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234,136 Structures from the PDB

1,068,577 Computed Structure Models (CSM)

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QUERY: Citation Author = "Feng, J."

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Search Summary

This query matches 209 Structures.

Refinements

Structure Determination Methodology

experimental (209)

Scientific Name of Source Organism

	Homo sapiens (105)
	Mus musculus (21)
	Severe acute respiratory syndrome coronavirus 2 (14)
	synthetic construct (13)
	Arabidopsis thaliana (12)
	Hepatitis C virus JFH-1 (12)
	Isatis tinctoria (7)
	Saccharomyces cerevisiae (6)
	Lentilactobacillus kefiri (5)
	Saccharomyces cerevisiae S288C (5)

More...

Taxonomy

	Eukaryota (159)
	Riboviria (31)
	Bacteria (30)
	other sequences (13)
	Duplodnaviria (2)
	Archaea (1)

Experimental Method

	X-RAY DIFFRACTION (166)
	ELECTRON MICROSCOPY (42)
	SOLUTION NMR (1)

Polymer Entity Type

	Protein (209)
	RNA (11)
	DNA (6)

Refinement Resolution (Å)

	0.5 - 1.0 (1)
	1.0 - 1.5 (12)
	1.5 - 2.0 (58)
	2.0 - 2.5 (64)
	2.5 - 3.0 (50)
	3.0 - 3.5 (14)
	3.5 - 4.0 (3)
	4.0 - 4.5 (3)
	> 4.5 (3)

Release Date

	2005 - 2009 (6)
	2010 - 2014 (22)
	2015 - 2019 (52)
	2020 - 2024 (119)
	2025 - 2029 (10)

Enzyme Classification Name

	Transferases (78)
	Hydrolases (31)
	Oxidoreductases (24)
	Ligases (5)
	Isomerases (2)
	Lyases (2)

Membrane Protein Annotation

	PDBTM (3)
	mpstruc (3)
	MemProtMD (1)
	OPM (1)

Symmetry Type

	Asymmetric (142)
	Cyclic (56)
	Dihedral (16)
	Octahedral (1)

SCOP Classification

	Alpha and beta proteins (a/b) (37)
	All beta proteins (25)
	Alpha and beta proteins (a+b) (21)
	Artifacts (19)
	All alpha proteins (3)
	Coiled coil proteins (1)
	Multi-domain proteins (alpha and beta) (1)
	Small proteins (1)

AllSelected

1 to 25 of 209 Structures

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2HWZ \| pdb_00002hwz	Download File View File

Fab fragment of Humanized anti-viral antibody MEDI-493 (Synagis TM)

Braden, B.

To be published

Released	2007-08-14
Method	X-RAY DIFFRACTION 1.8 Å
Organisms	Homo sapiens Mus musculus
Macromolecule	Immunoglobulin Fab heavy chain (protein) Immunoglobulin Fab light chain (protein)

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2M01 \| pdb_00002m01	Download File View File

Solution structure of Kunitz-type neurotoxin LmKKT-1a from scorpion venom

Luo, F., Jiang, L., Liu, M., Chen, Z., Wu, Y.

(2013) PLoS One 8: e60201-e60201

Released	2013-11-13
Method	SOLUTION NMR
Organisms	Lychas mucronatus
Macromolecule	Protease inhibitor LmKTT-1a (protein)

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2NSF \| pdb_00002nsf	Download File View File

Crystal structure of the mycothiol-dependent maleylpyruvate isomerase

Chang, W.R., Wang, R.

(2007) J Biological Chem 282: 16288-16294

Released	2007-04-10
Method	X-RAY DIFFRACTION 1.75 Å
Organisms	Corynebacterium glutamicum
Macromolecule	Hypothetical protein Cgl3021 (protein)
Unique Ligands	GOL, SO4, ZN

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2NSG \| pdb_00002nsg	Download File View File

Crystal structure of the mycothiol-dependent maleylpyruvate isomerase H52A mutant

Chang, W.R., Wang, R.

(2007) J Biological Chem 282: 16288-16294

Released	2007-04-10
Method	X-RAY DIFFRACTION 2.05 Å
Organisms	Corynebacterium glutamicum
Macromolecule	Hypothetical protein Cgl3021 (protein)
Unique Ligands	GOL, SO4

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2ONC \| pdb_00002onc	Download File View File

Crystal structure of human DPP-4

Feng, J., Zhang, Z., Wallace, M.B., Stafford, J.A., Kaldor, S.W., Kassel, D.B., Navre, M., Shi, L., Skene, R.J., Asakawa, T., Takeuchi, K., Xu, R., Webb, D.R., Gwaltney, S.L.

(2007) J Med Chem 50: 2297-2300

Released	2008-03-04
Method	X-RAY DIFFRACTION 2.55 Å
Organisms	Homo sapiens
Macromolecule	Dipeptidyl peptidase 4 (protein)
Unique Ligands	NAG, SY1
Unique branched monosaccharides	NAG

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3CCB \| pdb_00003ccb	Download File View File

Crystal Structure of Human DPP4 in complex with a benzimidazole derivative

Wallace, M.B., Skene, R.J.

(2008) Bioorg Med Chem Lett 18: 2362-2367

Released	2008-10-21
Method	X-RAY DIFFRACTION 2.49 Å
Organisms	Homo sapiens
Macromolecule	Dipeptidyl peptidase 4 (protein)
Unique Ligands	B2Y, NAG
Unique branched monosaccharides	NAG

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3CCC \| pdb_00003ccc	Download File View File

Crystal Structure of Human DPP4 in complex with a benzimidazole derivative

Wallace, M.B., Skene, R.J.

(2008) Bioorg Med Chem Lett 18: 2362-2367

Released	2008-10-21
Method	X-RAY DIFFRACTION 2.71 Å
Organisms	Homo sapiens
Macromolecule	Dipeptidyl peptidase 4 (protein)
Unique Ligands	7AC, NAG
Unique branched monosaccharides	NAG

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3G0B \| pdb_00003g0b	Download File View File

Crystal structure of dipeptidyl peptidase IV in complex with TAK-322

Zhang, Z., Wallace, M.B., Feng, J., Stafford, J.A., Kaldor, S.W., Shi, L., Skene, R.J., Aertgeerts, K., Lee, B., Jennings, A., Xu, R., Kassel, D., Webb, D.R., Gwaltney, S.L.

(2011) J Med Chem 54: 510-524

Released	2010-02-16
Method	X-RAY DIFFRACTION 2.25 Å
Organisms	Homo sapiens
Macromolecule	Dipeptidyl peptidase 4 (protein)
Unique Ligands	NAG, T22
Unique branched monosaccharides	NAG

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3G0C \| pdb_00003g0c	Download File View File

Crystal structure of dipeptidyl peptidase IV in complex with a pyrimidinedione inhibitor 1

Zhang, Z., Wallace, M.B., Feng, J., Stafford, J.A., Kaldor, S.W., Shi, L., Skene, R.J., Aertgeerts, K., Lee, B., Jennings, A., Xu, R., Kassel, D., Webb, D.R., Gwaltney, S.L.

(2011) J Med Chem 54: 510-524

Released	2010-02-16
Method	X-RAY DIFFRACTION 2.69 Å
Organisms	Homo sapiens
Macromolecule	Dipeptidyl peptidase 4 (protein)
Unique Ligands	NAG, RUF
Unique branched monosaccharides	NAG

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3G0D \| pdb_00003g0d	Download File View File

Crystal structure of dipeptidyl peptidase IV in complex with a pyrimidinedione inhibitor 2

Zhang, Z., Wallace, M.B., Feng, J., Stafford, J.A., Kaldor, S.W., Shi, L., Skene, R.J., Aertgeerts, K., Lee, B., Jennings, A., Xu, R., Kassel, D., Webb, D.R., Gwaltney, S.L.

(2011) J Med Chem 54: 510-524

Released	2010-02-16
Method	X-RAY DIFFRACTION 2.39 Å
Organisms	Homo sapiens
Macromolecule	Dipeptidyl peptidase 4 (protein)
Unique Ligands	NAG, XIH
Unique branched monosaccharides	NAG

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3G0G \| pdb_00003g0g	Download File View File

Crystal structure of dipeptidyl peptidase IV in complex with a pyrimidinone inhibitor 3

Zhang, Z., Wallace, M.B., Feng, J., Stafford, J.A., Kaldor, S.W., Shi, L., Skene, R.J., Aertgeerts, K., Lee, B., Jennings, A., Xu, R., Kassel, D., Webb, D.R., Gwaltney, S.L.

(2011) J Med Chem 54: 510-524

Released	2010-02-16
Method	X-RAY DIFFRACTION 2.45 Å
Organisms	Homo sapiens
Macromolecule	Dipeptidyl peptidase 4 (protein)
Unique Ligands	NAG, RUM
Unique branched monosaccharides	NAG

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3Q7J \| pdb_00003q7j	Download File View File

Engineered Thermoplasma Acidophilum F3 factor mimics human aminopeptidase N (APN) as a target for anticancer drug development

Su, J., Wang, Q., Feng, J., Zhang, C., Zhu, D., We, T., Xu, W., Gu, L.

(2011) Bioorg Med Chem 19: 2991-2996

Released	2011-07-27
Method	X-RAY DIFFRACTION 2.91 Å
Organisms	Thermoplasma acidophilum DSM 1728
Macromolecule	Tricorn protease-interacting factor F3 (protein)
Unique Ligands	FBO, ZN

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4I1Z \| pdb_00004i1z	Download File View File

Crystal structure of the monomeric (V948R) form of the gefitinib/erlotinib resistant EGFR kinase domain L858R+T790M

Gajiwala, K.S., Feng, J., Ferre, R., Ryan, K., Brodsky, O., Stewart, A.

(2013) Structure 21: 209-219

Released	2013-01-16
Method	X-RAY DIFFRACTION 3 Å
Organisms	Homo sapiens
Macromolecule	Epidermal growth factor receptor (protein)

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4I20 \| pdb_00004i20	Download File View File

Crystal structure of monomeric (V948R) primary oncogenic mutant L858R EGFR kinase domain

Gajiwala, K.S., Feng, J., Ferre, R., Ryan, K., Brodsky, O., Stewart, A.

(2013) Structure 21: 209-219

Released	2013-01-16
Method	X-RAY DIFFRACTION 3.34 Å
Organisms	Homo sapiens
Macromolecule	Epidermal growth factor receptor (protein)

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4I21 \| pdb_00004i21	Download File View File

Crystal structure of L858R + T790M EGFR kinase domain in complex with MIG6 peptide

Gajiwala, K.S., Feng, J., Ferre, R., Ryan, K., Brodsky, O., Stewart, A.

(2013) Structure 21: 209-219

Released	2013-01-16
Method	X-RAY DIFFRACTION 3.37 Å
Organisms	Homo sapiens
Macromolecule	ERBB receptor feedback inhibitor 1 (protein) Epidermal growth factor receptor (protein)

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4I22 \| pdb_00004i22	Download File View File

Structure of the monomeric (V948R)gefitinib/erlotinib resistant double mutant (L858R+T790M) EGFR kinase domain co-crystallized with gefitinib

Gajiwala, K.S., Feng, J., Ferre, R., Ryan, K., Brodsky, O., Stewart, A.

(2013) Structure 21: 209-219

Released	2013-01-16
Method	X-RAY DIFFRACTION 1.71 Å
Organisms	Homo sapiens
Macromolecule	Epidermal growth factor receptor (protein)
Unique Ligands	IRE, SO4

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4I23 \| pdb_00004i23	Download File View File

Crystal structure of the wild-type EGFR kinase domain in complex with dacomitinib (soaked)

Gajiwala, K.S., Feng, J., Ferre, R., Ryan, K., Brodsky, O., Stewart, A.

(2013) Structure 21: 209-219

Released	2013-01-16
Method	X-RAY DIFFRACTION 2.8 Å
Organisms	Homo sapiens
Macromolecule	Epidermal growth factor receptor (protein)
Unique Ligands	1C9

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4I24 \| pdb_00004i24	Download File View File

Structure of T790M EGFR kinase domain co-crystallized with dacomitinib

Gajiwala, K.S., Feng, J., Ferre, R., Ryan, K., Brodsky, O., Stewart, A.

(2013) Structure 21: 209-219

Released	2013-01-16
Method	X-RAY DIFFRACTION 1.8 Å
Organisms	Homo sapiens
Macromolecule	Epidermal growth factor receptor (protein)
Unique Ligands	1C9

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4ISE \| pdb_00004ise	Download File View File

Human glucokinase in complex with novel activator (2S)-3-cyclohexyl-2-(6-fluoro-4-oxoquinazolin-3(4H)-yl)-N-(1,3-thiazol-2-yl)propanamide

Hosfield, D., Skene, R.J.

(2013) Bioorg Med Chem Lett 23: 2166-2171

Released	2013-03-20
Method	X-RAY DIFFRACTION 1.78 Å
Organisms	Homo sapiens
Macromolecule	Glucokinase (protein)
Unique Ligands	1FW, GLC, IOD

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4ISF \| pdb_00004isf	Download File View File

Human glucokinase in complex with novel activator (2S)-3-cyclohexyl-2-(6-fluoro-2,4-dioxo-1,4-dihydroquinazolin-3(2H)-yl)-N-(1,3-thiazol-2-yl)propanamide

Hosfield, D., Skene, R.J.

(2013) Bioorg Med Chem Lett 23: 2166-2171

Released	2013-03-20
Method	X-RAY DIFFRACTION 2.09 Å
Organisms	Homo sapiens
Macromolecule	Glucokinase (protein)
Unique Ligands	1FX, GLC, IOD

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4ISG \| pdb_00004isg	Download File View File

Human glucokinase in complex with novel activator (2S)-3-cyclohexyl-2-[4-(methylsulfonyl)-2-oxopiperazin-1-yl]-N-(1,3-thiazol-2-yl)propanamide

Hosfield, D., Skene, R.J.

(2013) Bioorg Med Chem Lett 23: 2166-2171

Released	2013-03-20
Method	X-RAY DIFFRACTION 2.645 Å
Organisms	Homo sapiens
Macromolecule	Glucokinase (protein)
Unique Ligands	1FY, GLC, IOD

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4JH0 \| pdb_00004jh0	Download File View File

Crystal structure of dipeptidyl-peptidase 4 (CD26, adenosine deaminase complexing protein 2) (DPP-IV-WT) complex with bms-767778 AKA 2-(3-(aminomethyl)-4-(2,4- dichlorophenyl)-2-methyl-5-oxo-5,7-dihydro-6h-pyrrolo[3,4- b]pyridin-6-yl)-n,n-dimethylacetamide

Klei, H.E.

(2013) J Med Chem 56: 7343-7357

Released	2013-09-04
Method	X-RAY DIFFRACTION 2.35 Å
Organisms	Homo sapiens
Macromolecule	Dipeptidyl peptidase 4 (protein)
Unique Ligands	1MD

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4LKO \| pdb_00004lko	Download File View File

Crystal structure of human DPP-IV in complex with BMS-744891

Klei, H.E.

(2013) J Med Chem 56: 7343-7357

Released	2013-09-04
Method	X-RAY DIFFRACTION 2.43 Å
Organisms	Homo sapiens
Macromolecule	Dipeptidyl peptidase 4 (protein)
Unique Ligands	1WH

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4NSC \| pdb_00004nsc	Download File View File

Crystal Structure of CBARA1 in the Apo-form

Wang, L., Yang, X., Li, S., Shen, Y.

(2014) EMBO J 33: 594-604

Released	2014-02-26
Method	X-RAY DIFFRACTION 3.2 Å
Organisms	Homo sapiens
Macromolecule	Calcium uptake protein 1, mitochondrial (protein)

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4NSD \| pdb_00004nsd	Download File View File

Crystal Structure of CBARA1 in the Ca2+ Binding Form

Wang, L., Yang, X., Li, S., Shen, Y.

(2014) EMBO J 33: 594-604

Released	2014-02-26
Method	X-RAY DIFFRACTION 2.7 Å
Organisms	Homo sapiens
Macromolecule	Calcium uptake protein 1, mitochondrial (protein)
Unique Ligands	CA, CL, MPD

1 to 25 of 209 Structures

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Structure Determination Methodology

Scientific Name of Source Organism

Taxonomy

Experimental Method

Polymer Entity Type

Refinement Resolution (Å)

Release Date

Enzyme Classification Name

Membrane Protein Annotation

Symmetry Type

SCOP Classification

2HWZ | pdb_00002hwz

2M01 | pdb_00002m01

2NSF | pdb_00002nsf

2NSG | pdb_00002nsg

2ONC | pdb_00002onc

3CCB | pdb_00003ccb

3CCC | pdb_00003ccc

3G0B | pdb_00003g0b

3G0C | pdb_00003g0c

3G0D | pdb_00003g0d

3G0G | pdb_00003g0g

3Q7J | pdb_00003q7j

4I1Z | pdb_00004i1z

4I20 | pdb_00004i20

4I21 | pdb_00004i21

4I22 | pdb_00004i22

4I23 | pdb_00004i23

4I24 | pdb_00004i24

4ISE | pdb_00004ise

4ISF | pdb_00004isf

4ISG | pdb_00004isg

4JH0 | pdb_00004jh0

4LKO | pdb_00004lko

4NSC | pdb_00004nsc

4NSD | pdb_00004nsd