RCSB PDB: Search

Warning You are using a web browser that we do not support. Our website will not work properly. Please update to a newer version or download a new web browser, such as Chrome or Firefox.

Help

Help

RCSB PDB

Deposit
- PDBx/mmCIF file
- pdb_extract
- SF-Tool
- Ligand Expo
- MAXIT
- Validation Server
- Validation API
- Information for Journals
- Validation Task Forces
- wwPDB OneDep System
- PDB-IHM
Search
Visualize
Analyze
Download
Learn
- Training Courses
- Guide to PDB Data
- Molecule of the Month
- Educational Resources
- Curricula
- Browse
- News
- SciArt Galleries
- Irving Geis
- David Goodsell
About
Careers
COVID-19

234,136 Structures from the PDB

1,068,577 Computed Structure Models (CSM)

	Include CSM
Advanced Search \| Browse Annotations		Help

Search
Query History
Browse Annotations
MyPDB

QUERY: Citation Author = "Shafer, J.A."

MyPDB Login

Search API

Advanced Search Query Builder

Help

Full Text

Structure Attributes

Help

NOT

Count

Add Subquery

Chemical Attributes

Sequence Similarity

Sequence Motif

Structure Similarity

Structure Motif

Chemical Similarity

Return

grouped by

Include Computed Structure Models (CSM)

Count

Clear

Search Summary

This query matches 15 Structures.

Refinements

Structure Determination Methodology

experimental (15)

Scientific Name of Source Organism

	Human immunodeficiency virus 1 (8)
	Hirudo medicinalis (5)
	Homo sapiens (5)
	Human immunodeficiency virus 2 (1)
	Human immunodeficiency virus type 2 (ISOLATE ROD) (1)

Taxonomy

	Riboviria (10)
	Eukaryota (5)
	Eukaryota (eukaryotes) (1)

Experimental Method

X-RAY DIFFRACTION (15)

Polymer Entity Type

Protein (15)

Refinement Resolution (Å)

	1.5 - 2.0 (6)
	2.0 - 2.5 (3)
	2.5 - 3.0 (6)

Release Date

	1995 - 1999 (9)
	2000 - 2004 (5)
	2005 - 2009 (1)

Enzyme Classification Name

Hydrolases (15)

Symmetry Type

	Cyclic (10)
	Asymmetric (5)

SCOP Classification

All beta proteins (15)

AllSelected

1 to 15 of 15 Structures

Page 1 of 1

Sort by

Explore in 3D

1AHT \| pdb_00001aht	Download File View File

CRYSTAL STRUCTURE OF HUMAN ALPHA-THROMBIN COMPLEXED WITH HIRUGEN AND P-AMIDINOPHENYLPYRUVATE AT 1.6 ANGSTROMS RESOLUTION

Chen, Z.

(1995) Arch Biochem Biophys 322: 198-203

Released	1996-03-17
Method	X-RAY DIFFRACTION 1.6 Å
Organisms	Hirudo medicinalis Homo sapiens
Macromolecule	ALPHA-THROMBIN (LARGE SUBUNIT) (protein) ALPHA-THROMBIN (SMALL SUBUNIT) (protein) HIRUGEN (protein)
Unique Ligands	APA

Explore in 3D

1C6X \| pdb_00001c6x	Download File View File

ALTERNATE BINDING SITE FOR THE P1-P3 GROUP OF A CLASS OF POTENT HIV-1 PROTEASE INHIBITORS AS A RESULT OF CONCERTED STRUCTURAL CHANGE IN 80'S LOOP.

Munshi, S.

(2000) Acta Crystallogr D Biol Crystallogr 56: 381-388

Released	2000-12-28
Method	X-RAY DIFFRACTION 2.5 Å
Organisms	Human immunodeficiency virus 1
Macromolecule	PROTEIN (PROTEASE) (protein)
Unique Ligands	3IN

Explore in 3D

1C6Y \| pdb_00001c6y	Download File View File

ALTERNATE BINDING SITE FOR THE P1-P3 GROUP OF A CLASS OF POTENT HIV-1 PROTEASE INHIBITORS AS A RESULT OF CONCERTED STRUCTURAL CHANGE IN 80'S LOOP.

Munshi, S.

(2000) Acta Crystallogr D Biol Crystallogr 56: 381-388

Released	2000-12-28
Method	X-RAY DIFFRACTION 2.5 Å
Organisms	Human immunodeficiency virus 1
Macromolecule	PROTEIN (PROTEASE) (protein)
Unique Ligands	MK1

Explore in 3D

1HSG \| pdb_00001hsg	Download File View File

CRYSTAL STRUCTURE AT 1.9 ANGSTROMS RESOLUTION OF HUMAN IMMUNODEFICIENCY VIRUS (HIV) II PROTEASE COMPLEXED WITH L-735,524, AN ORALLY BIOAVAILABLE INHIBITOR OF THE HIV PROTEASES

Chen, Z.

(1994) J Biological Chem 269: 26344-26348

Released	1996-04-03
Method	X-RAY DIFFRACTION 2 Å
Organisms	Human immunodeficiency virus 1
Macromolecule	HIV-1 PROTEASE (protein)
Unique Ligands	MK1

Explore in 3D

1HSH \| pdb_00001hsh	Download File View File

CRYSTAL STRUCTURE AT 1.9 ANGSTROMS RESOLUTION OF HUMAN IMMUNODEFICIENCY VIRUS (HIV) II PROTEASE COMPLEXED WITH L-735,524, AN ORALLY BIOAVAILABLE INHIBITOR OF THE HIV PROTEASES

Chen, Z.

(1994) J Biological Chem 269: 26344-26348

Released	1996-04-03
Method	X-RAY DIFFRACTION 1.9 Å
Organisms	Human immunodeficiency virus type 2 (ISOLATE ROD)
Macromolecule	HIV-II PROTEASE (protein)
Unique Ligands	MK1

Explore in 3D

1HSI \| pdb_00001hsi	Download File View File

CRYSTAL STRUCTURE AT 1.9 ANGSTROMS RESOLUTION OF HUMAN IMMUNODEFICIENCY VIRUS (HIV) II PROTEASE COMPLEXED WITH L-735,524, AN ORALLY BIOAVAILABLE INHIBITOR OF THE HIV PROTEASES

Chen, Z.

(1994) J Biological Chem 269: 26344-26348

Released	1996-04-03
Method	X-RAY DIFFRACTION 2.5 Å
Organisms	Human immunodeficiency virus 2
Macromolecule	HIV-2 PROTEASE (protein)

Explore in 3D

1MU6 \| pdb_00001mu6	Download File View File

Crystal Structure of Thrombin in Complex with L-378,622

Burgey, C.S., Robinson, K.A., Lyle, T.A., Sanderson, P.E., Lewis, S.D., Lucas, B.J., Krueger, J.A., Singh, R., Miller-Stein, C., White, R.B., Wong, B., Lyle, E.A., Williams, P.D., Coburn, C.A., Dorsey, B.D., Barrow, J.C., Stranieri, M.T., Holahan, M.A., Sitko, G.R., Cook, J.J., McMasters, D.R., McDonough, C.M., Sanders, W.M., Wallace, A.A., Clayton, F.C., Bohn, D., Leonard, Y.M., Detwiler Jr., T.J., Lynch Jr., J.J., Yan, Y., Chen, Z., Kuo, L., Gardell, S.J., Shafer, J.A., Vacca, J.P.J.

(2003) J Med Chem 46: 461-473

Released	2004-04-06
Method	X-RAY DIFFRACTION 1.99 Å
Organisms	Hirudo medicinalis Homo sapiens
Macromolecule	HIRUDIN IIB (protein) THROMBIN (protein)
Unique Ligands	CDA

Explore in 3D

1MU8 \| pdb_00001mu8	Download File View File

thrombin-hirugen_l-378,650

(2003) J Med Chem 46: 461-473

Released	2004-04-06
Method	X-RAY DIFFRACTION 2 Å
Organisms	Hirudo medicinalis Homo sapiens
Macromolecule	HIRUDIN IIB (protein) THROMBIN (protein)
Unique Ligands	CDB

Explore in 3D

1MUE \| pdb_00001mue	Download File View File

Thrombin-Hirugen-L405,426

Burgey, C.S., Robinson, K.A., Lyle, T.A., Nantermet, P.G., Selnick, H.G., Isaacs, R.C., Lewis, S.D., Lucas, B.J., Krueger, J.A., Singh, R., Miller-Stein, C., White, R.B., Wong, B., Lyle, E.A., Stranieri, M.T., Cook, J.J., McMasters, D.R., Pellicore, J.M., Pal, S., Wallace, A.A., Clayton, F.C., Bohn, D., Welsh, D.C., Lynch, J.J., Yan, Y., Chen, Z., Kuo, L., Gardell, S.J., Shafer, J.A., Vacca, J.P.

(2003) Bioorg Med Chem Lett 13: 1353-1357

Released	2004-04-06
Method	X-RAY DIFFRACTION 2 Å
Organisms	Hirudo medicinalis Homo sapiens
Macromolecule	HIRUDIN IIB (protein) THROMBIN (protein)
Unique Ligands	CDD

Explore in 3D

1Z71 \| pdb_00001z71	Download File View File

thrombin and P2 pyridine N-oxide inhibitor complex structure

Nantermet, P.G., Burgey, C.S., Robinson, K.A., Pellicore, J.M., Newton, C.L., Deng, J.Z., Lyle, T.A., Selnick, H.G., Lewis, S.D., Lucas, B.J., Krueger, J.A., Miller-Stein, C., White, R.B., Wong, B., McMasters, D.R., Wallace, A.A., Lynch Jr., J.J., Yan, Y., Chen, Z., Kuo, L., Gardell, S.J., Shafer, J.A., Vacca, J.P.

(2005) Bioorg Med Chem Lett 15: 2771-2775

Released	2005-05-17
Method	X-RAY DIFFRACTION 1.8 Å
Organisms	Hirudo medicinalis Homo sapiens
Macromolecule	Hirudin IIIB' (protein) thrombin (protein)
Unique Ligands	L17