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234,440 Structures from the PDB

1,068,577 Computed Structure Models (CSM)

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QUERY: Citation Author = "Schmoker, A.M."

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Search Summary

This query matches 22 Structures.

Refinements

Structure Determination Methodology

experimental (22)

Scientific Name of Source Organism

Homo sapiens (22)

Taxonomy

Eukaryota (22)

Experimental Method

	X-RAY DIFFRACTION (21)
	ELECTRON MICROSCOPY (1)

Polymer Entity Type

Protein (22)

Refinement Resolution (Å)

	1.5 - 2.0 (1)
	2.0 - 2.5 (7)
	2.5 - 3.0 (4)
	3.0 - 3.5 (10)

Release Date

2020 - 2024 (22)

Enzyme Classification Name

Transferases (21)

Symmetry Type

	Cyclic (10)
	Asymmetric (12)

SCOP Classification

Alpha and beta proteins (a+b) (11)

AllSelected

1 to 22 of 22 Structures

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6V2W \| pdb_00006v2w	Download File View File

Crystal structure of the BRAF:MEK1 kinases in complex with AMPPNP

Li, K., Gonzalez Del-Pino, G., Park, E., Eck, M.J.

(2021) Proc Natl Acad Sci U S A 118:

Released	2020-12-02
Method	X-RAY DIFFRACTION 3.12 Å
Organisms	Homo sapiens
Macromolecule	Dual specificity mitogen-activated protein kinase kinase 1 (protein) Serine/threonine-protein kinase B-raf (protein)
Unique Ligands	ANP, MG

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6WA2 \| pdb_00006wa2	Download File View File

Crystal structure of EGFR(T790M/V948R) in complex with LN3753

Heppner, D.E., Eck, M.J.

(2022) J Med Chem 65: 1370-1383

Released	2021-03-31
Method	X-RAY DIFFRACTION 2.4 Å
Organisms	Homo sapiens
Macromolecule	Epidermal growth factor receptor (protein)
Unique Ligands	CL, TOV

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6WAK \| pdb_00006wak	Download File View File

A crystal structure of EGFR(T790M/V948R) in complex with LN3754

Heppner, D.E., Eck, M.J.

(2022) J Med Chem 65: 1370-1383

Released	2021-03-31
Method	X-RAY DIFFRACTION 2.4 Å
Organisms	Homo sapiens
Macromolecule	Epidermal growth factor receptor (protein)
Unique Ligands	ANP, MG, TQA

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6WXN \| pdb_00006wxn	Download File View File

EGFR(T790M/V948R) in complex with LN3844

Heppner, D.E., Eck, M.J.

(2022) J Med Chem 65: 1370-1383

Released	2021-05-19
Method	X-RAY DIFFRACTION 1.76 Å
Organisms	Homo sapiens
Macromolecule	Epidermal growth factor receptor (protein)
Unique Ligands	ANP, CL, MG, UEJ

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6XL4 \| pdb_00006xl4	Download File View File

EGFR(T790M/V948R) in complex with AZD9291 and DDC4002

Heppner, D.E., Beyett, T.S., Eck, M.J.

(2022) Nat Commun 13: 2530-2530

Released	2021-06-30
Method	X-RAY DIFFRACTION 2.06 Å
Organisms	Homo sapiens
Macromolecule	Epidermal growth factor receptor (protein)
Unique Ligands	ANP, MG, NQ1, Q6K

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7JXI \| pdb_00007jxi	Download File View File

EGFR kinase (T790M/V948R) in complex with PF-06747775

Beyett, T.S., Eck, M.J.

(2022) Nat Commun 13: 2530

Released	2021-09-08
Method	X-RAY DIFFRACTION 3 Å
Organisms	Homo sapiens
Macromolecule	Epidermal growth factor receptor (protein)
Unique Ligands	8BS

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7JXK \| pdb_00007jxk	Download File View File

EGFR kinase (T790M/V948R) in complex with PF-06747775 and JBJ-04-125-02

Beyett, T.S., Eck, M.J.

(2022) Nat Commun 13: 2530

Released	2021-09-08
Method	X-RAY DIFFRACTION 3.1 Å
Organisms	Homo sapiens
Macromolecule	Epidermal growth factor receptor (protein)
Unique Ligands	8BS, ANP, JBJ, MG

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7JXL \| pdb_00007jxl	Download File View File

EGFR kinase (T790M/V948R) in complex with AZ5104

Beyett, T.S., Eck, M.J.

(2022) Nat Commun 13: 2530

Released	2021-09-08
Method	X-RAY DIFFRACTION 2.4 Å
Organisms	Homo sapiens
Macromolecule	Epidermal growth factor receptor (protein)
Unique Ligands	VO7

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7JXM \| pdb_00007jxm	Download File View File

EGFR kinase (T790M/V948R) in complex with osimertinib and EAI045

Beyett, T.S., Eck, M.J.

(2022) Nat Commun 13: 2530

Released	2021-09-08
Method	X-RAY DIFFRACTION 2.192 Å
Organisms	Homo sapiens
Macromolecule	Epidermal growth factor receptor (protein)
Unique Ligands	9LL, ANP, MG, YY3

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7JXP \| pdb_00007jxp	Download File View File

EGFR kinase (T790M/V948R) in complex with osimertinib and JBJ-04-125-02

Beyett, T.S., Eck, M.J.

(2022) Nat Commun 13: 2530

Released	2021-09-08
Method	X-RAY DIFFRACTION 2.16 Å
Organisms	Homo sapiens
Macromolecule	Epidermal growth factor receptor (protein)
Unique Ligands	ANP, JBJ, MG, YY3

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7JXW \| pdb_00007jxw	Download File View File

EGFR kinase (T790M/V948R) in complex with osimertinib and JBJ-09-063

Beyett, T.S., Eck, M.J.

(2022) Nat Commun 13: 2530

Released	2021-09-08
Method	X-RAY DIFFRACTION 2.5 Å
Organisms	Homo sapiens
Macromolecule	Epidermal growth factor receptor (protein)
Unique Ligands	VNS, YY3

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7K1H \| pdb_00007k1h	Download File View File

EGFR L858R/V948R in complex with osimertinib and allosteric inhibitor JBJ-09-063

Beyett, T.S., Eck, M.J.

(2022) Nat Commun 13: 2530

Released	2021-09-15
Method	X-RAY DIFFRACTION 2.602 Å
Organisms	Homo sapiens
Macromolecule	Epidermal growth factor receptor (protein)
Unique Ligands	VNS, YY3

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7K1I \| pdb_00007k1i	Download File View File

EGFR kinase (L858R/V948R) in complex with allosteric inhibitor JBJ-09-063

Beyett, T.S., Eck, M.J.

(2022) Nat Commun 13: 2530

Released	2021-09-15
Method	X-RAY DIFFRACTION 3.202 Å
Organisms	Homo sapiens
Macromolecule	Epidermal growth factor receptor (protein)
Unique Ligands	ANP, MG, VNS

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7LG8 \| pdb_00007lg8	Download File View File

EGFR (T79M/V948R) in complex with naquotinib and an allosteric inhibitor

Beyett, T.S., Eck, M.J.

(2022) Nat Commun 13: 2530-2530

Released	2022-02-23
Method	X-RAY DIFFRACTION 2.93 Å
Organisms	Homo sapiens
Macromolecule	Epidermal growth factor receptor (protein)
Unique Ligands	8RC, VNS

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7M0T \| pdb_00007m0t	Download File View File

Crystal structure of the BRAF:MEK1 kinases in complex with AMPPNP and Selumetinib

Li, K., Gonzalez Del-Pino, G., Ha, B.H., Park, E., Eck, M.J.

(2021) Proc Natl Acad Sci U S A 118:

Released	2021-04-21
Method	X-RAY DIFFRACTION 3.19 Å
Organisms	Homo sapiens
Macromolecule	Dual specificity mitogen-activated protein kinase kinase 1 (protein) Serine/threonine-protein kinase B-raf (protein)
Unique Ligands	3EW, ANP, MG

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7M0U \| pdb_00007m0u	Download File View File

Crystal structure of the BRAF:MEK1 kinases in complex with AMPPNP and Binimetinib

Li, K., Gonzalez Del-Pino, G., Ha, B.H., Park, E., Eck, M.J.

(2021) Proc Natl Acad Sci U S A 118:

Released	2021-04-21
Method	X-RAY DIFFRACTION 3.09 Å
Organisms	Homo sapiens
Macromolecule	Dual specificity mitogen-activated protein kinase kinase 1 (protein) Serine/threonine-protein kinase B-raf (protein)
Unique Ligands	ANP, MG, QO7

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7M0V \| pdb_00007m0v	Download File View File

Crystal structure of the BRAF:MEK1 kinases in complex with AMPPNP and Cobimetinib

Li, K., Gonzalez Del-Pino, G., Ha, B.H., Park, E., Eck, M.J.

(2021) Proc Natl Acad Sci U S A 118:

Released	2021-04-21
Method	X-RAY DIFFRACTION 3.16 Å
Organisms	Homo sapiens
Macromolecule	Dual specificity mitogen-activated protein kinase kinase 1 (protein) Serine/threonine-protein kinase B-raf (protein)
Unique Ligands	ANP, EUI, MG

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7M0W \| pdb_00007m0w	Download File View File

Crystal structure of the BRAF:MEK1 kinases in complex with AMPPNP and Pimasertib

Li, K., Gonzalez Del-Pino, G., Ha, B.H., Park, E., Eck, M.J.

(2021) Proc Natl Acad Sci U S A 118:

Released	2021-04-21
Method	X-RAY DIFFRACTION 3.09 Å
Organisms	Homo sapiens
Macromolecule	Dual specificity mitogen-activated protein kinase kinase 1 (protein) Serine/threonine-protein kinase B-raf (protein)
Unique Ligands	ANP, MG, QOA

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7M0X \| pdb_00007m0x	Download File View File

Crystal structure of the BRAF:MEK1 kinases in complex with AMPPNP and PD0325901

Li, K., Gonzalez Del-Pino, G., Ha, B.H., Park, E., Eck, M.J.

(2021) Proc Natl Acad Sci U S A 118:

Released	2021-04-21
Method	X-RAY DIFFRACTION 2.47 Å
Organisms	Homo sapiens
Macromolecule	Dual specificity mitogen-activated protein kinase kinase 1 (protein) Serine/threonine-protein kinase B-raf (protein)
Unique Ligands	4BM, ANP, CL, GOL, MG, SO4

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7M0Y \| pdb_00007m0y	Download File View File

Crystal structure of the BRAF:MEK1 kinases in complex with AMPPNP and Trametinib

Li, K., Gonzalez Del-Pino, G., Ha, B.H., Park, E., Eck, M.J.

(2021) Proc Natl Acad Sci U S A 118:

Released	2021-04-21
Method	X-RAY DIFFRACTION 3.45 Å
Organisms	Homo sapiens
Macromolecule	Dual specificity mitogen-activated protein kinase kinase 1 (protein) Serine/threonine-protein kinase B-raf (protein)
Unique Ligands	ANP, MG, QOM, SO4

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7M0Z \| pdb_00007m0z	Download File View File

Crystal structure of the BRAF:MEK1 kinases in complex with AMPPNP and CH5126766

Li, K., Gonzalez Del-Pino, G., Ha, B.H., Park, E., Eck, M.J.

(2021) Proc Natl Acad Sci U S A 118:

Released	2021-04-21
Method	X-RAY DIFFRACTION 3.12 Å
Organisms	Homo sapiens
Macromolecule	Dual specificity mitogen-activated protein kinase kinase 1 (protein) Serine/threonine-protein kinase B-raf (protein)
Unique Ligands	ANP, CHU, MG, SO4

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8TL6 \| pdb_00008tl6	Download File View File

Cryo-EM structure of DDB1deltaB-DDA1-DCAF5

Yue, H., Hunkeler, M., Roy Burman, S.S., Fischer, E.S.

(2024) Nature 628: 442-449

Released	2024-04-03
Method	ELECTRON MICROSCOPY 2.63 Å
Organisms	Homo sapiens
Macromolecule	DDB1- and CUL4-associated factor 5 (protein) DET1- and DDB1-associated protein 1 (protein) DNA damage-binding protein 1 (protein)

1 to 22 of 22 Structures

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Structure Determination Methodology

Scientific Name of Source Organism

Taxonomy

Experimental Method

Polymer Entity Type

Refinement Resolution (Å)

Release Date

Enzyme Classification Name

Symmetry Type

SCOP Classification

6V2W | pdb_00006v2w

6WA2 | pdb_00006wa2

6WAK | pdb_00006wak

6WXN | pdb_00006wxn

6XL4 | pdb_00006xl4

7JXI | pdb_00007jxi

7JXK | pdb_00007jxk

7JXL | pdb_00007jxl

7JXM | pdb_00007jxm

7JXP | pdb_00007jxp

7JXW | pdb_00007jxw

7K1H | pdb_00007k1h

7K1I | pdb_00007k1i

7LG8 | pdb_00007lg8

7M0T | pdb_00007m0t

7M0U | pdb_00007m0u

7M0V | pdb_00007m0v

7M0W | pdb_00007m0w

7M0X | pdb_00007m0x

7M0Y | pdb_00007m0y

7M0Z | pdb_00007m0z

8TL6 | pdb_00008tl6