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234,136 Structures from the PDB

1,068,577 Computed Structure Models (CSM)

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QUERY: Citation Author = "Tickle, I.J."

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Search Summary

This query matches 31 Structures.

Refinements

Structure Determination Methodology

experimental (31)

Scientific Name of Source Organism

	Homo sapiens (18)
	Escherichia coli (6)
	Rattus norvegicus (6)
	Mus musculus (1)

Taxonomy

	Eukaryota (25)
	Bacteria (6)

Experimental Method

	X-RAY DIFFRACTION (30)
	ELECTRON MICROSCOPY (1)

Polymer Entity Type

Protein (31)

Refinement Resolution (Å)

	1.0 - 1.5 (6)
	1.5 - 2.0 (5)
	2.0 - 2.5 (9)
	2.5 - 3.0 (9)
	3.0 - 3.5 (2)

Release Date

	2000 - 2004 (2)
	2005 - 2009 (10)
	2015 - 2019 (11)
	2020 - 2024 (5)
	2025 - 2029 (3)

Enzyme Classification Name

	Transferases (16)
	Isomerases (6)
	Hydrolases (1)

Symmetry Type

	Asymmetric (11)
	Cyclic (22)
	Dihedral (2)

SCOP Classification

	Alpha and beta proteins (a+b) (12)
	Alpha and beta proteins (a/b) (9)
	All alpha proteins (3)
	All beta proteins (4)
	Artifacts (1)

AllSelected

1 to 25 of 31 Structures

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1PCQ \| pdb_00001pcq	Download File View File

Crystal structure of groEL-groES

Chaudhry, C., Farr, G.W., Todd, M.J., Rye, H.S., Brunger, A.T., Adams, P.D., Horwich, A.L., Sigler, P.B.

(2003) EMBO J 22: 4877-4887

Released	2003-10-14
Method	X-RAY DIFFRACTION 2.808 Å
Organisms	Escherichia coli
Macromolecule	groEL protein (protein) groES protein (protein)
Unique Ligands	ADP, AF3, K, MG

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1PF9 \| pdb_00001pf9	Download File View File

GroEL-GroES-ADP

Chaudhry, C., Farr, G.W., Todd, M.J., Rye, H.S., Brunger, A.T., Adams, P.D., Horwich, A.L., Sigler, P.B.

(2003) EMBO J 22: 4877-4887

Released	2003-11-04
Method	X-RAY DIFFRACTION 2.993 Å
Organisms	Escherichia coli
Macromolecule	groEL protein (protein) groES protein (protein)
Unique Ligands	ADP, MG

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1SS8 \| pdb_00001ss8	Download File View File

GroEL

Chaudhry, C., Horwich, A.L., Brunger, A.T., Adams, P.D.

(2004) J Mol Biology 342: 229-245

Released	2005-03-01
Method	X-RAY DIFFRACTION 2.7 Å
Organisms	Escherichia coli
Macromolecule	groEL protein (protein)

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1SVT \| pdb_00001svt	Download File View File

Crystal structure of GroEL14-GroES7-(ADP-AlFx)7

Chaudhry, C., Horwich, A.L., Brunger, A.T., Adams, P.D.

(2004) J Mol Biology 342: 229-245

Released	2005-03-01
Method	X-RAY DIFFRACTION 2.808 Å
Organisms	Escherichia coli
Macromolecule	groEL protein (protein) groES protein (protein)
Unique Ligands	ADP, AF3, K, MG

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1SX3 \| pdb_00001sx3	Download File View File

GroEL14-(ATPgammaS)14

Chaudhry, C., Horwich, A.L., Brunger, A.T., Adams, P.D.

(2004) J Mol Biology 342: 229-245

Released	2005-03-01
Method	X-RAY DIFFRACTION 2 Å
Organisms	Escherichia coli
Macromolecule	groEL protein (protein)
Unique Ligands	AGS, K, MG

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1SX4 \| pdb_00001sx4	Download File View File

GroEL-GroES-ADP7

Chaudhry, C., Horwich, A.L., Brunger, A.T., Adams, P.D.

(2004) J Mol Biology 342: 229-245

Released	2005-03-01
Method	X-RAY DIFFRACTION 3 Å
Organisms	Escherichia coli
Macromolecule	groEL protein (protein) groES protein (protein)
Unique Ligands	ADP, MG

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3G3F \| pdb_00003g3f	Download File View File

Crystal structure of the GluR6 ligand binding domain dimer with glutamate and NaCl at 1.38 Angstrom resolution

Chaudhry, C., Mayer, M.L.

(2009) EMBO J 28: 1518-1530

Released	2009-06-02
Method	X-RAY DIFFRACTION 1.377 Å
Organisms	Rattus norvegicus
Macromolecule	Glutamate receptor, ionotropic kainate 2 (protein)
Unique Ligands	CL, GLU, IPA, NA

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3G3G \| pdb_00003g3g	Download File View File

Crystal structure of the GluR6 ligand binding domain dimer K665R mutant with glutamate and NaCl at 1.3 Angstrom resolution

Chaudhry, C., Mayer, M.L.

(2009) EMBO J 28: 1518-1530

Released	2009-06-02
Method	X-RAY DIFFRACTION 1.303 Å
Organisms	Rattus norvegicus
Macromolecule	Glutamate receptor, ionotropic kainate 2 (protein)
Unique Ligands	CL, GLU, NA

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3G3H \| pdb_00003g3h	Download File View File

Crystal structure of the GluR6 ligand binding domain dimer K665R I749L Q753K mutant with glutamate and NaCl at 1.5 Angstrom resolution

Chaudhry, C., Mayer, M.L.

(2009) EMBO J 28: 1518-1530

Released	2009-06-02
Method	X-RAY DIFFRACTION 1.5 Å
Organisms	Rattus norvegicus
Macromolecule	Glutamate receptor, ionotropic kainate 2 (protein)
Unique Ligands	CL, GLU, NA

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3G3I \| pdb_00003g3i	Download File View File

Crystal structure of the GluR6 ligand binding domain dimer I442H K494E I749L Q753K mutant with glutamate and NaCl at 1.37 Angstrom resolution

Chaudhry, C., Mayer, M.L.

(2009) EMBO J 28: 1518-1530

Released	2009-06-02
Method	X-RAY DIFFRACTION 1.371 Å
Organisms	Rattus norvegicus
Macromolecule	Glutamate receptor, ionotropic kainate 2 (protein)
Unique Ligands	CL, GLU, NA

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3G3J \| pdb_00003g3j	Download File View File

Crystal structure of the GluR6 ligand binding domain dimer I442H K494E K665R I749L Q753K mutant with glutamate and NaCl at 1.32 Angstrom resolution

Chaudhry, C., Mayer, M.L.

(2009) EMBO J 28: 1518-1530

Released	2009-06-02
Method	X-RAY DIFFRACTION 1.321 Å
Organisms	Rattus norvegicus
Macromolecule	Glutamate receptor, ionotropic kainate 2 (protein)
Unique Ligands	CL, GLU, NA

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3G3K \| pdb_00003g3k	Download File View File

Crystal structure of the GluR6 ligand binding domain dimer I442H K494E K665R I749L Q753K E757Q mutant with glutamate and NaCl at 1.24 Angstrom resolution

Chaudhry, C., Mayer, M.L.

(2009) EMBO J 28: 1518-1530

Released	2009-06-02
Method	X-RAY DIFFRACTION 1.24 Å
Organisms	Rattus norvegicus
Macromolecule	Glutamate receptor, ionotropic kainate 2 (protein)
Unique Ligands	CL, GLU, IPA, NA

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5TKB \| pdb_00005tkb	Download File View File

CRYSTAL STRUCTURE OF HUMAN PHOSPHODIESTERASE 4D IN COMPLEX WITH A TETRAFLUORANLINE COMPOUND

Sack, J.S.

(2017) Medchemcomm 8: 700-712

Released	2016-12-28
Method	X-RAY DIFFRACTION 2.16 Å
Organisms	Homo sapiens
Macromolecule	cAMP-specific 3',5'-cyclic phosphodiesterase 4D (protein)
Unique Ligands	7DJ, EOH, MG, SO4, ZN

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5TKD \| pdb_00005tkd	Download File View File

CRYSTAL STRUCTURE OF TYROSINE KINASE 2 JH2 (PSEUDO KINASE DOMAIN) COMPLEXED WITH 6-[(3,5-DIMETHYLPHE NYL)AMINO]-8- (METHYLAMINO)IMIDAZO[1,2-B]PYRIDAZINE-3-CARBO XAMIDE

Muckelbauer, J.K.

(2017) Medchemcomm 8: 700-712

Released	2016-12-28
Method	X-RAY DIFFRACTION 1.92 Å
Organisms	Homo sapiens
Macromolecule	Non-receptor tyrosine-protein kinase TYK2 (protein)
Unique Ligands	7GL, SO4

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5WFJ \| pdb_00005wfj	Download File View File

THE JAK3 KINASE DOMAIN IN COMPLEX WITH A COVALENT INHIBITOR

Sack, J.

(2017) Bioorg Med Chem Lett 27: 4622-4625

Released	2017-10-04
Method	X-RAY DIFFRACTION 2.48 Å
Organisms	Homo sapiens
Macromolecule	Tyrosine-protein kinase JAK3 (protein)
Unique Ligands	9Z4

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6NSL \| pdb_00006nsl	Download File View File

CRYSTAL STRUCTURE OF TYROSINE KINASE 2 JH2 (PSEUDO KINASE DOMAIN) COMPLEXED WITH Compound-6c AKA 6-((1-(4-CYANOPHENY L)-2-OXO-1,2-DIHYDRO-3-PYRIDINYL)AMINO)-N-CYCLOPROPYL-8-(M ETHYLAMINO)IMIDAZO[1,2-B]PYRIDAZINE-3-CARBOXAMIDE

Muckelbauer, J.M., Khan, J.A.

(2019) ACS Med Chem Lett 10: 383-388

Released	2020-01-29
Method	X-RAY DIFFRACTION 2.15 Å
Organisms	Homo sapiens
Macromolecule	Non-receptor tyrosine-protein kinase TYK2 (protein)
Unique Ligands	KZJ, SO4

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6NZE \| pdb_00006nze	Download File View File

CRYSTAL STRUCTURE OF TYROSINE KINASE 2 JH2 (PSEUDO KINASE DOMAIN) COMPLEXED WITH Compound_5 AKA 4-[(2-CARBAMOYLPHEN YL)AMINO]-6-[(5-FLUOROPYRIDIN-2-YL)AMINO]-N-METHYLPYRIDINE -3-CARBOXAMIDE

Muckelbauer, J.M.

(2019) J Med Chem 62: 8953-8972

Released	2019-07-24
Method	X-RAY DIFFRACTION 1.96 Å
Organisms	Homo sapiens
Macromolecule	Non-receptor tyrosine-protein kinase TYK2 (protein)
Unique Ligands	L8Y, SO4

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6NZF \| pdb_00006nzf	Download File View File

CRYSTAL STRUCTURE OF TYROSINE KINASE 2 JH2 (PSEUDO KINASE DOMAIN) COMPLEXED WITH Compound_5 AKA 4-[(2-CARBAMOYLPHEN YL)AMINO]-6-[(5-FLUOROPYRIDIN-2-YL)AMINO]-N-METHYLPYRIDINE -3-CARBOXAMIDE

Muckelbauer, J.M.

(2019) J Med Chem 62: 8953-8972

Released	2019-07-24
Method	X-RAY DIFFRACTION 2.39 Å
Organisms	Homo sapiens
Macromolecule	Non-receptor tyrosine-protein kinase TYK2 (protein)
Unique Ligands	L91, SO4

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6NZH \| pdb_00006nzh	Download File View File

CRYSTAL STRUCTURE OF TYROSINE KINASE 2 JH2 (PSEUDO KINASE DOMAIN) COMPLEXED WITH Compound_40 AKA 6-cyclopropaneamido-4-[(2-methanesulfonylphenyl)amino]-N-methylpyridine-3-carboxamide

Muckelbauer, J.M.

(2019) J Med Chem 62: 8953-8972

Released	2019-07-24
Method	X-RAY DIFFRACTION 2.73 Å
Organisms	Homo sapiens
Macromolecule	Non-receptor tyrosine-protein kinase TYK2 (protein)
Unique Ligands	L9A

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6NZP \| pdb_00006nzp	Download File View File

CRYSTAL STRUCTURE OF TYROSINE KINASE 2 JH2 (PSEUDO KINASE DOMAIN) COMPLEXED WITH COMPOUND-11 AKA 6-CYCLOPROPANEAMIDO-4-{[2-METHOXY-3-(1-METHYL-1H-1,2,4-TRI AZOL-3-YL)PHENYL]AMINO}-N-(?H?)METHYLPYRIDAZINE-3-CARBOXAMIDE

Khan, J.A.

(2019) J Med Chem 62: 8973-8995

Released	2019-07-31
Method	X-RAY DIFFRACTION 2.35 Å
Organisms	Homo sapiens
Macromolecule	Non-receptor tyrosine-protein kinase TYK2 (protein)
Unique Ligands	CL, LB7

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6NZQ \| pdb_00006nzq	Download File View File

CRYSTAL STRUCTURE OF TYROSINE KINASE 2 JH2 (PSEUDO KINASE DOMAIN) COMPLEXED WITH Compound_29 AKA 6-[(5-FLUORO-4-METH YLPYRIDIN-2-YL)AMINO]-4-({2-METHOXY-3-[(PYRIDIN-2-YLMETHYL )CARBAMOYL]PHENYL}AMINO)-N-METHYLPYRIDINE-3-CARBOXAMIDE

Khan, J.A.

(2019) J Med Chem 62: 8973-8995

Released	2019-07-31
Method	X-RAY DIFFRACTION 2.11 Å
Organisms	Homo sapiens
Macromolecule	Non-receptor tyrosine-protein kinase TYK2 (protein)
Unique Ligands	LB4

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6NZR \| pdb_00006nzr	Download File View File

CRYSTAL STRUCTURE OF TYROSINE KINASE 2 JH2 (PSEUDO KINASE DOMAIN) COMPLEXED WITH Compound_12 AKA 4-[(2-methanesulfonylphenyl)amino]-N-(H3)methyl-6-[(pyridin-2- yl)amino]pyridazine-3-carboxamide

Khan, J.A.

(2019) J Med Chem 62: 8973-8995

Released	2019-07-31
Method	X-RAY DIFFRACTION 2.56 Å
Organisms	Homo sapiens
Macromolecule	Non-receptor tyrosine-protein kinase TYK2 (protein)
Unique Ligands	LAJ, SO4

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6O8I \| pdb_00006o8i	Download File View File

BTK In Complex With Inhibitor

Pokross, M., Tebben, A.J., Watterson, S.H.

(2019) J Med Chem 62: 3228-3250

Released	2019-04-03
Method	X-RAY DIFFRACTION 1.42 Å
Organisms	Homo sapiens
Macromolecule	Tyrosine-protein kinase BTK (protein)
Unique Ligands	LTJ

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6OKO \| pdb_00006oko	Download File View File

Crystal structure of mRIPK3 complexed with N-(3-fluoro-4-{1H-pyrrolo[2,3-b]pyridin-4-yloxy}phenyl)-1-(4-fluorophenyl)-2-oxo-1,2-dihydropyridine-3-carboxamide

Pokross, M.E.

(2020) ACS Med Chem Lett 11: 266-271

Released	2019-07-17
Method	X-RAY DIFFRACTION 2.1 Å
Organisms	Mus musculus
Macromolecule	Receptor-interacting serine/threonine-protein kinase 3 (protein)
Unique Ligands	1FN

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7K7O \| pdb_00007k7o	Download File View File

CRYSTAL STRUCTURE OF TYROSINE KINASE 2 JH2 (PSEUDO KINASE DOMAIN) COMPLEXED WITH COMPOUND-12 AKA:6-[(cyclopropanecarbonyl)amino]-4-{[2-methoxy-3-(pyrimidin-2-yl)phenyl]amino}-N-methylpyridazine-3-carboxamide

Khan, J.A.

(2021) J Med Chem 64: 677-694

Released	2021-08-04
Method	X-RAY DIFFRACTION 2.82 Å
Organisms	Homo sapiens
Macromolecule	Non-receptor tyrosine-protein kinase TYK2 (protein)
Unique Ligands	VZJ

1 to 25 of 31 Structures

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Structure Determination Methodology

Scientific Name of Source Organism

Taxonomy

Experimental Method

Polymer Entity Type

Refinement Resolution (Å)

Release Date

Enzyme Classification Name

Symmetry Type

SCOP Classification

1PCQ | pdb_00001pcq

1PF9 | pdb_00001pf9

1SS8 | pdb_00001ss8

1SVT | pdb_00001svt

1SX3 | pdb_00001sx3

1SX4 | pdb_00001sx4

3G3F | pdb_00003g3f

3G3G | pdb_00003g3g

3G3H | pdb_00003g3h

3G3I | pdb_00003g3i

3G3J | pdb_00003g3j

3G3K | pdb_00003g3k

5TKB | pdb_00005tkb

5TKD | pdb_00005tkd

5WFJ | pdb_00005wfj

6NSL | pdb_00006nsl

6NZE | pdb_00006nze

6NZF | pdb_00006nzf

6NZH | pdb_00006nzh

6NZP | pdb_00006nzp

6NZQ | pdb_00006nzq

6NZR | pdb_00006nzr

6O8I | pdb_00006o8i

6OKO | pdb_00006oko

7K7O | pdb_00007k7o