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235,183 Structures from the PDB

1,068,577 Computed Structure Models (CSM)

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QUERY: Citation Author = "van Montfort, R.L."

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Search Summary

This query matches 91 Structures.

Refinements

Structure Determination Methodology

experimental (91)

Scientific Name of Source Organism

	Homo sapiens (77)
	Bos taurus (10)
	Escherichia coli K-12 (3)
	Escherichia coli (2)

Taxonomy

	Eukaryota (87)
	Bacteria (4)

Experimental Method

	X-RAY DIFFRACTION (89)
	SOLUTION NMR (2)

Polymer Entity Type

Protein (91)

Refinement Resolution (Å)

	1.0 - 1.5 (1)
	1.5 - 2.0 (36)
	2.0 - 2.5 (34)
	2.5 - 3.0 (17)
	3.0 - 3.5 (1)

Release Date

	1995 - 1999 (2)
	2000 - 2004 (4)
	2005 - 2009 (5)
	2010 - 2014 (31)
	2015 - 2019 (49)

Enzyme Classification Name

	Transferases (52)
	Hydrolases (24)
	Oxidoreductases (13)

Symmetry Type

	Asymmetric (85)
	Cyclic (6)

SCOP Classification

	Alpha and beta proteins (a/b) (27)
	Artifacts (41)
	All beta proteins (13)
	Alpha and beta proteins (a+b) (29)
	Membrane and cell surface proteins and peptides (8)

AllSelected

1 to 25 of 91 Structures

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1A3A \| pdb_00001a3a	Download File View File

CRYSTAL STRUCTURE OF IIA MANNITOL FROM ESCHERICHIA COLI

Van Montfort, R.L.M., Pijning, T., Kalk, K.H., Hangyi, I., Kouwijzer, M.L.C.E., Robillard, G.T., Dijkstra, B.W.

(1998) Structure 6: 377-388

Released	1998-08-12
Method	X-RAY DIFFRACTION 1.8 Å
Organisms	Escherichia coli K-12
Macromolecule	MANNITOL-SPECIFIC EII (protein)

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1IIB \| pdb_00001iib	Download File View File

CRYSTAL STRUCTURE OF IIBCELLOBIOSE FROM ESCHERICHIA COLI

Van Montfort, R.L.M., Pijning, T., Kalk, K.H., Reizer, J., Saier, M.H., Thunnissen, M.M.G.M., Robillard, G.T., Dijkstra, B.W.

(1997) Structure 5: 217-225

Released	1997-12-24
Method	X-RAY DIFFRACTION 1.8 Å
Organisms	Escherichia coli K-12
Macromolecule	ENZYME IIB OF THE CELLOBIOSE-SPECIFIC PHOSPHOTRANSFERASE SYSTEM (protein)

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1OES \| pdb_00001oes	Download File View File

Oxidation state of protein tyrosine phosphatase 1B

van Montfort, R.L.M., Congreve, M., Tisi, D., Carr, R., Jhoti, H.

(2003) Nature 423: 773-777

Released	2003-06-12
Method	X-RAY DIFFRACTION 2.2 Å
Organisms	Homo sapiens
Macromolecule	PROTEIN-TYROSINE PHOSPHATASE, NON-RECEPTOR TYPE 1 (protein)
Unique Ligands	MG

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1OET \| pdb_00001oet	Download File View File

Oxidation state of protein tyrosine phosphatase 1B

van Montfort, R.L.M., Congreve, M., Tisi, D., Carr, R., Jhoti, H.

(2003) Nature 423: 773-777

Released	2003-06-12
Method	X-RAY DIFFRACTION 2.3 Å
Organisms	Homo sapiens
Macromolecule	-TYROSINE PHOSPHATASE, NON-RECEPTOR TYPE 1 (protein)
Unique Ligands	MG

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1OEU \| pdb_00001oeu	Download File View File

Oxidation state of protein tyrosine phosphatase 1B

van Montfort, R.L.M., Congreve, M., Tisi, D., Carr, R., Jhoti, H.

(2003) Nature 423: 773-777

Released	2003-06-12
Method	X-RAY DIFFRACTION 2.5 Å
Organisms	Homo sapiens
Macromolecule	PROTEIN-TYROSINE PHOSPHATASE, NON-RECEPTOR TYPE 1 (protein)
Unique Ligands	MG

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1OEV \| pdb_00001oev	Download File View File

Oxidation state of protein tyrosine phosphatase 1B

van Montfort, R.L.M., Congreve, M., Tisi, D., Carr, R., Jhoti, H.

(2003) Nature 423: 773-777

Released	2003-06-12
Method	X-RAY DIFFRACTION 2.2 Å
Organisms	Homo sapiens
Macromolecule	PROTEIN-TYROSINE PHOSPHATASE, NON-RECEPTOR TYPE 1 (protein)
Unique Ligands	MG

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2W5A \| pdb_00002w5a	Download File View File

Human Nek2 kinase ADP-bound

Westwood, I., Bayliss, R.

(2009) J Mol Biology 386: 476

Released	2008-12-23
Method	X-RAY DIFFRACTION 1.55 Å
Organisms	Homo sapiens
Macromolecule	SERINE/THREONINE-PROTEIN KINASE NEK2 (protein)
Unique Ligands	ADP, EDO, MG

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2W5B \| pdb_00002w5b	Download File View File

Human Nek2 kinase ATPgammaS-bound

Bayliss, R.

(2009) J Mol Biology 386: 476

Released	2008-12-23
Method	X-RAY DIFFRACTION 2.4 Å
Organisms	Homo sapiens
Macromolecule	SERINE/THREONINE-PROTEIN KINASE NEK2 (protein)
Unique Ligands	AGS, CL, MG

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2W5H \| pdb_00002w5h	Download File View File

Human Nek2 kinase Apo

Bayliss, R.

(2009) J Mol Biology 386: 476

Released	2008-12-23
Method	X-RAY DIFFRACTION 2.33 Å
Organisms	Homo sapiens
Macromolecule	SERINE/THREONINE-PROTEIN KINASE NEK2 (protein)

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2WWV \| pdb_00002wwv	Download File View File

NMR structure of the IIAchitobiose-IIBchitobiose complex of the N,N'- diacetylchitoboise brance of the E. coli phosphotransferase system.

Sang, Y.S., Cai, M., Clore, G.M.

(2010) J Biological Chem 285: 4173

Released	2009-12-08
Method	SOLUTION NMR
Organisms	Escherichia coli Escherichia coli K-12
Macromolecule	N\,N'-DIACETYLCHITOBIOSE-SPECIFIC PHOSPHOTRANSFERASE ENZYME IIA COMPONENT (protein) N\,N'-DIACETYLCHITOBIOSE-SPECIFIC PHOSPHOTRANSFERASE ENZYME IIB COMPONENT (protein)

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2WY2 \| pdb_00002wy2	Download File View File

NMR structure of the IIAchitobiose-IIBchitobiose phosphoryl transition state complex of the N,N'-diacetylchitoboise brance of the E. coli phosphotransferase system.

Sang, Y.S., Cai, M., Clore, G.M.

(2010) J Biological Chem 285: 4173

Released	2009-12-08
Method	SOLUTION NMR
Organisms	Escherichia coli
Macromolecule	N\,N'-DIACETYLCHITOBIOSE-SPECIFIC PHOSPHOTRANSFERASE ENZYME IIA COMPONENT (protein) N\,N'-DIACETYLCHITOBIOSE-SPECIFIC PHOSPHOTRANSFERASE ENZYME IIB COMPONENT (protein)
Unique Ligands	PO3

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2XK3 \| pdb_00002xk3	Download File View File

Structure of Nek2 bound to Aminopyrazine compound 35

Mas-Droux, C., Bayliss, R.

(2010) J Med Chem 53: 7682

Released	2010-10-27
Method	X-RAY DIFFRACTION 2.2 Å
Organisms	Homo sapiens
Macromolecule	SERINE/THREONINE-PROTEIN KINASE NEK2 (protein)
Unique Ligands	CL, XK3

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2XK4 \| pdb_00002xk4	Download File View File

Structure of Nek2 bound to aminopyrazine compound 17

Mas-Droux, C., Bayliss, R.

(2010) J Med Chem 53: 7682

Released	2010-10-27
Method	X-RAY DIFFRACTION 2.1 Å
Organisms	Homo sapiens
Macromolecule	SERINE/THREONINE-PROTEIN KINASE NEK2 (protein)
Unique Ligands	CL, OL2

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2XK6 \| pdb_00002xk6	Download File View File

Structure of Nek2 bound to aminopyrazine compound 36

Mas-Droux, C., Bayliss, R.

(2010) J Med Chem 53: 7682

Released	2010-10-27
Method	X-RAY DIFFRACTION 2.2 Å
Organisms	Homo sapiens
Macromolecule	SERINE/THREONINE-PROTEIN KINASE NEK2 (protein)
Unique Ligands	CL, EQH

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2XK7 \| pdb_00002xk7	Download File View File

Structure of Nek2 bound to aminopyrazine compound 23

Mas-Droux, C., Bayliss, R.

(2010) J Med Chem 53: 7682

Released	2010-10-27
Method	X-RAY DIFFRACTION 1.992 Å
Organisms	Homo sapiens
Macromolecule	SERINE/THREONINE-PROTEIN KINASE NEK2 (protein)
Unique Ligands	30E, CL

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2XK8 \| pdb_00002xk8	Download File View File

Structure of Nek2 bound to aminopyrazine compound 15

Mas-Droux, C., Bayliss, R.

(2010) J Med Chem 53: 7682

Released	2010-10-27
Method	X-RAY DIFFRACTION 2.001 Å
Organisms	Homo sapiens
Macromolecule	SERINE/THREONINE-PROTEIN KINASE NEK2 (protein)
Unique Ligands	5R1, CL

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2XKC \| pdb_00002xkc	Download File View File

Structure of Nek2 bound to aminopyrazine compound 14

Mas-Droux, C., Bayliss, R.

(2010) J Med Chem 53: 7682

Released	2010-10-27
Method	X-RAY DIFFRACTION 2.5 Å
Organisms	Homo sapiens
Macromolecule	SERINE/THREONINE-PROTEIN KINASE NEK2 (protein)
Unique Ligands	4VQ, CL

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2XKD \| pdb_00002xkd	Download File View File

Structure of Nek2 bound to aminopyrazine compound 12

Mas-Droux, C., Bayliss, R.

(2010) J Med Chem 53: 7682

Released	2010-10-27
Method	X-RAY DIFFRACTION 1.96 Å
Organisms	Homo sapiens
Macromolecule	SERINE/THREONINE-PROTEIN KINASE NEK2 (protein)
Unique Ligands	CL, T3M

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2XKE \| pdb_00002xke	Download File View File

Structure of Nek2 bound to Aminipyrazine Compound 5

Mas-Droux, C., Bayliss, R.

(2010) J Med Chem 53: 7682

Released	2010-11-03
Method	X-RAY DIFFRACTION 2.203 Å
Organisms	Homo sapiens
Macromolecule	SERINE/THREONINE-PROTEIN KINASE NEK2 (protein)
Unique Ligands	CL, WI2

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2XKF \| pdb_00002xkf	Download File View File

Structure of Nek2 bound to aminopyrazine compound 2

Mas-Droux, C., Bayliss, R.

(2010) J Med Chem 53: 7682

Released	2010-10-27
Method	X-RAY DIFFRACTION 2.35 Å
Organisms	Homo sapiens
Macromolecule	SERINE/THREONINE-PROTEIN KINASE NEK2 (protein)
Unique Ligands	BX1, CL

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2XNM \| pdb_00002xnm	Download File View File

Structure of NEK2 bound to CCT

Mas-Droux, C., Bayliss, R.

(2011) J Med Chem 54: 1626

Released	2011-03-30
Method	X-RAY DIFFRACTION 1.85 Å
Organisms	Homo sapiens
Macromolecule	SERINE/THREONINE-PROTEIN KINASE NEK2 (protein)
Unique Ligands	CL, EDO, TRS, WGZ

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2XNN \| pdb_00002xnn	Download File View File

Structure of Nek2 bound to CCT242430

Mas-Droux, C., Bayliss, R.

(2011) J Med Chem 54: 1626

Released	2011-03-30
Method	X-RAY DIFFRACTION 2.5 Å
Organisms	Homo sapiens
Macromolecule	SERINE/THREONINE-PROTEIN KINASE NEK2 (protein)
Unique Ligands	430, CL, EDO

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2XNO \| pdb_00002xno	Download File View File

Structure of Nek2 bound to CCT243779

Mas-Droux, C., Bayliss, R.

(2011) J Med Chem 54: 1626

Released	2011-03-30
Method	X-RAY DIFFRACTION 1.98 Å
Organisms	Homo sapiens
Macromolecule	SERINE/THREONINE-PROTEIN KINASE NEK2 (protein)
Unique Ligands	CL, DMS, ED8, EDO, GOL

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2XNP \| pdb_00002xnp	Download File View File

Structure of Nek2 bound to CCT244858

Mas-Droux, C., Bayliss, R.

(2011) J Med Chem 54: 1626

Released	2011-03-30
Method	X-RAY DIFFRACTION 1.98 Å
Organisms	Homo sapiens
Macromolecule	SERINE/THREONINE-PROTEIN KINASE NEK2 (protein)
Unique Ligands	CL, EDO, WCX

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3ZO1 \| pdb_00003zo1	Download File View File

The Synthesis and Evaluation of Diazaspirocyclic Protein Kinase Inhibitors

Allen, C.E., Chow, C.L., Caldwell, J.J., Westwood, I.M., van Montfort, R.L., Collins, I.

(2013) Bioorg Med Chem 21: 5707-5724

Released	2013-03-06
Method	X-RAY DIFFRACTION 2 Å
Organisms	Bos taurus
Macromolecule	CAMP-DEPENDENT PROTEIN KINASE CATALYTIC SUBUNIT ALPHA (protein) CAMP-DEPENDENT PROTEIN KINASE INHIBITOR ALPHA (protein)
Unique Ligands	GOL, MOH, SIJ

1 to 25 of 91 Structures

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Structure Determination Methodology

Scientific Name of Source Organism

Taxonomy

Experimental Method

Polymer Entity Type

Refinement Resolution (Å)

Release Date

Enzyme Classification Name

Symmetry Type

SCOP Classification

1A3A | pdb_00001a3a

1IIB | pdb_00001iib

1OES | pdb_00001oes

1OET | pdb_00001oet

1OEU | pdb_00001oeu

1OEV | pdb_00001oev

2W5A | pdb_00002w5a

2W5B | pdb_00002w5b

2W5H | pdb_00002w5h

2WWV | pdb_00002wwv

2WY2 | pdb_00002wy2

2XK3 | pdb_00002xk3

2XK4 | pdb_00002xk4

2XK6 | pdb_00002xk6

2XK7 | pdb_00002xk7

2XK8 | pdb_00002xk8

2XKC | pdb_00002xkc

2XKD | pdb_00002xkd

2XKE | pdb_00002xke

2XKF | pdb_00002xkf

2XNM | pdb_00002xnm

2XNN | pdb_00002xnn

2XNO | pdb_00002xno

2XNP | pdb_00002xnp

3ZO1 | pdb_00003zo1