organisms	Homo sapiens
Macromolecule	Membrane-associated tyrosine- and threonine-specific cdc2-inhibitory kinase (protein)
Unique Ligands	QG5, SO4

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8WJY \| pdb_00008wjy	Download File View File

PKMYT1_Cocrystal_Cpd 4

Wang, Y., Wang, C., Liu, T., Qi, H., Chen, S., Cai, X., Zhang, M., Aliper, A., Ren, F., Ding, X., Zhavoronkov, A.

(2024) J Med Chem 67: 420-432

Released	2023-11-22
Method	X-RAY DIFFRACTION 1.88 Å
Organisms	Homo sapiens
Macromolecule	Membrane-associated tyrosine- and threonine-specific cdc2-inhibitory kinase (protein)
Unique Ligands	DMS, GOL, W9X

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8ZTX \| pdb_00008ztx	Download File View File

Crystal Structure of Human Myt1 Kinase domain Bounded with compound 6b

Zhang, Z.M., Zhou, Z.Q.

(2024) J Med Chem 67: 15816-15836

Released	2024-09-11
Method	X-RAY DIFFRACTION 1.70033228795 Å
Organisms	Homo sapiens
Macromolecule	Membrane-associated tyrosine- and threonine-specific cdc2-inhibitory kinase (protein)
Unique Ligands	A1D83

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8ZU2 \| pdb_00008zu2	Download File View File

Crystal Structure of Human Myt1 Kinase domain Bounded with compound 8g

Zhang, Z.M., Zhou, Z.Q.

(2024) J Med Chem 67: 15816-15836

Released	2024-09-11
Method	X-RAY DIFFRACTION 1.79888582046 Å
Organisms	Homo sapiens
Macromolecule	Membrane-associated tyrosine- and threonine-specific cdc2-inhibitory kinase (protein)
Unique Ligands	A1D85, GLY

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8ZUD \| pdb_00008zud	Download File View File

Crystal Structure of Human Myt1 Kinase domain Bounded with compound 8f

Zhang, Z.M., Zhou, Z.Q.

(2024) J Med Chem 67: 15816-15836

Released	2024-09-11
Method	X-RAY DIFFRACTION 1.5051008788 Å
Organisms	Homo sapiens
Macromolecule	Membrane-associated tyrosine- and threonine-specific cdc2-inhibitory kinase (protein)
Unique Ligands	A1D82

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8ZUL \| pdb_00008zul	Download File View File

Crystal Structure of Human Myt1 Kinase domain Bounded with compound 8m

Zhang, Z.M., Zhou, Z.Q.

(2024) J Med Chem 67: 15816-15836

Released	2024-09-11
Method	X-RAY DIFFRACTION 1.80026162696 Å
Organisms	Homo sapiens
Macromolecule	Membrane-associated tyrosine- and threonine-specific cdc2-inhibitory kinase (protein)
Unique Ligands	A1D84

1 to 18 of 18 Structures

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RCSB PDB Core Operations are funded by the U.S. National Science Foundation (DBI-2321666), the US Department of Energy (DE-SC0019749), and the National Cancer Institute, National Institute of Allergy and Infectious Diseases, and National Institute of General Medical Sciences of the National Institutes of Health under grant R01GM157729.

3P1A | pdb_00003p1a

Structure of human Membrane-associated Tyrosine- and Threonine-specific cdc2-inhibitory kinase MYT1 (PKMYT1)

5VCV | pdb_00005vcv

CRYSTAL STRUCTURE OF HUMAN MYT1 KINASE DOMAIN IN COMPLEX WITH Dasatinib

5VCW | pdb_00005vcw

CRYSTAL STRUCTURE OF HUMAN MYT1 KINASE DOMAIN IN COMPLEX WITH Pelitinib

5VCX | pdb_00005vcx

CRYSTAL STRUCTURE OF HUMAN MYT1 KINASE DOMAIN (UNTREATED) IN COMPLEX WITH SARACATINIB

5VCY | pdb_00005vcy

CRYSTAL STRUCTURE OF HUMAN MYT1 KINASE DOMAIN IN COMPLEX WITH BOSUTINIB

5VCZ | pdb_00005vcz

CRYSTAL STRUCTURE OF HUMAN MYT1 KINASE DOMAIN IN COMPLEX WITH Bosutinib isomer

5VD0 | pdb_00005vd0

CRYSTAL STRUCTURE OF HUMAN MYT1 KINASE DOMAIN IN COMPLEX WITH MK1775

5VD1 | pdb_00005vd1

CRYSTAL STRUCTURE OF HUMAN MYT1 KINASE DOMAIN IN COMPLEX WITH PHA-848125

5VD3 | pdb_00005vd3

CRYSTAL STRUCTURE OF HUMAN MYT1 KINASE DOMAIN (de-phosphorylated) IN COMPLEX WITH SARACATINIB

8D6C | pdb_00008d6c

Crystal Structure of Human Myt1 Kinase domain Bounded with compound 28

8D6D | pdb_00008d6d

Crystal Structure of Human Myt1 Kinase domain Bounded with compound 39

8D6E | pdb_00008d6e

Crystal Structure of Human Myt1 Kinase domain Bounded with RP-6306

8D6F | pdb_00008d6f

Crystal Structure of Human Myt1 Kinase domain Bounded with Eph receptor inhibitor / compound 41

8WJY | pdb_00008wjy

PKMYT1_Cocrystal_Cpd 4

8ZTX | pdb_00008ztx

Crystal Structure of Human Myt1 Kinase domain Bounded with compound 6b

8ZU2 | pdb_00008zu2

Crystal Structure of Human Myt1 Kinase domain Bounded with compound 8g

8ZUD | pdb_00008zud

Crystal Structure of Human Myt1 Kinase domain Bounded with compound 8f

8ZUL | pdb_00008zul

Crystal Structure of Human Myt1 Kinase domain Bounded with compound 8m

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Structure Determination Methodology

Scientific Name of Source Organism

Taxonomy

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Enzyme Classification Name

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3P1A | pdb_00003p1a

5VCV | pdb_00005vcv

5VCW | pdb_00005vcw

5VCX | pdb_00005vcx

5VCY | pdb_00005vcy

5VCZ | pdb_00005vcz

5VD0 | pdb_00005vd0

5VD1 | pdb_00005vd1

5VD3 | pdb_00005vd3

8D6C | pdb_00008d6c

8D6D | pdb_00008d6d

8D6E | pdb_00008d6e

8D6F | pdb_00008d6f

8WJY | pdb_00008wjy

8ZTX | pdb_00008ztx

8ZU2 | pdb_00008zu2

8ZUD | pdb_00008zud

8ZUL | pdb_00008zul