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235,183 Structures from the PDB

1,068,577 Computed Structure Models (CSM)

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Search Summary

This query matches 65 Structures.

Refinements

Structure Determination Methodology

experimental (65)

Scientific Name of Source Organism

	Rattus norvegicus (24)
	Homo sapiens (10)
	Cryptococcus neoformans var. grubii H99 (8)
	Aspergillus fumigatus Af293 (3)
	Escherichia coli (2)
	Methanosarcina acetivorans C2A (2)
	Streptomyces showdoensis (2)
	Trichoderma atroviride (2)
	Alternaria alternata (1)
	Arabidopsis thaliana (1)

More...

Taxonomy

	Eukaryota (53)
	Bacteria (10)
	Archaea (2)
	Eukaryota (eukaryotes) (1)
	unclassified sequences (1)

Experimental Method

X-RAY DIFFRACTION (65)

Polymer Entity Type

Protein (65)

Refinement Resolution (Å)

	1.0 - 1.5 (1)
	1.5 - 2.0 (17)
	2.0 - 2.5 (31)
	2.5 - 3.0 (13)
	3.0 - 3.5 (2)
	3.5 - 4.0 (1)

Release Date

	1995 - 1999 (3)
	2000 - 2004 (12)
	2005 - 2009 (14)
	2010 - 2014 (15)
	2015 - 2019 (5)
	2020 - 2024 (16)

Enzyme Classification Name

	Transferases (50)
	Lyases (5)
	Hydrolases (2)
	Isomerases (2)

Membrane Protein Annotation

	MemProtMD (1)
	PDBTM (1)

Symmetry Type

	Asymmetric (51)
	Cyclic (14)
	Dihedral (1)

SCOP Classification

	All alpha proteins (40)
	Alpha and beta proteins (a/b) (4)
	Alpha and beta proteins (a+b) (1)

AllSelected

1 to 25 of 65 Structures

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1FPP \| pdb_00001fpp	Download File View File

PROTEIN FARNESYLTRANSFERASE COMPLEX WITH FARNESYL DIPHOSPHATE

Dunten, P., Kammlott, U., Crowther, R., Weber, D., Palermo, R., Birktoft, J.

(1998) Biochemistry 37: 7907-7912

Released	1999-06-08
Method	X-RAY DIFFRACTION 2.75 Å
Organisms	Rattus norvegicus
Macromolecule	PROTEIN FARNESYLTRANSFERASE (protein)
Unique Ligands	FPP, PO4, ZN

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1FT2 \| pdb_00001ft2	Download File View File

CO-CRYSTAL STRUCTURE OF PROTEIN FARNESYLTRANSFERASE COMPLEXED WITH A FARNESYL DIPHOSPHATE SUBSTRATE

Beese, L.S., Casey, P.J., Long, S.B.

(1998) Biochemistry 37: 9612-9618

Released	1998-11-04
Method	X-RAY DIFFRACTION 3.4 Å
Organisms	Rattus norvegicus
Macromolecule	PROTEIN FARNESYLTRANSFERASE (protein)
Unique Ligands	FPP, ZN

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1JCQ \| pdb_00001jcq	Download File View File

CRYSTAL STRUCTURE OF HUMAN PROTEIN FARNESYLTRANSFERASE COMPLEXED WITH FARNESYL DIPHOSPHATE AND THE PEPTIDOMIMETIC INHIBITOR L-739,750

Long, S.B., Casey, P.J., Beese, L.S.

(2001) Proc Natl Acad Sci U S A 98: 12948-12953

Released	2001-11-02
Method	X-RAY DIFFRACTION 2.3 Å
Organisms	Homo sapiens
Macromolecule	PROTEIN FARNESYLTRANSFERASE, ALPHA SUBUNIT (protein) PROTEIN FARNESYLTRANSFERASE, BETA SUBUNIT (protein)
Unique Ligands	739, ACY, FPP, ZN
Unique branched monosaccharides	FRU, GLC

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1JCR \| pdb_00001jcr	Download File View File

CRYSTAL STRUCTURE OF RAT PROTEIN FARNESYLTRANSFERASE COMPLEXED WITH THE NON-SUBSTRATE TETRAPEPTIDE INHIBITOR CVFM AND FARNESYL DIPHOSPHATE SUBSTRATE

Long, S.B., Casey, P.J., Beese, L.S.

(2001) Proc Natl Acad Sci U S A 98: 12948-12953

Released	2001-11-02
Method	X-RAY DIFFRACTION 2 Å
Organisms	Rattus norvegicus
Macromolecule	PROTEIN FARNESYLTRANSFERASE, ALPHA SUBUNIT (protein) PROTEIN FARNESYLTRANSFERASE, BETA SUBUNIT (protein) SYNTHETIC TETRAPEPTIDE CVFM (protein)
Unique Ligands	ACY, FPP, ZN

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1KZO \| pdb_00001kzo	Download File View File

PROTEIN FARNESYLTRANSFERASE COMPLEXED WITH FARNESYLATED K-RAS4B PEPTIDE PRODUCT AND FARNESYL DIPHOSPHATE SUBSTRATE BOUND SIMULTANEOUSLY

Long, S.B., Casey, P.J., Beese, L.S.

(2002) Nature 419: 645-650

Released	2002-10-16
Method	X-RAY DIFFRACTION 2.2 Å
Organisms	Homo sapiens Rattus norvegicus
Macromolecule	Farnesylated K-Ras4B peptide product (protein) Protein Farnesyltransferase alpha subunit (protein) Protein Farnesyltransferase beta subunit (protein)
Unique Ligands	ACY, FAR, FPP, ZN

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1LD7 \| pdb_00001ld7	Download File View File

Co-crystal structure of Human Farnesyltransferase with farnesyldiphosphate and inhibitor compound 66

Taylor, J.S., Terry, K.L., Beese, L.S.

(2002) J Med Chem 45: 2388-2409

Released	2002-06-19
Method	X-RAY DIFFRACTION 2 Å
Organisms	Homo sapiens
Macromolecule	protein farnesyltransferase alpha subunit (protein) protein farnesyltransferase beta subunit (protein)
Unique Ligands	FPP, U66, ZN
Unique branched monosaccharides	FRU, GLC

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1LD8 \| pdb_00001ld8	Download File View File

Co-crystal structure of Human Farnesyltransferase with farnesyldiphosphate and inhibitor compound 49

Taylor, J.S., Terry, K.L., Beese, L.S.

(2002) J Med Chem 45: 2388-2409

Released	2002-06-19
Method	X-RAY DIFFRACTION 1.8 Å
Organisms	Homo sapiens
Macromolecule	protein farnesyltransferase alpha subunit (protein) protein farnesyltransferase beta subunit (protein)
Unique Ligands	ACY, FPP, U49, ZN
Unique branched monosaccharides	FRU, GLC

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1MZC \| pdb_00001mzc	Download File View File

Co-Crystal Structure Of Human Farnesyltransferase With Farnesyldiphosphate and Inhibitor Compound 33a

deSolms, S.J., Ciccarone, T.M., MacTough, S.C., Shaw, A.W., Buser, C.A., Ellis-Hutchings, M., Fernandes, C., Hamilton, K.A., Huber, H.E., Kohl, N.E., Lobell, R.B., Robinson, R.G., Tsou, N.N., Walsh, E.S., Graham, S.L., Beese, L.S., Taylor, J.S.

(2003) J Med Chem 46: 2973-2984

Released	2003-07-08
Method	X-RAY DIFFRACTION 2 Å
Organisms	Homo sapiens
Macromolecule	Protein Farnesyltransferase alpha Subunit (protein) Protein Farnesyltransferase beta Subunit (protein)
Unique Ligands	BNE, FPP, ZN
Unique branched monosaccharides	FRU, GLC

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1O5M \| pdb_00001o5m	Download File View File

Structure of FPT bound to the inhibitor SCH66336

Strickland, C.L., Weber, P.C., Ganguly, A.K.

(1999) J Med Chem 42: 2125-2135

Released	2003-10-21
Method	X-RAY DIFFRACTION 2.3 Å
Organisms	Rattus norvegicus
Macromolecule	Protein farnesyltransferase alpha subunit (protein) Protein farnesyltransferase beta subunit (protein)
Unique Ligands	336, FPP, ZN

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1S63 \| pdb_00001s63	Download File View File

Human protein farnesyltransferase complexed with L-778,123 and FPP

Long, S.B., Casey, P.J., Beese, L.S.

(2004) Biochemistry 43: 9000-9008

Released	2004-07-27
Method	X-RAY DIFFRACTION 1.9 Å
Organisms	Homo sapiens
Macromolecule	Protein farnesyltransferase beta subunit (protein) Protein farnesyltransferase/geranylgeranyltransferase type I alpha subunit (protein)
Unique Ligands	778, FPP, ZN
Unique branched monosaccharides	FRU, GLC

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1SA4 \| pdb_00001sa4	Download File View File

human protein farnesyltransferase complexed with FPP and R115777

Reid, T.S., Beese, L.S.

(2004) Biochemistry 43: 6877-6884

Released	2004-06-08
Method	X-RAY DIFFRACTION 2.1 Å
Organisms	Homo sapiens
Macromolecule	Protein farnesyltransferase beta subunit (protein) Protein farnesyltransferase/geranylgeranyltransferase type I alpha subunit (protein)
Unique Ligands	FPP, JAN, ZN
Unique branched monosaccharides	FRU, GLC

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1SA5 \| pdb_00001sa5	Download File View File

Rat protein farnesyltransferase complexed with FPP and BMS-214662

Reid, T.S., Beese, L.S.

(2004) Biochemistry 43: 6877-6884

Released	2004-06-08
Method	X-RAY DIFFRACTION 2.6 Å
Organisms	Rattus norvegicus
Macromolecule	Protein farnesyltransferase beta subunit (protein) Protein farnesyltransferase/geranylgeranyltransferase type I alpha subunit (protein)
Unique Ligands	ACY, BMV, FPP, ZN

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1T0A \| pdb_00001t0a	Download File View File

Crystal Structure of 2C-Methyl-D-Erythritol-2,4-cyclodiphosphate Synthase from Shewanella Oneidensis

Ni, S., Robinson, H., Marsing, G.C., Bussiere, D.E., Kennedy, M.A.

(2004) Acta Crystallogr D Biol Crystallogr 60: 1949-1957

Released	2004-10-26
Method	X-RAY DIFFRACTION 1.6 Å
Organisms	Shewanella oneidensis MR-1
Macromolecule	2C-methyl-D-erythritol 2,4-cyclodiphosphate synthase (protein)
Unique Ligands	CO, FPP, ZN

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1UBX \| pdb_00001ubx	Download File View File

STRUCTURE OF FARNESYL PYROPHOSPHATE SYNTHETASE

Tarshis, L.C., Proteau, P., Poulter, C.D., Sacchettini, J.C.

(1996) Proc Natl Acad Sci U S A 93: 15018-15023

Released	1997-03-12
Method	X-RAY DIFFRACTION 2.5 Å
Organisms	Gallus gallus
Macromolecule	FARNESYL DIPHOSPHATE SYNTHASE (protein)
Unique Ligands	FPP, MG

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1V7U \| pdb_00001v7u	Download File View File

Crystal structure of Undecaprenyl Pyrophosphate Synthase with farnesyl pyrophosphate

Chang, S.-Y., Ko, T.-P., Chen, A.P.-C., Wang, A.H.-J., Liang, P.-H.

(2004) Protein Sci 13: 971-978

Released	2004-01-13
Method	X-RAY DIFFRACTION 2.35 Å
Organisms	Escherichia coli
Macromolecule	Undecaprenyl pyrophosphate synthetase (protein)
Unique Ligands	FPP

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2BED \| pdb_00002bed	Download File View File

Structure of FPT bound to inhibitor SCH207736

Strickland, C.

(2006) Bioorg Med Chem Lett 16: 984-988

Released	2006-08-08
Method	X-RAY DIFFRACTION 2.7 Å
Organisms	Rattus norvegicus
Macromolecule	Protein farnesyltransferase beta subunit (protein) Protein farnesyltransferase/geranylgeranyltransferase type I alpha subunit (protein)
Unique Ligands	736, FPP, ZN

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2E90 \| pdb_00002e90	Download File View File

S. cerevisiae geranylgeranyl pyrophosphate synthase in complex with magnesium, pyrophosphate and FPP

Guo, R.T., Ko, T.P., Chen, C.K.-M., Jeng, W.Y., Chang, T.H., Liang, P.H., Oldfield, E., Wang, A.H.-J.

(2007) Proc Natl Acad Sci U S A 104: 10022-10027

Released	2007-06-12
Method	X-RAY DIFFRACTION 2.55 Å
Organisms	Saccharomyces cerevisiae
Macromolecule	Geranylgeranyl pyrophosphate synthetase (protein)
Unique Ligands	FPP, MG, PPV

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2F0Y \| pdb_00002f0y	Download File View File

Crystal Structure Of Human Protein Farnesyltransferase Complexed With Farnesyl Diphosphate and hydantoin derivative

Kim, K.H., Lee, J., Kim, J.

To be published

Released	2006-11-14
Method	X-RAY DIFFRACTION 2.7 Å
Organisms	Homo sapiens
Macromolecule	Protein farnesyltransferase beta subunit (protein) Protein farnesyltransferase/geranylgeranyltransferase type I alpha subunit (protein)
Unique Ligands	3MN, FPP, ZN

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2R2L \| pdb_00002r2l	Download File View File

Structure of Farnesyl Protein Transferase bound to PB-93

Strickland, C.O., Voorhis, W.

(2007) Antimicrob Agents Chemother 51: 3659-3671

Released	2008-03-11
Method	X-RAY DIFFRACTION 2.23 Å
Organisms	Rattus norvegicus
Macromolecule	Farnesyltransferase subunit alpha (protein) Farnesyltransferase subunit beta (protein)
Unique Ligands	FPP, PB9, ZN

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2VG1 \| pdb_00002vg1	Download File View File

Rv1086 E,E-farnesyl diphosphate complex

Naismith, J.H., Wang, W., Dong, C.

(2008) J Mol Biology 381: 129-140

Released	2007-11-13
Method	X-RAY DIFFRACTION 1.7 Å
Organisms	Mycobacterium tuberculosis
Macromolecule	SHORT-CHAIN Z-ISOPRENYL DIPHOSPHATE SYNTHETASE (protein)
Unique Ligands	FPP, GOL, PO4

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2ZIR \| pdb_00002zir	Download File View File

Crystal Structure of rat protein farnesyltransferase complexed with a benzofuran inhibitor and FPP

Fukami, T.A., Sogabe, S., Nagata, Y., Kondoh, O., Ishii, N.

(2009) Bioorg Med Chem Lett 19: 1753-1757

Released	2009-02-24
Method	X-RAY DIFFRACTION 2.4 Å
Organisms	Rattus norvegicus
Macromolecule	Protein farnesyltransferase subunit alpha (protein) Protein farnesyltransferase subunit beta (protein)
Unique Ligands	FPP, GOL, NH7, ZN

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2ZIS \| pdb_00002zis	Download File View File

Crystal Structure of rat protein farnesyltransferase complexed with a bezoruran inhibitor and FPP

Fukami, T.A., Sogabe, S., Nagata, Y., Kondoh, O., Ishii, N.

(2009) Bioorg Med Chem Lett 19: 1753-1757

Released	2009-02-24
Method	X-RAY DIFFRACTION 2.6 Å
Organisms	Rattus norvegicus
Macromolecule	Protein farnesyltransferase subunit alpha (protein) Protein farnesyltransferase subunit beta (protein)
Unique Ligands	ACY, FPP, GOL, NH8, ZN

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3AQ0 \| pdb_00003aq0	Download File View File

Ligand-bound form of Arabidopsis medium/long-chain length prenyl pyrophosphate synthase (surface polar residue mutant)

Hsieh, F.-L., Chang, T.-H., Ko, T.-P., Wang, A.H.-J.

(2011) Plant Physiol 155: 1079-1090

Released	2011-01-19
Method	X-RAY DIFFRACTION 2.65 Å
Organisms	Arabidopsis thaliana
Macromolecule	Geranyl diphosphate synthase (protein)
Unique Ligands	FPP, ISY, MG, PEG, PPV

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3BNX \| pdb_00003bnx	Download File View File

Crystal structure of Aristolochene synthase complexed with farnesyl diphosphate

Shishova, E.Y., Christianson, D.W.

(2008) J Biological Chem 283: 15431-15439

Released	2008-03-25
Method	X-RAY DIFFRACTION 2.1 Å
Organisms	Aspergillus terreus
Macromolecule	Aristolochene synthase (protein)
Unique Ligands	BME, FPP, GOL, MG, POP

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3DPY \| pdb_00003dpy	Download File View File

Protein farnesyltransferase complexed with FPP and caged TKCVIM substrate

Hast, M.A., Beese, L.S.

(2008) Chem Biol Drug Des 72: 171-181

Released	2008-09-30
Method	X-RAY DIFFRACTION 2.7 Å
Organisms	Rattus norvegicus
Macromolecule	Protein farnesyltransferase subunit beta (protein) Protein farnesyltransferase/geranylgeranyltransferase type-1 subunit alpha (protein) caged substrate (protein)
Unique Ligands	ACY, FPP, ZN

1 to 25 of 65 Structures

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Structure Determination Methodology

Scientific Name of Source Organism

Taxonomy

Experimental Method

Polymer Entity Type

Refinement Resolution (Å)

Release Date

Enzyme Classification Name

Membrane Protein Annotation

Symmetry Type

SCOP Classification

1FPP | pdb_00001fpp

1FT2 | pdb_00001ft2

1JCQ | pdb_00001jcq

1JCR | pdb_00001jcr

1KZO | pdb_00001kzo

1LD7 | pdb_00001ld7

1LD8 | pdb_00001ld8

1MZC | pdb_00001mzc

1O5M | pdb_00001o5m

1S63 | pdb_00001s63

1SA4 | pdb_00001sa4

1SA5 | pdb_00001sa5

1T0A | pdb_00001t0a

1UBX | pdb_00001ubx

1V7U | pdb_00001v7u

2BED | pdb_00002bed

2E90 | pdb_00002e90

2F0Y | pdb_00002f0y

2R2L | pdb_00002r2l

2VG1 | pdb_00002vg1

2ZIR | pdb_00002zir

2ZIS | pdb_00002zis

3AQ0 | pdb_00003aq0

3BNX | pdb_00003bnx

3DPY | pdb_00003dpy