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234,136 Structures from the PDB

1,068,577 Computed Structure Models (CSM)

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QUERY: Citation Author = "Mak, J.Y.W."

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Search Summary

This query matches 56 Structures.

Refinements

Structure Determination Methodology

experimental (56)

Scientific Name of Source Organism

	synthetic construct (24)
	Homo sapiens (21)
	Severe acute respiratory syndrome coronavirus 2 (8)
	uncultured archaeon (2)
	Human immunodeficiency virus 1 (1)
	Porphyromonas gingivalis W83 (1)

Taxonomy

	other sequences (24)
	Eukaryota (21)
	Riboviria (9)
	Archaea (2)
	Bacteria (1)

Experimental Method

	X-RAY DIFFRACTION (53)
	ELECTRON MICROSCOPY (2)
	SOLUTION NMR (1)

Polymer Entity Type

	Protein (56)
	RNA (2)
	DNA (1)

Refinement Resolution (Å)

	1.0 - 1.5 (12)
	1.5 - 2.0 (15)
	2.0 - 2.5 (16)
	2.5 - 3.0 (8)
	3.0 - 3.5 (4)

Release Date

	2015 - 2019 (8)
	2020 - 2024 (47)
	2025 - 2029 (1)

Enzyme Classification Name

	Transferases (19)
	Hydrolases (10)

Membrane Protein Annotation

	MemProtMD (1)
	OPM (1)

Symmetry Type

	Cyclic (35)
	Asymmetric (18)
	Dihedral (4)

SCOP Classification

	Alpha and beta proteins (a+b) (4)
	All beta proteins (8)
	Alpha and beta proteins (a/b) (2)
	Artifacts (1)

AllSelected

1 to 25 of 56 Structures

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5CX8 \| pdb_00005cx8	Download File View File

Structure of RagB, a major immunodominant virulence factor of Porphyromonas gingivalis.

Goulas, T., Garcia-Ferrer, I., Hutcherson, J.A., Potempa, B.A., Potempa, J., Scott, D.A., Gomis-Ruth, F.X.

(2016) Mol Oral Microbiol 31: 472-485

Released	2015-10-21
Method	X-RAY DIFFRACTION 2.4 Å
Organisms	Porphyromonas gingivalis W83
Macromolecule	Lipoprotein RagB (protein)
Unique Ligands	3DO, ACT, GOL, RP3, TG6

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5EBT \| pdb_00005ebt	Download File View File

Tankyrase 1 with Phthalazinone 2

Kazmirski, S.L., Johannes, J.

(2015) Bioorg Med Chem Lett 25: 5743-5747

Released	2016-03-02
Method	X-RAY DIFFRACTION 2.24 Å
Organisms	Homo sapiens
Macromolecule	Tankyrase-1 (protein)
Unique Ligands	5N8, BU3, ZN

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5ECE \| pdb_00005ece	Download File View File

Tankyrase 1 with Phthalazinone 1

Kazmirski, S.L., Johannes, J., Read, J.A., Howard, T., Larsen, N.A., Ferguson, A.D.

(2015) Bioorg Med Chem Lett 25: 5743-5747

Released	2015-11-25
Method	X-RAY DIFFRACTION 2.2 Å
Organisms	Homo sapiens
Macromolecule	Tankyrase-1 (protein)
Unique Ligands	5N2, ACT, EDO, ZN

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5V9L \| pdb_00005v9l	Download File View File

KRAS G12C in bound to quinazoline based switch II pocket (SWIIP) binder

Westover, K., Lu, J.

(2017) Cell Chem Biol 24: 1005-1016.e3

Released	2017-08-23
Method	X-RAY DIFFRACTION 1.981 Å
Organisms	Homo sapiens
Macromolecule	GTPase KRas (protein)
Unique Ligands	91D, GDP, MG

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5V9O \| pdb_00005v9o	Download File View File

KRAS G12C inhibitor

Westover, K., Lu, J.

(2017) Cell Chem Biol 24: 1005-1016.e3

Released	2017-08-23
Method	X-RAY DIFFRACTION 1.56 Å
Organisms	Homo sapiens
Macromolecule	GTPase KRas (protein)
Unique Ligands	91G, GDP, MG

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6P1D \| pdb_00006p1d	Download File View File

Crystal structure of EGFR with mutant-selective dihydrodibenzodiazepinone allosteric inhibitor

Heppner, D.E., Eck, M.J.

(2019) ACS Med Chem Lett 10: 1549-1553

Released	2019-12-18
Method	X-RAY DIFFRACTION 2.4 Å
Organisms	Homo sapiens
Macromolecule	Epidermal growth factor receptor (protein)
Unique Ligands	ANP, MG, NQ1

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6P1L \| pdb_00006p1l	Download File View File

Crystal structure of EGFR in complex with EAI045

Heppner, D.E., Eck, M.J.

(2019) ACS Med Chem Lett 10: 1549-1553

Released	2019-12-18
Method	X-RAY DIFFRACTION 2.8 Å
Organisms	Homo sapiens
Macromolecule	Epidermal growth factor receptor (protein)
Unique Ligands	9LL, ANP, MG

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6P8Q \| pdb_00006p8q	Download File View File

EGFR in complex with a dihydrodibenzodiazepinone allosteric inhibitor.

Yun, C.H., Heppner, D.E., Eck, M.J.

(2019) ACS Med Chem Lett 10: 1549-1553

Released	2019-12-18
Method	X-RAY DIFFRACTION 1.9 Å
Organisms	Homo sapiens
Macromolecule	Epidermal growth factor receptor (protein)
Unique Ligands	AMP, ANP, EDO, MG, O57

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6V4T \| pdb_00006v4t	Download File View File

MPER-TMD of HIV-1 Env bound with the entry inhibitor S2C3

Xiao, T., Frey, G., Fu, Q., Lavine, C.L., Scott, D.A., Seaman, M.S., Chou, J.J., Chen, B.

(2020) Nat Chem Biol 16: 529-537

Released	2020-04-01
Method	SOLUTION NMR
Organisms	Human immunodeficiency virus 1
Macromolecule	Envelope glycoprotein gp160 (protein)
Unique Ligands	QOJ

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6XL4 \| pdb_00006xl4	Download File View File

EGFR(T790M/V948R) in complex with AZD9291 and DDC4002

Heppner, D.E., Beyett, T.S., Eck, M.J.

(2022) Nat Commun 13: 2530-2530

Released	2021-06-30
Method	X-RAY DIFFRACTION 2.06 Å
Organisms	Homo sapiens
Macromolecule	Epidermal growth factor receptor (protein)
Unique Ligands	ANP, MG, NQ1, Q6K

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7JPY \| pdb_00007jpy	Download File View File

Crystal structure of the SARS-CoV-2 main protease in its apo-form

Yang, K., Liu, W.

(2021) ChemMedChem 16: 942-948

Released	2020-12-23
Method	X-RAY DIFFRACTION 1.6 Å
Organisms	Severe acute respiratory syndrome coronavirus 2
Macromolecule	3C-like proteinase (protein)

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7JPZ \| pdb_00007jpz	Download File View File

Structure of the SARS-CoV-2 main protease in complex with inhibitor MPI1

Yang, K., Liu, W.

(2021) ChemMedChem 16: 942-948

Released	2020-12-23
Method	X-RAY DIFFRACTION 1.6 Å
Organisms	Severe acute respiratory syndrome coronavirus 2
Macromolecule	3C-like proteinase (protein)
Unique Ligands	GHX

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7JQ0 \| pdb_00007jq0	Download File View File

Structure of the SARS-CoV-2 main protease in complex with inhibitor MPI3

Yang, K., Liu, W.

(2021) ChemMedChem 16: 942-948

Released	2020-12-23
Method	X-RAY DIFFRACTION 1.65 Å
Organisms	Severe acute respiratory syndrome coronavirus 2
Macromolecule	3C-like proteinase (protein)
Unique Ligands	VHV

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7JQ1 \| pdb_00007jq1	Download File View File

Structure of the SARS-CoV-2 main protease in complex with inhibitor MPI4

Yang, K., Liu, W.

(2021) ChemMedChem 16: 942-948

Released	2020-12-23
Method	X-RAY DIFFRACTION 1.65 Å
Organisms	Severe acute respiratory syndrome coronavirus 2
Macromolecule	3C-like proteinase (protein)
Unique Ligands	VHJ

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7JQ2 \| pdb_00007jq2	Download File View File

Structure of the SARS-CoV-2 main protease in complex with inhibitor MPI5

Yang, K., Liu, W.

(2021) ChemMedChem 16: 942-948

Released	2020-12-23
Method	X-RAY DIFFRACTION 1.4 Å
Organisms	Severe acute respiratory syndrome coronavirus 2
Macromolecule	3C-like proteinase (protein)
Unique Ligands	VHM

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7JQ3 \| pdb_00007jq3	Download File View File

Structure of the SARS-CoV-2 main protease in complex with inhibitor MPI6

Yang, K., Liu, W.

(2021) ChemMedChem 16: 942-948

Released	2020-12-23
Method	X-RAY DIFFRACTION 2.1 Å
Organisms	Severe acute respiratory syndrome coronavirus 2
Macromolecule	3C-like proteinase (protein)
Unique Ligands	VHP

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7JQ4 \| pdb_00007jq4	Download File View File

Structure of the SARS-CoV-2 main protease in complex with inhibitor MPI7

Yang, K., Liu, W.

(2021) ChemMedChem 16: 942-948

Released	2020-12-23
Method	X-RAY DIFFRACTION 1.65 Å
Organisms	Severe acute respiratory syndrome coronavirus 2
Macromolecule	3C-like proteinase (protein)
Unique Ligands	XM2

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7JQ5 \| pdb_00007jq5	Download File View File

Structure of the SARS-CoV-2 main protease in complex with inhibitor MPI8

Yang, K., Liu, W.

(2021) ChemMedChem 16: 942-948

Released	2020-12-23
Method	X-RAY DIFFRACTION 1.9 Å
Organisms	Severe acute respiratory syndrome coronavirus 2
Macromolecule	3C-like proteinase (protein)
Unique Ligands	NOL

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7JXI \| pdb_00007jxi	Download File View File

EGFR kinase (T790M/V948R) in complex with PF-06747775

Beyett, T.S., Eck, M.J.

(2022) Nat Commun 13: 2530

Released	2021-09-08
Method	X-RAY DIFFRACTION 3 Å
Organisms	Homo sapiens
Macromolecule	Epidermal growth factor receptor (protein)
Unique Ligands	8BS

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7JXK \| pdb_00007jxk	Download File View File

EGFR kinase (T790M/V948R) in complex with PF-06747775 and JBJ-04-125-02

Beyett, T.S., Eck, M.J.

(2022) Nat Commun 13: 2530

Released	2021-09-08
Method	X-RAY DIFFRACTION 3.1 Å
Organisms	Homo sapiens
Macromolecule	Epidermal growth factor receptor (protein)
Unique Ligands	8BS, ANP, JBJ, MG

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7JXL \| pdb_00007jxl	Download File View File

EGFR kinase (T790M/V948R) in complex with AZ5104

Beyett, T.S., Eck, M.J.

(2022) Nat Commun 13: 2530

Released	2021-09-08
Method	X-RAY DIFFRACTION 2.4 Å
Organisms	Homo sapiens
Macromolecule	Epidermal growth factor receptor (protein)
Unique Ligands	VO7

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7JXM \| pdb_00007jxm	Download File View File

EGFR kinase (T790M/V948R) in complex with osimertinib and EAI045

Beyett, T.S., Eck, M.J.

(2022) Nat Commun 13: 2530

Released	2021-09-08
Method	X-RAY DIFFRACTION 2.192 Å
Organisms	Homo sapiens
Macromolecule	Epidermal growth factor receptor (protein)
Unique Ligands	9LL, ANP, MG, YY3

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7JXP \| pdb_00007jxp	Download File View File

EGFR kinase (T790M/V948R) in complex with osimertinib and JBJ-04-125-02

Beyett, T.S., Eck, M.J.

(2022) Nat Commun 13: 2530

Released	2021-09-08
Method	X-RAY DIFFRACTION 2.16 Å
Organisms	Homo sapiens
Macromolecule	Epidermal growth factor receptor (protein)
Unique Ligands	ANP, JBJ, MG, YY3

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7JXQ \| pdb_00007jxq	Download File View File

EGFR kinase (T790M/V948R) in complex with allosteric inhibitor JBJ-09-063

Beyett, T.S., Eck, M.J.

(2022) Nat Cancer 3: 402-417

Released	2021-09-08
Method	X-RAY DIFFRACTION 1.83 Å
Organisms	Homo sapiens
Macromolecule	Epidermal growth factor receptor (protein)
Unique Ligands	ANP, MG, VNS