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234,136 Structures from the PDB

1,068,577 Computed Structure Models (CSM)

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QUERY: Citation Author = "Le, N.H."

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Search Summary

This query matches 121 Structures.

Refinements

Structure Determination Methodology

experimental (121)

Scientific Name of Source Organism

	Homo sapiens (71)
	Saccharomyces cerevisiae S288C (11)
	Saccharomyces cerevisiae BY4741 (10)
	Escherichia coli (5)
	Spodoptera exigua (5)
	Mus musculus (4)
	Saccharomyces cerevisiae (4)
	Thermomyces lanuginosus (4)
	Sphingopyxis sp. (3)
	synthetic construct (3)

More...

Taxonomy

	Eukaryota (107)
	Bacteria (15)
	other sequences (3)
	Archaea (1)
	Eukaryota (eukaryotes) (1)

Experimental Method

	ELECTRON MICROSCOPY (69)
	X-RAY DIFFRACTION (51)
	SOLUTION NMR (1)

Polymer Entity Type

	Protein (121)
	RNA (6)

Refinement Resolution (Å)

	1.0 - 1.5 (2)
	1.5 - 2.0 (10)
	2.0 - 2.5 (13)
	2.5 - 3.0 (29)
	3.0 - 3.5 (32)
	3.5 - 4.0 (15)
	4.0 - 4.5 (10)
	> 4.5 (9)

Release Date

	2000 - 2004 (3)
	2005 - 2009 (3)
	2010 - 2014 (8)
	2015 - 2019 (26)
	2020 - 2024 (81)

Enzyme Classification Name

	Transferases (33)
	Hydrolases (16)
	Translocases (15)
	Isomerases (3)

Membrane Protein Annotation

	PDBTM (55)
	OPM (46)
	MemProtMD (43)
	mpstruc (40)

Symmetry Type

	Asymmetric (94)
	Cyclic (28)
	Dihedral (1)

SCOP Classification

	Alpha and beta proteins (a+b) (19)
	Artifacts (2)
	All beta proteins (2)
	Small proteins (2)
	Membrane and cell surface proteins and peptides (1)

AllSelected

1 to 25 of 121 Structures

Page 1 of 5

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1KOZ \| pdb_00001koz	Download File View File

SOLUTION STRUCTURE OF OMEGA-GRAMMOTOXIN SIA

Takeuchi, K., Park, E.J., Lee, C.W., Kim, J.I., Takahashi, H., Swartz, K.J., Shimada, I.

(2002) J Mol Biology 321: 517-526

Released	2002-08-28
Method	SOLUTION NMR
Organisms	Grammostola rosea
Macromolecule	Voltage-dependent Channel Inhibitor (protein)

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1NYC \| pdb_00001nyc	Download File View File

Staphostatins resemble lipocalins, not cystatins in fold.

Rzychon, M., Filipek, R., Sabat, A., Kosowska, K., Dubin, A., Potempa, J., Bochtler, M.

(2003) Protein Sci 12: 2252-2256

Released	2003-09-30
Method	X-RAY DIFFRACTION 1.4 Å
Organisms	Staphylococcus aureus subsp. aureus MW2
Macromolecule	cysteine protease inhibitor (protein)
Unique Ligands	CL, SO4

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1PXV \| pdb_00001pxv	Download File View File

The staphostatin-staphopain complex: a forward binding inhibitor in complex with its target cysteine protease

Filipek, R., Rzychon, M., Oleksy, A., Gruca, M., Dubin, A., Potempa, J., Bochtler, M.

(2003) J Biological Chem 278: 40959-40966

Released	2003-10-21
Method	X-RAY DIFFRACTION 1.8 Å
Organisms	Staphylococcus aureus
Macromolecule	cysteine protease (protein) cysteine protease Inhibitor (protein)
Unique Ligands	GAI, SO4

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3BO0 \| pdb_00003bo0	Download File View File

Ribosome-SecY complex

Akey, C.W., Menetret, J.F.

(2007) Mol Cell 28: 1083-1092

Released	2008-12-09
Method	ELECTRON MICROSCOPY 9.6 Å
Organisms	Escherichia coli
Macromolecule	Unique protein chains: 3 Unique nucleic acid chains: 4

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3BO1 \| pdb_00003bo1	Download File View File

Ribosome-SecY complex

Akey, C.W., Menetret, J.F.

(2007) Mol Cell 28: 1083-1092

Released	2008-12-09
Method	ELECTRON MICROSCOPY 9.6 Å
Organisms	Escherichia coli
Macromolecule	Unique protein chains: 3 Unique nucleic acid chains: 4

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3DKN \| pdb_00003dkn	Download File View File

Sec61 in the Canine ribosome-channel complex from the endoplasmic reticulum

Menetret, J.-F., Akey, C.

(2008) Structure 16: 1126-1137

Released	2008-08-19
Method	ELECTRON MICROSCOPY 8.7 Å
Organisms	Canis lupus familiaris
Macromolecule	Unique protein chains: 3 Unique nucleic acid chains: 3

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3J45 \| pdb_00003j45	Download File View File

Structure of a non-translocating SecY protein channel with the 70S ribosome

Menetret, J.F., Park, E., Gumbart, J.C., Ludtke, S.J., Li, W., Whynot, A., Rapoport, T.A., Akey, C.W.

(2013) Nature 506: 102-106

Released	2013-10-23
Method	ELECTRON MICROSCOPY 9.5 Å
Organisms	Escherichia coli
Macromolecule	Unique protein chains: 6 Unique nucleic acid chains: 5

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3J46 \| pdb_00003j46	Download File View File

Structure of the SecY protein translocation channel in action

Akey, C.W., Park, E., Menetret, J.F., Gumbart, J.C., Ludtke, S.J., Li, W., Whynot, A., Rapoport, T.A.

(2013) Nature 506: 102-106

Released	2013-10-23
Method	ELECTRON MICROSCOPY 10.1 Å
Organisms	Escherichia coli
Macromolecule	Unique protein chains: 8 Unique nucleic acid chains: 6

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3OKQ \| pdb_00003okq	Download File View File

Crystal structure of a core domain of yeast actin nucleation cofactor Bud6

Tu, D., Eck, M.J.

(2012) Proc Natl Acad Sci U S A 109: E3424-E3433

Released	2011-09-14
Method	X-RAY DIFFRACTION 2.044 Å
Organisms	Saccharomyces cerevisiae
Macromolecule	Bud site selection protein 6 (protein)

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3ONX \| pdb_00003onx	Download File View File

Crystal structure of a domain of a protein involved in formation of actin cytoskeleton

Tu, D., Eck, M.J.

(2012) Proc Natl Acad Sci U S A 109: E3424-E3433

Released	2011-10-12
Method	X-RAY DIFFRACTION 2.904 Å
Organisms	Saccharomyces cerevisiae
Macromolecule	Bud site selection protein 6 (protein)

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4G4E \| pdb_00004g4e	Download File View File

Crystal structure of the L88A mutant of HslV from Escherichia coli

Lee, J.W., Park, E., Yoo, H.M., Ha, B.H., An, J.Y., Jeon, Y.J., Seol, J.H., Eom, S.H., Chung, C.H.

(2013) J Mol Biology 425: 2940-2954

Released	2013-06-12
Method	X-RAY DIFFRACTION 2.888 Å
Organisms	Escherichia coli K-12
Macromolecule	ATP-dependent protease subunit HslV (protein)

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4LQM \| pdb_00004lqm	Download File View File

EGFR L858R in complex with PD168393

Yun, C.H., Eck, M.J.

(2013) Sci Transl Med 5: 216ra177-216ra177

Released	2014-01-15
Method	X-RAY DIFFRACTION 2.5 Å
Organisms	Homo sapiens
Macromolecule	Epidermal growth factor receptor (protein)
Unique Ligands	CL, DJK

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4LRM \| pdb_00004lrm	Download File View File

EGFR D770_N771insNPG in complex with PD168393

Yun, C.H., Eck, M.J.

(2013) Sci Transl Med 5: 216ra177-216ra177

Released	2014-01-15
Method	X-RAY DIFFRACTION 3.526 Å
Organisms	Homo sapiens
Macromolecule	Epidermal growth factor receptor (protein)
Unique Ligands	YUN

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4R3P \| pdb_00004r3p	Download File View File

Crystal structures of EGFR in complex with Mig6

Park, E., Kim, N., Yi, Z., Cho, A., Kim, K., Ficarro, S.B., Park, A., Park, W.Y., Murray, B., Meyerson, M., Beroukim, R., Marto, J.A., Cho, J., Eck, M.J.

(2015) Nat Struct Mol Biol 22: 703-711

Released	2015-08-12
Method	X-RAY DIFFRACTION 2.905 Å
Organisms	Homo sapiens
Macromolecule	Epidermal growth factor receptor (protein) peptide from ERBB receptor feedback inhibitor 1 (protein)

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4R3R \| pdb_00004r3r	Download File View File

Crystal structures of EGFR in complex with Mig6

Park, E., Kim, N., Yi, Z., Cho, A., Kim, K., Ficarro, S.B., Park, A., Park, W.Y., Murray, B., Meyerson, M., Beroukim, R., Marto, J.A., Cho, J., Eck, M.J.

(2015) Nat Struct Mol Biol 22: 703-711

Released	2015-08-12
Method	X-RAY DIFFRACTION 3.25 Å
Organisms	Homo sapiens
Macromolecule	Epidermal growth factor receptor (protein) peptide from ERBB receptor feedback inhibitor 1' (protein)

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4V4N \| pdb_00004v4n	Download File View File

Structure of the Methanococcus jannaschii ribosome-SecYEBeta channel complex

Menetret, J.F., Park, E., Gumbart, J.C., Ludtke, S.J., Li, W., Whynot, A., Rapoport, T.A., Akey, C.W.

(2013) Nature 506: 102-106

Released	2014-07-09
Method	ELECTRON MICROSCOPY 9 Å
Organisms	Methanocaldococcus jannaschii
Macromolecule	Unique protein chains: 63 Unique nucleic acid chains: 4

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4WYB \| pdb_00004wyb	Download File View File

Structure of the Bud6 flank domain in complex with actin

Eck, M.J., Park, E., Zheng, W.

(2015) Structure 23: 1492-1499

Released	2015-08-19
Method	X-RAY DIFFRACTION 3.493 Å
Organisms	Oryctolagus cuniculus Saccharomyces cerevisiae S288C
Macromolecule	Actin, alpha skeletal muscle (protein) Bud site selection protein 6 (protein)
Unique Ligands	ATP, CA

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4ZJV \| pdb_00004zjv	Download File View File

crystal structure of EGFR kinase domain in complex with Mitogen-inducible gene 6 protein

Eck, M.J., Park, E., Lee, B.

(2015) Nat Struct Mol Biol 22: 703-711

Released	2015-08-12
Method	X-RAY DIFFRACTION 2.7 Å
Organisms	Homo sapiens
Macromolecule	ERBB receptor feedback inhibitor 1 (protein) Epidermal growth factor receptor (protein)

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5D41 \| pdb_00005d41	Download File View File

EGFR kinase domain in complex with mutant selective allosteric inhibitor

Yun, C.-H., Park, E., Eck, M.J.

(2016) Nature 534: 129-132

Released	2016-06-08
Method	X-RAY DIFFRACTION 2.31 Å
Organisms	Homo sapiens
Macromolecule	Epidermal growth factor receptor (protein)
Unique Ligands	57N, ANP, MG

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5EUL \| pdb_00005eul	Download File View File

Structure of the SecA-SecY complex with a translocating polypeptide substrate

Li, L., Park, E., Ling, J., Ingram, J., Ploegh, H., Rapoport, T.A.

(2016) Nature 531: 395-399

Released	2016-03-09
Method	X-RAY DIFFRACTION 3.7 Å
Organisms	Bacillus subtilis subsp. subtilis str. 168 Geobacillus thermodenitrificans NG80-2 Vicugna pacos synthetic construct
Macromolecule	AYC08 (protein) Preprotein translocase SecE subunit (protein) Protein translocase subunit SecA, Insertion Peptide Chimera (protein) Protein translocase subunit SecY (protein)
Unique Ligands	ADP, BEF, MG, TBR

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5SYB \| pdb_00005syb	Download File View File

Crystal structure of human PHF5A

Tsai, J.H.C., Teng, T., Zhu, P., Fekkes, P., Larsen, N.A.

(2017) Nat Commun 8: 15522-15522

Released	2016-09-07
Method	X-RAY DIFFRACTION 1.82 Å
Organisms	Homo sapiens
Macromolecule	PHD finger-like domain-containing protein 5A (protein)
Unique Ligands	EDO, ZN

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5TQQ \| pdb_00005tqq	Download File View File

Cryo-electron microscopy structure of a bovine CLC-K chloride channel, main (class 1) conformation

Park, E., MacKinnon, R.

(2017) Nature 541: 500-505

Released	2017-01-04
Method	ELECTRON MICROSCOPY 3.76 Å
Organisms	Bos taurus Mus musculus
Macromolecule	Chloride channel protein (protein) Monoclonal antibody, Fab fragment, heavy chain (protein) Monoclonal antibody, Fab fragment, light chain (protein)

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5TR1 \| pdb_00005tr1	Download File View File

Cryo-electron microscopy structure of a bovine CLC-K chloride channel, alternate (class 2) conformation

Park, E., MacKinnon, R.

(2017) Nature 541: 500-505

Released	2017-01-11
Method	ELECTRON MICROSCOPY 3.95 Å
Organisms	Bos taurus Mus musculus
Macromolecule	Chloride channel protein (protein) Monoclonal antibody, Fab fragment, heavy chain (protein) Monoclonal antibody, Fab fragment, light chain (protein)
Unique Ligands	Y01

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5VND \| pdb_00005vnd	Download File View File

Crystal structure of FGFR1-Y563C (FGFR4 surrogate) covalently bound to H3B-6527

Tsai, J.H.C., Reynolds, D., Fekkes, P., Smith, P., Larsen, N.A.

(2017) Cancer Res 77: 6999-7013

Released	2017-05-24
Method	X-RAY DIFFRACTION 2.2 Å
Organisms	Homo sapiens
Macromolecule	Fibroblast growth factor receptor 1 (protein)
Unique Ligands	9ES, EDO, SO4