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234,136 Structures from the PDB

1,068,577 Computed Structure Models (CSM)

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QUERY: Structure Author = "Sicheri, F."

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Search Summary

This query matches 145 Structures.

Refinements

Structure Determination Methodology

experimental (145)

Scientific Name of Source Organism

	Homo sapiens (104)
	Saccharomyces cerevisiae (14)
	synthetic construct (9)
	Mus musculus (8)
	Methanocaldococcus jannaschii (6)
	Drosophila melanogaster (4)
	Pyrococcus furiosus DSM 3638 (3)
	Saccharomyces cerevisiae S288C (3)
	Sus scrofa (3)
	Pseudopleuronectes americanus (2)

More...

Taxonomy

	Eukaryota (136)
	other sequences (9)
	Archaea (7)
	Bacteria (3)
	Varidnaviria (1)

Experimental Method

	X-RAY DIFFRACTION (135)
	ELECTRON MICROSCOPY (7)
	SOLUTION NMR (3)

Polymer Entity Type

	Protein (144)
	RNA (5)
	DNA (3)

Refinement Resolution (Å)

	1.0 - 1.5 (4)
	1.5 - 2.0 (28)
	2.0 - 2.5 (43)
	2.5 - 3.0 (35)
	3.0 - 3.5 (24)
	3.5 - 4.0 (5)
	4.0 - 4.5 (1)
	> 4.5 (2)

Release Date

	1995 - 1999 (7)
	2000 - 2004 (5)
	2005 - 2009 (23)
	2010 - 2014 (34)
	2015 - 2019 (28)
	2020 - 2024 (48)

Enzyme Classification Name

	Transferases (79)
	Hydrolases (22)
	Ligases (10)
	Oxidoreductases (3)
	Isomerases (1)

Membrane Protein Annotation

OPM (2)

Symmetry Type

	Asymmetric (106)
	Cyclic (43)
	Dihedral (2)

SCOP Classification

	Alpha and beta proteins (a+b) (49)
	Artifacts (28)
	All alpha proteins (15)
	All beta proteins (10)
	Peptides (2)
	Alpha and beta proteins (a/b) (2)
	Small proteins (1)

AllSelected

1 to 25 of 145 Structures

Page 1 of 6

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1AD5 \| pdb_00001ad5	Download File View File

SRC FAMILY KINASE HCK-AMP-PNP COMPLEX

Sicheri, F., Moarefi, I., Kuriyan, J.

(1997) Nature 385: 602-609

Released	1997-05-15
Method	X-RAY DIFFRACTION 2.6 Å
Organisms	Homo sapiens
Macromolecule	HAEMATOPOETIC CELL KINASE HCK (protein)
Unique Ligands	ANP, CA

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1B0X \| pdb_00001b0x	Download File View File

THE CRYSTAL STRUCTURE OF AN EPH RECEPTOR SAM DOMAIN REVEALS A MECHANISM FOR MODULAR DIMERIZATION.

Stapleton, D., Balan, I., Pawson, T., Sicheri, F.

(1999) Nat Struct Biol 6: 44-49

Released	1999-05-03
Method	X-RAY DIFFRACTION 2 Å
Organisms	Mus musculus
Macromolecule	PROTEIN (EPHA4 RECEPTOR TYROSINE KINASE) (protein)

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1JPA \| pdb_00001jpa	Download File View File

Crystal Structure of unphosphorylated EphB2 receptor tyrosine kinase and juxtamembrane region

Wybenga-Groot, L.E., Pawson, T., Sicheri, F.

(2001) Cell 106: 745-757

Released	2001-10-03
Method	X-RAY DIFFRACTION 1.91 Å
Organisms	Mus musculus
Macromolecule	neural kinase, Nuk=Eph/Elk/Eck family receptor-like tyrosine kinase (protein)
Unique Ligands	ANP

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1LUZ \| pdb_00001luz	Download File View File

Crystal Structure of the K3L Protein From Vaccinia Virus (Wisconsin Strain)

Dar, A.C., Sicheri, F.

(2002) Mol Cell 10: 295-305

Released	2002-08-28
Method	X-RAY DIFFRACTION 1.8 Å
Organisms	Vaccinia virus WR
Macromolecule	Protein K3 (protein)

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1MBY \| pdb_00001mby	Download File View File

Murine Sak Polo Domain

Leung, G.C., Hudson, J.W., Kozarova, A., Davidson, A., Dennis, J.W., Sicheri, F.

(2002) Nat Struct Biol 9: 719-724

Released	2002-10-30
Method	X-RAY DIFFRACTION 2 Å
Organisms	Mus musculus
Macromolecule	serine/threonine kinase (protein)

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1NEX \| pdb_00001nex	Download File View File

Crystal Structure of ScSkp1-ScCdc4-CPD peptide complex

Orlicky, S., Tang, X., Willems, A., Tyers, M., Sicheri, F.

(2003) Cell 112: 243-256

Released	2003-02-18
Method	X-RAY DIFFRACTION 2.7 Å
Organisms	Saccharomyces cerevisiae
Macromolecule	CDC4 protein (protein) Centromere DNA-binding protein complex CBF3 subunit D (protein) GLL(TPO)PPQSG (protein)

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1OPS \| pdb_00001ops	Download File View File

ICE-BINDING SURFACE ON A TYPE III ANTIFREEZE PROTEIN FROM OCEAN POUT

Yang, D.S.C., Hon, W.-C., Bubanko, S., Xue, Y., Seetharaman, J., Hew, C.L., Sicheri, F.

(1998) Biophys J 74: 2142-2151

Released	1998-05-20
Method	X-RAY DIFFRACTION 2 Å
Organisms	Zoarces americanus
Macromolecule	TYPE III ANTIFREEZE PROTEIN (protein)

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1Q8H \| pdb_00001q8h	Download File View File

Crystal structure of porcine osteocalcin

Hoang, Q.Q., Sicheri, F., Howard, A.J., Yang, D.S.

(2003) Nature 425: 977-980

Released	2003-11-11
Method	X-RAY DIFFRACTION 2 Å
Organisms	Sus scrofa
Macromolecule	Osteocalcin (protein)
Unique Ligands	CA

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1QCF \| pdb_00001qcf	Download File View File

CRYSTAL STRUCTURE OF HCK IN COMPLEX WITH A SRC FAMILY-SELECTIVE TYROSINE KINASE INHIBITOR

Schindler, T., Sicheri, F., Pico, A., Gazit, A., Levitzki, A., Kuriyan, J.

(1999) Mol Cell 3: 639-648

Released	1999-06-08
Method	X-RAY DIFFRACTION 2 Å
Organisms	Homo sapiens
Macromolecule	Tyrosine-protein kinase HCK (protein)
Unique Ligands	PP1

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1WFA \| pdb_00001wfa	Download File View File

WINTER FLOUNDER ANTIFREEZE PROTEIN ISOFORM HPLC6 AT 4 DEGREES C

Yang, D.S.C., Sicheri, F.

(1995) Nature 375: 427-431

Released	1995-06-03
Method	X-RAY DIFFRACTION 1.7 Å
Organisms	Pseudopleuronectes americanus
Macromolecule	ANTIFREEZE PROTEIN ISOFORM HPLC6 (protein)

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1WFB \| pdb_00001wfb	Download File View File

WINTER FLOUNDER ANTIFREEZE PROTEIN ISOFORM HPLC6 AT-180 DEGREES C

Yang, D.S.C., Sicheri, F.

(1995) Nature 375: 427-431

Released	1995-06-03
Method	X-RAY DIFFRACTION 1.5 Å
Organisms	Pseudopleuronectes americanus
Macromolecule	ANTIFREEZE PROTEIN ISOFORM HPLC6 (protein)

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1ZVD \| pdb_00001zvd	Download File View File

Regulation of Smurf2 Ubiquitin Ligase Activity by Anchoring the E2 to the HECT domain

Ogunjimi, A.A., Briant, D.J., Pece-Barbara, N., Le Roy, C., Di Guglielmo, G.M., Kavsak, P., Rasmussen, R.K., Seet, B.T., Sicheri, F., Wrana, J.L.

(2005) Mol Cell 19: 297-308

Released	2005-08-09
Method	X-RAY DIFFRACTION 2.1 Å
Organisms	Homo sapiens
Macromolecule	Smad ubiquitination regulatory factor 2 (protein)
Unique Ligands	NA, PO4

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2A19 \| pdb_00002a19	Download File View File

PKR kinase domain- eIF2alpha- AMP-PNP complex.

Dar, A.C., Dever, T.E., Sicheri, F.

(2005) Cell 122: 887-900

Released	2005-09-27
Method	X-RAY DIFFRACTION 2.5 Å
Organisms	Homo sapiens Saccharomyces cerevisiae
Macromolecule	Eukaryotic translation initiation factor 2 alpha subunit (protein) Interferon-induced, double-stranded RNA-activated protein kinase (protein)
Unique Ligands	ANP, MG, PO4

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2A1A \| pdb_00002a1a	Download File View File

PKR kinase domain-eIF2alpha Complex

Dar, A.C., Dever, T.E., Sicheri, F.

(2005) Cell 122: 887-900

Released	2005-09-27
Method	X-RAY DIFFRACTION 2.8 Å
Organisms	Homo sapiens Saccharomyces cerevisiae
Macromolecule	Eukaryotic translation initiation factor 2 alpha subunit (protein) Interferon-induced, double-stranded RNA-activated protein kinase (protein)

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2D3D \| pdb_00002d3d	Download File View File

crystal structure of the RNA binding SAM domain of saccharomyces cerevisiae Vts1

Aviv, T., Amborski, A.N., Zhao, X.S., Kwan, J.J., Johnson, P.E., Sicheri, F., Donaldson, L.W.

(2006) J Mol Biology 356: 274-279

Released	2006-02-14
Method	X-RAY DIFFRACTION 1.6 Å
Organisms	Saccharomyces cerevisiae
Macromolecule	Vts1 protein (protein)
Unique Ligands	CA

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2F8K \| pdb_00002f8k	Download File View File

Sequence specific recognition of RNA hairpins by the SAM domain of Vts1

Aviv, T., Lin, Z., Ben-Ari, G., Smibert, C.A., Sicheri, F.

(2006) Nat Struct Mol Biol 13: 168-176

Released	2006-01-24
Method	X-RAY DIFFRACTION 2 Å
Organisms	Saccharomyces cerevisiae
Macromolecule	Protein VTS1 (protein) 5'-R(UPAPAPUPCPUPUPUPGPAPCPAPGPAPUPU)-3' (nucleic acid)

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2HCK \| pdb_00002hck	Download File View File

SRC FAMILY KINASE HCK-QUERCETIN COMPLEX

Sicheri, F., Moarefi, I., Kuriyan, J.

(1997) Nature 385: 602-609

Released	1997-08-20
Method	X-RAY DIFFRACTION 3 Å
Organisms	Homo sapiens
Macromolecule	HEMATOPOETIC CELL KINASE HCK (protein)
Unique Ligands	CA, QUE

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2HEL \| pdb_00002hel	Download File View File

Crystal structure of a mutant EphA4 kinase domain (Y742A)

Wybenga-Groot, L.E., Sicheri, F., Pawson, T.

(2006) EMBO J 25: 4686-4696

Released	2007-02-13
Method	X-RAY DIFFRACTION 2.35 Å
Organisms	Mus musculus
Macromolecule	Eph receptor A4 (protein)

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2HEN \| pdb_00002hen	Download File View File

Crystal Structure of the EphB2 Receptor Kinase domain in complex with ADP

Wybenga-Groot, L.E., Sicheri, F., Pawson, T.

(2006) EMBO J 25: 4686-4696

Released	2007-02-13
Method	X-RAY DIFFRACTION 2.6 Å
Organisms	Mus musculus
Macromolecule	Ephrin type-B receptor 2 (protein)
Unique Ligands	ADP, MG

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2HJN \| pdb_00002hjn	Download File View File

Structural and functional analysis of Saccharomyces cerevisiae Mob1

Mrkobrada, S., Ceccarelli, D.F., Sicheri, F.

(2006) J Mol Biology 362: 430-440

Released	2006-09-26
Method	X-RAY DIFFRACTION 2 Å
Organisms	Saccharomyces cerevisiae
Macromolecule	Maintenance of ploidy protein MOB1 (protein)
Unique Ligands	SO4, ZN