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234,785 Structures from the PDB

1,068,577 Computed Structure Models (CSM)

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QUERY: Citation Author = "Cantley, L.C."

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Search Summary

This query matches 33 Structures.

Refinements

Structure Determination Methodology

experimental (33)

Scientific Name of Source Organism

	Homo sapiens (28)
	Bacillus anthracis (5)
	Escherichia coli H489 (2)
	Mus musculus (1)
	synthetic construct (1)

Taxonomy

	Eukaryota (28)
	Bacteria (7)
	Eukaryota (eukaryotes) (3)
	other sequences (1)

Experimental Method

X-RAY DIFFRACTION (33)

Polymer Entity Type

Protein (33)

Refinement Resolution (Å)

	1.0 - 1.5 (2)
	1.5 - 2.0 (6)
	2.0 - 2.5 (13)
	2.5 - 3.0 (10)
	3.0 - 3.5 (1)
	3.5 - 4.0 (1)

Release Date

	1995 - 1999 (6)
	2000 - 2004 (6)
	2005 - 2009 (6)
	2010 - 2014 (3)
	2015 - 2019 (7)
	2020 - 2024 (5)

Enzyme Classification Name

	Transferases (14)
	Hydrolases (7)
	Oxidoreductases (5)

Membrane Protein Annotation

OPM (1)

Symmetry Type

	Asymmetric (20)
	Cyclic (9)
	Dihedral (8)

SCOP Classification

	Alpha and beta proteins (a+b) (12)
	Alpha and beta proteins (a/b) (4)
	All alpha proteins (4)
	Artifacts (3)
	All beta proteins (1)

AllSelected

1 to 25 of 33 Structures

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1D1Z \| pdb_00001d1z	Download File View File

CRYSTAL STRUCTURE OF THE XLP PROTEIN SAP

Poy, F., Yaffe, M.B., Sayos, J., Saxena, K., Eck, M.J.

(1999) Mol Cell 4: 555-561

Released	1999-10-13
Method	X-RAY DIFFRACTION 1.4 Å
Organisms	Homo sapiens
Macromolecule	SAP SH2 DOMAIN (protein)
Unique Ligands	SO4

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1D4T \| pdb_00001d4t	Download File View File

CRYSTAL STRUCTURE OF THE XLP PROTEIN SAP IN COMPLEX WITH A SLAM PEPTIDE

Poy, F., Yaffe, M.B., Sayos, J., Saxena, K., Eck, M.J.

(1999) Mol Cell 4: 555-561

Released	1999-10-14
Method	X-RAY DIFFRACTION 1.1 Å
Organisms	Homo sapiens
Macromolecule	SIGNALING LYMPHOCYTIC ACTIVATION MOLECULE (protein) T CELL SIGNAL TRANSDUCTION MOLECULE SAP (protein)

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1D4W \| pdb_00001d4w	Download File View File

CRYSTAL STRUCTURE OF THE XLP PROTEIN SAP IN COMPLEX WITH SLAM PHOSPHOPEPTIDE

Poy, F., Yaffe, M.B., Sayos, J., Saxena, K., Eck, M.J.

(1999) Mol Cell 4: 555-561

Released	1999-10-14
Method	X-RAY DIFFRACTION 1.8 Å
Organisms	Homo sapiens
Macromolecule	SIGNALING LYMPHOCYTIC ACTIVATION MOLECULE (protein) T CELL SIGNAL TRANSDUCTION MOLECULE SAP (protein)

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1I3Z \| pdb_00001i3z	Download File View File

MURINE EAT2 SH2 DOMAIN IN COMPLEX WITH SLAM PHOSPHOPEPTIDE

Lu, J., Poy, F., Morra, M., Terhorst, C., Eck, M.J.

(2001) Eur J Biochem 20: 5840-5852

Released	2003-04-08
Method	X-RAY DIFFRACTION 2.15 Å
Organisms	Homo sapiens Mus musculus
Macromolecule	EWS/FLI1 ACTIVATED TRANSCRIPT 2 (protein) SIGNALING LYMPHOCYTIC ACTIVATION MOLECULE (protein)

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1PBW \| pdb_00001pbw	Download File View File

STRUCTURE OF BCR-HOMOLOGY (BH) DOMAIN

Musacchio, A., Cantley, L.C., Harrison, S.C.

(1996) Proc Natl Acad Sci U S A 93: 14373-14378

Released	1997-03-12
Method	X-RAY DIFFRACTION 2 Å
Organisms	Homo sapiens
Macromolecule	PHOSPHATIDYLINOSITOL 3-KINASE (protein)

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1PWP \| pdb_00001pwp	Download File View File

Crystal Structure of the Anthrax Lethal Factor complexed with Small Molecule Inhibitor NSC 12155

Wong, T.Y., Schwarzenbacher, R., Liddington, R.C.

(2004) Nat Struct Mol Biol 11: 67-72

Released	2004-01-13
Method	X-RAY DIFFRACTION 2.9 Å
Organisms	Bacillus anthracis
Macromolecule	Lethal factor (protein)
Unique Ligands	NSC, ZN

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1PWQ \| pdb_00001pwq	Download File View File

Crystal structure of Anthrax Lethal Factor complexed with Thioacetyl-Tyr-Pro-Met-Amide, a metal-chelating peptidyl small molecule inhibitor

Wong, T.Y., Schwarzenbacher, R., Liddington, R.C.

(2004) Nat Struct Mol Biol 11: 60-66

Released	2004-01-13
Method	X-RAY DIFFRACTION 3.52 Å
Organisms	Bacillus anthracis
Macromolecule	Lethal factor (protein)
Unique Ligands	SD2, ZN

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1PWU \| pdb_00001pwu	Download File View File

Crystal Structure of Anthrax Lethal Factor complexed with (3-(N-hydroxycarboxamido)-2-isobutylpropanoyl-Trp-methylamide), a known small molecule inhibitor of matrix metalloproteases.

Wong, T.Y., Schwarzenbacher, R., Liddington, R.C.

(2004) Nat Struct Mol Biol 11: 60-66

Released	2004-02-03
Method	X-RAY DIFFRACTION 2.7 Å
Organisms	Bacillus anthracis
Macromolecule	Lethal factor (protein)
Unique Ligands	GM6, ZN

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1PWV \| pdb_00001pwv	Download File View File

Crystal structure of Anthrax Lethal Factor wild-type protein complexed with an optimised peptide substrate.

Wong, T.Y., Schwarzenbacher, R., Liddington, R.C.

(2004) Nat Struct Mol Biol 11: 60-66

Released	2004-02-03
Method	X-RAY DIFFRACTION 2.85 Å
Organisms	Bacillus anthracis
Macromolecule	LF20 (protein) Lethal factor (protein)

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1PWW \| pdb_00001pww	Download File View File

Crystal structure of Anthrax Lethal Factor active site mutant protein complexed with an optimised peptide substrate in the presence of zinc.

Wong, T.Y., Schwarzenbacher, R., Liddington, R.C.

(2004) Nat Struct Mol Biol 11: 60-66

Released	2004-01-27
Method	X-RAY DIFFRACTION 2.8 Å
Organisms	Bacillus anthracis
Macromolecule	LF20 (protein) Lethal factor (protein)
Unique Ligands	ZN

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1QJA \| pdb_00001qja	Download File View File

14-3-3 ZETA/PHOSPHOPEPTIDE COMPLEX (MODE 2)

Rittinger, K., Budman, J., Xu, J., Volinia, S., Cantley, L.C., Smerdon, S.J., Gamblin, S.J., Yaffe, M.B.

(1999) Mol Cell 4: 153

Released	1999-09-15
Method	X-RAY DIFFRACTION 2 Å
Organisms	Homo sapiens
Macromolecule	14-3-3 PROTEIN ZETA (protein) PHOSPHOPEPTIDE (protein)

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1QJB \| pdb_00001qjb	Download File View File

14-3-3 ZETA/PHOSPHOPEPTIDE COMPLEX (MODE 1)

Rittinger, K., Budman, J., Xu, J., Volinia, S., Cantley, L.C., Smerdon, S.J., Gamblin, S.J., Yaffe, M.B.

(1999) Mol Cell 4: 153

Released	1999-09-15
Method	X-RAY DIFFRACTION 2 Å
Organisms	Homo sapiens
Macromolecule	14-3-3 PROTEIN ZETA/DELTA (protein) PHOSPHOPEPTIDE (protein)

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1YRK \| pdb_00001yrk	Download File View File

The C2 Domain of PKC<delta> is a new Phospho-Tyrosine Binding Domain

Benes, C.H., Wu, N., Elia, A.E., Dharia, T., Cantley, L.C., Soltoff, S.P.

(2005) Cell 121: 271-280

Released	2005-07-26
Method	X-RAY DIFFRACTION 1.7 Å
Organisms	Homo sapiens
Macromolecule	13-residue peptide (protein) Protein kinase C, delta type (protein)
Unique Ligands	ACY

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2P6B \| pdb_00002p6b	Download File View File

Crystal Structure of Human Calcineurin in Complex with PVIVIT Peptide

Li, H., Zhang, L., Rao, A., Harrison, S.C., Hogan, P.G.

(2007) J Mol Biology 369: 1296-1306

Released	2007-06-05
Method	X-RAY DIFFRACTION 2.3 Å
Organisms	Homo sapiens
Macromolecule	Calcineurin subunit B isoform 1 (protein) Calmodulin-dependent calcineurin A subunit alpha isoform (protein) PVIVIT 14-mer Peptide (protein)
Unique Ligands	CA, FE, PO4, ZN

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3BJF \| pdb_00003bjf	Download File View File

Pyruvate kinase M2 is a phosphotyrosine binding protein

Wu, N.

(2008) Nature 452: 181-186

Released	2008-03-04
Method	X-RAY DIFFRACTION 2.03 Å
Organisms	Homo sapiens
Macromolecule	Pyruvate kinase isozymes M1/M2 (protein)
Unique Ligands	FBP, K, MG, OXL

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3BJT \| pdb_00003bjt	Download File View File

Pyruvate kinase M2 is a phosphotyrosine binding protein

Wu, N.

(2008) Nature 452: 181-186

Released	2008-03-04
Method	X-RAY DIFFRACTION 2.5 Å
Organisms	Homo sapiens
Macromolecule	Pyruvate kinase isozymes M1/M2 (protein)
Unique Ligands	MG, OXL

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3E4A \| pdb_00003e4a	Download File View File

Human IDE-inhibitor complex at 2.6 angstrom resolution

Malito, E., Leissring, M.A., Choi, S., Cuny, G.D., Tang, W.J.

(2010) PLoS One 5: e10504-e10504

Released	2009-05-19
Method	X-RAY DIFFRACTION 2.6 Å
Organisms	Homo sapiens synthetic construct
Macromolecule	HYDROXAMATE PEPTIDE II1 (protein) Insulin-degrading enzyme (protein)
Unique Ligands	ACY, DIO, QIX, ZN

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3INM \| pdb_00003inm	Download File View File

Crystal structure of human cytosolic NADP(+)-dependent isocitrate dehydrogenase R132H mutant in complex with NADPH, ALPHA-KETOGLUTARATE and CALCIUM(2+)

Fontano, E., Brown, R.S., Suto, R.K., Bhyravbhatla, B.

(2009) Nature 462: 739-744

Released	2009-11-24
Method	X-RAY DIFFRACTION 2.1 Å
Organisms	Homo sapiens
Macromolecule	Isocitrate dehydrogenase [NADP] cytoplasmic (protein)
Unique Ligands	AKG, CA, GOL, NA, NDP

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3ME3 \| pdb_00003me3	Download File View File

Activator-Bound Structure of Human Pyruvate Kinase M2

Hong, B., Dimov, S., Tempel, W., Auld, D., Thomas, C., Boxer, M., Jianq, J.-K., Skoumbourdis, A., Min, S., Southall, N., Arrowsmith, C.H., Edwards, A.M., Bountra, C., Weigelt, J., Bochkarev, A., Inglese, J., Park, H., Structural Genomics Consortium (SGC)

(2012) Nat Chem Biol 8: 839-847

Released	2010-04-28
Method	X-RAY DIFFRACTION 1.95 Å
Organisms	Homo sapiens
Macromolecule	Pyruvate kinase isozymes M1/M2 (protein)
Unique Ligands	3SZ, FBP, SO4, UNX

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3U2Z \| pdb_00003u2z	Download File View File

Activator-Bound Structure of Human Pyruvate Kinase M2

Hong, B., Dimov, S., Tempel, W., Auld, D., Thomas, C., Boxer, M., Jianq, J.-K., Skoumbourdis, A., Min, S., Southall, N., Arrowsmith, C.H., Edwards, A.M., Bountra, C., Weigelt, J., Inglese, J., Park, H., Structural Genomics Consortium (SGC)

(2012) Nat Chem Biol 8: 839-847

Released	2012-09-12
Method	X-RAY DIFFRACTION 2.1 Å
Organisms	Homo sapiens
Macromolecule	Pyruvate kinase isozymes M1/M2 (protein)
Unique Ligands	07T, FBP, UNX

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4G1N \| pdb_00004g1n	Download File View File

PKM2 in complex with an activator

Kung, C., Hixon, J., Dang, L., DeLaBarre, B., Qian, K.C.

(2012) Chem Biol 19: 1187-1198

Released	2012-10-10
Method	X-RAY DIFFRACTION 2.3 Å
Organisms	Homo sapiens
Macromolecule	Pyruvate kinase isozymes M1/M2 (protein)
Unique Ligands	MG, NZT, OXL

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5CZH \| pdb_00005czh	Download File View File

EGFR L858R MUTANT IN COMPLEX WITH AN OPTIMAL PEPTIDE SUBSTRATE

Yun, C.H., Eck, M.J.

(2015) Nat Struct Mol Biol 22: 983-990

Released	2015-09-30
Method	X-RAY DIFFRACTION 2.8 Å
Organisms	Escherichia coli H489 Homo sapiens
Macromolecule	Epidermal growth factor receptor (protein) Peptide substrate (protein)

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5CZI \| pdb_00005czi	Download File View File

EGFR L858R MUTANT IN COMPLEX WITH A SHC PEPTIDE SUBSTRATE

Yun, C.H., Eck, M.J.

(2015) Nat Struct Mol Biol 22: 983-990

Released	2015-09-30
Method	X-RAY DIFFRACTION 2.6 Å
Organisms	Escherichia coli H489 Homo sapiens
Macromolecule	Epidermal growth factor receptor (protein) SHC Peptide substrate (protein)

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6DNA \| pdb_00006dna	Download File View File

Crystal structure of T110A mutant human Glutamate oxaloacetate transaminase 1 (GOT1)

Assar, Z., Holt, M.C., Stein, A.J., Lairson, L., Lyssiotis, C.A.

(2018) Biochemistry 57: 6604-6614

Released	2018-11-14
Method	X-RAY DIFFRACTION 3 Å
Organisms	Homo sapiens
Macromolecule	Aspartate aminotransferase, cytoplasmic (protein)
Unique Ligands	PG4, PLP

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6DNB \| pdb_00006dnb	Download File View File

Crystal structure of T110A:S256A mutant human Glutamate oxaloacetate transaminase 1 (GOT1)

Assar, Z., Holt, M.C., Stein, A.J., Lairson, L., Lyssiotis, C.A.

(2018) Biochemistry 57: 6604-6614

Released	2018-11-14
Method	X-RAY DIFFRACTION 1.7 Å
Organisms	Homo sapiens
Macromolecule	Aspartate aminotransferase, cytoplasmic (protein)
Unique Ligands	GOL, PG4, PO4

1 to 25 of 33 Structures

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Structure Determination Methodology

Scientific Name of Source Organism

Taxonomy

Experimental Method

Polymer Entity Type

Refinement Resolution (Å)

Release Date

Enzyme Classification Name

Membrane Protein Annotation

Symmetry Type

SCOP Classification

1D1Z | pdb_00001d1z

1D4T | pdb_00001d4t

1D4W | pdb_00001d4w

1I3Z | pdb_00001i3z

1PBW | pdb_00001pbw

1PWP | pdb_00001pwp

1PWQ | pdb_00001pwq

1PWU | pdb_00001pwu

1PWV | pdb_00001pwv

1PWW | pdb_00001pww

1QJA | pdb_00001qja

1QJB | pdb_00001qjb

1YRK | pdb_00001yrk

2P6B | pdb_00002p6b

3BJF | pdb_00003bjf

3BJT | pdb_00003bjt

3E4A | pdb_00003e4a

3INM | pdb_00003inm

3ME3 | pdb_00003me3

3U2Z | pdb_00003u2z

4G1N | pdb_00004g1n

5CZH | pdb_00005czh

5CZI | pdb_00005czi

6DNA | pdb_00006dna

6DNB | pdb_00006dnb