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234,136 Structures from the PDB

1,068,577 Computed Structure Models (CSM)

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QUERY: Citation Author = "De Clercq, D.J.H."

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Search Summary

This query matches 15 Structures.

Refinements

Structure Determination Methodology

experimental (15)

Scientific Name of Source Organism

Homo sapiens (15)

Taxonomy

Eukaryota (15)

Experimental Method

X-RAY DIFFRACTION (15)

Polymer Entity Type

Protein (15)

Refinement Resolution (Å)

	1.5 - 2.0 (1)
	2.0 - 2.5 (6)
	2.5 - 3.0 (5)
	3.0 - 3.5 (3)

Release Date

	2015 - 2019 (5)
	2020 - 2024 (10)

Enzyme Classification Name

Transferases (15)

Symmetry Type

	Cyclic (12)
	Asymmetric (3)

SCOP Classification

Alpha and beta proteins (a+b) (6)

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1 to 15 of 15 Structures

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Explore in 3D

6D8E \| pdb_00006d8e	Download File View File

Discovery of a Highly Potent and Broadly Effective EGFR and HER2 Exon 20 Insertion Mutant Inhibitor

Park, E., Eck, M.J.

(2018) Angew Chem Int Ed Engl 57: 11629-11633

Released	2018-07-18
Method	X-RAY DIFFRACTION 2.537 Å
Organisms	Homo sapiens
Macromolecule	Epidermal growth factor receptor (protein)
Unique Ligands	FZP

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6DUK \| pdb_00006duk	Download File View File

EGFR with an allosteric inhibitor

Park, E., Eck, M.J.

(2019) Cancer Discov 9: 926-943

Released	2019-06-05
Method	X-RAY DIFFRACTION 2.2 Å
Organisms	Homo sapiens
Macromolecule	Epidermal growth factor receptor (protein)
Unique Ligands	ANP, JBJ, MG

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6P1D \| pdb_00006p1d	Download File View File

Crystal structure of EGFR with mutant-selective dihydrodibenzodiazepinone allosteric inhibitor

Heppner, D.E., Eck, M.J.

(2019) ACS Med Chem Lett 10: 1549-1553

Released	2019-12-18
Method	X-RAY DIFFRACTION 2.4 Å
Organisms	Homo sapiens
Macromolecule	Epidermal growth factor receptor (protein)
Unique Ligands	ANP, MG, NQ1

Explore in 3D

6P1L \| pdb_00006p1l	Download File View File

Crystal structure of EGFR in complex with EAI045

Heppner, D.E., Eck, M.J.

(2019) ACS Med Chem Lett 10: 1549-1553

Released	2019-12-18
Method	X-RAY DIFFRACTION 2.8 Å
Organisms	Homo sapiens
Macromolecule	Epidermal growth factor receptor (protein)
Unique Ligands	9LL, ANP, MG

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6P8Q \| pdb_00006p8q	Download File View File

EGFR in complex with a dihydrodibenzodiazepinone allosteric inhibitor.

Yun, C.H., Heppner, D.E., Eck, M.J.

(2019) ACS Med Chem Lett 10: 1549-1553

Released	2019-12-18
Method	X-RAY DIFFRACTION 1.9 Å
Organisms	Homo sapiens
Macromolecule	Epidermal growth factor receptor (protein)
Unique Ligands	AMP, ANP, EDO, MG, O57

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6XL4 \| pdb_00006xl4	Download File View File

EGFR(T790M/V948R) in complex with AZD9291 and DDC4002

Heppner, D.E., Beyett, T.S., Eck, M.J.

(2022) Nat Commun 13: 2530-2530

Released	2021-06-30
Method	X-RAY DIFFRACTION 2.06 Å
Organisms	Homo sapiens
Macromolecule	Epidermal growth factor receptor (protein)
Unique Ligands	ANP, MG, NQ1, Q6K

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7JXI \| pdb_00007jxi	Download File View File

EGFR kinase (T790M/V948R) in complex with PF-06747775

Beyett, T.S., Eck, M.J.

(2022) Nat Commun 13: 2530

Released	2021-09-08
Method	X-RAY DIFFRACTION 3 Å
Organisms	Homo sapiens
Macromolecule	Epidermal growth factor receptor (protein)
Unique Ligands	8BS

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7JXK \| pdb_00007jxk	Download File View File

EGFR kinase (T790M/V948R) in complex with PF-06747775 and JBJ-04-125-02

Beyett, T.S., Eck, M.J.

(2022) Nat Commun 13: 2530

Released	2021-09-08
Method	X-RAY DIFFRACTION 3.1 Å
Organisms	Homo sapiens
Macromolecule	Epidermal growth factor receptor (protein)
Unique Ligands	8BS, ANP, JBJ, MG

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7JXL \| pdb_00007jxl	Download File View File

EGFR kinase (T790M/V948R) in complex with AZ5104

Beyett, T.S., Eck, M.J.

(2022) Nat Commun 13: 2530

Released	2021-09-08
Method	X-RAY DIFFRACTION 2.4 Å
Organisms	Homo sapiens
Macromolecule	Epidermal growth factor receptor (protein)
Unique Ligands	VO7

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7JXM \| pdb_00007jxm	Download File View File

EGFR kinase (T790M/V948R) in complex with osimertinib and EAI045

Beyett, T.S., Eck, M.J.

(2022) Nat Commun 13: 2530

Released	2021-09-08
Method	X-RAY DIFFRACTION 2.192 Å
Organisms	Homo sapiens
Macromolecule	Epidermal growth factor receptor (protein)
Unique Ligands	9LL, ANP, MG, YY3

Explore in 3D

7JXP \| pdb_00007jxp	Download File View File

EGFR kinase (T790M/V948R) in complex with osimertinib and JBJ-04-125-02

Beyett, T.S., Eck, M.J.

(2022) Nat Commun 13: 2530

Released	2021-09-08
Method	X-RAY DIFFRACTION 2.16 Å
Organisms	Homo sapiens
Macromolecule	Epidermal growth factor receptor (protein)
Unique Ligands	ANP, JBJ, MG, YY3

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7JXW \| pdb_00007jxw	Download File View File

EGFR kinase (T790M/V948R) in complex with osimertinib and JBJ-09-063

Beyett, T.S., Eck, M.J.

(2022) Nat Commun 13: 2530

Released	2021-09-08
Method	X-RAY DIFFRACTION 2.5 Å
Organisms	Homo sapiens
Macromolecule	Epidermal growth factor receptor (protein)
Unique Ligands	VNS, YY3

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7K1H \| pdb_00007k1h	Download File View File

EGFR L858R/V948R in complex with osimertinib and allosteric inhibitor JBJ-09-063

Beyett, T.S., Eck, M.J.

(2022) Nat Commun 13: 2530

Released	2021-09-15
Method	X-RAY DIFFRACTION 2.602 Å
Organisms	Homo sapiens
Macromolecule	Epidermal growth factor receptor (protein)
Unique Ligands	VNS, YY3

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7K1I \| pdb_00007k1i	Download File View File

EGFR kinase (L858R/V948R) in complex with allosteric inhibitor JBJ-09-063

Beyett, T.S., Eck, M.J.

(2022) Nat Commun 13: 2530

Released	2021-09-15
Method	X-RAY DIFFRACTION 3.202 Å
Organisms	Homo sapiens
Macromolecule	Epidermal growth factor receptor (protein)
Unique Ligands	ANP, MG, VNS

Explore in 3D

7LG8 \| pdb_00007lg8	Download File View File

EGFR (T79M/V948R) in complex with naquotinib and an allosteric inhibitor

Beyett, T.S., Eck, M.J.

(2022) Nat Commun 13: 2530-2530

Released	2022-02-23
Method	X-RAY DIFFRACTION 2.93 Å
Organisms	Homo sapiens
Macromolecule	Epidermal growth factor receptor (protein)
Unique Ligands	8RC, VNS

1 to 15 of 15 Structures

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RCSB PDB Core Operations are funded by the U.S. National Science Foundation (DBI-2321666), the US Department of Energy (DE-SC0019749), and the National Cancer Institute, National Institute of Allergy and Infectious Diseases, and National Institute of General Medical Sciences of the National Institutes of Health under grant R01GM157729.

6D8E | pdb_00006d8e

Discovery of a Highly Potent and Broadly Effective EGFR and HER2 Exon 20 Insertion Mutant Inhibitor

6DUK | pdb_00006duk

EGFR with an allosteric inhibitor

6P1D | pdb_00006p1d

Crystal structure of EGFR with mutant-selective dihydrodibenzodiazepinone allosteric inhibitor

6P1L | pdb_00006p1l

Crystal structure of EGFR in complex with EAI045

6P8Q | pdb_00006p8q

EGFR in complex with a dihydrodibenzodiazepinone allosteric inhibitor.

6XL4 | pdb_00006xl4

EGFR(T790M/V948R) in complex with AZD9291 and DDC4002

7JXI | pdb_00007jxi

EGFR kinase (T790M/V948R) in complex with PF-06747775

7JXK | pdb_00007jxk

EGFR kinase (T790M/V948R) in complex with PF-06747775 and JBJ-04-125-02

7JXL | pdb_00007jxl

EGFR kinase (T790M/V948R) in complex with AZ5104

7JXM | pdb_00007jxm

EGFR kinase (T790M/V948R) in complex with osimertinib and EAI045

7JXP | pdb_00007jxp

EGFR kinase (T790M/V948R) in complex with osimertinib and JBJ-04-125-02

7JXW | pdb_00007jxw

EGFR kinase (T790M/V948R) in complex with osimertinib and JBJ-09-063

7K1H | pdb_00007k1h

EGFR L858R/V948R in complex with osimertinib and allosteric inhibitor JBJ-09-063

7K1I | pdb_00007k1i

EGFR kinase (L858R/V948R) in complex with allosteric inhibitor JBJ-09-063

7LG8 | pdb_00007lg8

EGFR (T79M/V948R) in complex with naquotinib and an allosteric inhibitor

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Structure Determination Methodology

Scientific Name of Source Organism

Taxonomy

Experimental Method

Polymer Entity Type

Refinement Resolution (Å)

Release Date

Enzyme Classification Name

Symmetry Type

SCOP Classification

6D8E | pdb_00006d8e

6DUK | pdb_00006duk

6P1D | pdb_00006p1d

6P1L | pdb_00006p1l

6P8Q | pdb_00006p8q

6XL4 | pdb_00006xl4

7JXI | pdb_00007jxi

7JXK | pdb_00007jxk

7JXL | pdb_00007jxl

7JXM | pdb_00007jxm

7JXP | pdb_00007jxp

7JXW | pdb_00007jxw

7K1H | pdb_00007k1h

7K1I | pdb_00007k1i

7LG8 | pdb_00007lg8