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234,136 Structures from the PDB

1,068,577 Computed Structure Models (CSM)

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QUERY: Structure Author = "Wu, P."

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Search Summary

This query matches 77 Structures.

Refinements

Structure Determination Methodology

experimental (77)

Scientific Name of Source Organism

	Homo sapiens (53)
	Acinetobacter baumannii (4)
	Escherichia coli (4)
	Mus musculus (4)
	unclassified Marinobacter (4)
	Staphylococcus aureus (3)
	synthetic construct (3)
	Mycobacterium tuberculosis (2)
	Bacteroides fragilis (1)
	Trypanosoma brucei (1)

Taxonomy

	Eukaryota (58)
	Bacteria (18)
	other sequences (3)

Experimental Method

	X-RAY DIFFRACTION (71)
	SOLUTION NMR (5)
	ELECTRON MICROSCOPY (1)

Polymer Entity Type

	Protein (74)
	RNA (5)

Refinement Resolution (Å)

	1.0 - 1.5 (4)
	1.5 - 2.0 (25)
	2.0 - 2.5 (29)
	2.5 - 3.0 (11)
	3.0 - 3.5 (2)
	4.0 - 4.5 (1)

Release Date

	2000 - 2004 (1)
	2005 - 2009 (7)
	2010 - 2014 (19)
	2015 - 2019 (21)
	2020 - 2024 (21)
	2025 - 2029 (8)

Enzyme Classification Name

	Transferases (39)
	Oxidoreductases (12)
	Hydrolases (10)

Symmetry Type

	Asymmetric (44)
	Cyclic (35)
	Dihedral (5)

SCOP Classification

	All beta proteins (14)
	Alpha and beta proteins (a+b) (25)
	Artifacts (7)
	All alpha proteins (3)
	Small proteins (1)

AllSelected

1 to 25 of 77 Structures

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1NGN \| pdb_00001ngn	Download File View File

Mismatch repair in methylated DNA. Structure of the mismatch-specific thymine glycosylase domain of methyl-CpG-binding protein MBD4

Wu, P., Qiu, C., Sohail, A., Zhang, X., Bhagwat, A.S., Cheng, X.

(2003) J Biological Chem 278: 5285-5291

Released	2003-03-18
Method	X-RAY DIFFRACTION 2.1 Å
Organisms	Mus musculus
Macromolecule	methyl-CpG binding protein MBD4 (protein)

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2AQ5 \| pdb_00002aq5	Download File View File

Crystal Structure of Murine Coronin-1

Appleton, B.A., Wu, P., Wiesmann, C.

(2006) Structure 14: 87-96

Released	2005-12-06
Method	X-RAY DIFFRACTION 1.75 Å
Organisms	Mus musculus
Macromolecule	Coronin-1A (protein)

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2B4E \| pdb_00002b4e	Download File View File

Crystal Structure of Murine Coronin-1: monoclinic form

Appleton, B.A., Wu, P., Wiesmann, C.

(2006) Structure 14: 87-96

Released	2005-12-06
Method	X-RAY DIFFRACTION 2.3 Å
Organisms	Mus musculus
Macromolecule	Coronin-1A (protein)

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2H2B \| pdb_00002h2b	Download File View File

Crystal Structure of ZO-1 PDZ1 Bound to a Phage-Derived Ligand (WRRTTYL)

Appleton, B.A., Zhang, Y., Wu, P., Yin, J.P., Hunziker, W., Skelton, N.J., Sidhu, S.S., Wiesmann, C.

(2006) J Biological Chem 281: 22312-22320

Released	2006-06-13
Method	X-RAY DIFFRACTION 1.6 Å
Organisms	Homo sapiens
Macromolecule	Tight junction protein ZO-1 (protein)
Unique Ligands	ACY

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2H2C \| pdb_00002h2c	Download File View File

Crystal Structure of ZO-1 PDZ1 Bound to a Phage-Derived Ligand (WRRTTWV)

Appleton, B.A., Zhang, Y., Wu, P., Yin, J.P., Hunziker, W., Skelton, N.J., Sidhu, S.S., Wiesmann, C.

(2006) J Biological Chem 281: 22312-22320

Released	2006-06-13
Method	X-RAY DIFFRACTION 2 Å
Organisms	Homo sapiens
Macromolecule	Tight junction protein ZO-1 (protein)

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2H3L \| pdb_00002h3l	Download File View File

Crystal Structure of ERBIN PDZ

Appleton, B.A., Zhang, Y., Wu, P., Yin, J.P., Hunziker, W., Skelton, N.J., Sidhu, S.S., Wiesmann, C.

(2006) J Biological Chem 281: 22312-22320

Released	2006-06-13
Method	X-RAY DIFFRACTION 1 Å
Organisms	Homo sapiens
Macromolecule	LAP2 protein (protein)

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2H3M \| pdb_00002h3m	Download File View File

Crystal Structure of ZO-1 PDZ1

Appleton, B.A., Zhang, Y., Wu, P., Yin, J.P., Hunziker, W., Skelton, N.J., Sidhu, S.S., Wiesmann, C.

(2006) J Biological Chem 281: 22312-22320

Released	2006-06-13
Method	X-RAY DIFFRACTION 2.9 Å
Organisms	Homo sapiens
Macromolecule	Tight junction protein ZO-1 (protein)
Unique Ligands	SO4

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2JOA \| pdb_00002joa	Download File View File

HtrA1 bound to an optimized peptide: NMR assignment of PDZ domain and ligand resonances

Runyon, S.T., Zhang, Y., Appleton, B.A., Sazinksy, S.L., Wu, P., Pan, B., Wiesmann, C., Skelton, N.J., Sidhu, S.S.

(2007) Protein Sci 16: 2454-2471

Released	2007-11-20
Method	SOLUTION NMR
Organisms	Homo sapiens synthetic construct
Macromolecule	Peptide H1-C1 (protein) Serine protease HTRA1 (protein)

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2LKZ \| pdb_00002lkz	Download File View File

Solution structure of the second RRM domain of RBM5

Song, Z., Wu, P., Zhang, J., Wu, J., Shi, Y.

(2012) Biochemistry

Released	2012-08-08
Method	SOLUTION NMR
Organisms	Homo sapiens
Macromolecule	RNA-binding protein 5 (protein)

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3HHI \| pdb_00003hhi	Download File View File

Crystal Structure of Cathepsin B from T. brucei in complex with CA074

Wu, P., Kerr, I.D., Brinen, L.S.

(2010) PLoS Negl Trop Dis 4: e701-e701

Released	2010-05-26
Method	X-RAY DIFFRACTION 1.6 Å
Organisms	Trypanosoma brucei
Macromolecule	Cathepsin B-like cysteine protease (protein)
Unique Ligands	074, GOL, LI, MG, TRS

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3R1G \| pdb_00003r1g	Download File View File

Structure Basis of Allosteric Inhibition of BACE1 by an Exosite-Binding Antibody

Wang, W., Rouge, L., Wu, P., Chiu, C., Chen, Y., Wu, Y., Watts, R.J.

(2011) Sci Transl Med 3: 84ra43-84ra43

Released	2011-06-08
Method	X-RAY DIFFRACTION 2.8 Å
Organisms	Homo sapiens
Macromolecule	Beta-secretase 1 (protein) FAB of YW412.8.31 antibody heavy chain (protein) FAB of YW412.8.31 antibody light chain (protein)

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3T6P \| pdb_00003t6p	Download File View File

IAP antagonist-induced conformational change in cIAP1 promotes E3 ligase activation via dimerization

Dueber, E.C., Schoeffler, A.J., Lingel, A., Elliott, M., Fedorova, A.V., Giannetti, A.M., Zobel, K., Maurer, B., Varfolomeev, E., Wu, P., Wallweber, H., Hymowitz, S., Deshayes, K., Vucic, D., Fairbrother, W.J.

(2011) Science 334: 376-380

Released	2011-11-02
Method	X-RAY DIFFRACTION 1.897 Å
Organisms	Homo sapiens
Macromolecule	Baculoviral IAP repeat-containing protein 2 (protein)
Unique Ligands	ZN

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4HLE \| pdb_00004hle	Download File View File

Compound 21 (1-alkyl-substituted 1,2,4-triazoles)

Murray, J.M., Rouge, L., Wu, P.

(2013) Bioorg Med Chem Lett 23: 897-901

Released	2013-01-09
Method	X-RAY DIFFRACTION 2.78 Å
Organisms	Homo sapiens
Macromolecule	Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit gamma isoform (protein)
Unique Ligands	17V

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4J6I \| pdb_00004j6i	Download File View File

Discovery of thiazolobenzoxepin PI3-kinase inhibitors that spare the PI3-kinase beta isoform

Murray, J.M., Rouge, L., Wu, P.

(2013) Bioorg Med Chem Lett 23: 2606-2613

Released	2013-08-28
Method	X-RAY DIFFRACTION 2.9 Å
Organisms	Homo sapiens
Macromolecule	Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit gamma isoform (protein)
Unique Ligands	1JV

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4L7G \| pdb_00004l7g	Download File View File

Diethylaminosulfur Trifluoride-Mediated Intramolecular Cyclization of 2-hydroxy-benzylureas to Fused Bicyclic Aminooxazoline Compounds and Evaluation of Their Biochemical Activity Against Beta-Secretase-1 (BACE1)

Huestis, M.P., Liu, W., Volgraf, M., Purkey, H., Wang, W., Yu, C., Wu, P., Smith, D., Vigers, G., Dutcher, D., Geck Do, M.K., Hunt, K.W., Siu, M.

(2013) Tetrahedron Lett

Released	2013-09-18
Method	X-RAY DIFFRACTION 1.38 Å
Organisms	Homo sapiens
Macromolecule	Beta-secretase 1 (protein)
Unique Ligands	1W0, DMS

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4L7H \| pdb_00004l7h	Download File View File

Diethylaminosulfur Trifluoride-Mediated Intramolecular Cyclization of 2-hydroxy-benzylureas to Fused Bicyclic Aminooxazoline Compounds and Evaluation of Their Biochemical Activity Against Beta-Secretase-1 (BACE-1)

Huestis, M.P., Liu, W., Volgraf, M., Purkey, H.E., Wang, W., Yu, C., Wu, P., Smith, D., Vigers, G., Dutcher, D., Geck Do, M.K., Hunt, K.W., Siu, M.

(2013) Tetrahedron Lett

Released	2013-09-18
Method	X-RAY DIFFRACTION 1.85 Å
Organisms	Homo sapiens
Macromolecule	Beta-secretase 1 (protein)
Unique Ligands	1W1, ACT, DMS

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4L7J \| pdb_00004l7j	Download File View File

Diethylaminosulfur Trifluoride-Mediated Intramolecular Cyclization of 2-hydroxy-benzylureas to Fused Bicyclic Aminooxazoline Compounds and Evaluation of Their Biochemical Activity Against Beta-Secretase-1 (BACE-1)

Huestis, M.P., Liu, W., Volgraf, M., Purkey, H.E., Wang, W., Yu, C., Wu, P., Smith, D., Vigers, G., Dutcher, D., Geck Do, M.K., Hunt, K.W., Siu, M.

(2013) Tetrahedron Lett

Released	2013-09-18
Method	X-RAY DIFFRACTION 1.651 Å
Organisms	Homo sapiens
Macromolecule	Beta-secretase 1 (protein)
Unique Ligands	1W2, ACT

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4OBO \| pdb_00004obo	Download File View File

MAP4K4 in complex with inhibitor (compound 22), 6-(3-CHLOROPHENYL)QUINAZOLIN-4-AMINE

Harris, S.F., Wu, P., Coons, M.

(2014) J Med Chem 57: 3484-3493

Released	2014-04-23
Method	X-RAY DIFFRACTION 2.1 Å
Organisms	Homo sapiens
Macromolecule	Mitogen-activated protein kinase kinase kinase kinase 4 (protein)
Unique Ligands	2QV, MES, NA

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4OBP \| pdb_00004obp	Download File View File

MAP4K4 in complex with inhibitor (compound 29), 6-(2-FLUOROPYRIDIN-4-YL)PYRIDO[3,2-D]PYRIMIDIN-4-AMINE

Harris, S.F., Wu, P.

(2014) J Med Chem 57: 3484-3493

Released	2014-04-23
Method	X-RAY DIFFRACTION 2.27 Å
Organisms	Homo sapiens
Macromolecule	Mitogen-activated protein kinase kinase kinase kinase 4 (protein)
Unique Ligands	2QU, MES, MG

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4OBQ \| pdb_00004obq	Download File View File

MAP4K4 in complex with inhibitor (compound 31), N-[3-(4-AMINOQUINAZOLIN-6-YL)-5-FLUOROPHENYL]-2-(PYRROLIDIN-1-YL)ACETAMIDE

Harris, S.F., Wu, P., Coons, M.

(2014) J Med Chem 57: 3484-3493

Released	2014-04-23
Method	X-RAY DIFFRACTION 2.19 Å
Organisms	Homo sapiens
Macromolecule	Mitogen-activated protein kinase kinase kinase kinase 4 (protein)
Unique Ligands	2QT, MES, MG