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234,136 Structures from the PDB

1,068,577 Computed Structure Models (CSM)

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QUERY: Citation Author = "Clackson, T."

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Search Summary

This query matches 19 Structures.

Refinements

Structure Determination Methodology

experimental (19)

Scientific Name of Source Organism

	Homo sapiens (9)
	Mus musculus (6)
	Oryctolagus cuniculus (4)
	Peptide display vector fth1 (1)
	synthetic construct (1)

Taxonomy

	Eukaryota (19)
	other sequences (2)

Experimental Method

X-RAY DIFFRACTION (19)

Polymer Entity Type

Protein (19)

Refinement Resolution (Å)

	1.0 - 1.5 (1)
	1.5 - 2.0 (6)
	2.0 - 2.5 (7)
	2.5 - 3.0 (3)
	3.0 - 3.5 (2)

Release Date

	1995 - 1999 (2)
	2000 - 2004 (1)
	2005 - 2009 (3)
	2010 - 2014 (7)
	2015 - 2019 (1)
	2020 - 2024 (5)

Enzyme Classification Name

	Transferases (10)
	Oxidoreductases (4)
	Isomerases (2)

Symmetry Type

	Asymmetric (13)
	Dihedral (4)
	Cyclic (3)

SCOP Classification

	Alpha and beta proteins (a+b) (13)
	Alpha and beta proteins (a/b) (4)
	Artifacts (4)
	All alpha proteins (1)
	All beta proteins (1)

AllSelected

1 to 19 of 19 Structures

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1A22 \| pdb_00001a22	Download File View File

HUMAN GROWTH HORMONE BOUND TO SINGLE RECEPTOR

De Vos, A.M., Ultsch, M.

(1998) J Mol Biology 277: 1111-1128

Released	1998-04-29
Method	X-RAY DIFFRACTION 2.6 Å
Organisms	Homo sapiens
Macromolecule	GROWTH HORMONE (protein) GROWTH HORMONE RECEPTOR (protein)

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1BL4 \| pdb_00001bl4	Download File View File

FKBP MUTANT F36V COMPLEXED WITH REMODELED SYNTHETIC LIGAND

Hatada, M.H., Clackson, T., Yang, W., Rozamus, L.W., Amara, J., Rollins, C.T., Stevenson, L.F., Magari, S.R., Wood, S.A., Courage, N.L., Lu, X., Cerasoli Junior, F., Gilman, M., Holt, D.

(1998) Proc Natl Acad Sci U S A 95: 10437-10442

Released	1998-09-02
Method	X-RAY DIFFRACTION 1.9 Å
Organisms	Homo sapiens
Macromolecule	PROTEIN (FK506 BINDING PROTEIN) (protein)
Unique Ligands	AP1

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1EYM \| pdb_00001eym	Download File View File

FK506 BINDING PROTEIN MUTANT, HOMODIMERIC COMPLEX

Rollins, C.T., Rivera, V.M., Woolfson, D.N., Keenan, T., Hatada, M., Adams, S.E., Andrade, L.J., Yaeger, D., van Schravendijk, M.R., Holt, D.A., Gilman, M., Clackson, T.

(2000) Proc Natl Acad Sci U S A 97: 7096-7101

Released	2000-08-09
Method	X-RAY DIFFRACTION 2 Å
Organisms	Homo sapiens
Macromolecule	FK506 BINDING PROTEIN (protein)

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3IK3 \| pdb_00003ik3	Download File View File

AP24534, a Pan-BCR-ABL Inhibitor for Chronic Myeloid Leukemia, Potently Inhibits the T315I Mutant and Overcomes Mutation-Based Resistance

Zhou, T.

(2009) Cancer Cell 16: 401-412

Released	2009-11-03
Method	X-RAY DIFFRACTION 1.9 Å
Organisms	Mus musculus
Macromolecule	Proto-oncogene tyrosine-protein kinase ABL1 (protein)
Unique Ligands	0LI

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3KF4 \| pdb_00003kf4	Download File View File

Structural analysis of DFG-in and DFG-out dual Src-Abl inhibitors sharing a common vinyl purine template

Zhou, T.

(2010) Chem Biol Drug Des 75: 18-28

Released	2009-12-22
Method	X-RAY DIFFRACTION 1.9 Å
Organisms	Mus musculus
Macromolecule	Tyrosine-protein kinase ABL1 (protein)
Unique Ligands	B90

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3KFA \| pdb_00003kfa	Download File View File

Structural analysis of DFG-in and DFG-out dual Src-Abl inhibitors sharing a common vinyl purine template

Zhou, T.

(2010) Chem Biol Drug Des 75: 18-28

Released	2009-12-22
Method	X-RAY DIFFRACTION 1.22 Å
Organisms	Mus musculus
Macromolecule	Tyrosine-protein kinase ABL1 (protein)
Unique Ligands	B91

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3OXZ \| pdb_00003oxz	Download File View File

Crystal structure of ABL kinase domain bound with a DFG-out inhibitor AP24534

Zhou, T., Huang, W.S., Wang, Y., Thomas, M., Keats, J., Xu, Q., Rivera, V., Shakespeare, W.C., Clackson, T., Dalgarno, D.C., Zhu, X.

(2011) Chem Biol Drug Des 77: 1-11

Released	2010-12-15
Method	X-RAY DIFFRACTION 2.2 Å
Organisms	Mus musculus
Macromolecule	Tyrosine-protein kinase ABL1 (protein)
Unique Ligands	0LI

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3OY3 \| pdb_00003oy3	Download File View File

Crystal structure of ABL T315I mutant kinase domain bound with a DFG-out inhibitor AP24589

Zhou, T., Commodore, L., Huang, W.S., Wang, Y., Thomas, M., Keats, J., Xu, Q., Rivera, V., Shakespeare, W.C., Clackson, T., Dalgarno, D.C., Zhu, X.

(2011) Chem Biol Drug Des 77: 1-11

Released	2010-12-15
Method	X-RAY DIFFRACTION 1.95 Å
Organisms	Mus musculus
Macromolecule	Tyrosine-protein kinase ABL1 (protein)
Unique Ligands	XY3

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4I8X \| pdb_00004i8x	Download File View File

Crystal structure of rabbit LDHA in complex with AP27460

Zhou, T., Stephan, Z.G., Kohlmann, A., Li, F., Commodore, L., Greenfield, M.T., Zhu, X., Dalgarno, D.C.

(2013) J Med Chem 56: 1023-1040

Released	2013-01-23
Method	X-RAY DIFFRACTION 2.23 Å
Organisms	Oryctolagus cuniculus
Macromolecule	L-lactate dehydrogenase A chain (protein)
Unique Ligands	6P3

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4I9H \| pdb_00004i9h	Download File View File

Crystal structure of rabbit LDHA in complex with AP28669

Zhou, T., Stephan, Z.G., Kohlmann, A., Li, F., Commodore, L., Greenfield, M.T., Shakespeare, W.C., Zhu, X., Dalgarno, D.C.

(2013) J Med Chem 56: 1023-1040

Released	2013-01-23
Method	X-RAY DIFFRACTION 2.17 Å
Organisms	Oryctolagus cuniculus
Macromolecule	L-lactate dehydrogenase A chain (protein)
Unique Ligands	1E4

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4I9N \| pdb_00004i9n	Download File View File

Crystal structure of rabbit LDHA in complex with AP28161 and AP28122

Zhou, T., Kohlmann, A., Stephan, Z.G., Li, F., Commodore, L., Greenfield, M.T., Shakespeare, W.C., Zhu, X., Dalgarno, D.C.

(2013) J Med Chem 56: 1023-1040

Released	2013-01-23
Method	X-RAY DIFFRACTION 2.35 Å
Organisms	Oryctolagus cuniculus
Macromolecule	L-lactate dehydrogenase A chain (protein)
Unique Ligands	1E5, 1E6

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4I9U \| pdb_00004i9u	Download File View File

Crystal structure of rabbit LDHA in complex with a fragment inhibitor AP26256

Zhou, T., Kohlmann, A., Stephan, Z.G., Commodore, L., Greenfield, M.T., Zhu, X., Dalgarno, D.C.

(2013) J Med Chem 56: 1023-1040

Released	2013-01-23
Method	X-RAY DIFFRACTION 2.5 Å
Organisms	Oryctolagus cuniculus
Macromolecule	L-lactate dehydrogenase A chain (protein)
Unique Ligands	1E7

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4U0I \| pdb_00004u0i	Download File View File

Crystal structure of KIT in complex with ponatinib

Zhou, T., Zhu, X., Dalgarno, D.C.

(2014) Clin Cancer Res 20: 5745-5755

Released	2014-10-08
Method	X-RAY DIFFRACTION 2 Å
Organisms	Homo sapiens
Macromolecule	Mast/stem cell growth factor receptor Kit,Mast/stem cell growth factor receptor Kit (protein)
Unique Ligands	0LI, PO4

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6MX8 \| pdb_00006mx8	Download File View File

Crystal structure of anaplastic lymphoma kinase (ALK) bound by Brigatinib

Dougan, D.R., Zhou, T.

(2016) J Med Chem 59: 4948-4964

Released	2018-12-12
Method	X-RAY DIFFRACTION 1.96 Å
Organisms	Homo sapiens
Macromolecule	ALK tyrosine kinase receptor (protein)
Unique Ligands	6GY

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7LGS \| pdb_00007lgs	Download File View File

Structure of EGFR_D770_N771insNPG/V948R in complex with covalent inhibitor Osimertinib.

Skene, R.J., Lane, W.

(2021) Cancer Discov 11: 1672-1687

Released	2021-09-22
Method	X-RAY DIFFRACTION 3.1 Å
Organisms	Homo sapiens
Macromolecule	Epidermal growth factor receptor (protein)
Unique Ligands	CIT, EDO, Q6K

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7T4I \| pdb_00007t4i	Download File View File

Crystal Structure of wild type EGFR in complex with TAK-788

Skene, R.J., Lane, W.

(2022) Bioorg Med Chem Lett 80: 129084-129084

Released	2022-12-07
Method	X-RAY DIFFRACTION 2.61 Å
Organisms	Homo sapiens
Macromolecule	Epidermal growth factor receptor (protein)
Unique Ligands	R28

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7T4J \| pdb_00007t4j	Download File View File

Crystal Structure of EGFR_D770_N771insNPG/V948R in complex with TAK-788

Skene, R.J., Lane, W., Hu, Y.

(2022) Bioorg Med Chem Lett 80: 129084-129084

Released	2022-12-07
Method	X-RAY DIFFRACTION 2.2 Å
Organisms	Homo sapiens
Macromolecule	Epidermal growth factor receptor (protein)
Unique Ligands	CIT, EDO, R28

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8G2M \| pdb_00008g2m	Download File View File

The tumor activated anti-CTLA-4 monoclonal antibody XTX101 demonstrates tumor-growth inhibition and tumor-selective pharmacodynamics in mouse models of cancer

Williams, J.C., Williams, J.C.

(2023) J Immunother Cancer 11:

Released	2024-02-14
Method	X-RAY DIFFRACTION 1.8 Å
Organisms	Mus musculus Peptide display vector fth1
Macromolecule	Heavy chain of humanized IgG (protein) Light chain of humanized IgG (protein) masking peptide (protein)
Unique Ligands	CIT

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8G8N \| pdb_00008g8n	Download File View File

CTLA4 Fab with peptide

Williams, J.C.

(2023) J Immunother Cancer 11:

Released	2024-01-17
Method	X-RAY DIFFRACTION 3 Å
Organisms	Homo sapiens synthetic construct
Macromolecule	CYS-PRO-GLY-LYS-GLY-LEU-PRO-SER-CYS (protein) Fab heavy chain (protein) Fab light chain (protein)

1 to 19 of 19 Structures

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RCSB PDB Core Operations are funded by the U.S. National Science Foundation (DBI-2321666), the US Department of Energy (DE-SC0019749), and the National Cancer Institute, National Institute of Allergy and Infectious Diseases, and National Institute of General Medical Sciences of the National Institutes of Health under grant R01GM157729.

1A22 | pdb_00001a22

HUMAN GROWTH HORMONE BOUND TO SINGLE RECEPTOR

1BL4 | pdb_00001bl4

FKBP MUTANT F36V COMPLEXED WITH REMODELED SYNTHETIC LIGAND

1EYM | pdb_00001eym

FK506 BINDING PROTEIN MUTANT, HOMODIMERIC COMPLEX

3IK3 | pdb_00003ik3

AP24534, a Pan-BCR-ABL Inhibitor for Chronic Myeloid Leukemia, Potently Inhibits the T315I Mutant and Overcomes Mutation-Based Resistance

3KF4 | pdb_00003kf4

Structural analysis of DFG-in and DFG-out dual Src-Abl inhibitors sharing a common vinyl purine template

3KFA | pdb_00003kfa

Structural analysis of DFG-in and DFG-out dual Src-Abl inhibitors sharing a common vinyl purine template

3OXZ | pdb_00003oxz

Crystal structure of ABL kinase domain bound with a DFG-out inhibitor AP24534

3OY3 | pdb_00003oy3

Crystal structure of ABL T315I mutant kinase domain bound with a DFG-out inhibitor AP24589

4I8X | pdb_00004i8x

Crystal structure of rabbit LDHA in complex with AP27460

4I9H | pdb_00004i9h

Crystal structure of rabbit LDHA in complex with AP28669

4I9N | pdb_00004i9n

Crystal structure of rabbit LDHA in complex with AP28161 and AP28122

4I9U | pdb_00004i9u

Crystal structure of rabbit LDHA in complex with a fragment inhibitor AP26256

4U0I | pdb_00004u0i

Crystal structure of KIT in complex with ponatinib

6MX8 | pdb_00006mx8

Crystal structure of anaplastic lymphoma kinase (ALK) bound by Brigatinib

7LGS | pdb_00007lgs

Structure of EGFR_D770_N771insNPG/V948R in complex with covalent inhibitor Osimertinib.

7T4I | pdb_00007t4i

Crystal Structure of wild type EGFR in complex with TAK-788

7T4J | pdb_00007t4j

Crystal Structure of EGFR_D770_N771insNPG/V948R in complex with TAK-788

8G2M | pdb_00008g2m

The tumor activated anti-CTLA-4 monoclonal antibody XTX101 demonstrates tumor-growth inhibition and tumor-selective pharmacodynamics in mouse models of cancer

8G8N | pdb_00008g8n

CTLA4 Fab with peptide

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Structure Determination Methodology

Scientific Name of Source Organism

Taxonomy

Experimental Method

Polymer Entity Type

Refinement Resolution (Å)

Release Date

Enzyme Classification Name

Symmetry Type

SCOP Classification

1A22 | pdb_00001a22

1BL4 | pdb_00001bl4

1EYM | pdb_00001eym

3IK3 | pdb_00003ik3

3KF4 | pdb_00003kf4

3KFA | pdb_00003kfa

3OXZ | pdb_00003oxz

3OY3 | pdb_00003oy3

4I8X | pdb_00004i8x

4I9H | pdb_00004i9h

4I9N | pdb_00004i9n

4I9U | pdb_00004i9u

4U0I | pdb_00004u0i

6MX8 | pdb_00006mx8

7LGS | pdb_00007lgs

7T4I | pdb_00007t4i

7T4J | pdb_00007t4j

8G2M | pdb_00008g2m

8G8N | pdb_00008g8n