RCSB PDB: Search

Warning You are using a web browser that we do not support. Our website will not work properly. Please update to a newer version or download a new web browser, such as Chrome or Firefox.

Help

Help

RCSB PDB

Deposit
- PDBx/mmCIF file
- pdb_extract
- SF-Tool
- Ligand Expo
- MAXIT
- Validation Server
- Validation API
- Information for Journals
- Validation Task Forces
- wwPDB OneDep System
- PDB-IHM
Search
Visualize
Analyze
Download
Learn
- Training Courses
- Guide to PDB Data
- Molecule of the Month
- Educational Resources
- Curricula
- Browse
- News
- SciArt Galleries
- Irving Geis
- David Goodsell
About
Careers
COVID-19

234,440 Structures from the PDB

1,068,577 Computed Structure Models (CSM)

	Include CSM
Advanced Search \| Browse Annotations		Help

Search
Query History
Browse Annotations
MyPDB

QUERY: Gene Name = "MIHB"

MyPDB Login

Search API

Advanced Search Query Builder

Help

Full Text

Structure Attributes

Help

NOT

Count

Add Subquery

Chemical Attributes

Sequence Similarity

Sequence Motif

Structure Similarity

Structure Motif

Chemical Similarity

Return

grouped by

Include Computed Structure Models (CSM)

Count

Clear

Search Summary

This query matches 345 Structures.

Refinements

Structure Determination Methodology

experimental (345)

Scientific Name of Source Organism

	Homo sapiens (345)
	synthetic construct (4)

Taxonomy

	Eukaryota (345)
	other sequences (4)

Experimental Method

X-RAY DIFFRACTION (345)

Polymer Entity Type

Protein (345)

Refinement Resolution (Å)

	1.0 - 1.5 (7)
	1.5 - 2.0 (162)
	2.0 - 2.5 (128)
	2.5 - 3.0 (46)
	3.0 - 3.5 (2)

Release Date

	2000 - 2004 (4)
	2005 - 2009 (53)
	2010 - 2014 (166)
	2015 - 2019 (82)
	2020 - 2024 (40)

Enzyme Classification Name

Hydrolases (345)

Symmetry Type

	Asymmetric (343)
	Cyclic (21)

SCOP Classification

	All beta proteins (285)
	Artifacts (37)

AllSelected

1 to 25 of 345 Structures

Page 1 of 14

Sort by

Explore in 3D

1M4H \| pdb_00001m4h	Download File View File

Crystal Structure of Beta-secretase complexed with Inhibitor OM00-3

Hong, L., Turner, R.T., Koelsch, G., Ghosh, A.K., Tang, J.

(2002) Biochemistry 41: 10963-10967

Released	2002-08-28
Method	X-RAY DIFFRACTION 2.1 Å
Organisms	Homo sapiens synthetic construct
Macromolecule	Inhibitor OM00-3 (protein) beta-Secretase (protein)

Explore in 3D

1SGZ \| pdb_00001sgz	Download File View File

Crystal Structure of Unbound Beta-Secretase Catalytic Domain.

Hong, L., Tang, J.

(2004) Biochemistry 43: 4689-4695

Released	2004-05-04
Method	X-RAY DIFFRACTION 2 Å
Organisms	Homo sapiens
Macromolecule	Beta-secretase (protein)

Explore in 3D

1TQF \| pdb_00001tqf	Download File View File

Crystal structure of human Beta secretase complexed with inhibitor

Munshi, S., Chen, Z., Kuo, L.

(2004) J Med Chem 47: 6117-6119

Released	2004-11-09
Method	X-RAY DIFFRACTION 1.8 Å
Organisms	Homo sapiens
Macromolecule	Beta-secretase 1 (protein)
Unique Ligands	32P

Explore in 3D

1XN2 \| pdb_00001xn2	Download File View File

New substrate binding pockets for beta-secretase.

Turner III, R.T., Hong, L., Koelsch, G., Ghosh, A.K., Tang, J.

(2005) Biochemistry 44: 105-112

Released	2005-03-22
Method	X-RAY DIFFRACTION 1.9 Å
Organisms	Homo sapiens
Macromolecule	Beta-secretase 1 (protein) OM03-4 (protein)

Explore in 3D

1XN3 \| pdb_00001xn3	Download File View File

Crystal structure of Beta-secretase bound to a long inhibitor with additional upstream residues.

Turner III, R.T., Hong, L., Koelsch, G., Ghosh, A.K., Tang, J.

(2005) Biochemistry 44: 105-112

Released	2005-03-22
Method	X-RAY DIFFRACTION 2 Å
Organisms	Homo sapiens
Macromolecule	Beta-secretase 1 (protein) Peptidic inhibitor (protein)

Explore in 3D

1XS7 \| pdb_00001xs7	Download File View File

Crystal Structure of a cycloamide-urethane-derived novel inhibitor bound to human brain memapsin 2 (beta-secretase).

Ghosh, A., Devasamudram, T., Hong, L., DeZutter, C., Xu, X., Weerasena, V., Koelsch, G., Bilcer, G., Tang, J.

(2005) Bioorg Med Chem Lett 15: 15-20

Released	2004-12-21
Method	X-RAY DIFFRACTION 2.8 Å
Organisms	Homo sapiens
Macromolecule	Beta-secretase 1 (protein)
Unique Ligands	MMI

Explore in 3D

2B8L \| pdb_00002b8l	Download File View File

Crystal structure of human beta secretase complexed with inhibitor

Munshi, S.K., Kuo, L.

(2006) Bioorg Med Chem Lett 16: 641-644

Released	2005-10-18
Method	X-RAY DIFFRACTION 1.7 Å
Organisms	Homo sapiens
Macromolecule	Beta-secretase 1 (protein)
Unique Ligands	5HA

Explore in 3D

2B8V \| pdb_00002b8v	Download File View File

Crystal structure of human Beta-secretase complexed with L-L000430,469

Stachel, S.J., Coburn, C.A., Steele, T.G., Crouthamel, M.-C., Pietrak, B.L., Lai, M.-T., Holloway, M.K., Munshi, S.K., Graham, S.L., Vacca, J.P.

(2006) Bioorg Med Chem Lett 16: 641-644

Released	2005-12-06
Method	X-RAY DIFFRACTION 1.8 Å
Organisms	Homo sapiens
Macromolecule	Beta-secretase 1 (protein)
Unique Ligands	3BN

Explore in 3D

2F3E \| pdb_00002f3e	Download File View File

Crystal Structure of the Bace complex with AXQ093, a macrocyclic inhibitor

Rondeau, J.-M.

(2006) J Med Chem 49: 4544-4567

Released	2006-09-05
Method	X-RAY DIFFRACTION 2.11 Å
Organisms	Homo sapiens
Macromolecule	Beta-secretase 1 (protein)
Unique Ligands	AXQ

Explore in 3D

2F3F \| pdb_00002f3f	Download File View File

Crystal Structure of the Bace complex with BDF488, a macrocyclic inhibitor

Rondeau, J.-M.

(2006) J Med Chem 49: 4544-4567

Released	2006-09-05
Method	X-RAY DIFFRACTION 2.3 Å
Organisms	Homo sapiens
Macromolecule	Beta-secretase 1 (protein)
Unique Ligands	AXF

Explore in 3D

2G94 \| pdb_00002g94	Download File View File

Crystal structure of beta-secretase bound to a potent and highly selective inhibitor.

Hong, L., Ghosh, A., Tang, J.

(2006) J Am Chem Soc 128: 5310-5311

Released	2006-04-25
Method	X-RAY DIFFRACTION 1.86 Å
Organisms	Homo sapiens
Macromolecule	Beta-secretase 1 (protein)
Unique Ligands	ZPQ

Explore in 3D

2HIZ \| pdb_00002hiz	Download File View File

Crystal Structure of human beta-secretase (BACE) in the presence of an inhibitor

Benson, T.E., Prince, D.B., Tomasselli, A.G., Emmons, T.L., Paddock, D.J.

(2007) Bioorg Med Chem Lett 17: 73-77

Released	2007-01-23
Method	X-RAY DIFFRACTION 2.5 Å
Organisms	Homo sapiens
Macromolecule	Beta-secretase 1 (protein)
Unique Ligands	LIJ, PO4

Explore in 3D

2HM1 \| pdb_00002hm1	Download File View File

Crystal Structure of human beta-secretase (BACE) in the presence of an inhibitor (2)

Benson, T.E., Prince, D.B., Tomasselli, A.G., Emmons, T.L., Paddock, D.J.

(2007) Bioorg Med Chem Lett 17: 78-81

Released	2007-01-23
Method	X-RAY DIFFRACTION 2.2 Å
Organisms	Homo sapiens
Macromolecule	Beta-secretase 1 (protein)
Unique Ligands	LIQ

Explore in 3D

2IQG \| pdb_00002iqg	Download File View File

Crystal Structure of Hydroxyethyl Secondary Amine-based Peptidomimetic Inhibitor of Human Beta-Secretase (BACE)

Benson, T.E., Woods, D.D., Prince, D.B., Tomasselli, A.G., Emmons, T.L.

(2007) J Med Chem 50: 776-781

Released	2007-02-27
Method	X-RAY DIFFRACTION 1.7 Å
Organisms	Homo sapiens
Macromolecule	Beta-secretase 1 (protein)
Unique Ligands	F2I

Explore in 3D

2IRZ \| pdb_00002irz	Download File View File

Crystal structure of human Beta-secretase complexed with inhibitor

Munshi, S.

(2006) J Med Chem 49: 7270-7273

Released	2006-11-14
Method	X-RAY DIFFRACTION 1.8 Å
Organisms	Homo sapiens
Macromolecule	Beta-secretase 1 (protein)
Unique Ligands	I02

Explore in 3D

2IS0 \| pdb_00002is0	Download File View File

Crystal structure of human Beta-secretase complexed with inhibitor

Munshi, S.

(2006) J Med Chem 49: 7270-7273

Released	2006-11-14
Method	X-RAY DIFFRACTION 2.2 Å
Organisms	Homo sapiens
Macromolecule	Beta-secretase 1 (protein)
Unique Ligands	I03

Explore in 3D

2NTR \| pdb_00002ntr	Download File View File

Crystal structure of Human Bace-1 bound to inhibitor

Munshi, S.

(2007) Bioorg Med Chem Lett 17: 1117-1121

Released	2007-11-13
Method	X-RAY DIFFRACTION 1.8 Å
Organisms	Homo sapiens
Macromolecule	Beta-secretase 1 (protein)
Unique Ligands	L00

Explore in 3D

2OAH \| pdb_00002oah	Download File View File

Crystal Structure of Human Beta Secretase Complexed with inhibitor

Munshi, S.

(2007) Bioorg Med Chem Lett 17: 1788-1792

Released	2007-08-14
Method	X-RAY DIFFRACTION 1.8 Å
Organisms	Homo sapiens
Macromolecule	Beta-secretase 1 (protein)
Unique Ligands	QIN

Explore in 3D

2OF0 \| pdb_00002of0	Download File View File

X-ray crystal structure of beta secretase complexed with compound 5

Patel, S.

(2007) J Med Chem 50: 1116-1123

Released	2007-03-13
Method	X-RAY DIFFRACTION 2.25 Å
Organisms	Homo sapiens
Macromolecule	Beta-secretase 1 (protein)
Unique Ligands	CMZ, DMS, IOD

Explore in 3D

2OHK \| pdb_00002ohk	Download File View File

X-ray crystal structure of beta secretase complexed with 1-amino-isoquinoline

Patel, S.

(2007) J Med Chem 50: 1116-1123

Released	2007-03-13
Method	X-RAY DIFFRACTION 2.2 Å
Organisms	Homo sapiens
Macromolecule	Beta-secretase 1 (protein)
Unique Ligands	1SQ, DMS, IOD

Explore in 3D

2OHL \| pdb_00002ohl	Download File View File

X-ray crystal structure of beta secretase complexed with 2-aminoquinoline

Patel, S.

(2007) J Med Chem 50: 1116-1123

Released	2007-03-13
Method	X-RAY DIFFRACTION 2.65 Å
Organisms	Homo sapiens
Macromolecule	Beta-secretase 1 (protein)
Unique Ligands	2AQ, DMS, IOD

Explore in 3D

2OHM \| pdb_00002ohm	Download File View File

X-ray crystal structure of beta secretase complexed with N~3~-benzylpyridine-2,3-diamine

Patel, S.

(2007) J Med Chem 50: 1116-1123

Released	2007-03-13
Method	X-RAY DIFFRACTION 2.7 Å
Organisms	Homo sapiens
Macromolecule	Beta-secretase 1 (protein)
Unique Ligands	8AP, DMS, IOD

Explore in 3D

2OHN \| pdb_00002ohn	Download File View File

X-ray crystal structure of beta secretase complexed with 4-(4-fluorobenzyl)piperidine

Patel, S.

(2007) J Med Chem 50: 1116-1123

Released	2007-03-13
Method	X-RAY DIFFRACTION 2.15 Å
Organisms	Homo sapiens
Macromolecule	Beta-secretase 1 (protein)
Unique Ligands	4FP, DMS, IOD

Explore in 3D

2OHP \| pdb_00002ohp	Download File View File

X-ray crystal structure of beta secretase complexed with compound 3

Patel, S.

(2007) J Med Chem 50: 1124-1132

Released	2007-05-01
Method	X-RAY DIFFRACTION 2.25 Å
Organisms	Homo sapiens
Macromolecule	Beta-secretase 1 (protein)
Unique Ligands	6IP, DMS, IOD

Explore in 3D

2OHQ \| pdb_00002ohq	Download File View File

X-ray crystal structure of beta secretase complexed with compound 4

Patel, S.

(2007) J Med Chem 50: 1124-1132

Released	2007-03-13
Method	X-RAY DIFFRACTION 2.1 Å
Organisms	Homo sapiens
Macromolecule	Beta-secretase 1 (protein)
Unique Ligands	7IP, DMS, GOL, IOD

1 to 25 of 345 Structures

Page 1 of 14

Sort by

About
About Us
Citing Us
Publications
Team
Careers
Usage & Privacy

Support
Contact Us
Help
Website FAQ
Glossary
Service Status

RCSB PDB is hosted by

RCSB PDB is a member of the

RCSB Partners
Nucleic Acid Knowledgebase

wwPDB Partners
RCSB PDB
PDBe
PDBj
BMRB
EMDB

RCSB PDB Core Operations are funded by the U.S. National Science Foundation (DBI-2321666), the US Department of Energy (DE-SC0019749), and the National Cancer Institute, National Institute of Allergy and Infectious Diseases, and National Institute of General Medical Sciences of the National Institutes of Health under grant R01GM157729.

Prepare Data

Validate Data

Deposit Data

Help and Resources

Structure Determination Methodology

Scientific Name of Source Organism

Taxonomy

Experimental Method

Polymer Entity Type

Refinement Resolution (Å)

Release Date

Enzyme Classification Name

Symmetry Type

SCOP Classification

1M4H | pdb_00001m4h

1SGZ | pdb_00001sgz

1TQF | pdb_00001tqf

1XN2 | pdb_00001xn2

1XN3 | pdb_00001xn3

1XS7 | pdb_00001xs7

2B8L | pdb_00002b8l

2B8V | pdb_00002b8v

2F3E | pdb_00002f3e

2F3F | pdb_00002f3f

2G94 | pdb_00002g94

2HIZ | pdb_00002hiz

2HM1 | pdb_00002hm1

2IQG | pdb_00002iqg

2IRZ | pdb_00002irz

2IS0 | pdb_00002is0

2NTR | pdb_00002ntr

2OAH | pdb_00002oah

2OF0 | pdb_00002of0

2OHK | pdb_00002ohk

2OHL | pdb_00002ohl

2OHM | pdb_00002ohm

2OHN | pdb_00002ohn

2OHP | pdb_00002ohp

2OHQ | pdb_00002ohq