RCSB PDB: Search

Warning You are using a web browser that we do not support. Our website will not work properly. Please update to a newer version or download a new web browser, such as Chrome or Firefox.

Help

Help

RCSB PDB

Deposit
- PDBx/mmCIF file
- pdb_extract
- SF-Tool
- Ligand Expo
- MAXIT
- Validation Server
- Validation API
- Information for Journals
- Validation Task Forces
- wwPDB OneDep System
- PDB-IHM
Search
Visualize
Analyze
Download
Learn
- Training Courses
- Guide to PDB Data
- Molecule of the Month
- Educational Resources
- Curricula
- Browse
- News
- SciArt Galleries
- Irving Geis
- David Goodsell
About
Careers
COVID-19

234,136 Structures from the PDB

1,068,577 Computed Structure Models (CSM)

	Include CSM
Advanced Search \| Browse Annotations		Help

Search
Query History
Browse Annotations
MyPDB

QUERY: Gene Name = "BTK"

MyPDB Login

Search API

Advanced Search Query Builder

Help

Full Text

Structure Attributes

Help

NOT

Count

Add Subquery

Chemical Attributes

Sequence Similarity

Sequence Motif

Structure Similarity

Structure Motif

Chemical Similarity

Return

grouped by

Include Computed Structure Models (CSM)

Count

Clear

Search Summary

This query matches 134 Structures.

Refinements

Structure Determination Methodology

experimental (134)

Scientific Name of Source Organism

	Homo sapiens (124)
	Mus musculus (7)
	Bos taurus (3)
	synthetic construct (1)

Taxonomy

	Eukaryota (134)
	other sequences (1)

Experimental Method

	X-RAY DIFFRACTION (133)
	SOLUTION NMR (1)

Polymer Entity Type

Protein (134)

Refinement Resolution (Å)

	1.0 - 1.5 (33)
	1.5 - 2.0 (63)
	2.0 - 2.5 (27)
	2.5 - 3.0 (8)
	3.0 - 3.5 (1)
	3.5 - 4.0 (1)

Release Date

	2005 - 2009 (1)
	2010 - 2014 (21)
	2015 - 2019 (54)
	2020 - 2024 (58)

Enzyme Classification Name

Transferases (134)

Symmetry Type

	Asymmetric (129)
	Cyclic (7)

SCOP Classification

	Alpha and beta proteins (a+b) (85)
	Artifacts (23)
	All beta proteins (9)
	Small proteins (1)

AllSelected

1 to 25 of 134 Structures

Page 1 of 6

Sort by

Explore in 3D

2GE9 \| pdb_00002ge9	Download File View File

Solution Structures of the SH2 domain of Bruton's Tyrosine Kinase

Cheng, J.-W., Huang, K.-C.

(2006) J Biomol NMR 36: 73-78

Released	2006-10-24
Method	SOLUTION NMR
Organisms	Homo sapiens
Macromolecule	Tyrosine-protein kinase BTK (protein)

Explore in 3D

3GEN \| pdb_00003gen	Download File View File

The 1.6 A crystal structure of human bruton's tyrosine kinase bound to a pyrrolopyrimidine-containing compound

Marcotte, D.J., Liu, Y.T., Arduini, R.M., Hession, C.A., Miatkowski, K., Wildes, C.P., Cullen, P.F., Hopkins, B., Mertsching, E., Jenkins, T.J., Romanowski, M.J., Baker, D.P., Silvian, L.F.

(2010) Protein Sci 19: 429-439

Released	2010-01-19
Method	X-RAY DIFFRACTION 1.6 Å
Organisms	Homo sapiens
Macromolecule	Tyrosine-protein kinase BTK (protein)
Unique Ligands	B43

Explore in 3D

3K54 \| pdb_00003k54	Download File View File

Structures of human Bruton's tyrosine kinase in active and inactive conformations suggests a mechanism of activation for TEC family kinases.

Marcotte, D.J., Liu, Y.-T., Arduini, R.M., Hession, C.A., Miatkowski, K., Wildes, C.P., Cullen, P.F., Hopkins, B.T., Mertsching, E., Jenkins, T.J., Romanowski, M.J., Baker, D.P., Silvian, L.F.

(2010) Protein Sci 19: 429-439

Released	2010-01-19
Method	X-RAY DIFFRACTION 1.94 Å
Organisms	Homo sapiens
Macromolecule	Tyrosine-protein kinase BTK (protein)
Unique Ligands	1N1

Explore in 3D

3OCS \| pdb_00003ocs	Download File View File

Crystal structure of bruton's tyrosine kinase in complex with inhibitor CGI1746

Davies, D.R., Gallion, S.L., Staker, B.L.

To be published

Released	2010-11-03
Method	X-RAY DIFFRACTION 1.8 Å
Organisms	Homo sapiens
Macromolecule	Tyrosine-protein kinase BTK (protein)
Unique Ligands	746, BME, SO4

Explore in 3D

3OCT \| pdb_00003oct	Download File View File

Crystal structure of bruton's tyrosine kinase mutant V555R in complex with dasatinib

Davies, D.R., Staker, B.L.

To be published

Released	2010-11-03
Method	X-RAY DIFFRACTION 1.95 Å
Organisms	Homo sapiens
Macromolecule	Tyrosine-protein kinase BTK (protein)
Unique Ligands	1N1

Explore in 3D

3P08 \| pdb_00003p08	Download File View File

Crystal structure of the human BTK kinase domain

Yu, C.L., Hymowitz, S.G.

To be published

Released	2010-11-03
Method	X-RAY DIFFRACTION 2.3 Å
Organisms	Homo sapiens
Macromolecule	Tyrosine-protein kinase BTK (protein)

Explore in 3D

3PIX \| pdb_00003pix	Download File View File

Crystal structure of BTK kinase domain complexed with 2-Isopropyl-7-(4-methyl-piperazin-1-yl)-4-(5-methyl-2H-pyrazol-3-ylamino)-2H-phthalazin-1-one

Kuglstatter, A., Wong, A.

(2011) Protein Sci 20: 428-436

Released	2011-01-12
Method	X-RAY DIFFRACTION 1.85 Å
Organisms	Homo sapiens
Macromolecule	Tyrosine-protein kinase BTK (protein)
Unique Ligands	027

Explore in 3D

3PIY \| pdb_00003piy	Download File View File

Crystal structure of BTK kinase domain complexed with R406

Kuglstatter, A., Wong, A.

(2011) Protein Sci 20: 428-436

Released	2011-01-12
Method	X-RAY DIFFRACTION 2.55 Å
Organisms	Homo sapiens
Macromolecule	Tyrosine-protein kinase BTK (protein)
Unique Ligands	585

Explore in 3D

3PIZ \| pdb_00003piz	Download File View File

Crystal structure of BTK kinase domain complexed with (5-Amino-1-o-tolyl-1H-pyrazol-4-yl)-[3-(1-methanesulfonyl-piperidin-4-yl)-phenyl]-methanone

Kuglstatter, A., Wong, A.

(2011) Protein Sci 20: 428-436

Released	2011-01-12
Method	X-RAY DIFFRACTION 2.21 Å
Organisms	Homo sapiens
Macromolecule	Tyrosine-protein kinase BTK (protein)
Unique Ligands	03C

Explore in 3D

3PJ1 \| pdb_00003pj1	Download File View File

Crystal structure of BTK kinase domain complexed with 3-(2,6-Dichloro-phenyl)-7-[4-(2-diethylamino-ethoxy)-phenylamino]-1-methyl-3,4-dihydro-1H-pyrimido[4,5-d]pyrimidin-2-one

Kuglstatter, A., Wong, A.

(2011) Protein Sci 20: 428-436

Released	2011-01-12
Method	X-RAY DIFFRACTION 2 Å
Organisms	Homo sapiens
Macromolecule	Tyrosine-protein kinase BTK (protein)
Unique Ligands	LHL

Explore in 3D

3PJ2 \| pdb_00003pj2	Download File View File

Crystal structure of BTK kinase domain complexed with 2-[4-(2-Diethylamino-ethoxy)-phenylamino]-6-(4-fluoro-phenoxy)-8-methyl-8H-pyrido[2,3-d]pyrimidin-7-one

Kuglstatter, A., Wong, A.

(2011) Protein Sci 20: 428-436

Released	2011-01-12
Method	X-RAY DIFFRACTION 1.75 Å
Organisms	Homo sapiens
Macromolecule	Tyrosine-protein kinase BTK (protein)
Unique Ligands	04K

Explore in 3D

3PJ3 \| pdb_00003pj3	Download File View File

Crystal structure of BTK kinase domain complexed with 2-Methyl-5-[(E)-(3-phenyl-acryloyl)amino]-N-(2-phenyl-3H-imidazo[4,5-b]pyridin-6-yl)-benzamide

Kuglstatter, A., Wong, A.

(2011) Protein Sci 20: 428-436

Released	2011-01-12
Method	X-RAY DIFFRACTION 1.85 Å
Organisms	Homo sapiens
Macromolecule	Tyrosine-protein kinase BTK (protein)
Unique Ligands	04L

Explore in 3D

3SXR \| pdb_00003sxr	Download File View File

Crystal structure of BMX non-receptor tyrosine kinase complex with dasatinib

Sack, J., Muckelbauer, J.

(2011) Chem Biol Drug Des 78: 739-748

Released	2011-09-21
Method	X-RAY DIFFRACTION 2.4 Å
Organisms	Homo sapiens
Macromolecule	Cytoplasmic tyrosine-protein kinase BMX (protein)
Unique Ligands	1N1, SO4

Explore in 3D

3SXS \| pdb_00003sxs	Download File View File

Crystal structure of BMX non-receptor tyrosine kinase complexed with PP2

Sack, J., Muckelbauer, J.

(2011) Chem Biol Drug Des 78: 739-748

Released	2011-09-21
Method	X-RAY DIFFRACTION 1.89 Å
Organisms	Homo sapiens
Macromolecule	Cytoplasmic tyrosine-protein kinase BMX (protein)
Unique Ligands	PP2

Explore in 3D

4NWM \| pdb_00004nwm	Download File View File

Crystal structure of Bruton agammaglobulinemia tyrosine kinase complexed with BMS-809959 aka 4-tert-butyl-n-[2-me thyl-3-(6-{[4-(morpholine-4-carbonyl)phenyl]amino}-9h- purin-2-yl)phenyl]benzamide

Muckelbauer, J.K.

(2014) Bioorg Med Chem Lett 24: 2206-2211

Released	2014-04-02
Method	X-RAY DIFFRACTION 2.03 Å
Organisms	Homo sapiens
Macromolecule	Tyrosine-protein kinase BTK (protein)
Unique Ligands	2P5

Explore in 3D

4OT5 \| pdb_00004ot5	Download File View File

Crystal structure of BTK kinase domain complexed with 4-tert-Butyl-N-(3-{8-[4-(4-methyl-piperazine-1-carbonyl)-phenylamino]-imidazo[1,2-a]pyrazin-6-yl}-phenyl)-benzamide

Kuglstatter, A., Wong, A.

(2015) J Med Chem 58: 512-516

Released	2014-05-14
Method	X-RAY DIFFRACTION 1.55 Å
Organisms	Homo sapiens
Macromolecule	Tyrosine-protein kinase BTK (protein)
Unique Ligands	481, DMS

Explore in 3D

4OT6 \| pdb_00004ot6	Download File View File

Crystal structure of BTK kinase domain complexed with 4-Methanesulfonyl-N-(3-{8-[4-(morpholine-4-carbonyl)-phenylamino]-imidazo[1,2-a]pyrazin-6-yl}-phenyl)-benzamide

Kuglstatter, A., Wong, A.

(2015) J Med Chem 58: 512-516

Released	2014-05-14
Method	X-RAY DIFFRACTION 2.05 Å
Organisms	Homo sapiens
Macromolecule	Tyrosine-protein kinase BTK (protein)
Unique Ligands	2V1

Explore in 3D

4OTF \| pdb_00004otf	Download File View File

Crystal structure of the kinase domain of Bruton's Tyrosine kinase with GDC0834

Hymowitz, S.G., Maurer, B.

(2015) Bioorg Med Chem Lett 25: 1333-1337

Released	2015-01-28
Method	X-RAY DIFFRACTION 1.95 Å
Organisms	Homo sapiens
Macromolecule	Tyrosine-protein kinase BTK (protein)
Unique Ligands	2VL, SO4

Explore in 3D

4OTQ \| pdb_00004otq	Download File View File

Crystal structure of BTK kinase domain complexed with 1-[5-[3-(7-tert-butyl-4-oxo-quinazolin-3-yl)-2-methyl-phenyl]-1-methyl-2-oxo-3-pyridyl]-3-methyl-urea

Kuglstatter, A., Wong, A.

(2015) J Med Chem 58: 512-516

Released	2014-05-14
Method	X-RAY DIFFRACTION 1.55 Å
Organisms	Homo sapiens
Macromolecule	Tyrosine-protein kinase BTK (protein)
Unique Ligands	2V2, DMS

Explore in 3D

4OTR \| pdb_00004otr	Download File View File

Crystal structure of BTK kinase domain complexed with 6-cyclopropyl-2-[3-[5-[[5-(4-ethylpiperazin-1-yl)-2-pyridyl]amino]-1-methyl-6-oxo-3-pyridyl]-2-(hydroxymethyl)phenyl]-8-fluoro-isoquinolin-1-one

Kuglstatter, A., Wong, A.

(2015) J Med Chem 58: 512-516

Released	2014-05-14
Method	X-RAY DIFFRACTION 1.95 Å
Organisms	Homo sapiens
Macromolecule	Tyrosine-protein kinase BTK (protein)
Unique Ligands	2V3, DMS

Explore in 3D

4RFY \| pdb_00004rfy	Download File View File

Crystal structure of BTK kinase domain complexed with 6-(dimethylamino)-2-[2-(hydroxymethyl)-3-[1-methyl-5-[[5-(morpholine-4-carbonyl)-2-pyridyl]amino]-6-oxo-3-pyridyl]phenyl]-3,4-dihydroisoquinolin-1-one

Kuglstatter, A., Wong, A.

(2015) Bioorg Med Chem Lett 25: 367-371

Released	2014-12-24
Method	X-RAY DIFFRACTION 1.7 Å
Organisms	Homo sapiens
Macromolecule	Tyrosine-protein kinase BTK (protein)
Unique Ligands	3OU, DMS

Explore in 3D

4RFZ \| pdb_00004rfz	Download File View File

Crystal structure of BTK kinase domain complexed with 6-(dimethylamino)-8-fluoro-2-[2-(hydroxymethyl)-3-[1-methyl-5-[[5-(morpholine-4-carbonyl)-2-pyridyl]amino]-6-oxo-3-pyridyl]phenyl]isoquinolin-1-one

Kuglstatter, A., Wong, A.

(2015) Bioorg Med Chem Lett 25: 367-371

Released	2014-12-24
Method	X-RAY DIFFRACTION 1.17 Å
Organisms	Homo sapiens
Macromolecule	Tyrosine-protein kinase BTK (protein)
Unique Ligands	3OV, DMS

Explore in 3D

4RG0 \| pdb_00004rg0	Download File View File

Crystal structure of BTK kinase domain complexed with 2-[8-fluoro-2-[2-(hydroxymethyl)-3-[1-methyl-5-[[5-(4-methylpiperazin-1-yl)-2-pyridyl]amino]-6-oxo-3-pyridyl]phenyl]-1-oxo-3,4-dihydroisoquinolin-6-yl]-2-methyl-propanenitrile

Kuglstatter, A., Wong, A.

(2015) Bioorg Med Chem Lett 25: 367-371

Released	2014-12-24
Method	X-RAY DIFFRACTION 2.5 Å
Organisms	Homo sapiens
Macromolecule	Tyrosine-protein kinase BTK (protein)
Unique Ligands	3P0

Explore in 3D

4RX5 \| pdb_00004rx5	Download File View File

Bruton's tyrosine kinase (BTK) with pyridazinone compound 23

Eigenbrot, C., Yu, C.

(2016) Bioorg Med Chem Lett 26: 575-579

Released	2015-12-02
Method	X-RAY DIFFRACTION 1.356 Å
Organisms	Homo sapiens
Macromolecule	Tyrosine-protein kinase BTK (protein)
Unique Ligands	3YO, GOL, PG0, SO4