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234,785 Structures from the PDB

1,068,577 Computed Structure Models (CSM)

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QUERY: Citation Author = "Stevens, F."

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Search Summary

This query matches 79 Structures.

Refinements

Structure Determination Methodology

experimental (79)

Scientific Name of Source Organism

	Homo sapiens (18)
	Campylobacter jejuni (6)
	Helicobacter pylori (6)
	Helicobacter pylori J99 (6)
	Trypanosoma cruzi strain CL Brener (6)
	Salmonella enterica subsp. enterica serovar Choleraesuis str. SCSA50 (5)
	Mycobacterium tuberculosis (3)
	Bos taurus (2)
	Clostridioides difficile (2)
	Escherichia coli (2)

More...

Taxonomy

	Bacteria (40)
	Eukaryota (39)

Experimental Method

X-RAY DIFFRACTION (79)

Polymer Entity Type

Protein (79)

Refinement Resolution (Å)

	1.0 - 1.5 (9)
	1.5 - 2.0 (44)
	2.0 - 2.5 (19)
	2.5 - 3.0 (7)

Release Date

	1995 - 1999 (4)
	2000 - 2004 (8)
	2005 - 2009 (13)
	2010 - 2014 (13)
	2015 - 2019 (24)
	2020 - 2024 (11)
	2025 - 2029 (6)

Enzyme Classification Name

	Hydrolases (40)
	Transferases (36)
	Lyases (1)
	Ligases (1)

Symmetry Type

	Cyclic (65)
	Dihedral (11)
	Asymmetric (7)

SCOP Classification

	Alpha and beta proteins (a/b) (61)
	Artifacts (28)
	Alpha and beta proteins (a+b) (1)

AllSelected

1 to 25 of 79 Structures

Page 1 of 4

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1B8N \| pdb_00001b8n	Download File View File

PURINE NUCLEOSIDE PHOSPHORYLASE

Fedorov, A.A., Kicska, G.A., Fedorov, E.V., Strokopytov, B.V., Tyler, P.C., Furneaux, R.H., Schramm, V.L., Almo, S.C.

(2002) Biochemistry 41: 14489-14498

Released	1999-02-08
Method	X-RAY DIFFRACTION 2 Å
Organisms	Bos taurus
Macromolecule	PURINE NUCLEOSIDE PHOSPHORYLASE (protein)
Unique Ligands	IMG, MG, PO4

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1B8O \| pdb_00001b8o	Download File View File

PURINE NUCLEOSIDE PHOSPHORYLASE

Fedorov, A.A., Kicska, G.A., Fedorov, E.V., Shi, W., Tyler, P.C., Furneaux, R.H., Schramm, V.L., Almo, S.C.

(2001) Biochemistry 40: 853-860

Released	1999-02-08
Method	X-RAY DIFFRACTION 1.5 Å
Organisms	Bos taurus
Macromolecule	PURINE NUCLEOSIDE PHOSPHORYLASE (protein)
Unique Ligands	IMH, MG, PO4

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1BZY \| pdb_00001bzy	Download File View File

HUMAN HGPRTASE WITH TRANSITION STATE INHIBITOR

Shi, W., Li, C., Tyler, P.C., Furneaux, R.H., Grubmeyer, C., Schramm, V.L., Almo, S.C.

(1999) Nat Struct Biol 6: 588-593

Released	1999-06-22
Method	X-RAY DIFFRACTION 2 Å
Organisms	Homo sapiens
Macromolecule	HYPOXANTHINE-GUANINE PHOSPHORIBOSYLTRANSFERASE (protein)
Unique Ligands	IMU, MG, POP

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1CJB \| pdb_00001cjb	Download File View File

MALARIAL PURINE PHOSPHORIBOSYLTRANSFERASE

Shi, W., Li, C.M., Tyler, P.C., Furneaux, R.H., Cahill, S.M., Girvin, M.E., Grubmeyer, C., Schramm, V.L., Almo, S.C.

(1999) Biochemistry 38: 9872-9880

Released	1999-08-18
Method	X-RAY DIFFRACTION 2 Å
Organisms	Plasmodium falciparum
Macromolecule	PROTEIN (HYPOXANTHINE-GUANINE PHOSPHORIBOSYLTRANSFERASE) (protein)
Unique Ligands	IRP, MG, POP

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1DQN \| pdb_00001dqn	Download File View File

CRYSTAL STRUCTURE OF GIARDIA GUANINE PHOSPHORIBOSYLTRANSFERASE COMPLEXED WITH A TRANSITION STATE ANALOGUE

Shi, W., Munagala, N.R., Wang, C.C., Li, C.M., Tyler, P.C., Furneaux, R.H., Grubmeyer, C., Schramm, V.L., Almo, S.C.

(2000) Biochemistry 39: 6781-6790

Released	2000-07-26
Method	X-RAY DIFFRACTION 1.75 Å
Organisms	Giardia intestinalis
Macromolecule	GUANINE PHOSPHORIBOSYLTRANSFERASE (protein)
Unique Ligands	IMU, IPA, MG, POP

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1DQP \| pdb_00001dqp	Download File View File

CRYSTAL STRUCTURE OF GIARDIA GUANINE PHOSPHORIBOSYLTRANSFERASE COMPLEXED WITH IMMUCILLING

Shi, W., Munagala, N.R., Wang, C.C., Li, C.M., Tyler, P.C., Furneaux, R.H., Grubmeyer, C., Schramm, V.L., Almo, S.C.

(2000) Biochemistry 39: 6781-6790

Released	2000-07-26
Method	X-RAY DIFFRACTION 1.75 Å
Organisms	Giardia intestinalis
Macromolecule	GUANINE PHOSPHORIBOSYLTRANSFERASE (protein)
Unique Ligands	IMG, IPA

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1G2O \| pdb_00001g2o	Download File View File

CRYSTAL STRUCTURE OF PURINE NUCLEOSIDE PHOSPHORYLASE FROM MYCOBACTERIUM TUBERCULOSIS IN COMPLEX WITH A TRANSITION-STATE INHIBITOR

Shi, W., Basso, L.A., Tyler, P.C., Furneaux, R.H., Blanchard, J.S., Almo, S.C., Schramm, V.L.

(2001) Biochemistry 40: 8204-8215

Released	2001-08-01
Method	X-RAY DIFFRACTION 1.75 Å
Organisms	Mycobacterium tuberculosis
Macromolecule	PURINE NUCLEOSIDE PHOSPHORYLASE (protein)
Unique Ligands	IMH, PO4

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1I80 \| pdb_00001i80	Download File View File

CRYSTAL STRUCTURE OF M. TUBERCULOSIS PNP IN COMPLEX WITH IMINORIBITOL, 9-DEAZAHYPOXANTHINE AND PHOSPHATE ION

Shi, W., Basso, L.A., Tyler, P.C., Furneaux, R.H., Blanchard, J.S., Almo, S.C., Schramm, V.L.

(2001) Biochemistry 40: 8204-8215

Released	2001-08-01
Method	X-RAY DIFFRACTION 2 Å
Organisms	Mycobacterium tuberculosis
Macromolecule	PURINE NUCLEOSIDE PHOSPHORYLASE (protein)
Unique Ligands	9HX, IMR, PO4

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1K27 \| pdb_00001k27	Download File View File

Crystal Structure of 5'-Deoxy-5'-Methylthioadenosine Phosphorylase in Complex with a Transition State Analogue

Shi, W., Singh, V., Tyler, P.C., Furneaux, R.H., Almo, S.C., Schramm, V.L.

(2004) Biochemistry 43: 9-18

Released	2003-09-30
Method	X-RAY DIFFRACTION 1.95 Å
Organisms	Homo sapiens
Macromolecule	5'-Deoxy-5'-Methylthioadenosine Phosphorylase (protein)
Unique Ligands	MTM, PO4

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1N3I \| pdb_00001n3i	Download File View File

Crystal Structure of Mycobacterium tuberculosis PNP with transition state analog DADMe-ImmH

Lewandowicz, A., Shi, W., Evans, G.B., Tyler, P.C., Furneaux, R.H., Basso, L.A., Santos, D.S., Almo, S.C., Schramm, V.L.

(2003) Biochemistry 42: 6057-6066

Released	2003-09-30
Method	X-RAY DIFFRACTION 1.9 Å
Organisms	Mycobacterium tuberculosis
Macromolecule	Purine Nucleoside Phosphorylase (protein)
Unique Ligands	DIH, PO4

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1NW4 \| pdb_00001nw4	Download File View File

Crystal Structure of Plasmodium falciparum Purine Nucleoside Phosphorylase in complex with ImmH and Sulfate

Shi, W., Ting, L.M., Kicska, G.A., Lewandowicz, A., Tyler, P.C., Evans, G.B., Furneaux, R.H., Kim, K., Almo, S.C., Schramm, V.L.

(2004) J Biological Chem 279: 18103-18106

Released	2004-03-16
Method	X-RAY DIFFRACTION 2.2 Å
Organisms	Plasmodium falciparum 3D7
Macromolecule	uridine phosphorylase, putative (protein)
Unique Ligands	IMH, IPA, SO4

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1Q1G \| pdb_00001q1g	Download File View File

Crystal structure of Plasmodium falciparum PNP with 5'-methylthio-immucillin-H

Shi, W., Ting, L.M., Kicska, G.A., Lewandowicz, A., Tyler, P.C., Evans, G.B., Furneaux, R.H., Kim, K., Almo, S.C., Schramm, V.L.

(2004) J Biological Chem 279: 18103-18106

Released	2004-03-16
Method	X-RAY DIFFRACTION 2.02 Å
Organisms	Plasmodium falciparum 3D7
Macromolecule	Uridine phosphorylase putative (protein)
Unique Ligands	IPA, MTI, SO4

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1RR6 \| pdb_00001rr6	Download File View File

Structure of human purine nucleoside phosphorylase in complex with Immucillin-H and phosphate

Shi, W., Lewandowicz, A., Tyler, P.C., Furneaux, R.H., Almo, S.C., Schramm, V.L.

(2004) J Biological Chem 279: 18103-18106

Released	2005-02-22
Method	X-RAY DIFFRACTION 2.5 Å
Organisms	Homo sapiens
Macromolecule	Purine nucleoside phosphorylase (protein)
Unique Ligands	IMH, PO4

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1RSZ \| pdb_00001rsz	Download File View File

Structure of human purine nucleoside phosphorylase in complex with DADMe-Immucillin-H and sulfate

Shi, W., Lewandowicz, A., Tyler, P.C., Furneaux, R.H., Almo, S.C., Schramm, V.L.

To be published

Released	2005-02-22
Method	X-RAY DIFFRACTION 2.2 Å
Organisms	Homo sapiens
Macromolecule	Purine nucleoside phosphorylase (protein)
Unique Ligands	DIH, SO4

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1RT9 \| pdb_00001rt9	Download File View File

Structure of human purine nucleoside phosphorylase in complex with Immucillin-H and sulfate

Shi, W., Lewandowicz, A., Tyler, P.C., Furneaux, R.H., Almo, S.C., Schramm, V.L.

To be published

Released	2005-02-22
Method	X-RAY DIFFRACTION 2.3 Å
Organisms	Homo sapiens
Macromolecule	Purine nucleoside phosphorylase (protein)
Unique Ligands	IMH, SO4

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1Y6Q \| pdb_00001y6q	Download File View File

Cyrstal structure of MTA/AdoHcy nucleosidase complexed with MT-DADMe-ImmA

Lee, J.E., Singh, V., Evans, G.B., Tyler, P.C., Furneaux, R.H., Cornell, K.A., Riscoe, M.K., Schramm, V.L., Howell, P.L.

(2005) J Biological Chem 280: 18274-18282

Released	2005-03-01
Method	X-RAY DIFFRACTION 2.2 Å
Organisms	Escherichia coli
Macromolecule	MTA/SAH nucleosidase (protein)
Unique Ligands	CL, TDI

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1Y6R \| pdb_00001y6r	Download File View File

Crystal structure of MTA/AdoHcy nucleosidase complexed with MT-ImmA.

Lee, J.E., Singh, V., Evans, G.B., Tyler, P.C., Furneaux, R.H., Cornell, K.A., Riscoe, M.K., Schramm, V.L., Howell, P.L.

(2005) J Biological Chem 280: 18274-18282

Released	2005-03-01
Method	X-RAY DIFFRACTION 2.2 Å
Organisms	Escherichia coli
Macromolecule	MTA/SAH nucleosidase (protein)
Unique Ligands	MTM

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1ZOS \| pdb_00001zos	Download File View File

Structure of 5'-methylthionadenosine/S-Adenosylhomocysteine nucleosidase from S. pneumoniae with a transition-state inhibitor MT-ImmA

Shi, W., Singh, V., Zhen, R., Tyler, P.C., Furneaux, R.H., Almo, S.C., Schramm, V.L.

(2006) Biochemistry 45: 12929-12941

Released	2006-04-25
Method	X-RAY DIFFRACTION 1.6 Å
Organisms	Streptococcus pneumoniae R6
Macromolecule	5'-methylthioadenosine / S-adenosylhomocysteine nucleosidase (protein)
Unique Ligands	MTM

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2I4T \| pdb_00002i4t	Download File View File

Crystal structure of Purine Nucleoside Phosphorylase from Trichomonas vaginalis with Imm-A

Rinaldo-Matthis, A., Schramm, V.L., Almo, S.C.

(2007) Biochemistry 46: 659-668

Released	2007-06-05
Method	X-RAY DIFFRACTION 2.74 Å
Organisms	Trichomonas vaginalis
Macromolecule	Trichomonas vaginalis purine nucleoside phosphorylase (protein)
Unique Ligands	PO4, UA2

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2ISC \| pdb_00002isc	Download File View File

Crystal structure of Purine Nucleoside Phosphorylase from Trichomonas vaginalis with DADMe-Imm-A

Rinaldo-Matthis, A., Almo, S.C., Schramm, V.L.

(2007) Biochemistry 46: 659-668

Released	2007-06-05
Method	X-RAY DIFFRACTION 2.7 Å
Organisms	Trichomonas vaginalis
Macromolecule	purine nucleoside phosphorylase (protein)
Unique Ligands	223, PO4

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2Q7O \| pdb_00002q7o	Download File View File

Structure of human purine nucleoside phosphorylase in complex with L-Immucillin-H

Rinaldo-Matthis, A., Almo, S.C., Schramm, V.L.

(2008) J Am Chem Soc 130: 842-844

Released	2008-01-15
Method	X-RAY DIFFRACTION 2.9 Å
Organisms	Homo sapiens
Macromolecule	Purine nucleoside phosphorylase (protein)
Unique Ligands	IMH, PO4

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3BGS \| pdb_00003bgs	Download File View File

Structure of human purine nucleoside phosphorylase with L-DADMe-ImmH and phosphate

Murkin, A.S., Ramagopal, U.A., Almo, S.C., Schramm, V.L.

(2008) J Am Chem Soc 130: 842-844

Released	2008-01-08
Method	X-RAY DIFFRACTION 2.099 Å
Organisms	Homo sapiens
Macromolecule	purine nucleoside phosphorylase (protein)
Unique Ligands	DIH, PO4

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3EEI \| pdb_00003eei	Download File View File

Crystal structure of 5'-methylthioadenosine/S-adenosylhomocysteine nucleosidase from neisseria meningitidis in complex with methylthio-immucillin-A

Ho, M., Rinaldo-matthis, A., Brown, R.L., Norris, G.E., Tyler, P.C., Furneaux, R.H., Almo, S.C., Schramm, V.L.

To be published

Released	2009-09-08
Method	X-RAY DIFFRACTION 1.78 Å
Organisms	Neisseria meningitidis serogroup B
Macromolecule	5-methylthioadenosine nucleosidase/S-adenosylhomocysteine nucleosidase (protein)
Unique Ligands	MTM