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235,183 Structures from the PDB

1,068,577 Computed Structure Models (CSM)

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QUERY: Gene Name = "MDLC"

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Search Summary

This query matches 34 Structures.

Refinements

Structure Determination Methodology

experimental (34)

Scientific Name of Source Organism

	Homo sapiens (23)
	Saccharomyces cerevisiae (5)
	Mus musculus (3)
	Saccharomyces cerevisiae S288C (3)

Taxonomy

Eukaryota (34)

Experimental Method

X-RAY DIFFRACTION (34)

Polymer Entity Type

Protein (34)

Refinement Resolution (Å)

	1.5 - 2.0 (2)
	2.0 - 2.5 (10)
	2.5 - 3.0 (12)
	3.0 - 3.5 (7)
	3.5 - 4.0 (2)
	> 4.5 (1)

Release Date

	2005 - 2009 (3)
	2010 - 2014 (10)
	2015 - 2019 (9)
	2020 - 2024 (12)

Enzyme Classification Name

	Hydrolases (34)
	Transferases (34)

Symmetry Type

	Cyclic (23)
	Asymmetric (15)

SCOP Classification

Alpha and beta proteins (a+b) (1)

AllSelected

1 to 25 of 34 Structures

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2BE1 \| pdb_00002be1	Download File View File

Structure of the compact lumenal domain of yeast Ire1

Credle, J.J., Finer-Moore, J.S., Papa, F.R., Stroud, R.M., Walter, P.

(2005) Proc Natl Acad Sci U S A 102: 18773-18784

Released	2005-12-13
Method	X-RAY DIFFRACTION 2.983 Å
Organisms	Saccharomyces cerevisiae
Macromolecule	Serine/threonine-protein kinase/endoribonuclease IRE1 (protein) peptide (protein)

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2RIO \| pdb_00002rio	Download File View File

Structure of the dual enzyme Ire1 reveals the basis for catalysis and regulation of non-conventional splicing

Lee, K.P., Dey, M., Neculai, D., Cao, C., Dever, T.E., Sicheri, F.

(2008) Cell 132: 89-100

Released	2008-01-29
Method	X-RAY DIFFRACTION 2.4 Å
Organisms	Saccharomyces cerevisiae
Macromolecule	Serine/threonine-protein kinase/endoribonuclease IRE1 (protein)
Unique Ligands	ADP, MG, SR

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3FBV \| pdb_00003fbv	Download File View File

Crystal structure of the oligomer formed by the kinase-ribonuclease domain of Ire1

Korennykh, A.V., Egea, P.F., Korostelev, A.A., Finer-Moore, J., Zhang, C., Shokat, K.M., Stroud, R.M., Walter, P.

(2009) Nature 457: 687-693

Released	2008-12-16
Method	X-RAY DIFFRACTION 3.2 Å
Organisms	Saccharomyces cerevisiae S288C
Macromolecule	Serine/threonine-protein kinase/endoribonuclease IRE1 (protein)
Unique Ligands	APJ

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3LJ0 \| pdb_00003lj0	Download File View File

IRE1 complexed with ADP and Quercetin

Lee, K.P.K., Sicheri, F.

(2010) Mol Cell 38: 291-304

Released	2010-05-12
Method	X-RAY DIFFRACTION 3.2 Å
Organisms	Saccharomyces cerevisiae
Macromolecule	Serine/threonine-protein kinase/endoribonuclease IRE1 (protein)
Unique Ligands	ADP, MG, QUE, SR

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3LJ1 \| pdb_00003lj1	Download File View File

IRE1 complexed with Cdk1/2 Inhibitor III

Lee, K.P.K., Sicheri, F.

(2010) Mol Cell 38: 291-304

Released	2010-05-12
Method	X-RAY DIFFRACTION 3.33 Å
Organisms	Saccharomyces cerevisiae
Macromolecule	Serine/threonine-protein kinase/endoribonuclease IRE1 (protein)
Unique Ligands	DKI

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3LJ2 \| pdb_00003lj2	Download File View File

IRE1 complexed with JAK Inhibitor I

Lee, K.P.K., Sicheri, F.

(2010) Mol Cell 38: 291-304

Released	2010-05-12
Method	X-RAY DIFFRACTION 3.33 Å
Organisms	Saccharomyces cerevisiae
Macromolecule	Serine/threonine-protein kinase/endoribonuclease IRE1 (protein)
Unique Ligands	IZA

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3P23 \| pdb_00003p23	Download File View File

Crystal structure of the Human kinase and RNase domains in complex with ADP

Ali, M.M.U., Pearl, L.H.

(2011) EMBO J 30: 894-905

Released	2011-02-23
Method	X-RAY DIFFRACTION 2.7 Å
Organisms	Homo sapiens
Macromolecule	Serine/threonine-protein kinase/endoribonuclease IRE1 (protein)
Unique Ligands	ADP, MG, SO4

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3SDJ \| pdb_00003sdj	Download File View File

Structure of RNase-inactive point mutant of oligomeric kinase/RNase Ire1

Korennykh, A., Korostelev, A., Egea, P., Finer-Moore, J., Zhang, C., Stroud, R., Shokat, K., Walter, P.

(2011) BMC Biol 9: 47-47

Released	2011-07-13
Method	X-RAY DIFFRACTION 3.65 Å
Organisms	Saccharomyces cerevisiae S288C
Macromolecule	Serine/threonine-protein kinase/endoribonuclease IRE1 (protein)
Unique Ligands	APJ

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3SDM \| pdb_00003sdm	Download File View File

Structure of oligomeric kinase/RNase Ire1 in complex with an oligonucleotide

Korennykh, A., Korostelev, A., Egea, P., Finer-Moore, J., Zhang, C., Stroud, R., Shokat, K., Walter, P.

(2011) BMC Biol 9: 48-48

Released	2011-07-13
Method	X-RAY DIFFRACTION 6.6 Å
Organisms	Saccharomyces cerevisiae S288C
Macromolecule	Serine/threonine-protein kinase/endoribonuclease IRE1 (protein)

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4PL3 \| pdb_00004pl3	Download File View File

Crystal structure of murine IRE1 in complex with MKC9989 inhibitor

Sanches, M., Duffy, N., Talukdar, M., Thevakumaran, N., Chiovitti, D., Al-awar, R., Patterson, J.B., Sicheri, F.

(2014) Nat Commun 5: 4202-4202

Released	2014-09-03
Method	X-RAY DIFFRACTION 2.9 Å
Organisms	Mus musculus
Macromolecule	Serine/threonine-protein kinase/endoribonuclease IRE1 (protein)
Unique Ligands	31J, ADP, MG

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4PL4 \| pdb_00004pl4	Download File View File

Crystal structure of murine IRE1 in complex with OICR464 inhibitor

Sanches, M., Duffy, N., Talukdar, M., Thevakumaran, N., Chiovitti, D., Al-awar, R., Patterson, J.B., Sicheri, F.

(2014) Nat Commun 5: 4202-4202

Released	2014-09-03
Method	X-RAY DIFFRACTION 3 Å
Organisms	Mus musculus
Macromolecule	Serine/threonine-protein kinase/endoribonuclease IRE1 (protein)
Unique Ligands	31K, ADP, MG, PEU

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4PL5 \| pdb_00004pl5	Download File View File

Crystal structure of murine IRE1 in complex with OICR573 inhibitor

Sanches, M., Duffy, N., Talukdar, M., Thevakumaran, N., Chiovitti, D., Al-awar, R., Patterson, J.B., Sicheri, F.

(2014) Nat Commun 5: 4202-4202

Released	2014-09-03
Method	X-RAY DIFFRACTION 3.4 Å
Organisms	Mus musculus
Macromolecule	Serine/threonine-protein kinase/endoribonuclease IRE1 (protein)
Unique Ligands	31L, ADP, MG, PEU

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4U6R \| pdb_00004u6r	Download File View File

Crystal structure of human IRE1 cytoplasmic domains in complex with a sulfonamide inhibitor.

Mohr, C.

(2015) ACS Med Chem Lett 6: 68-72

Released	2014-10-08
Method	X-RAY DIFFRACTION 2.5 Å
Organisms	Homo sapiens
Macromolecule	Serine/threonine-protein kinase/endoribonuclease IRE1 (protein)
Unique Ligands	3E4, EDO, EPE, SO4

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4YZ9 \| pdb_00004yz9	Download File View File

Crystal Structure of human phosphorylated IRE1alpha in complex with a type III kinase inhibitor (GSK2850163A)

Concha, N.O.

(2015) Mol Pharmacol 88: 1011-1023

Released	2015-11-11
Method	X-RAY DIFFRACTION 2.463 Å
Organisms	Homo sapiens
Macromolecule	Serine/threonine-protein kinase/endoribonuclease IRE1 (protein)
Unique Ligands	4K7

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4YZC \| pdb_00004yzc	Download File View File

Crystal structure of pIRE1alpha in complex with staurosporine

Concha, N.O.

(2015) Mol Pharmacol 88: 1011-1023

Released	2015-11-11
Method	X-RAY DIFFRACTION 2.494 Å
Organisms	Homo sapiens
Macromolecule	Serine/threonine-protein kinase/endoribonuclease IRE1 (protein)
Unique Ligands	STU

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4YZD \| pdb_00004yzd	Download File View File

Crystal Structure of human phosphorylated IRE1alpha in complex with ADP-Mg

Concha, N.O.

(2015) Mol Pharmacol 88: 1011-1023

Released	2015-11-11
Method	X-RAY DIFFRACTION 3.102 Å
Organisms	Homo sapiens
Macromolecule	Serine/threonine-protein kinase/endoribonuclease IRE1 (protein)
Unique Ligands	ADP, MG

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4Z7G \| pdb_00004z7g	Download File View File

Crystal structure of human IRE1 cytoplasmic kinase-RNase region - apo

Bayliss, R., Joshi, A.

(2015) Oncotarget 6: 13019-13035

Released	2015-05-27
Method	X-RAY DIFFRACTION 2.6 Å
Organisms	Homo sapiens
Macromolecule	Serine/threonine-protein kinase/endoribonuclease IRE1 (protein)
Unique Ligands	NA

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4Z7H \| pdb_00004z7h	Download File View File

Crystal structure of human IRE1 cytoplasmic kinase-RNase region - complex with imidazopyridine compound 3

Joshi, A., Bayliss, R.

(2015) Oncotarget 6: 13019-13035

Released	2015-05-27
Method	X-RAY DIFFRACTION 2.9 Å
Organisms	Homo sapiens
Macromolecule	Serine/threonine-protein kinase/endoribonuclease IRE1 (protein)
Unique Ligands	4L5, SO4

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5HGI \| pdb_00005hgi	Download File View File

Crystal structure of apo human IRE1 alpha

Feldman, H.C., Tong, M., Wang, L., Meza-Acevedo, R., Gobillot, T.A., Gliedt, J.M., Hari, S.B., Mitra, A.K., Backes, B.J., Papa, F.R., Seeliger, M.A., Maly, D.J.

(2016) ACS Chem Biol 11: 2195-2205

Released	2016-06-08
Method	X-RAY DIFFRACTION 2.584 Å
Organisms	Homo sapiens
Macromolecule	Serine/threonine-protein kinase/endoribonuclease IRE1 (protein)
Unique Ligands	BME, CL, CS, DTT, GOL, NA

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6HV0 \| pdb_00006hv0	Download File View File

IRE1 kinase/RNase in complex with imidazo[1,2-b]pyridazin-8-amine compound 33

Bayliss, R., Bhatia, C., Collins, I.

(2019) J Med Chem 62: 2447-2465

Released	2019-02-27
Method	X-RAY DIFFRACTION 2.73 Å
Organisms	Homo sapiens
Macromolecule	Serine/threonine-protein kinase/endoribonuclease IRE1 (protein)
Unique Ligands	GUK

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6HX1 \| pdb_00006hx1	Download File View File

IRE1 ALPHA IN COMPLEX WITH imidazo[1,2-b]pyridazin-8-amine compound 2

Augustin, M.A., Krapp, S., Bayliss, R., Collins, I.

(2019) J Med Chem 62: 2447-2465

Released	2019-02-27
Method	X-RAY DIFFRACTION 2.14 Å
Organisms	Homo sapiens
Macromolecule	Serine/threonine-protein kinase/endoribonuclease IRE1 (protein)
Unique Ligands	GXK

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6SHC \| pdb_00006shc	Download File View File

Crystal structure of human IRE1 luminal domain Q105C

Yan, Y., Ron, D.

(2019) Elife 8:

Released	2020-01-08
Method	X-RAY DIFFRACTION 3.55 Å
Organisms	Homo sapiens
Macromolecule	Serine/threonine-protein kinase/endoribonuclease IRE1 (protein)

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6URC \| pdb_00006urc	Download File View File

Crystal structure of IRE1a in complex with compound 18

Wallweber, H.H., Wang, W.

(2019) Proc Natl Acad Sci U S A 116: 16420-16429

Released	2019-11-06
Method	X-RAY DIFFRACTION 2.2 Å
Organisms	Homo sapiens
Macromolecule	Serine/threonine-protein kinase/endoribonuclease IRE1 (protein)
Unique Ligands	GOL, QFV

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6W39 \| pdb_00006w39	Download File View File

Structure of unphosphorylated IRE1 in complex with G-1749

Ferri, E., Wang, W., Joachim, R., Mortara, K.

(2020) Nat Commun 11: 6387-6387

Released	2020-12-09
Method	X-RAY DIFFRACTION 1.736 Å
Organisms	Homo sapiens
Macromolecule	Serine/threonine-protein kinase/endoribonuclease IRE1 (protein)
Unique Ligands	SJG

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6W3A \| pdb_00006w3a	Download File View File

Structure of unphosphorylated IRE1 in complex with G-7658

Ferri, E., Wang, W., Joachim, R., Mortara, K.

(2020) Nat Commun 11: 6387-6387

Released	2020-12-09
Method	X-RAY DIFFRACTION 2.606 Å
Organisms	Homo sapiens
Macromolecule	Serine/threonine-protein kinase/endoribonuclease IRE1 (protein)
Unique Ligands	SJM

1 to 25 of 34 Structures

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Structure Determination Methodology

Scientific Name of Source Organism

Taxonomy

Experimental Method

Polymer Entity Type

Refinement Resolution (Å)

Release Date

Enzyme Classification Name

Symmetry Type

SCOP Classification

2BE1 | pdb_00002be1

2RIO | pdb_00002rio

3FBV | pdb_00003fbv

3LJ0 | pdb_00003lj0

3LJ1 | pdb_00003lj1

3LJ2 | pdb_00003lj2

3P23 | pdb_00003p23

3SDJ | pdb_00003sdj

3SDM | pdb_00003sdm

4PL3 | pdb_00004pl3

4PL4 | pdb_00004pl4

4PL5 | pdb_00004pl5

4U6R | pdb_00004u6r

4YZ9 | pdb_00004yz9

4YZC | pdb_00004yzc

4YZD | pdb_00004yzd

4Z7G | pdb_00004z7g

4Z7H | pdb_00004z7h

5HGI | pdb_00005hgi

6HV0 | pdb_00006hv0

6HX1 | pdb_00006hx1

6SHC | pdb_00006shc

6URC | pdb_00006urc

6W39 | pdb_00006w39

6W3A | pdb_00006w3a