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234,136 Structures from the PDB

1,068,577 Computed Structure Models (CSM)

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QUERY: Citation Author = "Fuchs, R.T."

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Search Summary

This query matches 19 Structures.

Refinements

Structure Determination Methodology

experimental (19)

Scientific Name of Source Organism

	Homo sapiens (10)
	Oryctolagus cuniculus (5)
	Bos taurus (2)
	Caenorhabditis elegans (1)
	Saccharomyces cerevisiae (1)

Taxonomy

Eukaryota (19)

Experimental Method

X-RAY DIFFRACTION (19)

Polymer Entity Type

Protein (19)

Refinement Resolution (Å)

	1.0 - 1.5 (1)
	1.5 - 2.0 (8)
	2.0 - 2.5 (5)
	2.5 - 3.0 (4)
	3.0 - 3.5 (1)

Release Date

	1995 - 1999 (6)
	2000 - 2004 (4)
	2005 - 2009 (7)
	2015 - 2019 (2)

Enzyme Classification Name

	Transferases (10)
	Hydrolases (9)

Symmetry Type

	Cyclic (10)
	Asymmetric (8)
	Dihedral (1)

SCOP Classification

	Alpha and beta proteins (a+b) (11)
	Alpha and beta proteins (a/b) (2)
	All beta proteins (2)

AllSelected

1 to 19 of 19 Structures

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1EMS \| pdb_00001ems	Download File View File

CRYSTAL STRUCTURE OF THE C. ELEGANS NITFHIT PROTEIN

Pace, H.C., Hodawadekar, S.C., Draganescu, A., Huang, J., Bieganowski, P., Pekarsky, Y., Croce, C.M., Brenner, C.

(2000) Curr Biol 10: 907-917

Released	2000-07-20
Method	X-RAY DIFFRACTION 2.8 Å
Organisms	Caenorhabditis elegans
Macromolecule	NIT-FRAGILE HISTIDINE TRIAD FUSION PROTEIN (protein)
Unique Ligands	EMC, MPD, NA

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1F89 \| pdb_00001f89	Download File View File

Crystal structure of Saccharomyces cerevisiae Nit3, a member of branch 10 of the nitrilase superfamily

Kumaran, D., Eswaramoorthy, S., Studier, F.W., Swaminathan, S., Burley, S.K., New York SGX Research Center for Structural Genomics (NYSGXRC)

(2003) Proteins 52: 283-291

Released	2001-10-04
Method	X-RAY DIFFRACTION 2.4 Å
Organisms	Saccharomyces cerevisiae
Macromolecule	32.5 KDA PROTEIN YLR351C (protein)

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1FHI \| pdb_00001fhi	Download File View File

SUBSTRATE ANALOG (IB2) COMPLEX WITH THE FRAGILE HISTIDINE TRIAD PROTEIN, FHIT

Pace, H.C., Garrison, P.N., Barnes, L.D., Draganescu, A., Rosler, A., Blackburn, G.M., Siprashvili, Z., Croce, C.M., Huebner, K., Brenner, C.

(1998) Proc Natl Acad Sci U S A 95: 5484-5489

Released	1998-06-17
Method	X-RAY DIFFRACTION 3.1 Å
Organisms	Homo sapiens
Macromolecule	FRAGILE HISTIDINE TRIAD PROTEIN (protein)
Unique Ligands	IB2

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1JSY \| pdb_00001jsy	Download File View File

Crystal structure of bovine arrestin-2

Milano, S.K., Pace, H.C., Kim, Y.M., Brenner, C., Benovic, J.L.

(2002) Biochemistry 41: 3321-3328

Released	2002-03-27
Method	X-RAY DIFFRACTION 2.9 Å
Organisms	Bos taurus
Macromolecule	Bovine arrestin-2 (full length) (protein)

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1RZY \| pdb_00001rzy	Download File View File

Crystal structure of rabbit Hint complexed with N-ethylsulfamoyladenosine

Krakowiak, A.K., Pace, H.C., Blackburn, G.M., Adams, M., Mekhalfia, A., Kaczmarek, R., Baraniak, J., Stec, W.J., Brenner, C.

(2004) J Biological Chem 279: 18711-18716

Released	2004-03-09
Method	X-RAY DIFFRACTION 1.8 Å
Organisms	Oryctolagus cuniculus
Macromolecule	Histidine triad nucleotide-binding protein 1 (protein)
Unique Ligands	5AS

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1ZSH \| pdb_00001zsh	Download File View File

Crystal structure of bovine arrestin-2 in complex with inositol hexakisphosphate (IP6)

Milano, S.K., Kim, Y.M., Stefano, F.P., Benovic, J.L., Brenner, C.

(2006) J Biological Chem 281: 9812-9823

Released	2006-01-31
Method	X-RAY DIFFRACTION 2.9 Å
Organisms	Bos taurus
Macromolecule	Beta-arrestin 1 (protein)
Unique Ligands	IHP, MG

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2FHI \| pdb_00002fhi	Download File View File

SUBSTRATE ANALOG (IB2) COMPLEX WITH THE HIS 96 ASN SUBSTITUTION OF THE FRAGILE HISTIDINE TRIAD PROTEIN, FHIT

Pace, H.C., Garrison, P.N., Robinson, A.K., Barnes, L.D., Draganescu, A., Rosler, A., Blackburn, G.M., Siprashvili, Z., Croce, C.M., Heubner, K., Brenner, C.

(1998) Proc Natl Acad Sci U S A 95: 5484-5489

Released	1998-06-17
Method	X-RAY DIFFRACTION 2.6 Å
Organisms	Homo sapiens
Macromolecule	FRAGILE HISTIDINE TRIAD PROTEIN (protein)
Unique Ligands	IB2

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2P0E \| pdb_00002p0e	Download File View File

Human nicotinamide riboside kinase 1 in complex with tiazofurin

Rabeh, W.M., Tempel, W., Nedyalkova, L., Landry, R., Arrowsmith, C.H., Edwards, A.M., Sundstrom, M., Weigelt, J., Bochkarev, A., Brenner, C., Park, H., Structural Genomics Consortium (SGC)

(2007) PLoS Biol 5: e263-e263

Released	2007-05-08
Method	X-RAY DIFFRACTION 1.8 Å
Organisms	Homo sapiens
Macromolecule	Nicotinamide riboside kinase 1 (protein)
Unique Ligands	CL, PO4, TIZ, UNX

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2QSY \| pdb_00002qsy	Download File View File

Human nicotinamide riboside kinase 1 in complex with ADP

Rabeh, W.M., Tempel, W., Nedyalkova, L., Landry, R., Arrowsmith, C.H., Edwards, A.M., Sundstrom, M., Weigelt, J., Bochkarev, A., Brenner, C., Park, H., Structural Genomics Consortium (SGC)

(2007) PLoS Biol 5: e263-e263

Released	2007-08-14
Method	X-RAY DIFFRACTION 1.95 Å
Organisms	Homo sapiens
Macromolecule	Nicotinamide riboside kinase 1 (protein)
Unique Ligands	ADP, MG, UNX

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2QSZ \| pdb_00002qsz	Download File View File

Human nicotinamide riboside kinase 1 in complex with nicotinamide mononucleotide

Rabeh, W.M., Tempel, W., Nedyalkova, L., Landry, R., Arrowsmith, C.H., Edwards, A.M., Sundstrom, M., Weigelt, J., Bochkarev, A., Brenner, C., Park, H., Structural Genomics Consortium (SGC)

(2007) PLoS Biol 5: e263-e263

Released	2007-08-14
Method	X-RAY DIFFRACTION 1.9 Å
Organisms	Homo sapiens
Macromolecule	Nicotinamide riboside kinase 1 (protein)
Unique Ligands	CL, NMN, PO4, UNX

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2QT0 \| pdb_00002qt0	Download File View File

Human nicotinamide riboside kinase 1 in complex with nicotinamide riboside and an ATP analogue

Rabeh, W.M., Tempel, W., Nedyalkova, L., Landry, R., Arrowsmith, C.H., Edwards, A.M., Sundstrom, M., Weigelt, J., Bochkarev, A., Brenner, C., Park, H., Structural Genomics Consortium (SGC)

(2007) PLoS Biol 5: e263-e263

Released	2007-08-14
Method	X-RAY DIFFRACTION 1.92 Å
Organisms	Homo sapiens
Macromolecule	Nicotinamide riboside kinase 1 (protein)
Unique Ligands	ANP, MG, NNR

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2QT1 \| pdb_00002qt1	Download File View File

Human nicotinamide riboside kinase 1 in complex with nicotinamide riboside

Rabeh, W.M., Tempel, W., Nedyalkova, L., Landry, R., Arrowsmith, C.H., Edwards, A.M., Sundstrom, M., Weigelt, J., Bochkarev, A., Brenner, C., Park, H., Structural Genomics Consortium (SGC)

(2007) PLoS Biol 5: e263-e263

Released	2007-08-14
Method	X-RAY DIFFRACTION 1.32 Å
Organisms	Homo sapiens
Macromolecule	Nicotinamide riboside kinase 1 (protein)
Unique Ligands	NNR, PO4, UNX

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3EPZ \| pdb_00003epz	Download File View File

Structure of the replication foci-targeting sequence of human DNA cytosine methyltransferase DNMT1

Walker, J.R., Avvakumov, G.V., Xue, S., Li, Y., Bountra, C., Weigelt, J., Arrowsmith, C.H., Edwards, A.M., Bochkarev, A., Dhe-Paganon, S., Structural Genomics Consortium (SGC)

(2011) J Biological Chem 286: 15344-15351

Released	2008-11-25
Method	X-RAY DIFFRACTION 2.31 Å
Organisms	Homo sapiens
Macromolecule	DNA (cytosine-5)-methyltransferase 1 (protein)
Unique Ligands	BGC, GOL, NA, ZN

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3RHN \| pdb_00003rhn	Download File View File

HISTIDINE TRIAD NUCLEOTIDE-BINDING PROTEIN (HINT) FROM RABBIT COMPLEXED WITH GMP

Brenner, C., Garrison, P., Gilmour, J., Peisach, D., Ringe, D., Petsko, G.A., Lowenstein, J.M.

(1997) Nat Struct Biol 4: 231-238

Released	1997-06-16
Method	X-RAY DIFFRACTION 2.1 Å
Organisms	Oryctolagus cuniculus
Macromolecule	HISTIDINE TRIAD NUCLEOTIDE-BINDING PROTEIN (protein)
Unique Ligands	5GP

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4RHN \| pdb_00004rhn	Download File View File

HISTIDINE TRIAD NUCLEOTIDE-BINDING PROTEIN (HINT) FROM RABBIT COMPLEXED WITH ADENOSINE

Brenner, C., Garrison, P., Gilmour, J., Peisach, D., Ringe, D., Petsko, G.A., Lowenstein, J.M.

(1997) Nat Struct Biol 4: 231-238

Released	1997-06-16
Method	X-RAY DIFFRACTION 1.9 Å
Organisms	Oryctolagus cuniculus
Macromolecule	HISTIDINE TRIAD NUCLEOTIDE-BINDING PROTEIN (protein)
Unique Ligands	RIB

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5RHN \| pdb_00005rhn	Download File View File

HISTIDINE TRIAD NUCLEOTIDE-BINDING PROTEIN (HINT) FROM RABBIT COMPLEXED WITH 8-BR-AMP

Brenner, C., Garrison, P., Gilmour, J., Peisach, D., Ringe, D., Petsko, G.A., Lowenstein, J.M.

(1997) Nat Struct Biol 4: 231-238

Released	1997-06-16
Method	X-RAY DIFFRACTION 2.31 Å
Organisms	Oryctolagus cuniculus
Macromolecule	HISTIDINE TRIAD NUCLEOTIDE-BINDING PROTEIN (protein)
Unique Ligands	8BR

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5U2M \| pdb_00005u2m	Download File View File

Crystal structure of human NAMPT with A-1293201

Longenecker, K.L., Raich, D., Korepanova, A.V.

(2017) Mol Cancer Ther 16: 1236-1245

Released	2017-06-28
Method	X-RAY DIFFRACTION 1.89 Å
Organisms	Homo sapiens
Macromolecule	Nicotinamide phosphoribosyltransferase (protein)
Unique Ligands	7T7, SO4

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5U2N \| pdb_00005u2n	Download File View File

Crystal structure of human NAMPT with A-1326133

Longenecker, K.L., Raich, D., Korepanova, A.V.

(2017) Mol Cancer Ther 16: 1236-1245

Released	2017-06-28
Method	X-RAY DIFFRACTION 1.73 Å
Organisms	Homo sapiens
Macromolecule	Nicotinamide phosphoribosyltransferase (protein)
Unique Ligands	7TA, SO4

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6RHN \| pdb_00006rhn	Download File View File

HISTIDINE TRIAD NUCLEOTIDE-BINDING PROTEIN (HINT) FROM RABBIT WITHOUT NUCLEOTIDE

Brenner, C., Garrison, P., Gilmour, J., Peisach, D., Ringe, D., Petsko, G.A., Lowenstein, J.M.

(1997) Nat Struct Biol 4: 231-238

Released	1997-06-16
Method	X-RAY DIFFRACTION 2.15 Å
Organisms	Oryctolagus cuniculus
Macromolecule	HISTIDINE TRIAD NUCLEOTIDE-BINDING PROTEIN (protein)

1 to 19 of 19 Structures

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RCSB PDB Core Operations are funded by the U.S. National Science Foundation (DBI-2321666), the US Department of Energy (DE-SC0019749), and the National Cancer Institute, National Institute of Allergy and Infectious Diseases, and National Institute of General Medical Sciences of the National Institutes of Health under grant R01GM157729.

1EMS | pdb_00001ems

CRYSTAL STRUCTURE OF THE C. ELEGANS NITFHIT PROTEIN

1F89 | pdb_00001f89

Crystal structure of Saccharomyces cerevisiae Nit3, a member of branch 10 of the nitrilase superfamily

1FHI | pdb_00001fhi

SUBSTRATE ANALOG (IB2) COMPLEX WITH THE FRAGILE HISTIDINE TRIAD PROTEIN, FHIT

1JSY | pdb_00001jsy

Crystal structure of bovine arrestin-2

1RZY | pdb_00001rzy

Crystal structure of rabbit Hint complexed with N-ethylsulfamoyladenosine

1ZSH | pdb_00001zsh

Crystal structure of bovine arrestin-2 in complex with inositol hexakisphosphate (IP6)

2FHI | pdb_00002fhi

SUBSTRATE ANALOG (IB2) COMPLEX WITH THE HIS 96 ASN SUBSTITUTION OF THE FRAGILE HISTIDINE TRIAD PROTEIN, FHIT

2P0E | pdb_00002p0e

Human nicotinamide riboside kinase 1 in complex with tiazofurin

2QSY | pdb_00002qsy

Human nicotinamide riboside kinase 1 in complex with ADP

2QSZ | pdb_00002qsz

Human nicotinamide riboside kinase 1 in complex with nicotinamide mononucleotide

2QT0 | pdb_00002qt0

Human nicotinamide riboside kinase 1 in complex with nicotinamide riboside and an ATP analogue

2QT1 | pdb_00002qt1

Human nicotinamide riboside kinase 1 in complex with nicotinamide riboside

3EPZ | pdb_00003epz

Structure of the replication foci-targeting sequence of human DNA cytosine methyltransferase DNMT1

3RHN | pdb_00003rhn

HISTIDINE TRIAD NUCLEOTIDE-BINDING PROTEIN (HINT) FROM RABBIT COMPLEXED WITH GMP

4RHN | pdb_00004rhn

HISTIDINE TRIAD NUCLEOTIDE-BINDING PROTEIN (HINT) FROM RABBIT COMPLEXED WITH ADENOSINE

5RHN | pdb_00005rhn

HISTIDINE TRIAD NUCLEOTIDE-BINDING PROTEIN (HINT) FROM RABBIT COMPLEXED WITH 8-BR-AMP

5U2M | pdb_00005u2m

Crystal structure of human NAMPT with A-1293201

5U2N | pdb_00005u2n

Crystal structure of human NAMPT with A-1326133

6RHN | pdb_00006rhn

HISTIDINE TRIAD NUCLEOTIDE-BINDING PROTEIN (HINT) FROM RABBIT WITHOUT NUCLEOTIDE

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Structure Determination Methodology

Scientific Name of Source Organism

Taxonomy

Experimental Method

Polymer Entity Type

Refinement Resolution (Å)

Release Date

Enzyme Classification Name

Symmetry Type

SCOP Classification

1EMS | pdb_00001ems

1F89 | pdb_00001f89

1FHI | pdb_00001fhi

1JSY | pdb_00001jsy

1RZY | pdb_00001rzy

1ZSH | pdb_00001zsh

2FHI | pdb_00002fhi

2P0E | pdb_00002p0e

2QSY | pdb_00002qsy

2QSZ | pdb_00002qsz

2QT0 | pdb_00002qt0

2QT1 | pdb_00002qt1

3EPZ | pdb_00003epz

3RHN | pdb_00003rhn

4RHN | pdb_00004rhn

5RHN | pdb_00005rhn

5U2M | pdb_00005u2m

5U2N | pdb_00005u2n

6RHN | pdb_00006rhn