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234,136 Structures from the PDB

1,068,577 Computed Structure Models (CSM)

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QUERY: Structure Author = "Tittmann, K."

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Search Summary

This query matches 105 Structures.

Refinements

Structure Determination Methodology

experimental (105)

Scientific Name of Source Organism

	Homo sapiens (47)
	Thermoplasma acidophilum DSM 1728 (12)
	Neisseria gonorrhoeae (7)
	Escherichia coli K-12 (6)
	Lactiplantibacillus plantarum (6)
	Escherichia coli (5)
	Neisseria gonorrhoeae FA 1090 (4)
	synthetic construct (4)
	Janthinobacterium sp. HH01 (3)
	Lactiplantibacillus plantarum JDM1 (3)

More...

Taxonomy

	Eukaryota (52)
	Bacteria (38)
	Archaea (12)
	other sequences (4)
	Riboviria (3)

Experimental Method

	X-RAY DIFFRACTION (101)
	ELECTRON MICROSCOPY (4)

Polymer Entity Type

Protein (105)

Refinement Resolution (Å)

	0.5 - 1.0 (10)
	1.0 - 1.5 (38)
	1.5 - 2.0 (31)
	2.0 - 2.5 (16)
	2.5 - 3.0 (7)
	> 4.5 (3)

Release Date

	2005 - 2009 (11)
	2010 - 2014 (16)
	2015 - 2019 (20)
	2020 - 2024 (58)

Enzyme Classification Name

	Hydrolases (17)
	Transferases (75)
	Lyases (28)
	Oxidoreductases (16)

Symmetry Type

	Cyclic (59)
	Dihedral (31)
	Asymmetric (14)
	Icosahedral (1)

SCOP Classification

	Alpha and beta proteins (a/b) (34)
	Alpha and beta proteins (a+b) (6)
	Artifacts (10)

AllSelected

1 to 25 of 105 Structures

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2EZ4 \| pdb_00002ez4	Download File View File

Pyruvate oxidase variant F479W

Wille, G., Meyer, D., Steinmetz, A., Hinze, E., Golbik, R., Tittmann, K.

(2006) Nat Chem Biol 2: 324-328

Released	2006-04-25
Method	X-RAY DIFFRACTION 2.03 Å
Organisms	Lactiplantibacillus plantarum
Macromolecule	Pyruvate oxidase (protein)
Unique Ligands	FAD, MG, NA, PO4, TPP

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2EZ8 \| pdb_00002ez8	Download File View File

Pyruvate oxidase variant F479W in complex with reaction intermediate 2-lactyl-thiamin diphosphate

Wille, G., Meyer, D., Steinmetz, A., Hinze, E., Golbik, R., Tittmann, K.

(2006) Nat Chem Biol 2: 324-328

Released	2006-04-25
Method	X-RAY DIFFRACTION 1.963 Å
Organisms	Lactiplantibacillus plantarum
Macromolecule	Pyruvate oxidase (protein)
Unique Ligands	FAD, MG, NA, PYR, TDL

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2EZ9 \| pdb_00002ez9	Download File View File

Pyruvate oxidase variant F479W in complex with reaction intermediate analogue 2-phosphonolactyl-thiamin diphosphate

Wille, G., Meyer, D., Steinmetz, A., Hinze, E., Golbik, R., Tittmann, K.

(2006) Nat Chem Biol 2: 324-328

Released	2006-04-25
Method	X-RAY DIFFRACTION 1.6 Å
Organisms	Lactiplantibacillus plantarum
Macromolecule	Pyruvate oxidase (protein)
Unique Ligands	FAD, MG, NA, TDK

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2EZT \| pdb_00002ezt	Download File View File

Pyruvate oxidase variant F479W in complex with reaction intermediate 2-hydroxyethyl-thiamin diphosphate

Wille, G., Meyer, D., Steinmetz, A., Hinze, E., Golbik, R., Tittmann, K.

(2006) Nat Chem Biol 2: 324-328

Released	2006-04-25
Method	X-RAY DIFFRACTION 2.29 Å
Organisms	Lactiplantibacillus plantarum
Macromolecule	Pyruvate oxidase (protein)
Unique Ligands	FAD, MG, NA, PO4, PYR, TDM

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2EZU \| pdb_00002ezu	Download File View File

Pyruvate oxidase variant F479W in complex with reaction intermediate 2-acetyl-thiamin diphosphate

Wille, G., Meyer, D., Steinmetz, A., Hinze, E., Golbik, R., Tittmann, K.

(2006) Nat Chem Biol 2: 324-328

Released	2006-04-25
Method	X-RAY DIFFRACTION 2.16 Å
Organisms	Lactiplantibacillus plantarum
Macromolecule	Pyruvate oxidase (protein)
Unique Ligands	FAD, HTL, MG, NA, PYR

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2R5N \| pdb_00002r5n	Download File View File

Crystal structure of transketolase from Escherichia coli in noncovalent complex with acceptor aldose ribose 5-phosphate

Parthier, C., Asztalos, P., Wille, G., Tittmann, K.

(2007) Biochemistry 46: 12037-12052

Released	2007-11-06
Method	X-RAY DIFFRACTION 1.6 Å
Organisms	Escherichia coli
Macromolecule	Transketolase 1 (protein)
Unique Ligands	CA, EDO, R5P, RP5, TPP

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2R8O \| pdb_00002r8o	Download File View File

Transketolase from E. coli in complex with substrate D-xylulose-5-phosphate

Wille, G., Asztalos, P., Weiss, M.S., Tittmann, K.

(2007) Biochemistry 46: 12037-12052

Released	2007-12-11
Method	X-RAY DIFFRACTION 1.47 Å
Organisms	Escherichia coli K-12
Macromolecule	Transketolase 1 (protein)
Unique Ligands	CA, EDO, T5X

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2R8P \| pdb_00002r8p	Download File View File

Transketolase from E. coli in complex with substrate D-fructose-6-phosphate

Wille, G., Asztalos, P., Weiss, M.S., Tittmann, K.

(2007) Biochemistry 46: 12037-12052

Released	2007-12-11
Method	X-RAY DIFFRACTION 1.65 Å
Organisms	Escherichia coli K-12
Macromolecule	Transketolase 1 (protein)
Unique Ligands	CA, EDO, T6F

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3EY9 \| pdb_00003ey9	Download File View File

Structural basis for membrane binding and catalytic activation of the peripheral membrane enzyme pyruvate oxidase from Escherichia coli

Neumann, P., Weidner, A., Pech, A., Stubbs, M.T., Tittmann, K.

(2008) Proc Natl Acad Sci U S A 105: 17390-17395

Released	2008-11-04
Method	X-RAY DIFFRACTION 2.9 Å
Organisms	Escherichia coli
Macromolecule	Pyruvate dehydrogenase [cytochrome] (protein)
Unique Ligands	FAD, MG, SO4, TPP

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3EYA \| pdb_00003eya	Download File View File

Structural basis for membrane binding and catalytic activation of the peripheral membrane enzyme pyruvate oxidase from Escherichia coli

Neumann, P., Weidner, A., Pech, A., Stubbs, M.T., Tittmann, K.

(2008) Proc Natl Acad Sci U S A 105: 17390-17395

Released	2008-11-04
Method	X-RAY DIFFRACTION 2.5 Å
Organisms	Escherichia coli
Macromolecule	Pyruvate dehydrogenase [cytochrome] (protein)
Unique Ligands	FAD, MG, PO4, TPP

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3FZN \| pdb_00003fzn	Download File View File

Intermediate analogue in benzoylformate decarboxylase

Bruning, M., Berheide, M., Meyer, D., Golbik, R., Bartunik, H., Liese, A., Tittmann, K.

(2009) Biochemistry 48: 3258-3268

Released	2009-05-05
Method	X-RAY DIFFRACTION 1.62 Å
Organisms	Pseudomonas putida
Macromolecule	Benzoylformate decarboxylase (protein)
Unique Ligands	CL, D7K, MG, PEG, PO4

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3MOS \| pdb_00003mos	Download File View File

The structure of human Transketolase

Parthier, C., Tittmann, K.

(2010) J Biological Chem 285: 31559-31570

Released	2010-07-28
Method	X-RAY DIFFRACTION 1.75 Å
Organisms	Homo sapiens
Macromolecule	Transketolase (protein)
Unique Ligands	CA, EDO, NA, TPP

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3OE1 \| pdb_00003oe1	Download File View File

Pyruvate decarboxylase variant Glu473Asp from Z. mobilis in complex with reaction intermediate 2-lactyl-ThDP

Meyer, D., Neumann, P., Parthier, C., Tittmann, K.

(2010) Biochemistry 49: 8197-8212

Released	2010-09-08
Method	X-RAY DIFFRACTION 1.985 Å
Organisms	Zymomonas mobilis
Macromolecule	Pyruvate decarboxylase (protein)
Unique Ligands	GOL, MG, TDL

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3S0C \| pdb_00003s0c	Download File View File

Transaldolase wt of Thermoplasma acidophilum

Lehwess-Litzmann, A., Neumann, P., Parthier, C., Tittmann, K.

(2011) Nat Chem Biol 7: 678-684

Released	2011-08-24
Method	X-RAY DIFFRACTION 1.78 Å
Organisms	Thermoplasma acidophilum DSM 1728
Macromolecule	Probable transaldolase (protein)
Unique Ligands	GOL

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3S1U \| pdb_00003s1u	Download File View File

Transaldolase from Thermoplasma acidophilum in complex with D-erythrose 4-phosphate

Lehwess-Litzmann, A., Neumann, P., Parthier, C., Tittmann, K.

(2011) Nat Chem Biol 7: 678-684

Released	2011-08-24
Method	X-RAY DIFFRACTION 1.9 Å
Organisms	Thermoplasma acidophilum DSM 1728
Macromolecule	Probable transaldolase (protein)
Unique Ligands	CL, E4P

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3S1V \| pdb_00003s1v	Download File View File

Transaldolase from Thermoplasma acidophilum in complex with D-fructose 6-phosphate Schiff-base intermediate

Lehwess-Litzmann, A., Neumann, P., Parthier, C., Tittmann, K.

(2011) Nat Chem Biol 7: 678-684

Released	2011-08-24
Method	X-RAY DIFFRACTION 1.8 Å
Organisms	Thermoplasma acidophilum DSM 1728
Macromolecule	Probable transaldolase (protein)
Unique Ligands	F6R, GOL

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3S1W \| pdb_00003s1w	Download File View File

Transaldolase variant Lys86Ala from Thermoplasma acidophilum in complex with glycerol and citrate

Lehwess-Litzmann, A., Neumann, P., Parthier, C., Tittmann, K.

(2011) Nat Chem Biol 7: 678-684

Released	2011-08-24
Method	X-RAY DIFFRACTION 1.8 Å
Organisms	Thermoplasma acidophilum DSM 1728
Macromolecule	Probable transaldolase (protein)
Unique Ligands	FLC, GOL

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3S1X \| pdb_00003s1x	Download File View File

Transaldolase from Thermoplasma acidophilum in complex with D-sedoheptulose 7-phosphate Schiff-base intermediate

Lehwess-Litzmann, A., Neumann, P., Parthier, C., Tittmann, K.

(2011) Nat Chem Biol 7: 678-684

Released	2011-08-24
Method	X-RAY DIFFRACTION 1.65 Å
Organisms	Thermoplasma acidophilum DSM 1728
Macromolecule	Probable transaldolase (protein)
Unique Ligands	I22

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4FEE \| pdb_00004fee	Download File View File

High-resolution structure of pyruvate oxidase in complex with reaction intermediate 2-hydroxyethyl-thiamin diphosphate carbanion-enamine, crystal B

Meyer, D., Neumann, P., Koers, E., Sjuts, H., Luedtke, S., Sheldrick, G.M., Ficner, R., Tittmann, K.

(2012) Proc Natl Acad Sci U S A 109: 10867-10872

Released	2012-06-20
Method	X-RAY DIFFRACTION 1.13 Å
Organisms	Lactiplantibacillus plantarum JDM1
Macromolecule	Pyruvate oxidase (protein)
Unique Ligands	FAD, GOL, MG, PO4, PYR, TDM

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4FEG \| pdb_00004feg	Download File View File

High-resolution structure of pyruvate oxidase in complex with reaction intermediate 2-hydroxyethyl-thiamin diphosphate carbanion-enamine, crystal A

Meyer, D., Neumann, P., Koers, E., Sjuts, H., Luedtke, S., Sheldrick, G.M., Ficner, R., Tittmann, K.

(2012) Proc Natl Acad Sci U S A 109: 10867-10872

Released	2012-06-20
Method	X-RAY DIFFRACTION 1.09 Å
Organisms	Lactiplantibacillus plantarum JDM1
Macromolecule	Pyruvate oxidase (protein)
Unique Ligands	FAD, GOL, MG, PO4, PYR, TDM

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4JQ9 \| pdb_00004jq9	Download File View File

Dihydrolipoyl dehydrogenase of Escherichia coli pyruvate dehydrogenase complex

Tietzel, M., Neumann, P., Meyer, D., Ficner, R., Tittmann, K.

To be published

Released	2014-04-02
Method	X-RAY DIFFRACTION 2.17 Å
Organisms	Escherichia coli
Macromolecule	Dihydrolipoyl dehydrogenase (protein)
Unique Ligands	CL, FAD, GOL, IMD, SO4

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4KGD \| pdb_00004kgd	Download File View File

High-resolution crystal structure of pyruvate oxidase from L. plantarum in complex with phosphate

Neumann, P., Tittmann, K.

(2013) Nat Chem Biol 9: 488-490

Released	2013-06-12
Method	X-RAY DIFFRACTION 1.06 Å
Organisms	Lactiplantibacillus plantarum JDM1
Macromolecule	Pyruvate oxidase (protein)
Unique Ligands	FAD, GOL, K, MG, PO4, TPP